JP2020503870A5 - - Google Patents
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- JP2020503870A5 JP2020503870A5 JP2019536936A JP2019536936A JP2020503870A5 JP 2020503870 A5 JP2020503870 A5 JP 2020503870A5 JP 2019536936 A JP2019536936 A JP 2019536936A JP 2019536936 A JP2019536936 A JP 2019536936A JP 2020503870 A5 JP2020503870 A5 JP 2020503870A5
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- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 25
- 239000011230 binding agent Substances 0.000 claims 14
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 8
- 102000048362 human PDCD1 Human genes 0.000 claims 8
- 229940127121 immunoconjugate Drugs 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 241000283984 Rodentia Species 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000009261 transgenic effect Effects 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 2
- 238000002619 cancer immunotherapy Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 241000699660 Mus musculus Species 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
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- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
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- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 101150117115 V gene Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004404 adrenal cortex Anatomy 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000003101 oviduct Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 238000011830 transgenic mouse model Methods 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
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- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022177574A JP2023010753A (ja) | 2017-01-06 | 2022-11-04 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1700207.2 | 2017-01-06 | ||
| GB1700210.6 | 2017-01-06 | ||
| GBGB1700210.6A GB201700210D0 (en) | 2017-01-06 | 2017-01-06 | Single domain antibodies to programmed cell death (PD-1) |
| GBGB1700207.2A GB201700207D0 (en) | 2017-01-06 | 2017-01-06 | Single domain antibodies to prgrammed cell death (PD-1) |
| GB1700208.0 | 2017-01-06 | ||
| GBGB1700208.0A GB201700208D0 (en) | 2017-01-06 | 2017-01-06 | Single domain antibodies to programmed cell death (PD-1) |
| PCT/GB2018/050036 WO2018127710A1 (en) | 2017-01-06 | 2018-01-08 | Single domain antibodies to programmed cell death (pd-1) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022177574A Division JP2023010753A (ja) | 2017-01-06 | 2022-11-04 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503870A JP2020503870A (ja) | 2020-02-06 |
| JP2020503870A5 true JP2020503870A5 (https=) | 2021-08-12 |
| JP7267921B2 JP7267921B2 (ja) | 2023-05-02 |
Family
ID=60953895
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536937A Active JP7183163B2 (ja) | 2017-01-06 | 2018-01-08 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| JP2019536936A Active JP7267921B2 (ja) | 2017-01-06 | 2018-01-08 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| JP2022158582A Active JP7525567B2 (ja) | 2017-01-06 | 2022-09-30 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| JP2022177574A Pending JP2023010753A (ja) | 2017-01-06 | 2022-11-04 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536937A Active JP7183163B2 (ja) | 2017-01-06 | 2018-01-08 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022158582A Active JP7525567B2 (ja) | 2017-01-06 | 2022-09-30 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| JP2022177574A Pending JP2023010753A (ja) | 2017-01-06 | 2022-11-04 | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US11312771B2 (https=) |
| EP (3) | EP3565842A1 (https=) |
| JP (4) | JP7183163B2 (https=) |
| CN (2) | CN110167966B (https=) |
| WO (3) | WO2018127709A1 (https=) |
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| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| JP7183163B2 (ja) * | 2017-01-06 | 2022-12-05 | クレシェンド・バイオロジックス・リミテッド | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| WO2019092452A1 (en) | 2017-11-13 | 2019-05-16 | Crescendo Biologics Limited | Molecules that bind to cd137 and psma |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| WO2020077257A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
| WO2020098785A1 (zh) * | 2018-11-16 | 2020-05-22 | 南京金斯瑞生物科技有限公司 | 人源化抗人pd-l1单克隆抗体及其制备方法和用途 |
| CN114144433A (zh) * | 2019-03-22 | 2022-03-04 | 反射制药有限公司 | 用于目标蛋白的多价d-肽化合物 |
| CN110003336B (zh) * | 2019-04-12 | 2023-05-12 | 深圳普瑞金生物药业股份有限公司 | Pd-1单域抗体、核苷酸序列及试剂盒 |
| WO2020216348A1 (en) * | 2019-04-26 | 2020-10-29 | Wuxi Biologics (Shanghai) Co., Ltd. | Bispecific antibodies against pd-1 and lag-3 |
| EP3733708A1 (en) * | 2019-05-02 | 2020-11-04 | Randox Laboratories Ltd | Immune checkpoint molecule inhibitor |
| CN113840835B (zh) * | 2019-05-15 | 2024-06-25 | 克雷森多生物制剂有限公司 | 结合分子 |
| TW202124437A (zh) * | 2019-08-19 | 2021-07-01 | 美商潘迪恩營運公司 | 以ｐｄ－１促效劑進行之標靶免疫耐受性 |
| CN112409483B (zh) * | 2019-08-22 | 2024-08-27 | 浙江道尔生物科技有限公司 | 抗pd-l1纳米抗体 |
| CN114430746B (zh) | 2019-09-25 | 2023-09-01 | 上海药明生物技术有限公司 | 新型抗pd-l1抗体 |
| CN110950956B (zh) * | 2019-12-12 | 2022-03-08 | 源道隆（苏州）医学科技有限公司 | 可结合pd1的多肽及其应用 |
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| BR112022023989A2 (pt) | 2020-05-26 | 2023-02-07 | Boehringer Ingelheim Int | Anticorpos anti-pd-1 |
| WO2022068919A1 (zh) * | 2020-09-30 | 2022-04-07 | 正大天晴康方(上海)生物医药科技有限公司 | 结合pd-1抗体的肽及其应用 |
| CN118240082A (zh) * | 2020-12-28 | 2024-06-25 | 浙江纳米抗体技术中心有限公司 | Pd-1结合分子及其应用 |
| US20240101673A1 (en) | 2021-02-03 | 2024-03-28 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| US11993654B2 (en) * | 2021-03-31 | 2024-05-28 | Merus N.V. | PD-1 binding domains |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| GB202205589D0 (en) * | 2022-04-14 | 2022-06-01 | Crescendo Biologics Ltd | Mesothelin binders |
| CN117866905B (zh) * | 2024-03-12 | 2024-06-04 | 北京贝来药业有限公司 | 基于纳米抗体基因修饰的干细胞及其制备方法和产品 |
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| WO2017060144A1 (en) | 2015-10-07 | 2017-04-13 | F. Hoffmann-La Roche Ag | Bispecific antibodies with tetravalency for a costimulatory tnf receptor |
| MA43260A (fr) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Liants pd1 et/ou lag3 |
| KR20180096789A (ko) | 2016-01-11 | 2018-08-29 | 인히브릭스, 인크. | 다가 및 다중특이적 41bb-결합 융합 단백질 |
| WO2017122019A1 (en) | 2016-01-12 | 2017-07-20 | Crescendo Biologics Limited | Immunoconjugates that bind prostate specific membrane antigen (psma) |
| GB201607968D0 (en) | 2016-05-06 | 2016-06-22 | Crescendo Biolog Ltd | Chimeric antigen receptor |
| JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス，インク． | 単一ドメイン血清アルブミン結合タンパク質 |
| RU2022101604A (ru) | 2016-12-07 | 2022-03-29 | Аблинкс Нв | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| JP7183163B2 (ja) | 2017-01-06 | 2022-12-05 | クレシェンド・バイオロジックス・リミテッド | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| EP3579879A4 (en) | 2017-02-09 | 2020-12-16 | Memorial Sloan Kettering Cancer Center | ANTI-BODY ANTI-KIR3DL1 |
| WO2018224439A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-hsa antibodies |
| EP3425763B1 (en) | 2017-07-03 | 2020-11-18 | France Brevets | Coupling interface and method of operation |
| EA202090005A1 (ru) | 2017-07-06 | 2020-06-18 | Мерус Н.В. | Антитела, модулирующие биологическую активность, проявляемую клеткой |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| EP3470426A1 (en) | 2017-10-10 | 2019-04-17 | Numab Therapeutics AG | Multispecific antibody |
| WO2019092452A1 (en) | 2017-11-13 | 2019-05-16 | Crescendo Biologics Limited | Molecules that bind to cd137 and psma |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| GB201818460D0 (en) | 2018-11-13 | 2018-12-26 | Crescendo Biologics Ltd | Single domain antibodies that bind human serum albumin |
| CN113840835B (zh) | 2019-05-15 | 2024-06-25 | 克雷森多生物制剂有限公司 | 结合分子 |
-
2018
- 2018-01-08 JP JP2019536937A patent/JP7183163B2/ja active Active
- 2018-01-08 US US16/475,599 patent/US11312771B2/en active Active
- 2018-01-08 CN CN201880006096.9A patent/CN110167966B/zh not_active Expired - Fee Related
- 2018-01-08 US US16/475,590 patent/US11814429B2/en active Active
- 2018-01-08 EP EP18700245.6A patent/EP3565842A1/en not_active Withdrawn
- 2018-01-08 US US16/475,597 patent/US11591398B2/en active Active
- 2018-01-08 WO PCT/GB2018/050035 patent/WO2018127709A1/en not_active Ceased
- 2018-01-08 WO PCT/GB2018/050036 patent/WO2018127710A1/en not_active Ceased
- 2018-01-08 EP EP18700244.9A patent/EP3565841A1/en not_active Withdrawn
- 2018-01-08 CN CN201880005715.2A patent/CN110121510B/zh active Active
- 2018-01-08 WO PCT/GB2018/050037 patent/WO2018127711A1/en not_active Ceased
- 2018-01-08 EP EP18700243.1A patent/EP3565840A1/en not_active Withdrawn
- 2018-01-08 JP JP2019536936A patent/JP7267921B2/ja active Active
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2022
- 2022-03-29 US US17/706,839 patent/US20220306744A1/en not_active Abandoned
- 2022-09-30 JP JP2022158582A patent/JP7525567B2/ja active Active
- 2022-11-04 JP JP2022177574A patent/JP2023010753A/ja active Pending
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2023
- 2023-02-10 US US18/167,318 patent/US20230357405A1/en not_active Abandoned
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