JP2021513848A5 - - Google Patents

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Publication number
JP2021513848A5
JP2021513848A5 JP2020543560A JP2020543560A JP2021513848A5 JP 2021513848 A5 JP2021513848 A5 JP 2021513848A5 JP 2020543560 A JP2020543560 A JP 2020543560A JP 2020543560 A JP2020543560 A JP 2020543560A JP 2021513848 A5 JP2021513848 A5 JP 2021513848A5
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JP
Japan
Prior art keywords
cancer
domain antibody
binder
lag
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020543560A
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English (en)
Japanese (ja)
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JP2021513848A (ja
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Publication date
Priority claimed from GBGB1802573.4A external-priority patent/GB201802573D0/en
Application filed filed Critical
Publication of JP2021513848A publication Critical patent/JP2021513848A/ja
Publication of JP2021513848A5 publication Critical patent/JP2021513848A5/ja
Priority to JP2024116130A priority Critical patent/JP2024156719A/ja
Pending legal-status Critical Current

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JP2020543560A 2018-02-16 2019-02-18 Lag3に結合する治療用分子 Pending JP2021513848A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024116130A JP2024156719A (ja) 2018-02-16 2024-07-19 Lag3に結合する治療用分子

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1802573.4A GB201802573D0 (en) 2018-02-16 2018-02-16 Therapeutic molecules that bind to LAG3
GB1802573.4 2018-02-16
PCT/GB2019/050425 WO2019158942A1 (en) 2018-02-16 2019-02-18 Therapeutic molecules that bind to lag3 and pd1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024116130A Division JP2024156719A (ja) 2018-02-16 2024-07-19 Lag3に結合する治療用分子

Publications (2)

Publication Number Publication Date
JP2021513848A JP2021513848A (ja) 2021-06-03
JP2021513848A5 true JP2021513848A5 (https=) 2022-02-24

Family

ID=61783706

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020543560A Pending JP2021513848A (ja) 2018-02-16 2019-02-18 Lag3に結合する治療用分子
JP2024116130A Pending JP2024156719A (ja) 2018-02-16 2024-07-19 Lag3に結合する治療用分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024116130A Pending JP2024156719A (ja) 2018-02-16 2024-07-19 Lag3に結合する治療用分子

Country Status (11)

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US (2) US11951172B2 (https=)
EP (1) EP3752188A1 (https=)
JP (2) JP2021513848A (https=)
KR (1) KR20200123164A (https=)
CN (1) CN111727057A (https=)
AU (1) AU2019220621A1 (https=)
CA (1) CA3089419A1 (https=)
GB (1) GB201802573D0 (https=)
IL (2) IL299443B2 (https=)
SG (1) SG11202006696UA (https=)
WO (1) WO2019158942A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3565841A1 (en) 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
EP3710478A1 (en) 2017-11-13 2020-09-23 Crescendo Biologics Limited Molecules that bind to cd137 and psma
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
WO2020125763A1 (en) * 2018-12-20 2020-06-25 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric lag3
CA3185657A1 (en) * 2020-06-04 2021-12-09 Leidos, Inc. Immunomodulatory compounds
WO2022109987A1 (en) * 2020-11-27 2022-06-02 Shanghai Benemae Pharmaceutical Corporation Novel anti-lag3 antibodies and methods of making and using the same
JP7847451B2 (ja) * 2021-03-02 2026-04-17 花王株式会社 アトピー性皮膚炎による皮膚痒みの症度悪化の検出方法
IL305600A (en) * 2021-03-31 2023-11-01 Incyte Corp Multispecific binding regions containing novel PD-1 binding regions
CN120019080A (zh) * 2022-08-09 2025-05-16 普腾泰科集团有限公司 用于抗体标记的多价接头
US20240101718A1 (en) * 2022-09-28 2024-03-28 Incyte Corporation Anti-pd-1/lag-3 bispecific antibodies and uses thereof
EP4685152A1 (en) * 2023-03-20 2026-01-28 Kyungpook National University Industry-Academic Cooperation Foundation Peptide binding to lag-3 and use thereof
WO2024241208A1 (ko) * 2023-05-19 2024-11-28 서울대학교산학협력단 Cd3 유전자 편집된 cd3 표적 스위처블 car-t 세포
CN120118187B (zh) * 2025-03-19 2025-09-19 珠海市人民医院 一种抗lag3抗体及其应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
JP5355839B2 (ja) 2001-10-23 2013-11-27 ピーエスエムエー デベロプメント カンパニー, エル.エル.シー. Psma抗体およびタンパク質マルチマー
GB2398784B (en) 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
GB0400440D0 (en) 2004-01-09 2004-02-11 Isis Innovation Receptor modulators
JP2008529556A (ja) 2005-02-18 2008-08-07 メダレックス, インク. 前立腺特異的膜抗原(psma)に対するヒトモノクローナル抗体
JP2009502207A (ja) 2005-08-03 2009-01-29 フラウンホーファー ユーエスエー, インコーポレイテッド イムノグロブリンの産生のための組成物および方法
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
WO2009117335A2 (en) 2008-03-17 2009-09-24 Allergan, Inc. S1p3 receptor inhibitors for treating inflammation
US20100122358A1 (en) 2008-06-06 2010-05-13 Crescendo Biologics Limited H-Chain-only antibodies
US8552154B2 (en) 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
US20130202623A1 (en) 2010-02-16 2013-08-08 Nicolas Chomont Pd-1 modulation and uses thereof for modulating hiv replication
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
WO2012072731A2 (en) 2010-12-01 2012-06-07 Glaxo Group Limited Improved anti-serum albumin binding single variable domains
CA3285826A1 (en) 2012-02-22 2026-03-02 The Trustees Of The University Of Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
EP4151658A1 (en) 2012-05-07 2023-03-22 Elasmogen Limited Single domain binding molecule
CN103087171B (zh) 2012-12-24 2015-01-14 中国人民解放军第四军医大学 一种用于前列腺癌早期诊断和治疗的抗psma/fitc双特异性抗体及其制备方法
WO2014141192A1 (en) 2013-03-15 2014-09-18 Erasmus University Medical Center Generation of heavy chain-only antibodies
CN103333249A (zh) 2013-06-14 2013-10-02 广州康合生物科技有限公司 一种抗前列腺特异性膜抗原(psma)的单克隆抗体及其应用
CN105705489B (zh) 2013-09-04 2019-04-26 百时美施贵宝公司 用作免疫调节剂的化合物
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
TWI681969B (zh) * 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
PE20170255A1 (es) 2014-01-24 2017-03-22 Dana Farber Cancer Inst Inc Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
HUE057817T2 (hu) 2014-01-28 2022-06-28 Bristol Myers Squibb Co Anti-LAG-3 antitestek haematológiai malignitások kezelésére
KR20150089702A (ko) 2014-01-28 2015-08-05 제일모직주식회사 신규 화합물, 신규 폴리머, 이를 포함하는 착색제, 이를 포함하는 감광성 수지 조성물 및 컬러필터
US20170335281A1 (en) 2014-03-15 2017-11-23 Novartis Ag Treatment of cancer using chimeric antigen receptor
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
AU2015244814B2 (en) 2014-04-07 2020-12-24 Chugai Seiyaku Kabushiki Kaisha Immunoactivating antigen-binding molecule
DK3134438T3 (da) 2014-04-25 2020-12-07 Pf Medicament IGF-1R-antistof og anvendelse heraf som adresseringsvehikel til behandling af cancer
TWI693232B (zh) * 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
KR102357893B1 (ko) 2014-08-05 2022-02-04 맵퀘스트 에스아 Pd-1 에 결합하는 면역학적 시약
AU2015301460B2 (en) 2014-08-14 2021-04-08 Novartis Ag Treatment of cancer using GFR alpha-4 chimeric antigen receptor
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
DK3209698T4 (da) 2014-10-22 2022-04-04 Crescendo Biologics Ltd Transgene mus
US11275080B2 (en) 2014-11-05 2022-03-15 The Regents Of The University Of California Methods for stratifying non-responders to therapies that block PD1/PDL1 axis
DK3237446T3 (en) 2014-12-22 2021-07-26 Pd 1 Acquisition Group Llc Anti-PD-1-antistoffer
EP3298030B1 (en) 2015-05-18 2023-01-18 Pieris Pharmaceuticals GmbH Anti-cancer fusion polypeptide
CN105061597B (zh) 2015-06-09 2016-04-27 北京东方百泰生物科技有限公司 一种抗pd-1的单克隆抗体及其获得方法
EP3328418A1 (en) * 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
HUE068868T2 (hu) 2015-07-30 2025-02-28 Macrogenics Inc PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
CN106397592A (zh) 2015-07-31 2017-02-15 苏州康宁杰瑞生物科技有限公司 针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白
CN105384825B (zh) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
AU2016334623A1 (en) 2015-10-07 2018-02-15 F. Hoffmann-La Roche Ag Bispecific antibodies with tetravalency for a costimulatory TNF receptor
IL300122A (en) * 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc Substances that bind to PD1 and/or LAG3
KR20180096789A (ko) 2016-01-11 2018-08-29 인히브릭스, 인크. 다가 및 다중특이적 41bb-결합 융합 단백질
EP3402825A1 (en) 2016-01-12 2018-11-21 Crescendo Biologics Limited Molecules that bind prostate specific membrane antigen (psma)
GB201607968D0 (en) 2016-05-06 2016-06-22 Crescendo Biolog Ltd Chimeric antigen receptor
EP3493844A4 (en) 2016-05-20 2021-03-24 Harpoon Therapeutics Inc. SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
BR112018074453A2 (pt) 2016-05-27 2019-03-19 Abbvie Biotherapeutics Inc. proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral
RU2022101604A (ru) 2016-12-07 2022-03-29 Аблинкс Нв Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином
EP3565841A1 (en) 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
CA3052291A1 (en) 2017-02-09 2018-08-16 Memorial Sloan Kettering Cancer Center Anti-kir3dl1 antibodies
WO2018224439A1 (en) 2017-06-05 2018-12-13 Numab Innovation Ag Novel anti-hsa antibodies
EP3425763B1 (en) * 2017-07-03 2020-11-18 France Brevets Coupling interface and method of operation
CN118027197A (zh) * 2017-07-06 2024-05-14 美勒斯公司 调节由细胞表达的生物活性的抗体
GB201711068D0 (en) 2017-07-10 2017-08-23 Crescendo Biologics Ltd Therapeutic molecules binding PSMA
EP3470426A1 (en) 2017-10-10 2019-04-17 Numab Therapeutics AG Multispecific antibody
EP3710478A1 (en) 2017-11-13 2020-09-23 Crescendo Biologics Limited Molecules that bind to cd137 and psma
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
GB201818460D0 (en) 2018-11-13 2018-12-26 Crescendo Biologics Ltd Single domain antibodies that bind human serum albumin
WO2020229844A1 (en) 2019-05-15 2020-11-19 Crescendo Biologics Limited Binding molecules

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