CN110121510B - 程序性细胞死亡(pd-1)的单结构域抗体 - Google Patents

程序性细胞死亡(pd-1)的单结构域抗体 Download PDF

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Publication number
CN110121510B
CN110121510B CN201880005715.2A CN201880005715A CN110121510B CN 110121510 B CN110121510 B CN 110121510B CN 201880005715 A CN201880005715 A CN 201880005715A CN 110121510 B CN110121510 B CN 110121510B
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single domain
cancer
domain antibody
binding
human
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CN110121510A (zh
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布赖恩·爱德华兹
卡罗琳·爱德华兹
詹姆斯·莱格
马蒂纳·莱万多夫斯卡
达妮埃拉·希多莱克
科莉特·约翰斯顿
克里斯蒂娜·罗桑
滕毓敏
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Crescendo Biologics Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/027—New or modified breeds of vertebrates
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    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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CN201880005715.2A 2017-01-06 2018-01-08 程序性细胞死亡(pd-1)的单结构域抗体 Expired - Fee Related CN110121510B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1700207.2A GB201700207D0 (en) 2017-01-06 2017-01-06 Single domain antibodies to prgrammed cell death (PD-1)
GBGB1700208.0A GB201700208D0 (en) 2017-01-06 2017-01-06 Single domain antibodies to programmed cell death (PD-1)
GB1700208.0 2017-01-06
GB1700207.2 2017-01-06
GB1700210.6 2017-01-06
GBGB1700210.6A GB201700210D0 (en) 2017-01-06 2017-01-06 Single domain antibodies to programmed cell death (PD-1)
PCT/GB2018/050035 WO2018127709A1 (en) 2017-01-06 2018-01-08 Single domain antibodies to programmed cell death (pd-1)

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CN110121510A CN110121510A (zh) 2019-08-13
CN110121510B true CN110121510B (zh) 2024-06-11

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CN201880005715.2A Expired - Fee Related CN110121510B (zh) 2017-01-06 2018-01-08 程序性细胞死亡(pd-1)的单结构域抗体
CN201880006096.9A Expired - Fee Related CN110167966B (zh) 2017-01-06 2018-01-08 程序性细胞死亡(pd-1)的单结构域抗体

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US (5) US11312771B2 (https=)
EP (3) EP3565841A1 (https=)
JP (4) JP7267921B2 (https=)
CN (2) CN110121510B (https=)
WO (3) WO2018127709A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383464B (es) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
EP3565841A1 (en) * 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
EP3710478A1 (en) 2017-11-13 2020-09-23 Crescendo Biologics Limited Molecules that bind to cd137 and psma
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
CN120623346A (zh) * 2018-10-11 2025-09-12 因荷布瑞克斯生物科学公司 Pd-1单结构域抗体及其治疗组合物
US12098204B2 (en) 2018-11-16 2024-09-24 Nanjing GenScript Biotech Co., Ltd. Humanized anti-human PD-L1 monoclonal antibody and preparation method therefor and use thereof
US20230051872A1 (en) * 2019-03-22 2023-02-16 Reflexion Pharmaceuticals, Inc. Multivalent D-Peptidic Compounds for Target Proteins
CN110003336B (zh) * 2019-04-12 2023-05-12 深圳普瑞金生物药业股份有限公司 Pd-1单域抗体、核苷酸序列及试剂盒
JP2022530496A (ja) * 2019-04-26 2022-06-29 ウーシー バイオロジクス アイルランド リミテッド Ｐｄ－１およびｌａｇ－３に対する二重特異性抗体
EP3733708A1 (en) * 2019-05-02 2020-11-04 Randox Laboratories Ltd Immune checkpoint molecule inhibitor
WO2020229844A1 (en) * 2019-05-15 2020-11-19 Crescendo Biologics Limited Binding molecules
BR112022003163A2 (pt) * 2019-08-19 2022-05-17 Pandion Operations Inc Imunotolerância alvejada com um agonista de pd-1
CN112409483B (zh) * 2019-08-22 2024-08-27 浙江道尔生物科技有限公司 抗pd-l1纳米抗体
WO2021057836A1 (en) * 2019-09-25 2021-04-01 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
CN110950956B (zh) * 2019-12-12 2022-03-08 源道隆（苏州）医学科技有限公司 可结合pd1的多肽及其应用
JP7512413B2 (ja) * 2020-03-31 2024-07-08 ビオテウス・インコーポレイテッド 抗ｐｄ－ｌ１およびｐｄ－ｌ２抗体ならびにその誘導体および用途
GB202007452D0 (en) * 2020-05-19 2020-07-01 Microbiotica Ltd Threrapeutic bacterial composition
CR20220596A (es) 2020-05-26 2023-01-23 Boehringer Ingelheim Int Anticuerpos anti-pd-1
CN114316022A (zh) * 2020-09-30 2022-04-12 正大天晴康方(上海)生物医药科技有限公司 结合pd-1抗体的肽及其应用
CN114685655B (zh) * 2020-12-28 2024-04-12 浙江纳米抗体技术中心有限公司 Pd-1结合分子及其应用
EP4288455A1 (en) 2021-02-03 2023-12-13 Mozart Therapeutics, Inc. Binding agents and methods of using the same
KR20230163503A (ko) * 2021-03-31 2023-11-30 메뤼스 엔.페. 신규한 pd-1 결합 도메인
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
GB202205589D0 (en) * 2022-04-14 2022-06-01 Crescendo Biologics Ltd Mesothelin binders
CN117866905B (zh) * 2024-03-12 2024-06-04 北京贝来药业有限公司 基于纳米抗体基因修饰的干细胞及其制备方法和产品

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892785A (zh) * 2010-03-11 2013-01-23 Ucb医药有限公司 生物学制品：人源化激动性抗-pd-1抗体
WO2016106159A1 (en) * 2014-12-22 2016-06-30 Enumeral Biomedical Holding, Inc. Anti-pd-1 antibodies

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9113120D0 (en) * 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
JP5355839B2 (ja) 2001-10-23 2013-11-27 ピーエスエムエー デベロプメント カンパニー， エル．エル．シー． Ｐｓｍａ抗体およびタンパク質マルチマー
GB2398784B (en) 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
GB0315450D0 (en) * 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) * 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
ES2551439T5 (es) * 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fragmentos Fab de anticuerpos modificados
GB0400440D0 (en) * 2004-01-09 2004-02-11 Isis Innovation Receptor modulators
CA2569509C (en) 2004-06-03 2014-08-12 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
JP2008529556A (ja) 2005-02-18 2008-08-07 メダレックス， インク． 前立腺特異的膜抗原（ｐｓｍａ）に対するヒトモノクローナル抗体
JP2009502207A (ja) 2005-08-03 2009-01-29 フラウンホーファー ユーエスエー， インコーポレイテッド イムノグロブリンの産生のための組成物および方法
EP2262837A4 (en) * 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
WO2009117335A2 (en) 2008-03-17 2009-09-24 Allergan, Inc. S1p3 receptor inhibitors for treating inflammation
US20100122358A1 (en) 2008-06-06 2010-05-13 Crescendo Biologics Limited H-Chain-only antibodies
US8552154B2 (en) 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
US20130202623A1 (en) * 2010-02-16 2013-08-08 Nicolas Chomont Pd-1 modulation and uses thereof for modulating hiv replication
WO2012072731A2 (en) 2010-12-01 2012-06-07 Glaxo Group Limited Improved anti-serum albumin binding single variable domains
CA3285826A1 (en) 2012-02-22 2026-03-02 The Trustees Of The University Of Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
EP4151658A1 (en) 2012-05-07 2023-03-22 Elasmogen Limited Single domain binding molecule
CN103087171B (zh) 2012-12-24 2015-01-14 中国人民解放军第四军医大学 一种用于前列腺癌早期诊断和治疗的抗psma/fitc双特异性抗体及其制备方法
WO2014141192A1 (en) 2013-03-15 2014-09-18 Erasmus University Medical Center Generation of heavy chain-only antibodies
CN103333249A (zh) 2013-06-14 2013-10-02 广州康合生物科技有限公司 一种抗前列腺特异性膜抗原（psma）的单克隆抗体及其应用
CN105705489B (zh) 2013-09-04 2019-04-26 百时美施贵宝公司 用作免疫调节剂的化合物
US20150201768A1 (en) 2014-01-22 2015-07-23 Thomas J. Bower Dining napkin with special perforation feature
PE20170255A1 (es) * 2014-01-24 2017-03-22 Dana Farber Cancer Inst Inc Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
KR20150089702A (ko) 2014-01-28 2015-08-05 제일모직주식회사 신규 화합물, 신규 폴리머, 이를 포함하는 착색제, 이를 포함하는 감광성 수지 조성물 및 컬러필터
HUE057817T2 (hu) 2014-01-28 2022-06-28 Bristol Myers Squibb Co Anti-LAG-3 antitestek haematológiai malignitások kezelésére
US20170335281A1 (en) 2014-03-15 2017-11-23 Novartis Ag Treatment of cancer using chimeric antigen receptor
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
DK3134438T3 (da) 2014-04-25 2020-12-07 Pf Medicament IGF-1R-antistof og anvendelse heraf som adresseringsvehikel til behandling af cancer
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
KR102357893B1 (ko) 2014-08-05 2022-02-04 맵퀘스트 에스아 Pd-1 에 결합하는 면역학적 시약
AU2015301460B2 (en) 2014-08-14 2021-04-08 Novartis Ag Treatment of cancer using GFR alpha-4 chimeric antigen receptor
DK3209698T4 (da) 2014-10-22 2022-04-04 Crescendo Biologics Ltd Transgene mus
US11275080B2 (en) 2014-11-05 2022-03-15 The Regents Of The University Of California Methods for stratifying non-responders to therapies that block PD1/PDL1 axis
EP3298030B1 (en) 2015-05-18 2023-01-18 Pieris Pharmaceuticals GmbH Anti-cancer fusion polypeptide
CN105061597B (zh) 2015-06-09 2016-04-27 北京东方百泰生物科技有限公司 一种抗pd-1的单克隆抗体及其获得方法
HUE068868T2 (hu) 2015-07-30 2025-02-28 Macrogenics Inc PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
CN106397592A (zh) 2015-07-31 2017-02-15 苏州康宁杰瑞生物科技有限公司 针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白
CN105384825B (zh) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
AU2016334623A1 (en) 2015-10-07 2018-02-15 F. Hoffmann-La Roche Ag Bispecific antibodies with tetravalency for a costimulatory TNF receptor
IL300122A (en) 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc Substances that bind to PD1 and/or LAG3
KR20180096789A (ko) 2016-01-11 2018-08-29 인히브릭스, 인크. 다가 및 다중특이적 41bb-결합 융합 단백질
EP3402825A1 (en) 2016-01-12 2018-11-21 Crescendo Biologics Limited Molecules that bind prostate specific membrane antigen (psma)
GB201607968D0 (en) 2016-05-06 2016-06-22 Crescendo Biolog Ltd Chimeric antigen receptor
EP3493844A4 (en) 2016-05-20 2021-03-24 Harpoon Therapeutics Inc. SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
RU2022101604A (ru) 2016-12-07 2022-03-29 Аблинкс Нв Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином
EP3565841A1 (en) 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
CA3052291A1 (en) 2017-02-09 2018-08-16 Memorial Sloan Kettering Cancer Center Anti-kir3dl1 antibodies
WO2018224439A1 (en) 2017-06-05 2018-12-13 Numab Innovation Ag Novel anti-hsa antibodies
EP3425763B1 (en) 2017-07-03 2020-11-18 France Brevets Coupling interface and method of operation
CN118027197A (zh) 2017-07-06 2024-05-14 美勒斯公司 调节由细胞表达的生物活性的抗体
GB201711068D0 (en) 2017-07-10 2017-08-23 Crescendo Biologics Ltd Therapeutic molecules binding PSMA
EP3470426A1 (en) 2017-10-10 2019-04-17 Numab Therapeutics AG Multispecific antibody
EP3710478A1 (en) 2017-11-13 2020-09-23 Crescendo Biologics Limited Molecules that bind to cd137 and psma
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
GB201818460D0 (en) 2018-11-13 2018-12-26 Crescendo Biologics Ltd Single domain antibodies that bind human serum albumin
WO2020229844A1 (en) 2019-05-15 2020-11-19 Crescendo Biologics Limited Binding molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892785A (zh) * 2010-03-11 2013-01-23 Ucb医药有限公司 生物学制品：人源化激动性抗-pd-1抗体
WO2016106159A1 (en) * 2014-12-22 2016-06-30 Enumeral Biomedical Holding, Inc. Anti-pd-1 antibodies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Single doman antibodies against immune checkpoint targets PD-1 and PD-L1;Yu Geng et al.;《Immunome Res》;20160731;摘要 *

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