JP2021534096A5 - - Google Patents
Info
- Publication number
- JP2021534096A5 JP2021534096A5 JP2021506582A JP2021506582A JP2021534096A5 JP 2021534096 A5 JP2021534096 A5 JP 2021534096A5 JP 2021506582 A JP2021506582 A JP 2021506582A JP 2021506582 A JP2021506582 A JP 2021506582A JP 2021534096 A5 JP2021534096 A5 JP 2021534096A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- chain variable
- sequence
- Prior art date
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862716113P | 2018-08-08 | 2018-08-08 | |
| US201862716109P | 2018-08-08 | 2018-08-08 | |
| US201862716106P | 2018-08-08 | 2018-08-08 | |
| US62/716,113 | 2018-08-08 | ||
| US62/716,109 | 2018-08-08 | ||
| US62/716,106 | 2018-08-08 | ||
| PCT/US2019/045723 WO2020033702A1 (en) | 2018-08-08 | 2019-08-08 | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534096A JP2021534096A (ja) | 2021-12-09 |
| JP2021534096A5 true JP2021534096A5 (https=) | 2022-08-15 |
| JPWO2020033702A5 JPWO2020033702A5 (https=) | 2022-08-15 |
Family
ID=69415684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506582A Pending JP2021534096A (ja) | 2018-08-08 | 2019-08-08 | Ｎｋｇ２ｄ、ｃｄ１６および腫瘍関連抗原に結合するタンパク質 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210206859A1 (https=) |
| EP (1) | EP3833686A4 (https=) |
| JP (1) | JP2021534096A (https=) |
| KR (1) | KR20210044237A (https=) |
| CN (1) | CN112789291A (https=) |
| AU (1) | AU2019319906A1 (https=) |
| BR (1) | BR112021002278A2 (https=) |
| CA (1) | CA3108915A1 (https=) |
| IL (1) | IL280673A (https=) |
| MX (1) | MX2021001510A (https=) |
| SG (1) | SG11202101294RA (https=) |
| WO (1) | WO2020033702A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CA2898100C (en) | 2013-01-14 | 2023-10-10 | Xencor, Inc. | Novel heterodimeric proteins |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN110894240B (zh) | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| WO2018005706A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
| WO2018089393A1 (en) * | 2016-11-10 | 2018-05-17 | Medimmune, Llc | Binding molecules specific for asct2 and uses thereof |
| SG11201907299XA (en) | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| IL268755B2 (en) | 2017-02-20 | 2025-12-01 | Dragonfly Therapeutics Inc | Proteins that bind her2, nkg2d, and cd16 |
| JP2021502100A (ja) | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体 |
| DK3749346T3 (da) | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| EA202091887A1 (ru) | 2018-02-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| WO2019195623A2 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| US12378318B2 (en) | 2018-08-08 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| CA3192204A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| MX2023008895A (es) * | 2021-02-09 | 2023-08-09 | Medilink Therapeutics Suzhou Co Ltd | Conjugado de sustancia bioactiva, metodo de preparacion y uso del mismo. |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Ｃｄ３及びｃｌｄｎ６に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体 |
| WO2022258691A1 (en) * | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| US20230151095A1 (en) * | 2021-11-12 | 2023-05-18 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| EP4466289A2 (en) * | 2022-01-20 | 2024-11-27 | Repertoire Immune Medicines, Inc. | Silent anti-cd8 antibodies and fusion proteins |
| CN119110809A (zh) | 2022-02-23 | 2024-12-10 | Xencor股份有限公司 | 抗CD28 x抗PSMA抗体 |
| CN115960234B (zh) * | 2022-10-27 | 2023-12-29 | 合肥天港免疫药物有限公司 | 抗cd16a的抗体及其应用 |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
| US20240166705A1 (en) | 2022-11-07 | 2024-05-23 | Xencor, Inc. | Il18-fc fusion proteins |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60333228D1 (de) * | 2002-12-02 | 2010-08-12 | Amgen Fremont Inc | Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen |
| JP5998060B2 (ja) * | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| PH12012501751A1 (en) * | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| SMT201800269T1 (it) * | 2011-04-25 | 2018-07-17 | Daiichi Sankyo Co Ltd | Anticorpo anti-b7-h3 |
| EP3152235B1 (en) * | 2014-05-29 | 2021-08-25 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
| JP6744313B2 (ja) * | 2015-01-02 | 2020-08-26 | ダイアックス コーポレーション | 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体 |
| WO2016207278A1 (en) * | 2015-06-23 | 2016-12-29 | Innate Pharma | Multispecific nk engager proteins |
| WO2017165464A1 (en) * | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| TWI781098B (zh) * | 2016-04-15 | 2022-10-21 | 美商宏觀基因股份有限公司 | 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法 |
| EP3458479B1 (en) * | 2016-06-08 | 2020-11-04 | AbbVie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| CN105906722B (zh) * | 2016-06-24 | 2020-02-07 | 安徽未名细胞治疗有限公司 | 一种Her2特异性嵌合抗原受体及其应用 |
| EP3507307A4 (en) * | 2016-09-01 | 2020-04-22 | Immunomab, Inc. | BISPECIFIC ANTIBODIES |
| SG11201907299XA (en) * | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| DK3749346T3 (da) * | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| EA202091887A1 (ru) * | 2018-02-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры |
| EA202091977A1 (ru) * | 2018-05-28 | 2021-02-09 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения |
| US20230151095A1 (en) * | 2021-11-12 | 2023-05-18 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
-
2019
- 2019-08-08 MX MX2021001510A patent/MX2021001510A/es unknown
- 2019-08-08 CN CN201980064178.3A patent/CN112789291A/zh active Pending
- 2019-08-08 KR KR1020217006244A patent/KR20210044237A/ko not_active Ceased
- 2019-08-08 BR BR112021002278-3A patent/BR112021002278A2/pt unknown
- 2019-08-08 JP JP2021506582A patent/JP2021534096A/ja active Pending
- 2019-08-08 EP EP19848152.5A patent/EP3833686A4/en active Pending
- 2019-08-08 SG SG11202101294RA patent/SG11202101294RA/en unknown
- 2019-08-08 WO PCT/US2019/045723 patent/WO2020033702A1/en not_active Ceased
- 2019-08-08 AU AU2019319906A patent/AU2019319906A1/en not_active Abandoned
- 2019-08-08 US US17/265,879 patent/US20210206859A1/en not_active Abandoned
- 2019-08-08 CA CA3108915A patent/CA3108915A1/en active Pending
-
2021
- 2021-02-05 IL IL280673A patent/IL280673A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021534096A5 (https=) | ||
| JPWO2020033702A5 (https=) | ||
| JP2020531438A5 (ja) | Ｎｋｇ２ｄ、ｃｄ１６、およびｈｌａ−ｅに結合するタンパク質 | |
| JP2021533159A5 (https=) | ||
| JP2021098733A5 (https=) | ||
| JP2021098732A5 (https=) | ||
| JP2020533311A5 (ja) | ＮＫＧ２Ｄ、ＣＤ１６およびＮｅｃｔｉｎ４に結合するタンパク質 | |
| JP2021522162A5 (https=) | ||
| FI3582806T3 (fi) | Her2:ta, nkg2d:tä ja cd16:ta sitovia proteiineja | |
| JP2020522473A5 (https=) | ||
| FI3749346T3 (fi) | Nkg2d-reseptoriin kohdistuvat vasta-aineen vaihtelevan domeenin yhdistelmät | |
| JP2021514396A5 (https=) | ||
| JP2020521448A5 (https=) | ||
| JP2020508997A5 (https=) | ||
| RU2021110369A (ru) | Белки, связывающие nkg2d, cd16 и опухолеассоциированный антиген | |
| JP2020510422A5 (https=) | ||
| JP2024056687A5 (https=) | ||
| JPWO2019157366A5 (https=) | ||
| JPWO2020033587A5 (https=) | ||
| JP2020522474A5 (https=) | ||
| JP2018507188A5 (https=) | ||
| JP2021523140A5 (https=) | ||
| JP2020507577A5 (https=) | ||
| JP2021520832A5 (https=) | ||
| JP2020502233A5 (https=) |