BR112019012040A2 - anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73. - Google Patents

anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73.

Info

Publication number
BR112019012040A2
BR112019012040A2 BR112019012040-8A BR112019012040A BR112019012040A2 BR 112019012040 A2 BR112019012040 A2 BR 112019012040A2 BR 112019012040 A BR112019012040 A BR 112019012040A BR 112019012040 A2 BR112019012040 A2 BR 112019012040A2
Authority
BR
Brazil
Prior art keywords
seq
treatment
methods
fragment
therapy
Prior art date
Application number
BR112019012040-8A
Other languages
English (en)
Portuguese (pt)
Inventor
Wang Zhengyi
Fang Lei
Guo Bingshi
Zang Jingwu
Original Assignee
I-Mab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I-Mab filed Critical I-Mab
Publication of BR112019012040A2 publication Critical patent/BR112019012040A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • G—PHYSICS
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • G01N2333/914—Hydrolases (3)
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BR112019012040-8A 2017-01-24 2018-01-23 anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73. BR112019012040A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/072445 2017-01-24
CN2017072445 2017-01-24
PCT/CN2018/073746 WO2018137598A1 (en) 2017-01-24 2018-01-23 Anti-cd73 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112019012040A2 true BR112019012040A2 (pt) 2019-11-12

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BR112019012040-8A BR112019012040A2 (pt) 2017-01-24 2018-01-23 anticorpo isolado ou fragmento do mesmo, composição, célula isolada, e, métodos para tratamento de câncer, para detecção da expressão de cd73 em uma amostra e para identificação de um paciente com câncer adequado para o tratamento com uma terapia anti-cd73.

Country Status (29)

Country Link
US (2) US10584169B2 (https=)
EP (2) EP4050030A1 (https=)
JP (1) JP7206193B2 (https=)
KR (3) KR20200108915A (https=)
CN (2) CN112279918A (https=)
AU (3) AU2018213549B2 (https=)
BR (1) BR112019012040A2 (https=)
CA (1) CA3045376C (https=)
CL (1) CL2019001756A1 (https=)
CO (1) CO2019006657A2 (https=)
DK (1) DK3383916T3 (https=)
EA (1) EA201991099A1 (https=)
ES (1) ES2908662T3 (https=)
HR (1) HRP20220629T1 (https=)
HU (1) HUE058975T2 (https=)
IL (3) IL290842B2 (https=)
LT (1) LT3383916T (https=)
MX (1) MX391656B (https=)
MY (1) MY188386A (https=)
NZ (1) NZ753714A (https=)
PE (1) PE20191208A1 (https=)
PH (1) PH12019550087A1 (https=)
PL (1) PL3383916T3 (https=)
PT (1) PT3383916T (https=)
RS (1) RS63195B1 (https=)
SI (1) SI3383916T1 (https=)
UA (1) UA126571C2 (https=)
WO (1) WO2018137598A1 (https=)
ZA (1) ZA201904619B (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7066696B2 (ja) 2016-10-11 2022-05-13 アジェナス インコーポレイテッド 抗ｌａｇ－３抗体及びその使用方法
TWI877770B (zh) 2018-02-27 2025-03-21 美商英塞特公司 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
WO2019173692A2 (en) 2018-03-09 2019-09-12 Agenus Inc. Anti-cd73 antibodies and methods of use thereof
EP3810610A1 (en) 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
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