JP2012516158A5 - - Google Patents
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- Publication number
- JP2012516158A5 JP2012516158A5 JP2011548315A JP2011548315A JP2012516158A5 JP 2012516158 A5 JP2012516158 A5 JP 2012516158A5 JP 2011548315 A JP2011548315 A JP 2011548315A JP 2011548315 A JP2011548315 A JP 2011548315A JP 2012516158 A5 JP2012516158 A5 JP 2012516158A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- residue substitutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 238000006467 substitution reaction Methods 0.000 claims 20
- 125000000539 amino acid group Chemical group 0.000 claims 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 206010006002 Bone pain Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029174 Nerve compression Diseases 0.000 claims 1
- 208000005890 Neuroma Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001032 spinal nerve Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14810609P | 2009-01-29 | 2009-01-29 | |
| US61/148,106 | 2009-01-29 | ||
| US18418209P | 2009-06-04 | 2009-06-04 | |
| US61/184,182 | 2009-06-04 | ||
| PCT/US2010/022478 WO2010088444A1 (en) | 2009-01-29 | 2010-01-29 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015123389A Division JP2016019517A (ja) | 2009-01-29 | 2015-06-19 | 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516158A JP2012516158A (ja) | 2012-07-19 |
| JP2012516158A5 true JP2012516158A5 (https=) | 2013-03-14 |
Family
ID=42396023
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548315A Pending JP2012516158A (ja) | 2009-01-29 | 2010-01-29 | 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 |
| JP2015123389A Pending JP2016019517A (ja) | 2009-01-29 | 2015-06-19 | 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 |
| JP2017112163A Pending JP2017206519A (ja) | 2009-01-29 | 2017-06-07 | 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015123389A Pending JP2016019517A (ja) | 2009-01-29 | 2015-06-19 | 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 |
| JP2017112163A Pending JP2017206519A (ja) | 2009-01-29 | 2017-06-07 | 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20120034212A1 (https=) |
| EP (1) | EP2391384A4 (https=) |
| JP (3) | JP2012516158A (https=) |
| KR (1) | KR20110108398A (https=) |
| CN (2) | CN104119438A (https=) |
| AU (1) | AU2010208125B2 (https=) |
| BR (1) | BRPI1007005A2 (https=) |
| CA (1) | CA2749200A1 (https=) |
| HK (1) | HK1201847A1 (https=) |
| MX (1) | MX337590B (https=) |
| RU (2) | RU2011135422A (https=) |
| SG (3) | SG10201704214VA (https=) |
| WO (1) | WO2010088444A1 (https=) |
| ZA (2) | ZA201104796B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| CN104119438A (zh) * | 2009-01-29 | 2014-10-29 | 米迪缪尼有限公司 | 延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 |
| WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| WO2011026948A1 (en) * | 2009-09-03 | 2011-03-10 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| JP6173911B2 (ja) * | 2010-09-10 | 2017-08-09 | メディミューン リミテド | 抗体誘導体 |
| WO2012083370A1 (en) * | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
| HUE029139T2 (hu) * | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| KR20140043724A (ko) | 2011-03-03 | 2014-04-10 | 아펙시젠, 인코포레이티드 | 항-il-6 수용체 항체 및 사용 방법 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| EP3680251A1 (en) | 2011-09-30 | 2020-07-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecules for promoting elimination of antigens |
| TW201945034A (zh) | 2011-09-30 | 2019-12-01 | 日商中外製藥股份有限公司 | 包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子 |
| SG10201805584YA (en) | 2012-02-24 | 2018-08-30 | Chugai Pharmaceutical Co Ltd | ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB |
| WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| KR102321372B1 (ko) * | 2012-10-22 | 2021-11-11 | 원니스 바이오테크 컴퍼니 리미티드 | 인터류킨-6에 대한 항체 및 그의 용도 |
| US20150239970A1 (en) * | 2012-10-25 | 2015-08-27 | Medimmune, Llc | Stable, Low Viscosity Antibody Formulation |
| US10772940B1 (en) * | 2012-12-11 | 2020-09-15 | University Of Kentucky Research Foundation | Cocaine hydrolase-FC fusion proteins for cocaine and methods for utilizing the same |
| EP3514175A1 (fr) * | 2012-12-17 | 2019-07-24 | Laboratoire Français du Fractionnement et des Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
| FR2999431B1 (fr) * | 2012-12-17 | 2016-03-18 | Lfb Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
| MX2016005686A (es) * | 2013-10-31 | 2016-08-11 | Regeneron Pharma | Ensayo de union competitiva al ligando para detectar anticuerpos neutralizantes. |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| PT3215530T (pt) | 2014-11-07 | 2019-11-21 | Sesen Bio Inc | Anticorpos de il-6 melhorados |
| CN108026582A (zh) * | 2015-07-31 | 2018-05-11 | 米迪缪尼有限公司 | 用于治疗海帕西啶介导的病症的方法 |
| EP3419599A4 (en) | 2016-02-23 | 2019-09-11 | Sesen Bio, Inc. | IL-6 ANTAGONIST FORMULATIONS AND USE THEREOF |
| MA44631A (fr) * | 2016-04-07 | 2019-02-13 | Janssen Biotech Inc | Traitement de la dépression à l'aide d'agents qui bloquent la liaison de l'il-6 au récepteur de l'il-6 |
| MX386014B (es) | 2016-08-10 | 2025-03-18 | Univ Ajou Ind Academic Coop Found | Citocina fusionada a fc heterodimérico, y composición farmacéutica que comprende la misma. |
| US10961314B2 (en) * | 2016-09-27 | 2021-03-30 | Fresenius Kabi Deutschland Gmbh | Liquid pharmaceutical composition comprising an anti-IL-6 receptor antibody |
| KR20200012823A (ko) | 2017-02-01 | 2020-02-05 | 예일 유니버시티 | 이뇨제 내성의 치료 |
| CA3087699A1 (en) * | 2018-01-05 | 2019-07-11 | Corvidia Therapeutics, Inc. | Methods for treating il-6 mediated inflammation without immunosuppression |
| TWI902669B (zh) | 2018-07-24 | 2025-11-01 | 美商麥迪紐有限責任公司 | 抗金黃色葡萄球菌凝集因子a(clfa)之抗體 |
| MX2021004114A (es) | 2018-10-09 | 2021-07-16 | Medimmune Llc | Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus. |
| CN113164602A (zh) | 2018-10-09 | 2021-07-23 | 免疫医疗有限责任公司 | 抗金黄色葡萄球菌抗体的组合 |
| CN113194925B (zh) * | 2018-12-14 | 2025-03-07 | 莫佛塞斯公司 | 抗体制剂 |
| CN113811544A (zh) | 2019-03-13 | 2021-12-17 | 免疫医疗有限责任公司 | 减少定殖患者中的金黄色葡萄球菌感染 |
| EP4591885A3 (en) | 2019-05-01 | 2025-11-19 | Novo Nordisk A/S | Anti-il-6 antibody formulation |
| CN111057152B (zh) * | 2019-12-11 | 2022-03-11 | 中国人民解放军第四军医大学 | 一种抗人IL-6Ra单克隆抗体及其应用 |
| AU2020418554A1 (en) * | 2019-12-31 | 2022-08-25 | Peptinov | Pharmaceutical composition for the prevention or treatment of post-surgical pain |
| WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
| FI4045533T3 (fi) | 2020-03-26 | 2024-02-02 | Univ Vanderbilt | Ihmisen monoklonaalisia vasta-aineita vakavalle akuutille koronavirus 2 -hengityselinoireyhtymälle (sars-cov-2) |
| AU2021275361A1 (en) | 2020-05-17 | 2023-01-19 | Astrazeneca Uk Limited | SARS-CoV-2 antibodies and methods of selecting and using the same |
| AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
| AU2021325339A1 (en) | 2020-08-10 | 2023-04-06 | Astrazeneca Uk Limited | SARS-CoV-2 antibodies for treatment and prevention of COVID-19 |
| CN114681592A (zh) * | 2020-12-31 | 2022-07-01 | 天境生物科技(杭州)有限公司 | 包含可溶性gp130二聚体的制剂和使用方法 |
| TW202342095A (zh) | 2021-11-05 | 2023-11-01 | 英商阿斯特捷利康英國股份有限公司 | 用於治療和預防ｃｏｖｉｄ—１９之組成物 |
| TW202342510A (zh) | 2022-02-18 | 2023-11-01 | 英商Ｒｑ生物科技有限公司 | 抗體 |
| JP2025514858A (ja) | 2022-04-29 | 2025-05-09 | アストラゼネカ・ユーケイ・リミテッド | ＳＡＲＳ－ＣｏＶ－２抗体、及びその使用方法 |
| JP2025534333A (ja) * | 2022-09-30 | 2025-10-15 | ソネット バイオセラピューティクス，インコーポレイテッド | 低用量ｉｌ－６製剤およびその使用方法 |
| WO2025106418A1 (en) * | 2023-11-13 | 2025-05-22 | Seaport Therapeutics, Inc. | Lipid prodrugs of allopregnanolone and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1074268T3 (da) * | 1998-03-17 | 2008-04-28 | Chugai Pharmaceutical Co Ltd | IL-6-receptorantagonistantistofholdige forebyggende eller terapeutiske midler mod inflammatoriske tarmsygdomme |
| US7658921B2 (en) * | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| PT1355919E (pt) * | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| BRPI0214168B8 (pt) * | 2001-11-14 | 2021-05-25 | Centocor Inc | anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos |
| ES2263984T3 (es) * | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
| CN1798575A (zh) * | 2003-04-04 | 2006-07-05 | 健泰科生物技术公司 | 高浓度抗体和蛋白制剂 |
| AU2005302453A1 (en) * | 2004-10-29 | 2006-05-11 | Medimmune, Llc | Methods of preventing and treating RSV infections and related conditions |
| PE20061324A1 (es) * | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
| WO2006130834A2 (en) * | 2005-05-31 | 2006-12-07 | Board Of Regents, The University Of Texas System | IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF |
| CA2614181A1 (en) * | 2005-07-01 | 2007-01-11 | Medimmune, Inc. | An integrated approach for generating multidomain protein therapeutics |
| CA2638811A1 (en) * | 2006-02-03 | 2007-08-16 | Medimmune, Llc | Protein formulations |
| WO2007104529A2 (en) * | 2006-03-13 | 2007-09-20 | Ablynx N.V. | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| TW200831528A (en) * | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| CA2674608A1 (en) * | 2007-01-09 | 2008-07-17 | Wyeth | Anti-il-13 antibody formulations and uses thereof |
| EP2068925A4 (en) * | 2007-05-07 | 2011-08-31 | Medimmune Llc | ANTI-ICOS ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER, TRANSPLANTATIONS AND AUTOIMMUNE DISEASES |
| HUE032563T2 (en) * | 2007-05-21 | 2017-09-28 | Alderbio Holdings Llc | Antibodies to IL-6 and their use |
| EP2170268A2 (en) * | 2007-06-25 | 2010-04-07 | Amgen, Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| US20110008329A1 (en) * | 2007-06-26 | 2011-01-13 | Medlmmune, Llc | Methods of Treating RSV Infections And Related Conditions |
| CN104119438A (zh) * | 2009-01-29 | 2014-10-29 | 米迪缪尼有限公司 | 延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 |
-
2010
- 2010-01-29 CN CN201410349897.9A patent/CN104119438A/zh active Pending
- 2010-01-29 RU RU2011135422/10A patent/RU2011135422A/ru not_active Application Discontinuation
- 2010-01-29 US US13/146,278 patent/US20120034212A1/en not_active Abandoned
- 2010-01-29 AU AU2010208125A patent/AU2010208125B2/en active Active
- 2010-01-29 BR BRPI1007005A patent/BRPI1007005A2/pt not_active Application Discontinuation
- 2010-01-29 EP EP10736433A patent/EP2391384A4/en not_active Ceased
- 2010-01-29 RU RU2015150249A patent/RU2650594C1/ru active
- 2010-01-29 KR KR1020117019221A patent/KR20110108398A/ko not_active Ceased
- 2010-01-29 MX MX2011007832A patent/MX337590B/es active IP Right Grant
- 2010-01-29 WO PCT/US2010/022478 patent/WO2010088444A1/en not_active Ceased
- 2010-01-29 JP JP2011548315A patent/JP2012516158A/ja active Pending
- 2010-01-29 CN CN2010800103915A patent/CN102387814A/zh active Pending
- 2010-01-29 CA CA2749200A patent/CA2749200A1/en not_active Abandoned
- 2010-01-29 SG SG10201704214VA patent/SG10201704214VA/en unknown
- 2010-01-29 SG SG2014007637A patent/SG2014007637A/en unknown
- 2010-01-29 SG SG2011046265A patent/SG172354A1/en unknown
-
2011
- 2011-06-28 ZA ZA2011/04796A patent/ZA201104796B/en unknown
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2012
- 2012-09-18 HK HK15102182.7A patent/HK1201847A1/xx unknown
- 2012-09-27 ZA ZA2012/07249A patent/ZA201207249B/en unknown
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2014
- 2014-04-15 US US14/253,161 patent/US20140302058A1/en not_active Abandoned
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2015
- 2015-06-19 JP JP2015123389A patent/JP2016019517A/ja active Pending
-
2016
- 2016-12-02 US US15/368,499 patent/US20170101468A1/en not_active Abandoned
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2017
- 2017-06-07 JP JP2017112163A patent/JP2017206519A/ja active Pending