HK1201847A1 - Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases il-6 - Google Patents
Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases il-6Info
- Publication number
- HK1201847A1 HK1201847A1 HK15102182.7A HK15102182A HK1201847A1 HK 1201847 A1 HK1201847 A1 HK 1201847A1 HK 15102182 A HK15102182 A HK 15102182A HK 1201847 A1 HK1201847 A1 HK 1201847A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- oncology
- antibodies
- extended
- life
- treatment
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14810609P | 2009-01-29 | 2009-01-29 | |
US18418209P | 2009-06-04 | 2009-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1201847A1 true HK1201847A1 (en) | 2015-09-11 |
Family
ID=42396023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102182.7A HK1201847A1 (en) | 2009-01-29 | 2012-09-18 | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases il-6 |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120034212A1 (xx) |
EP (1) | EP2391384A4 (xx) |
JP (3) | JP2012516158A (xx) |
KR (1) | KR20110108398A (xx) |
CN (2) | CN102387814A (xx) |
AU (1) | AU2010208125B2 (xx) |
BR (1) | BRPI1007005A2 (xx) |
CA (1) | CA2749200A1 (xx) |
HK (1) | HK1201847A1 (xx) |
MX (1) | MX337590B (xx) |
RU (2) | RU2011135422A (xx) |
SG (3) | SG172354A1 (xx) |
WO (1) | WO2010088444A1 (xx) |
ZA (2) | ZA201104796B (xx) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
AU2010208125B2 (en) * | 2009-01-29 | 2015-02-12 | Medimmune, Llc | Human anti-IL-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
EP2473528B1 (en) * | 2009-09-03 | 2014-12-03 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
JP6173911B2 (ja) * | 2010-09-10 | 2017-08-09 | メディミューン リミテド | 抗体誘導体 |
US9505826B2 (en) * | 2010-12-22 | 2016-11-29 | Teva Pharmaceuticals Australia Pty Ltd | Modified antibody with improved half-life |
HUE055284T2 (hu) | 2011-02-10 | 2021-11-29 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
WO2012118813A2 (en) | 2011-03-03 | 2012-09-07 | Apexigen, Inc. | Anti-il-6 receptor antibodies and methods of use |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
MX366968B (es) | 2011-09-30 | 2019-08-01 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. |
JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
WO2013047752A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 抗原の消失を促進する抗原結合分子 |
US20160046693A1 (en) | 2012-02-24 | 2016-02-18 | Chugai Seiyaku Kabushiki Kaisha | Antigen-Binding Molecule for Promoting Disappearance of Antigen via Fc gamma RIIB |
WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
AU2013335004B2 (en) | 2012-10-22 | 2018-06-28 | Oneness Biotech Co. LTD | Antibodies to interleukin-6 and uses thereof |
CN104768578A (zh) * | 2012-10-25 | 2015-07-08 | 米迪缪尼有限公司 | 稳定的低粘度抗体配制品 |
US10772940B1 (en) * | 2012-12-11 | 2020-09-15 | University Of Kentucky Research Foundation | Cocaine hydrolase-FC fusion proteins for cocaine and methods for utilizing the same |
EP3514175A1 (fr) * | 2012-12-17 | 2019-07-24 | Laboratoire Français du Fractionnement et des Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
FR2999431B1 (fr) * | 2012-12-17 | 2016-03-18 | Lfb Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
AU2014342316B2 (en) * | 2013-10-31 | 2019-07-25 | Regeneron Pharmaceuticals, Inc. | Competitive ligand binding assay for detecting neutralizing antibodies |
TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
SG11201703574VA (en) | 2014-11-07 | 2017-05-30 | Eleven Biotherapeutics Inc | Improved il-6 antibodies |
JP2018529756A (ja) | 2015-07-31 | 2018-10-11 | メディミューン リミテッド | ヘプシジン媒介性障害を治療するための方法 |
CN108718522A (zh) * | 2016-02-23 | 2018-10-30 | 赛森生物股份有限公司 | Il-6拮抗剂制剂及其用途 |
MA44631A (fr) * | 2016-04-07 | 2019-02-13 | Janssen Biotech Inc | Traitement de la dépression à l'aide d'agents qui bloquent la liaison de l'il-6 au récepteur de l'il-6 |
EP3576790A4 (en) * | 2017-02-01 | 2020-12-23 | Yale University | TREATMENT OF DIURETIC RESISTANCE |
CA3087699A1 (en) | 2018-01-05 | 2019-07-11 | Corvidia Therapeutics, Inc. | Methods for treating il-6 mediated inflammation without immunosuppression |
WO2020023644A2 (en) | 2018-07-24 | 2020-01-30 | Medimmune, Llc | Antibody directed against s. aureus clumping factor a (clfa) |
WO2020076790A1 (en) | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Antibodies directed against staphylococcus aureus leukotoxins |
CA3115633A1 (en) | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Combinations of anti-staphylococcus aureus antibodies |
CN113811544A (zh) | 2019-03-13 | 2021-12-17 | 免疫医疗有限责任公司 | 减少定殖患者中的金黄色葡萄球菌感染 |
MA55809A (fr) | 2019-05-01 | 2022-03-09 | Novo Nordisk As | Formulation d'anticorps anti-il-6 |
CN111057152B (zh) * | 2019-12-11 | 2022-03-11 | 中国人民解放军第四军医大学 | 一种抗人IL-6Ra单克隆抗体及其应用 |
WO2021136841A2 (fr) * | 2019-12-31 | 2021-07-08 | Peptinov | Composition pharmaceutique pour la prevention ou le traitement des douleurs post-operatoires |
WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
KR20230010749A (ko) | 2020-05-17 | 2023-01-19 | 아스트라제네카 유케이 리미티드 | Sars-cov-2 항체 및 이를 선택 및 이용하는 방법 |
AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
JP2023537078A (ja) | 2020-08-10 | 2023-08-30 | アストラゼネカ・ユーケイ・リミテッド | COVID-19を治療及び防止するためのSARS-CoV-2抗体 |
TW202342095A (zh) | 2021-11-05 | 2023-11-01 | 英商阿斯特捷利康英國股份有限公司 | 用於治療和預防covid—19之組成物 |
WO2023209177A1 (en) | 2022-04-29 | 2023-11-02 | Astrazeneca Uk Limited | Sars-cov-2 antibodies and methods of using the same |
WO2024073718A1 (en) * | 2022-09-30 | 2024-04-04 | Sonnet BioTherapeutics, Inc. | Low dose il-6 formulations and methods of use thereof |
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CN100374159C (zh) * | 1998-03-17 | 2008-03-12 | 中外制药株式会社 | 一种包含il-6拮抗剂活性成分的炎性肠道疾病的预防或治疗剂 |
ES2649037T3 (es) * | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
US7658921B2 (en) * | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
IL161968A0 (en) * | 2001-11-14 | 2005-11-20 | Centocor Inc | Anti-il-6 antibodies, compositions, methods and uses |
ATE328906T1 (de) * | 2002-06-28 | 2006-06-15 | Domantis Ltd | Dual-specifische liganden mit erhöhter halbwertszeit |
JP4869064B2 (ja) * | 2003-04-04 | 2012-02-01 | ジェネンテック, インコーポレイテッド | 高濃度抗体及びタンパク質製剤 |
CA2585891A1 (en) * | 2004-10-29 | 2006-05-11 | Medimmune, Inc. | Methods of preventing and treating rsv infections and related conditions |
PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
EP1896503B1 (en) * | 2005-05-31 | 2014-10-29 | Board of Regents, The University of Texas System | IgG1 ANTIBODIES WITH MUTATED Fc PORTION FOR INCREASED BINDING TO FcRn RECEPTOR AND USES TEHEREOF |
US8309690B2 (en) * | 2005-07-01 | 2012-11-13 | Medimmune, Llc | Integrated approach for generating multidomain protein therapeutics |
US20080071063A1 (en) * | 2006-02-03 | 2008-03-20 | Medimmune, Inc. | Protein Formulations |
AU2007224631A1 (en) * | 2006-03-13 | 2007-09-20 | Ablynx N.V. | Amino acid sequences directed against IL-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
TW200831528A (en) * | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
US20090060906A1 (en) * | 2007-01-09 | 2009-03-05 | Wyeth | Anti-IL-13 antibody formulations and uses thereof |
JP5575636B2 (ja) * | 2007-05-07 | 2014-08-20 | メディミューン,エルエルシー | 抗icos抗体ならびに、腫瘍、移植および自己免疫疾患の治療におけるその使用 |
PL2164514T3 (pl) * | 2007-05-21 | 2017-08-31 | Alderbio Holdings Llc | Przeciwciała przeciwko IL-6 i ich zastosowanie |
EP2170268A2 (en) * | 2007-06-25 | 2010-04-07 | Amgen, Inc. | Compositions of specific binding agents to hepatocyte growth factor |
EP2069400A4 (en) * | 2007-06-26 | 2012-03-07 | Medimmune Llc | METHOD FOR THE TREATMENT OF RSV INFECTIONS AND RELATED DISEASES |
AU2010208125B2 (en) * | 2009-01-29 | 2015-02-12 | Medimmune, Llc | Human anti-IL-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
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- 2010-01-29 CA CA2749200A patent/CA2749200A1/en not_active Abandoned
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- 2010-01-29 CN CN2010800103915A patent/CN102387814A/zh active Pending
- 2010-01-29 CN CN201410349897.9A patent/CN104119438A/zh active Pending
- 2010-01-29 RU RU2015150249A patent/RU2650594C1/ru active
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SG2014007637A (en) | 2014-03-28 |
CA2749200A1 (en) | 2010-08-05 |
BRPI1007005A2 (pt) | 2016-03-22 |
MX337590B (es) | 2016-03-11 |
ZA201207249B (en) | 2013-08-28 |
US20170101468A1 (en) | 2017-04-13 |
KR20110108398A (ko) | 2011-10-05 |
SG172354A1 (en) | 2011-07-28 |
JP2012516158A (ja) | 2012-07-19 |
RU2650594C1 (ru) | 2018-04-17 |
JP2017206519A (ja) | 2017-11-24 |
EP2391384A1 (en) | 2011-12-07 |
RU2011135422A (ru) | 2013-03-10 |
SG10201704214VA (en) | 2017-06-29 |
EP2391384A4 (en) | 2012-12-26 |
CN104119438A (zh) | 2014-10-29 |
AU2010208125B2 (en) | 2015-02-12 |
AU2010208125A1 (en) | 2011-07-21 |
JP2016019517A (ja) | 2016-02-04 |
US20140302058A1 (en) | 2014-10-09 |
ZA201104796B (en) | 2018-11-28 |
WO2010088444A1 (en) | 2010-08-05 |
US20120034212A1 (en) | 2012-02-09 |
CN102387814A (zh) | 2012-03-21 |
MX2011007832A (es) | 2011-10-06 |
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