HK1201847A1 - 延長體內半衰期的人抗 抗體及其在治療腫瘤、自身免疫性疾病和炎症性疾病中的應用 - Google Patents
延長體內半衰期的人抗 抗體及其在治療腫瘤、自身免疫性疾病和炎症性疾病中的應用Info
- Publication number
- HK1201847A1 HK1201847A1 HK15102182.7A HK15102182A HK1201847A1 HK 1201847 A1 HK1201847 A1 HK 1201847A1 HK 15102182 A HK15102182 A HK 15102182A HK 1201847 A1 HK1201847 A1 HK 1201847A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- oncology
- antibodies
- extended
- life
- treatment
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14810609P | 2009-01-29 | 2009-01-29 | |
US18418209P | 2009-06-04 | 2009-06-04 |
Publications (1)
Publication Number | Publication Date |
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HK1201847A1 true HK1201847A1 (zh) | 2015-09-11 |
Family
ID=42396023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102182.7A HK1201847A1 (zh) | 2009-01-29 | 2012-09-18 | 延長體內半衰期的人抗 抗體及其在治療腫瘤、自身免疫性疾病和炎症性疾病中的應用 |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120034212A1 (zh) |
EP (1) | EP2391384A4 (zh) |
JP (3) | JP2012516158A (zh) |
KR (1) | KR20110108398A (zh) |
CN (2) | CN104119438A (zh) |
AU (1) | AU2010208125B2 (zh) |
BR (1) | BRPI1007005A2 (zh) |
CA (1) | CA2749200A1 (zh) |
HK (1) | HK1201847A1 (zh) |
MX (1) | MX337590B (zh) |
RU (2) | RU2650594C1 (zh) |
SG (3) | SG10201704214VA (zh) |
WO (1) | WO2010088444A1 (zh) |
ZA (2) | ZA201104796B (zh) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
AU2010208125B2 (en) * | 2009-01-29 | 2015-02-12 | Medimmune, Llc | Human anti-IL-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
EP2403873A1 (en) | 2009-03-05 | 2012-01-11 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
EP2805731B1 (en) * | 2009-09-03 | 2018-10-31 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
CN103261222B (zh) | 2010-09-10 | 2017-07-28 | 医疗免疫有限公司 | 抗体衍生物 |
EP2654790B1 (en) * | 2010-12-22 | 2019-02-06 | Teva Pharmaceuticals Australia Pty Ltd | Modified antibody with improved half-life |
RS62238B1 (sr) | 2011-02-10 | 2021-09-30 | Roche Glycart Ag | Mutantni interleukin-2 polipeptidi |
US8753634B2 (en) | 2011-03-03 | 2014-06-17 | Apexigen, Inc. | Anti-IL-6 receptor antibodies and methods of use |
EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
US20140335089A1 (en) | 2011-09-30 | 2014-11-13 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting elimination of antigens |
CN110680920A (zh) | 2011-09-30 | 2020-01-14 | 中外制药株式会社 | 诱导针对靶抗原的免疫应答的抗原结合分子 |
WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
AU2013223087B2 (en) | 2012-02-24 | 2018-02-22 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting disappearance of antigen via FcgammaRIIb |
WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
RU2656162C2 (ru) * | 2012-10-22 | 2018-05-31 | Фоунтейн Биофарма Инк. | Антитела к интерлейкину 6 и их применение |
RU2015119547A (ru) * | 2012-10-25 | 2016-12-20 | МЕДИММЬЮН, ЭлЭлСи | Стабильный низковязкий состав с антителом |
US10772940B1 (en) * | 2012-12-11 | 2020-09-15 | University Of Kentucky Research Foundation | Cocaine hydrolase-FC fusion proteins for cocaine and methods for utilizing the same |
EP3514175A1 (fr) * | 2012-12-17 | 2019-07-24 | Laboratoire Français du Fractionnement et des Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
FR2999431B1 (fr) * | 2012-12-17 | 2016-03-18 | Lfb Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
RU2701684C2 (ru) * | 2013-10-31 | 2019-09-30 | Ридженерон Фармасьютикалз, Инк. | Анализ конкурентного связывания с лигандом для обнаружения нейтрализирующих антител |
TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
KR20240023450A (ko) | 2014-11-07 | 2024-02-21 | 에프. 호프만 라-로셰 엘티디 | 향상된 il-6 항체 |
EP3888752A1 (en) * | 2015-07-31 | 2021-10-06 | MedImmune Limited | Il-6 antibodies for use in treating cardiovascular diseases |
BR112018017031A2 (pt) * | 2016-02-23 | 2019-01-22 | Sesen Bio Inc | formulações de antagonista de il-6 e usos das mesmas |
AU2017248280A1 (en) * | 2016-04-07 | 2018-10-25 | Janssen Biotech, Inc. | Treatment of depression using agents that block binding of IL-6 to IL-6 receptor |
SG11201906852XA (en) * | 2017-02-01 | 2019-08-27 | Univ Yale | Treatment of diuretic resistance |
PE20211196A1 (es) * | 2018-01-05 | 2021-07-01 | Novo Nordisk As | Metodos para tratar inflamacion mediada por il-6 sin inmunosupresion |
CN112672788A (zh) | 2018-07-24 | 2021-04-16 | 免疫医疗有限责任公司 | 抗金黄色葡萄球菌凝集因子a(clfa)的抗体 |
AU2019357983A1 (en) | 2018-10-09 | 2021-05-27 | Medimmune, Llc | Combinations of anti-staphylococcus aureus antibodies |
JP7459075B2 (ja) | 2018-10-09 | 2024-04-01 | メディミューン,エルエルシー | スタフィロコッカス・アウレウス(Staphylococcus aureus)ロイコトキシンに対して向けられた抗体 |
WO2020185986A1 (en) | 2019-03-13 | 2020-09-17 | Medimmune, Llc | Decreasing staphylococcus aureus infections in colonized patients |
MA55809A (fr) | 2019-05-01 | 2022-03-09 | Novo Nordisk As | Formulation d'anticorps anti-il-6 |
CN111057152B (zh) * | 2019-12-11 | 2022-03-11 | 中国人民解放军第四军医大学 | 一种抗人IL-6Ra单克隆抗体及其应用 |
WO2021136841A2 (fr) * | 2019-12-31 | 2021-07-08 | Peptinov | Composition pharmaceutique pour la prevention ou le traitement des douleurs post-operatoires |
WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
TW202208423A (zh) | 2020-05-17 | 2022-03-01 | 英商阿斯特捷利康英國股份有限公司 | Sars-cov-2抗體及其選擇和使用方法 |
AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
CN116234577A (zh) | 2020-08-10 | 2023-06-06 | 阿斯利康(英国)有限公司 | 用于治疗和预防covid-19的sars-cov-2抗体 |
TW202342095A (zh) | 2021-11-05 | 2023-11-01 | 英商阿斯特捷利康英國股份有限公司 | 用於治療和預防covid—19之組成物 |
TW202342510A (zh) | 2022-02-18 | 2023-11-01 | 英商Rq生物科技有限公司 | 抗體 |
WO2023209177A1 (en) | 2022-04-29 | 2023-11-02 | Astrazeneca Uk Limited | Sars-cov-2 antibodies and methods of using the same |
WO2024073718A1 (en) * | 2022-09-30 | 2024-04-04 | Sonnet BioTherapeutics, Inc. | Low dose il-6 formulations and methods of use thereof |
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EP2737907A3 (en) * | 2007-05-07 | 2014-11-05 | MedImmune, LLC | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
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-
2010
- 2010-01-29 AU AU2010208125A patent/AU2010208125B2/en active Active
- 2010-01-29 US US13/146,278 patent/US20120034212A1/en not_active Abandoned
- 2010-01-29 RU RU2015150249A patent/RU2650594C1/ru active
- 2010-01-29 EP EP10736433A patent/EP2391384A4/en not_active Ceased
- 2010-01-29 BR BRPI1007005A patent/BRPI1007005A2/pt not_active Application Discontinuation
- 2010-01-29 MX MX2011007832A patent/MX337590B/es active IP Right Grant
- 2010-01-29 SG SG10201704214VA patent/SG10201704214VA/en unknown
- 2010-01-29 KR KR1020117019221A patent/KR20110108398A/ko not_active Application Discontinuation
- 2010-01-29 JP JP2011548315A patent/JP2012516158A/ja active Pending
- 2010-01-29 RU RU2011135422/10A patent/RU2011135422A/ru not_active Application Discontinuation
- 2010-01-29 SG SG2011046265A patent/SG172354A1/en unknown
- 2010-01-29 SG SG2014007637A patent/SG2014007637A/en unknown
- 2010-01-29 WO PCT/US2010/022478 patent/WO2010088444A1/en active Application Filing
- 2010-01-29 CN CN201410349897.9A patent/CN104119438A/zh active Pending
- 2010-01-29 CN CN2010800103915A patent/CN102387814A/zh active Pending
- 2010-01-29 CA CA2749200A patent/CA2749200A1/en not_active Abandoned
-
2011
- 2011-06-28 ZA ZA2011/04796A patent/ZA201104796B/en unknown
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2012
- 2012-09-18 HK HK15102182.7A patent/HK1201847A1/zh unknown
- 2012-09-27 ZA ZA2012/07249A patent/ZA201207249B/en unknown
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2014
- 2014-04-15 US US14/253,161 patent/US20140302058A1/en not_active Abandoned
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2015
- 2015-06-19 JP JP2015123389A patent/JP2016019517A/ja active Pending
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2016
- 2016-12-02 US US15/368,499 patent/US20170101468A1/en not_active Abandoned
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2017
- 2017-06-07 JP JP2017112163A patent/JP2017206519A/ja active Pending
Also Published As
Publication number | Publication date |
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CN104119438A (zh) | 2014-10-29 |
RU2011135422A (ru) | 2013-03-10 |
KR20110108398A (ko) | 2011-10-05 |
JP2016019517A (ja) | 2016-02-04 |
EP2391384A4 (en) | 2012-12-26 |
US20120034212A1 (en) | 2012-02-09 |
ZA201104796B (en) | 2018-11-28 |
US20170101468A1 (en) | 2017-04-13 |
BRPI1007005A2 (pt) | 2016-03-22 |
CA2749200A1 (en) | 2010-08-05 |
AU2010208125A1 (en) | 2011-07-21 |
JP2012516158A (ja) | 2012-07-19 |
US20140302058A1 (en) | 2014-10-09 |
MX2011007832A (es) | 2011-10-06 |
MX337590B (es) | 2016-03-11 |
EP2391384A1 (en) | 2011-12-07 |
ZA201207249B (en) | 2013-08-28 |
SG2014007637A (en) | 2014-03-28 |
WO2010088444A1 (en) | 2010-08-05 |
SG10201704214VA (en) | 2017-06-29 |
JP2017206519A (ja) | 2017-11-24 |
AU2010208125B2 (en) | 2015-02-12 |
SG172354A1 (en) | 2011-07-28 |
RU2650594C1 (ru) | 2018-04-17 |
CN102387814A (zh) | 2012-03-21 |
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