JP2018512380A5 - - Google Patents
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- JP2018512380A5 JP2018512380A5 JP2017542486A JP2017542486A JP2018512380A5 JP 2018512380 A5 JP2018512380 A5 JP 2018512380A5 JP 2017542486 A JP2017542486 A JP 2017542486A JP 2017542486 A JP2017542486 A JP 2017542486A JP 2018512380 A5 JP2018512380 A5 JP 2018512380A5
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- Prior art keywords
- tumor antigen
- individual
- antigen peptides
- cancer
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 122
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- 201000011510 cancer Diseases 0.000 claims description 28
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 16
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 16
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 16
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- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 claims description 3
- 238000003501 co-culture Methods 0.000 claims description 3
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- 206010006187 Breast cancer Diseases 0.000 claims description 2
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- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 2
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims description 2
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- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
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- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 102100021688 Rho guanine nucleotide exchange factor 5 Human genes 0.000 claims 1
- 101710149792 Triosephosphate isomerase, chloroplastic Proteins 0.000 claims 1
- 101710195516 Triosephosphate isomerase, glycosomal Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 20
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 230000001506 immunosuppresive effect Effects 0.000 description 3
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/074227 | 2015-03-13 | ||
| PCT/CN2015/074227 WO2016145578A1 (en) | 2015-03-13 | 2015-03-13 | Methods of cancer treatment using activated t cells |
| PCT/CN2016/076165 WO2016146035A1 (en) | 2015-03-13 | 2016-03-11 | Methods of cancer treatment using activated t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021009572A Division JP7244117B2 (ja) | 2015-03-13 | 2021-01-25 | 活性化ｔ細胞を用いるがん治療の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512380A JP2018512380A (ja) | 2018-05-17 |
| JP2018512380A5 true JP2018512380A5 (enExample) | 2019-04-18 |
| JP6856534B2 JP6856534B2 (ja) | 2021-04-07 |
Family
ID=56918222
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542486A Active JP6856534B2 (ja) | 2015-03-13 | 2016-03-11 | 活性化ｔ細胞を用いるがん治療の方法 |
| JP2021009572A Active JP7244117B2 (ja) | 2015-03-13 | 2021-01-25 | 活性化ｔ細胞を用いるがん治療の方法 |
| JP2022092917A Withdrawn JP2022111272A (ja) | 2015-03-13 | 2022-06-08 | 活性化ｔ細胞を用いるがん治療の方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021009572A Active JP7244117B2 (ja) | 2015-03-13 | 2021-01-25 | 活性化ｔ細胞を用いるがん治療の方法 |
| JP2022092917A Withdrawn JP2022111272A (ja) | 2015-03-13 | 2022-06-08 | 活性化ｔ細胞を用いるがん治療の方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10967054B2 (enExample) |
| EP (2) | EP4219690A3 (enExample) |
| JP (3) | JP6856534B2 (enExample) |
| KR (2) | KR102698909B1 (enExample) |
| CN (3) | CN115607659A (enExample) |
| CA (1) | CA2975602A1 (enExample) |
| IL (2) | IL253795B (enExample) |
| RU (1) | RU2729362C2 (enExample) |
| WO (2) | WO2016145578A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| ES2970865T3 (es) | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| US20170224796A1 (en) | 2016-02-05 | 2017-08-10 | Xeme Biopharma Inc. | Therapeutic Cancer Vaccine Containing Tumor-Associated Neoantigens and Immunostimulants in a Delivery System |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| JP7623784B2 (ja) | 2016-10-13 | 2025-01-29 | ジュノー セラピューティクス インコーポレイテッド | トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物 |
| JP7080458B2 (ja) * | 2016-10-14 | 2022-06-06 | 国立大学法人京都大学 | Ｐｄ－１経路阻害薬の薬剤感受性を判定する方法 |
| WO2018071576A1 (en) * | 2016-10-14 | 2018-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Treatment of tumors by inhibition of cd300f |
| GB201618291D0 (en) * | 2016-10-28 | 2016-12-14 | Bergen Teknologioverf�Ring As | Novel immunotherapeutic treatments for tumours |
| WO2018098636A1 (zh) * | 2016-11-29 | 2018-06-07 | 深圳华大基因研究院 | 多肽及其应用 |
| US20200095547A1 (en) * | 2016-12-02 | 2020-03-26 | Darya ALIZADEH | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
| JP2020506943A (ja) * | 2017-02-07 | 2020-03-05 | メモリアル スローン ケタリング キャンサー センター | 養子免疫療法における抗原特異的ｔ細胞と組み合わせた免疫チェックポイント調節剤の使用 |
| AU2018219862B2 (en) | 2017-02-07 | 2020-09-17 | Nant Holding IP, LLC | Maximizing T-cell memory and compositions and methods therefor |
| JP6664684B1 (ja) * | 2017-02-07 | 2020-03-13 | 学校法人 埼玉医科大学 | がん免疫療法の臨床効果を予測する免疫学的バイオマーカー |
| EP3642331B1 (en) * | 2017-06-22 | 2023-05-24 | NEOGAP Therapeutics AB | T-cell expansion method and uses |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| US20200363414A1 (en) * | 2017-09-05 | 2020-11-19 | Gritstone Oncology, Inc. | Neoantigen Identification for T-Cell Therapy |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| WO2019090156A1 (en) * | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| EP3707245A1 (en) * | 2017-11-06 | 2020-09-16 | Ludwig Institute for Cancer Research Ltd | Method for expansion of lymphocytes |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| US10363008B2 (en) * | 2017-11-27 | 2019-07-30 | Canon Medical Systems Usa, Inc. | Computed tomography perfusion (CTP) method and apparatus using blood flow for discriminating types of cancer |
| US20200368336A1 (en) * | 2017-12-01 | 2020-11-26 | Shanghai Jenomed Biotech Co., Ltd. | Method for preparing personalized cancer vaccine |
| CN111670040A (zh) * | 2018-01-08 | 2020-09-15 | 密歇根大学董事会 | Aldh1抗原冲击树突状细胞 |
| WO2019183924A1 (en) * | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196088A1 (en) * | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| WO2019196087A1 (en) * | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of cancer treatment using tumor antigen-specific t cells |
| JP2021526365A (ja) * | 2018-05-18 | 2021-10-07 | チルドレンズ ナショナル メディカル センターＣｈｉｌｄｒｅｎ’Ｓ Ｎａｔｉｏｎａｌ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 改善された標的化ｔ細胞療法 |
| WO2020023420A2 (en) | 2018-07-23 | 2020-01-30 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
| CA3106564A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for breast cancer |
| US20220349010A1 (en) | 2018-07-26 | 2022-11-03 | Frame Pharmaceuticals B.V. | Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database |
| US20210172961A1 (en) * | 2018-07-27 | 2021-06-10 | Board Of Regents, The University Of Texas System | Methods for identifying rna editing-derived epitopes that elicit immune responses in cancer |
| CN109337873A (zh) * | 2018-09-30 | 2019-02-15 | 北京鼎成肽源生物技术有限公司 | 一种lrff细胞 |
| CN109294997B (zh) * | 2018-09-30 | 2020-09-25 | 北京鼎成肽源生物技术有限公司 | 一种lrfft1细胞 |
| CN109295106B (zh) * | 2018-09-30 | 2020-07-24 | 北京鼎成肽源生物技术有限公司 | 一种hafft1细胞 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020092379A1 (en) * | 2018-10-29 | 2020-05-07 | Genocea Biosciences, Inc. | Treatment methods |
| WO2020106982A1 (en) * | 2018-11-21 | 2020-05-28 | Board Of Regents, The University Of Texas System | Methods of overcoming resistance to immune checkpoint inhibitors |
| CN113272419A (zh) * | 2018-12-04 | 2021-08-17 | 南托米克斯有限责任公司 | 制备治疗性t淋巴细胞的方法 |
| WO2020146434A2 (en) * | 2019-01-07 | 2020-07-16 | Children's National Medical Center | Ex vivo activated t-lymphocytic compositions and methods of using the same |
| WO2020160285A1 (en) * | 2019-02-01 | 2020-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | SIRPα EXPRESSION ON T CELLS IS A BIOMARKER FOR FUNCTIONAL T CELLS DURING EXHAUSTION |
| EP3930755A4 (en) * | 2019-03-01 | 2023-03-22 | Flow Pharma Inc. | DESIGN, MANUFACTURE AND USE OF PERSONALIZED CANCER VACCINES |
| CN111751545A (zh) * | 2019-03-28 | 2020-10-09 | 中国科学院上海药物研究所 | 一种筛选pd-l1/pd-1检测点抑制剂的方法 |
| WO2020227279A1 (en) * | 2019-05-06 | 2020-11-12 | Hasumi International Research Foundation | Therapy and methods of introducing immature dendritic cells and/or cytotoxic t lymphocyte and anti pd-1 / pd-l1 antibody for treatment of tumors |
| KR20220026575A (ko) * | 2019-06-25 | 2022-03-04 | 시티 오브 호프 | Pdl1 양성 nk 세포 암 치료 |
| JP7390740B2 (ja) * | 2019-10-31 | 2023-12-04 | 公立大学法人福島県立医科大学 | 腫瘍の治療及び／又は予防のための組成物 |
| MX2019015508A (es) | 2019-12-18 | 2021-06-21 | Univ Guadalajara | Nanopartículas para el tratamiento del cáncer. |
| CN111337681A (zh) * | 2020-03-20 | 2020-06-26 | 上海东方肝胆外科医院 | 评估肝细胞癌预后的标志物、试剂盒及方法 |
| CN115461062A (zh) * | 2020-04-28 | 2022-12-09 | 阿基里斯治疗英国有限公司 | T细胞疗法 |
| CN116018158A (zh) * | 2020-04-30 | 2023-04-25 | 转化基因组学研究所 | 新抗原知情的肿瘤浸润性淋巴细胞癌免疫疗法 |
| CN111575232A (zh) * | 2020-05-15 | 2020-08-25 | 暨南大学 | JQ1在抑制T淋巴细胞PD-1和/或Tim-3表达中的应用 |
| CN111647563A (zh) * | 2020-08-06 | 2020-09-11 | 北京翊博普惠生物科技发展有限公司 | 靶向Survivin全抗原的DC细胞、CTL细胞及其制备方法和应用 |
| WO2022059780A1 (ja) * | 2020-09-18 | 2022-03-24 | サイアス株式会社 | ｉＰＳ細胞を介する再生Ｔ細胞の製造方法 |
| CN112501308B (zh) * | 2020-11-30 | 2025-10-10 | 中国水产科学研究院珠江水产研究所 | 一组鳖科动物线粒体全基因组扩增通用引物 |
| CN113307859B (zh) * | 2021-03-24 | 2022-03-01 | 深圳市新靶向生物科技有限公司 | 一种与乳腺癌驱动基因突变相关的抗原肽组合及其应用 |
| JP7426165B2 (ja) * | 2021-06-30 | 2024-02-01 | ノバセラム株式会社 | 血中循環腫瘍細胞を含む試料を調製する方法 |
| WO2023072863A1 (en) * | 2021-10-25 | 2023-05-04 | Ellennbe Gmbh | Pharmaceutical composition and kit comprising an immunomodulatory substance for treating diseases |
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