JP2021520849A5 - - Google Patents
Info
- Publication number
- JP2021520849A5 JP2021520849A5 JP2021504566A JP2021504566A JP2021520849A5 JP 2021520849 A5 JP2021520849 A5 JP 2021520849A5 JP 2021504566 A JP2021504566 A JP 2021504566A JP 2021504566 A JP2021504566 A JP 2021504566A JP 2021520849 A5 JP2021520849 A5 JP 2021520849A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- tumor antigen
- acid sequence
- seq
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024046768A JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2018/082947 WO2019196088A1 (en) | 2018-04-13 | 2018-04-13 | Methods of obtaining tumor-specific t cell receptors |
| CNPCT/CN2018/082947 | 2018-04-13 | ||
| PCT/CN2019/082408 WO2019196924A1 (en) | 2018-04-13 | 2019-04-12 | Methods of obtaining tumor-specific t cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024046768A Division JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520849A JP2021520849A (ja) | 2021-08-26 |
| JP2021520849A5 true JP2021520849A5 (enExample) | 2022-04-20 |
| JP7549826B2 JP7549826B2 (ja) | 2024-09-12 |
Family
ID=68163041
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021504566A Active JP7549826B2 (ja) | 2018-04-13 | 2019-04-12 | 腫瘍特異的ｔ細胞受容体を得る方法 |
| JP2024046768A Pending JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024046768A Pending JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11390659B2 (enExample) |
| EP (1) | EP3775168A4 (enExample) |
| JP (2) | JP7549826B2 (enExample) |
| KR (1) | KR102805266B1 (enExample) |
| CN (4) | CN112534045A (enExample) |
| TW (1) | TW202012619A (enExample) |
| WO (2) | WO2019196088A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| WO2019196087A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of cancer treatment using tumor antigen-specific t cells |
| CN116298309B (zh) | 2018-08-13 | 2024-04-02 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
| WO2020206238A2 (en) | 2019-04-05 | 2020-10-08 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| US20220236253A1 (en) * | 2019-05-31 | 2022-07-28 | Modernatx, Inc. | Expanded t cell assay |
| BR112022000790A2 (pt) * | 2019-07-15 | 2022-04-12 | Neogene Therapeutics B V | Método para isolar genes tcr |
| EP4061487A4 (en) * | 2019-11-19 | 2023-12-20 | Rootpath Genomics, Inc. | COMPOSITIONS AND METHODS FOR IDENTIFYING T CELL RECEPTOR |
| WO2021108500A1 (en) * | 2019-11-26 | 2021-06-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | T cell receptors targeting mutations in rna splicing factors |
| EP4100051A2 (en) * | 2020-02-07 | 2022-12-14 | ISA Pharmaceuticals B.V. | Treatment of hpv-related diseases |
| CN111234005B (zh) * | 2020-03-13 | 2022-11-29 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | 氨苯砜药物超敏反应性t细胞受体及其用途 |
| MX2023003372A (es) * | 2020-09-24 | 2023-05-04 | Medigene Immunotherapies Gmbh | Nuevos receptores prame y usos de los mismos. |
| US20250073333A1 (en) * | 2021-07-19 | 2025-03-06 | Board Of Regents, The University Of Texas System | Peptides and engineered t cell receptors targeting fanci, rad51, and pbk antigens and methods of use |
| EP4405464A4 (en) * | 2021-09-21 | 2025-12-03 | Univ Chicago | METHODS AND COMPOSITION USING PATIENT-DERIVED AUTOLOGOUS NEOANTIGENS FOR CANCER TREATMENT |
| CN116063511B (zh) * | 2021-09-30 | 2023-10-03 | 北京可瑞生物科技有限公司 | 抗原结合蛋白及其应用 |
| US20250025499A1 (en) * | 2021-11-02 | 2025-01-23 | Fred Hutchinson Cancer Center | T cell immunotherapy for hematologic malignancies having an sf3b1 mutation |
| CN119677842A (zh) * | 2022-03-17 | 2025-03-21 | 科士华(南京)生物技术有限公司 | 人工合成肿瘤浸润淋巴细胞 |
| CN119032110A (zh) * | 2022-04-07 | 2024-11-26 | 恺兴生命科技(上海)有限公司 | 嵌合多肽及其应用 |
| CN116063457A (zh) * | 2022-04-27 | 2023-05-05 | 恒瑞源正(广州)生物科技有限公司 | Mage-a1特异性t细胞受体及其用途 |
| KR20250024532A (ko) * | 2022-05-10 | 2025-02-18 | 지노스 세라퓨틱스, 인크. | 개인 맞춤형 암 에피토프 및 이의 사용 방법 |
| CN114920824B (zh) * | 2022-05-27 | 2023-12-05 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
| WO2025011485A1 (en) * | 2023-07-07 | 2025-01-16 | The University Of Hong Kong | Convergent recombination-derived hepatocellular carcinoma-specific tcrs and applications thereof |
| CN117567595B (zh) * | 2024-01-17 | 2024-05-14 | 恒瑞源正(广州)生物科技有限公司 | Mage-a4特异性t细胞受体及其用途 |
| CN120518771A (zh) * | 2024-02-20 | 2025-08-22 | 上海信谱生物医药科技有限公司 | 一种识别kras突变的t细胞受体及其编码序列 |
| WO2025193663A2 (en) * | 2024-03-11 | 2025-09-18 | Affini-T Therapeutics, Inc. | Compositions and methods for treating neoplasia |
| CN119613530B (zh) * | 2024-12-13 | 2025-09-05 | 华中科技大学 | 一种靶向肝癌细胞甲胎蛋白抗原肽与hla-a24复合物的特异性tcr分子、tcr-t细胞及制备与应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| EP1320599A2 (en) | 2000-06-28 | 2003-06-25 | Genetics Institute, LLC | Pd-l2 molecules: pd-1 ligands and uses therefor |
| CN1609197A (zh) * | 2003-10-17 | 2005-04-27 | 上海普泛生物科技有限公司 | 一种用于发现肿瘤特异性抗原和肿瘤特异性抗原决定簇的高产率逆反免疫法 |
| US20090304679A1 (en) * | 2004-05-27 | 2009-12-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| JP5020935B2 (ja) | 2005-04-08 | 2012-09-05 | アルゴス セラピューティクス，インコーポレイティド | 樹状細胞組成物および方法 |
| EP1795599A1 (en) * | 2005-12-09 | 2007-06-13 | Schuler, Gerold, Prof. Dr. | Methods for generating antigen-specific effector T cells |
| EP2468763B1 (en) * | 2007-05-31 | 2014-06-18 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines |
| CA2704232C (en) | 2007-11-08 | 2017-05-02 | Dana-Farber Cancer Institute, Inc. | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28 |
| PT2271767T (pt) | 2008-04-03 | 2016-08-18 | Cb Biotechnologies Inc | Reação em cadeia de polimerase para captura de amplicões em multiplexo para amplificação de alvos múltiplos |
| EP2258719A1 (en) * | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| EP2567226B1 (en) | 2010-05-06 | 2016-08-10 | Adaptive Biotechnologies Corporation | Monitoring health and disease status using clonotype profiles |
| HRP20171164T1 (hr) | 2010-09-20 | 2017-10-20 | Biontech Cell & Gene Therapies Gmbh | Antigen-specifični t stanični receptori i t stanični epitopi |
| US9187534B2 (en) * | 2011-03-11 | 2015-11-17 | Universite De Geneve | Multi-epitopic vaccine |
| WO2013074820A1 (en) * | 2011-11-16 | 2013-05-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Immunogenic tumor associated stromal cell antigen peptides and methods of their use |
| JP6309209B2 (ja) * | 2013-05-31 | 2018-04-11 | 国立研究開発法人国立国際医療研究センター | 血管平滑筋細胞の増殖を抑制する血管内皮細胞の検出方法 |
| ES2932429T3 (es) * | 2013-07-15 | 2023-01-19 | Us Health | Métodos de preparación de células T anti-antígeno de virus del papiloma humano |
| ES2745472T3 (es) * | 2013-07-15 | 2020-03-02 | The U S A As Represented By The Secretary Department Of Health And Human Services Office Of Tech Tra | Receptores de células T anti-virus del papiloma humano 16 E6 |
| CA3017170C (en) | 2014-09-17 | 2021-03-23 | The Johns Hopkins University | Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells |
| CN104593325A (zh) * | 2014-12-09 | 2015-05-06 | 深圳源正细胞医疗技术有限公司 | 诱导dc成熟并分泌高浓度促炎因子的方法 |
| WO2016145578A1 (en) * | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| DK3271382T3 (da) * | 2015-03-16 | 2020-05-04 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek |
| US20180171294A1 (en) | 2015-03-26 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping |
| GB201604492D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| US20170319638A1 (en) * | 2016-05-06 | 2017-11-09 | Virttu Biologics Limited | Treatment of cancer |
| EP3468585A2 (en) | 2016-06-10 | 2019-04-17 | IO Biotech APS | Calr and jak2 vaccine compositions |
| US9642906B2 (en) * | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
| CN106645677B (zh) | 2016-11-15 | 2019-08-09 | 恒瑞源正（上海）生物科技有限公司 | 体外检测肿瘤新生抗原特异性t细胞的方法、试剂盒以及肿瘤疫苗 |
| KR20240007775A (ko) * | 2016-12-08 | 2024-01-16 | 이매틱스 바이오테크놀로지스 게엠베하 | T 세포 수용체 및 이를 사용하는 면역 요법 |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196087A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of cancer treatment using tumor antigen-specific t cells |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
-
2018
- 2018-04-13 WO PCT/CN2018/082947 patent/WO2019196088A1/en not_active Ceased
-
2019
- 2019-04-12 CN CN201980025587.2A patent/CN112534045A/zh active Pending
- 2019-04-12 JP JP2021504566A patent/JP7549826B2/ja active Active
- 2019-04-12 KR KR1020207032466A patent/KR102805266B1/ko active Active
- 2019-04-12 US US17/047,059 patent/US11390659B2/en active Active
- 2019-04-12 CN CN202110295574.6A patent/CN112979783B/zh active Active
- 2019-04-12 CN CN202110295872.5A patent/CN113185602B/zh active Active
- 2019-04-12 TW TW108112961A patent/TW202012619A/zh unknown
- 2019-04-12 EP EP19785434.2A patent/EP3775168A4/en active Pending
- 2019-04-12 WO PCT/CN2019/082408 patent/WO2019196924A1/en not_active Ceased
- 2019-04-12 CN CN202310140638.4A patent/CN116003575A/zh active Pending
-
2022
- 2022-06-17 US US17/843,916 patent/US12358967B2/en active Active
- 2022-06-17 US US17/843,917 patent/US20220403000A1/en active Pending
- 2022-06-17 US US17/843,912 patent/US20230023834A1/en active Pending
- 2022-06-17 US US17/843,920 patent/US20230212253A1/en active Pending
-
2023
- 2023-10-11 US US18/485,248 patent/US20240052010A1/en active Pending
-
2024
- 2024-03-22 JP JP2024046768A patent/JP2024069663A/ja active Pending
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