BR112022000790A2 - Método para isolar genes tcr - Google Patents

Método para isolar genes tcr

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Publication number
BR112022000790A2
BR112022000790A2 BR112022000790A BR112022000790A BR112022000790A2 BR 112022000790 A2 BR112022000790 A2 BR 112022000790A2 BR 112022000790 A BR112022000790 A BR 112022000790A BR 112022000790 A BR112022000790 A BR 112022000790A BR 112022000790 A2 BR112022000790 A2 BR 112022000790A2
Authority
BR
Brazil
Prior art keywords
tcr genes
repertoires
methods
cell receptor
present
Prior art date
Application number
BR112022000790A
Other languages
English (en)
Inventor
Nicolaas Maria Schumacher Antonius
Carsten Linnemann
Sophie SCHRIKKEMA Deborah
M Bendle Gavin
W J Van Heijst Jeroen
F C Gadiot Jules
Raquel Gomez-Eerland
Thomas Kuilman
Original Assignee
Neogene Therapeutics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neogene Therapeutics B V filed Critical Neogene Therapeutics B V
Publication of BR112022000790A2 publication Critical patent/BR112022000790A2/pt

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Abstract

método para isolar genes tcr. a presente invenção fornece métodos para recuperar repertórios de receptores de célula t (tcrs). em algumas modalidades, os repertórios de tcr são recuperados a partir de amostras não viáveis. em algumas modalidades, bibliotecas de pares de tcraß são criadas. em algumas modalidades, os métodos revelados são usados para imunoterapia de câncer ou para fins de diagnóstico. descritos na presente invenção, em algumas modalidades, são métodos de identificar sequências nucleotídicas codificando cadeias de receptor de células t a (tcra) e tcrß provenientes de uma biblioteca combinatória de ácidos nucleicos.
BR112022000790A 2019-07-15 2020-07-13 Método para isolar genes tcr BR112022000790A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962874125P 2019-07-15 2019-07-15
US202062975924P 2020-02-13 2020-02-13
US202063024341P 2020-05-13 2020-05-13
US202063034157P 2020-06-03 2020-06-03
US202063039346P 2020-06-15 2020-06-15
PCT/US2020/041824 WO2021011482A1 (en) 2019-07-15 2020-07-13 Method to isolate tcr genes

Publications (1)

Publication Number Publication Date
BR112022000790A2 true BR112022000790A2 (pt) 2022-04-12

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BR112022000790A BR112022000790A2 (pt) 2019-07-15 2020-07-13 Método para isolar genes tcr

Country Status (12)

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US (1) US20210040558A1 (pt)
EP (1) EP3999528A4 (pt)
JP (1) JP2022541181A (pt)
KR (1) KR20220075210A (pt)
CN (1) CN114502579A (pt)
AU (1) AU2020315325A1 (pt)
BR (1) BR112022000790A2 (pt)
CA (1) CA3146845A1 (pt)
CL (1) CL2022000085A1 (pt)
MX (1) MX2022000667A (pt)
TW (1) TW202117014A (pt)
WO (1) WO2021011482A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3428194T3 (pl) 2017-07-14 2022-01-17 Immatics Biotechnologies Gmbh Ulepszona cząsteczka polipeptydu o podwójnej specyficzności
KR20230146538A (ko) 2021-01-20 2023-10-19 네오진 테라퓨틱스 비.브이. 조작된 항원 제시 세포
AU2022270361A1 (en) 2021-05-05 2023-11-16 Immatics Biotechnologies Gmbh Antigen binding proteins specifically binding prame
WO2023010436A1 (zh) * 2021-08-05 2023-02-09 卡瑞济(北京)生命科技有限公司 Tcr表达构建体以及其制备方法和用途
WO2023114994A1 (en) * 2021-12-16 2023-06-22 Board Of Regents, The University Of Texas System Personalized ranking and identification of onco-reactive t cell receptors and uses thereof
CN114134221B (zh) * 2022-01-28 2022-04-08 北京肿瘤医院(北京大学肿瘤医院) 一种筛选肿瘤特异tcr的方法
WO2023183344A1 (en) * 2022-03-21 2023-09-28 Alaunos Therapeutics, Inc. Methods for identifying neoantigen-reactive t cell receptors

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HUE048014T2 (hu) * 2012-09-14 2020-05-28 Us Health MHC Class II-korlátozott MAGE-A3-at felismerõ T-sejt receptorok
EP3234130B1 (en) * 2014-12-19 2020-11-25 The Broad Institute, Inc. Methods for profiling the t-cell- receptor repertoire
WO2019196088A1 (en) * 2018-04-13 2019-10-17 Syz Cell Therapy Co. Methods of obtaining tumor-specific t cell receptors

Also Published As

Publication number Publication date
US20210040558A1 (en) 2021-02-11
CN114502579A (zh) 2022-05-13
AU2020315325A1 (en) 2022-02-17
TW202117014A (zh) 2021-05-01
KR20220075210A (ko) 2022-06-07
CA3146845A1 (en) 2021-01-21
EP3999528A4 (en) 2023-10-25
MX2022000667A (es) 2022-07-21
WO2021011482A1 (en) 2021-01-21
EP3999528A1 (en) 2022-05-25
JP2022541181A (ja) 2022-09-22
CL2022000085A1 (es) 2022-09-20

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