JP2018506986A5 - - Google Patents
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- JP2018506986A5 JP2018506986A5 JP2017546094A JP2017546094A JP2018506986A5 JP 2018506986 A5 JP2018506986 A5 JP 2018506986A5 JP 2017546094 A JP2017546094 A JP 2017546094A JP 2017546094 A JP2017546094 A JP 2017546094A JP 2018506986 A5 JP2018506986 A5 JP 2018506986A5
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- pdgf
- fgf2
- cell
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- 239000001963 growth medium Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 8
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 8
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 7
- 239000006143 cell culture medium Substances 0.000 claims 6
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 5
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 5
- 108010081589 Becaplermin Proteins 0.000 claims 4
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 4
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 3
- 101800003838 Epidermal growth factor Proteins 0.000 claims 3
- 229940116977 epidermal growth factor Drugs 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012894 fetal calf serum Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021042409A JP7410899B2 (ja) | 2015-03-04 | 2021-03-16 | 間葉系幹細胞の細胞培養法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015900752 | 2015-03-04 | ||
| AU2015900752A AU2015900752A0 (en) | 2015-03-04 | Cell culture method | |
| AU2015900777A AU2015900777A0 (en) | 2015-03-05 | Cell culture method | |
| AU2015900777 | 2015-03-05 | ||
| PCT/EP2016/054640 WO2016139340A1 (en) | 2015-03-04 | 2016-03-04 | Cell culture method for mesenchymal stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021042409A Division JP7410899B2 (ja) | 2015-03-04 | 2021-03-16 | 間葉系幹細胞の細胞培養法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506986A JP2018506986A (ja) | 2018-03-15 |
| JP2018506986A5 true JP2018506986A5 (enExample) | 2019-04-11 |
| JP6885870B2 JP6885870B2 (ja) | 2021-06-16 |
Family
ID=55453191
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546094A Active JP6885870B2 (ja) | 2015-03-04 | 2016-03-04 | 間葉系幹細胞の細胞培養法 |
| JP2021042409A Active JP7410899B2 (ja) | 2015-03-04 | 2021-03-16 | 間葉系幹細胞の細胞培養法 |
| JP2023173585A Pending JP2024001179A (ja) | 2015-03-04 | 2023-10-05 | 間葉系幹細胞の細胞培養法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021042409A Active JP7410899B2 (ja) | 2015-03-04 | 2021-03-16 | 間葉系幹細胞の細胞培養法 |
| JP2023173585A Pending JP2024001179A (ja) | 2015-03-04 | 2023-10-05 | 間葉系幹細胞の細胞培養法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20180037867A1 (enExample) |
| EP (2) | EP4008775A1 (enExample) |
| JP (3) | JP6885870B2 (enExample) |
| KR (1) | KR102635212B1 (enExample) |
| CN (2) | CN113957043A (enExample) |
| AU (2) | AU2016227607B2 (enExample) |
| BR (1) | BR112017018885A2 (enExample) |
| CA (1) | CA2977578C (enExample) |
| SG (1) | SG11201706886PA (enExample) |
| WO (1) | WO2016139340A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2334785B2 (en) | 2008-09-16 | 2019-08-14 | Mayo Foundation For Medical Education And Research | Compositions containing platelet contents |
| WO2012048093A2 (en) | 2010-10-08 | 2012-04-12 | Osiris Therapeutics, Inc. | Enhanced msc preparations |
| EP3143130B1 (en) | 2014-05-16 | 2024-03-06 | Mayo Foundation for Medical Education and Research | Cell culture media compositions for primary cells |
| US20180037867A1 (en) | 2015-03-04 | 2018-02-08 | Mesoblast International Sàrl | Cell culture method for mesenchymal stem cells |
| WO2019102268A1 (en) | 2017-11-22 | 2019-05-31 | Mesoblast International Sarl | Cellular compositions and methods of treatment i |
| CN108251358B (zh) * | 2017-12-15 | 2021-10-26 | 广东药科大学 | 一种相同供体来源人间充质干细胞的多批次原代分离方法 |
| WO2019186471A1 (en) * | 2018-03-28 | 2019-10-03 | Pluristem Ltd. | Methods for expanding adherent stromal cells and cells obtained thereby |
| CN108624554B (zh) * | 2018-05-14 | 2021-09-14 | 山东大学 | 一种非基因修饰光操控双向调节人脐带间充质干细胞增殖的方法 |
| US11364323B2 (en) | 2018-09-17 | 2022-06-21 | Rejuvablast LLC | Combination grafts for tissue repair or regeneration applications |
| JPWO2020067443A1 (ja) * | 2018-09-27 | 2021-08-30 | テルモ株式会社 | 体細胞のシート化方法 |
| US12702683B2 (en) | 2019-01-03 | 2026-08-11 | Mesoblast International Sárl | Method for improving visual acuity |
| WO2021176001A1 (en) | 2020-03-05 | 2021-09-10 | Mesoblast International Sàrl | Method for treating inflammatory lung diseases using mesenchymal lineage precursor or stem cells |
| CA3181611A1 (en) * | 2020-06-11 | 2021-12-16 | Paul Simmons | 3d culture of mesenchymal lineage precursor or stem cells |
| US20240352423A1 (en) * | 2021-03-10 | 2024-10-24 | Terasaki Institute For Biomedical Innovation | Methods and systems of producing products such as animal derived products |
| CN117529234A (zh) * | 2021-03-10 | 2024-02-06 | 寺崎生物医学创新研究所 | 生产产品例如动物源性产品的方法和系统 |
| WO2024121821A1 (en) | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Conditioned media and use of the same |
| EP4630018A1 (en) | 2022-12-09 | 2025-10-15 | Mesoblast International Sàrl | Method of treating inflammation with cellular compositions |
| JP2025538783A (ja) | 2022-12-09 | 2025-11-28 | メゾブラスト・インターナショナル・エスアーエールエル | 事前承認された組成物及び細胞培養方法 |
| AU2023389700A1 (en) | 2022-12-09 | 2025-07-10 | Mesoblast International Sarl | Method of treating heart failure in subjects with persistent inflammation |
| WO2024218715A1 (en) | 2023-04-19 | 2024-10-24 | Btl Healthcare Technologies A.S. | Culture media based on protein hydrolysate and a process for preparing thereof |
| WO2024225602A1 (ko) * | 2023-04-24 | 2024-10-31 | 파미셀 주식회사 | 뉴클레오시드 함유 세포 배양배지 및 이를 이용한 세포 배양 방법 |
| KR20260061190A (ko) | 2023-08-28 | 2026-05-06 | 메조블라스트 인터내셔널 에스에이알엘 | GvHD에 대한 3차 치료 |
| WO2025062365A1 (en) | 2023-09-22 | 2025-03-27 | Mesoblast International Sárl | Mesenchymal lineage precursor or stem cells (mlpscs) for use in methods of treating congenital heart disease |
| US12668774B2 (en) | 2023-10-12 | 2026-06-30 | Btl Healthcare Technologies A.S. | Product, system and method of cell cultivation |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| WO1993003679A1 (de) | 1991-08-12 | 1993-03-04 | Karl Storz Gmbh & Co. | Hochfrequenzchirurgiegenerator zum geregelten schneiden und koagulieren |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US6204053B1 (en) | 1994-11-08 | 2001-03-20 | Diacrin, Inc. | Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
| US6277372B1 (en) | 1994-11-08 | 2001-08-21 | Diacrin, Inc. | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
| CA2216963C (en) | 1995-04-06 | 2010-06-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligands, methods of making and uses thereof |
| JP2001508302A (ja) | 1997-01-10 | 2001-06-26 | ライフ テクノロジーズ，インコーポレイテッド | 胚性幹細胞血清置換 |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| IL142914A0 (en) * | 1998-11-09 | 2002-04-21 | Consorzio Per La Gestione Del | Serum free medium for chondrocyte-like cells |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| EP1227823A2 (en) | 1999-10-20 | 2002-08-07 | Stem Cells, Inc. | Methods for inducing (in vivo) proliferation and migration of transplanted progenitor cells in the brain |
| US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| EP2338983B1 (en) | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| US20030224345A1 (en) | 2001-08-24 | 2003-12-04 | Advanced Cell Technology | Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy |
| EP1482787A4 (en) | 2002-02-13 | 2006-02-15 | Anthrogenesis Corp | EMBRYONIC TYPE DERIVED STEM CELLS DERIVED FROM MAMMALIAN POST-PARTUM PLACENTA, USES THEREOF, AND METHODS OF TREATMENT BASED ON CELLS OF THIS TYPE |
| WO2003102171A1 (en) | 2002-05-28 | 2003-12-11 | Becton, Dickinson And Company | Expansion and transdifferentiation of human acinar cells |
| BR0311362A (pt) | 2002-05-28 | 2006-10-31 | Novocell Inc | métodos, composições e fatores de crescimento e de diferenciação para produzir células produtoras de insulina |
| US8491883B2 (en) | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| ES2569780T3 (es) | 2003-06-27 | 2016-05-12 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas |
| WO2005084119A2 (en) | 2004-02-26 | 2005-09-15 | Reliance Life Sciences Pvt. Ltd. | Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof |
| ES2621847T3 (es) | 2004-12-23 | 2017-07-05 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas |
| CA2589063C (en) | 2004-12-23 | 2016-08-09 | DePuy Synthes Products, Inc. | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| EP1831355A2 (en) | 2004-12-23 | 2007-09-12 | Ethicon, Inc. | Soft tissue repair and regeneration using postpartum-derived cells and cell products |
| WO2006071773A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incoporated | Treatment of osteochondral diseases using postpartum-derived cells and products thereof |
| WO2008020815A1 (en) * | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
| WO2007027157A1 (en) * | 2005-09-02 | 2007-03-08 | Agency For Science, Technology And Research | Method of deriving progenitor cell line |
| KR101107835B1 (ko) | 2006-01-13 | 2012-02-09 | 가부시키가이샤 투셀 | 동물 세포의 무혈청 배양에 사용하기 위한 배양 배지 첨가물, 키트 및 이의 용도 |
| US20090232777A1 (en) * | 2006-03-01 | 2009-09-17 | Evy Lundgren-Akerlund | Expansion and Differentiation of Mesenchymal Stem Cells |
| JP2008148643A (ja) * | 2006-12-19 | 2008-07-03 | Olympus Corp | 無血清培地および幹細胞の培養方法 |
| CN103356710A (zh) | 2007-02-12 | 2013-10-23 | 人类起源公司 | 利用胎盘干细胞治疗炎性疾病 |
| WO2008151390A1 (en) | 2007-06-15 | 2008-12-18 | Australian Stem Cell Centre Ltd | Differentiation of human embryonic stem cells |
| US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
| KR101224588B1 (ko) * | 2008-01-24 | 2013-01-22 | 삼성전자주식회사 | 멀티포인트 스트록을 감지하기 위한 ｕｉ 제공방법 및 이를적용한 멀티미디어 기기 |
| US20110110888A1 (en) | 2008-06-27 | 2011-05-12 | Hai-Qing Xian | Scaffold Coated and/or Impregnated with at Least One Bioactive Agent for Tissue Repair and Other Medical Applications |
| US20100055078A1 (en) * | 2008-08-15 | 2010-03-04 | The Government of the U.S.A, as represented by the Department of Veterans Affairs | Methods of making a transplantable bone repair system using multipotent stem cells |
| US20110212523A1 (en) | 2008-11-11 | 2011-09-01 | Yukio Kato | Differentiation-inducing culture medium additive and use thereof |
| CN102325878A (zh) | 2008-12-23 | 2012-01-18 | 斯特姆塞尔思加利福尼亚有限公司 | 少突胶质前体细胞的靶向细胞群及制备与使用方法 |
| US10894944B2 (en) | 2009-04-10 | 2021-01-19 | Monash University | Cell culture media |
| DK2545928T3 (en) * | 2010-03-10 | 2016-10-03 | Two Cells Co Ltd | CELL PREPARATION CONTAINING MESENYKYMAL STEM CELLS AND METHOD OF PRODUCING THEREOF |
| WO2011159359A2 (en) * | 2010-06-17 | 2011-12-22 | Stemrd, Inc. | Serum-free chemically defined cell culture medium |
| CN109749996A (zh) * | 2011-01-12 | 2019-05-14 | 城户常雄 | 获得和维持纯化或富集的哺乳动物神经干细胞群和/或神经祖细胞群的培养方法 |
| KR101523040B1 (ko) * | 2012-06-26 | 2015-05-26 | 라정찬 | 고농도의 줄기세포 제조방법 |
| WO2014082685A1 (en) * | 2012-11-30 | 2014-06-05 | Swiss Stem Cell Foundation | Serum-free medium for human mesenchymal stem cells |
| CN103396984B (zh) * | 2013-07-25 | 2016-02-10 | 宗兆文 | 一种利用皮肤来源的祖细胞制备组织工程脊髓的方法 |
| US20180037867A1 (en) | 2015-03-04 | 2018-02-08 | Mesoblast International Sàrl | Cell culture method for mesenchymal stem cells |
-
2016
- 2016-03-04 US US15/553,115 patent/US20180037867A1/en not_active Abandoned
- 2016-03-04 BR BR112017018885A patent/BR112017018885A2/pt not_active Application Discontinuation
- 2016-03-04 AU AU2016227607A patent/AU2016227607B2/en active Active
- 2016-03-04 WO PCT/EP2016/054640 patent/WO2016139340A1/en not_active Ceased
- 2016-03-04 CN CN202111251410.XA patent/CN113957043A/zh active Pending
- 2016-03-04 KR KR1020177025840A patent/KR102635212B1/ko active Active
- 2016-03-04 SG SG11201706886PA patent/SG11201706886PA/en unknown
- 2016-03-04 EP EP21205011.6A patent/EP4008775A1/en active Pending
- 2016-03-04 CN CN201680025469.8A patent/CN107567494A/zh active Pending
- 2016-03-04 EP EP16707810.4A patent/EP3265554B1/en active Active
- 2016-03-04 CA CA2977578A patent/CA2977578C/en active Active
- 2016-03-04 JP JP2017546094A patent/JP6885870B2/ja active Active
-
2019
- 2019-10-11 US US16/599,271 patent/US11685899B2/en active Active
-
2021
- 2021-03-16 JP JP2021042409A patent/JP7410899B2/ja active Active
- 2021-10-19 AU AU2021254538A patent/AU2021254538B2/en active Active
-
2023
- 2023-03-21 US US18/124,346 patent/US12215352B2/en active Active
- 2023-10-05 JP JP2023173585A patent/JP2024001179A/ja active Pending
-
2024
- 2024-12-24 US US19/001,125 patent/US20250129337A1/en active Pending
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