JP2011206064A5 - - Google Patents
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- JP2011206064A5 JP2011206064A5 JP2011165510A JP2011165510A JP2011206064A5 JP 2011206064 A5 JP2011206064 A5 JP 2011206064A5 JP 2011165510 A JP2011165510 A JP 2011165510A JP 2011165510 A JP2011165510 A JP 2011165510A JP 2011206064 A5 JP2011206064 A5 JP 2011206064A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- stem cells
- culture
- embryonic stem
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002609 medium Substances 0.000 claims 20
- 210000001671 embryonic stem cell Anatomy 0.000 claims 17
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 12
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 9
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 9
- 229940126864 fibroblast growth factor Drugs 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 102000004877 Insulin Human genes 0.000 claims 6
- 108090001061 Insulin Proteins 0.000 claims 6
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims 6
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 6
- 102000004338 Transferrin Human genes 0.000 claims 6
- 108090000901 Transferrin Proteins 0.000 claims 6
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- 229940125396 insulin Drugs 0.000 claims 6
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 claims 6
- 229910052744 lithium Inorganic materials 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 6
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 6
- 239000012581 transferrin Substances 0.000 claims 6
- 229940088594 vitamin Drugs 0.000 claims 6
- 229930003231 vitamin Natural products 0.000 claims 6
- 235000013343 vitamin Nutrition 0.000 claims 6
- 239000011782 vitamin Substances 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 5
- 229960001031 glucose Drugs 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 5
- 238000004113 cell culture Methods 0.000 claims 4
- 239000003636 conditioned culture medium Substances 0.000 claims 4
- 102000002584 Octamer Transcription Factor-3 Human genes 0.000 claims 3
- 108010068425 Octamer Transcription Factor-3 Proteins 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108060003393 Granulin Proteins 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 108010031318 Vitronectin Proteins 0.000 claims 2
- 102100035140 Vitronectin Human genes 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- FDJKUWYYUZCUJX-AJKRCSPLSA-N N-glycoloyl-beta-neuraminic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@@H]1O[C@](O)(C(O)=O)C[C@H](O)[C@H]1NC(=O)CO FDJKUWYYUZCUJX-AJKRCSPLSA-N 0.000 claims 1
- FDJKUWYYUZCUJX-UHFFFAOYSA-N N-glycolyl-beta-neuraminic acid Natural products OCC(O)C(O)C1OC(O)(C(O)=O)CC(O)C1NC(=O)CO FDJKUWYYUZCUJX-UHFFFAOYSA-N 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000012606 in vitro cell culture Methods 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 125000005629 sialic acid group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60804004P | 2004-09-08 | 2004-09-08 | |
| US60/608,040 | 2004-09-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531300A Division JP5420837B2 (ja) | 2004-09-08 | 2005-09-08 | 胚幹細胞の培地及び培養 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011206064A JP2011206064A (ja) | 2011-10-20 |
| JP2011206064A5 true JP2011206064A5 (enExample) | 2011-12-01 |
Family
ID=35351611
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531300A Expired - Lifetime JP5420837B2 (ja) | 2004-09-08 | 2005-09-08 | 胚幹細胞の培地及び培養 |
| JP2011165510A Pending JP2011206064A (ja) | 2004-09-08 | 2011-07-28 | 胚幹細胞の培地及び培養 |
| JP2013202449A Pending JP2014014373A (ja) | 2004-09-08 | 2013-09-27 | 胚幹細胞の培地及び培養 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531300A Expired - Lifetime JP5420837B2 (ja) | 2004-09-08 | 2005-09-08 | 胚幹細胞の培地及び培養 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013202449A Pending JP2014014373A (ja) | 2004-09-08 | 2013-09-27 | 胚幹細胞の培地及び培養 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7449334B2 (enExample) |
| EP (1) | EP1791948B1 (enExample) |
| JP (3) | JP5420837B2 (enExample) |
| KR (1) | KR101264940B1 (enExample) |
| CN (2) | CN101052712A (enExample) |
| AT (1) | ATE549395T1 (enExample) |
| AU (1) | AU2005282510B2 (enExample) |
| BR (1) | BRPI0514778B1 (enExample) |
| CA (1) | CA2579643C (enExample) |
| ES (1) | ES2383813T3 (enExample) |
| GB (1) | GB2432846B (enExample) |
| IL (1) | IL181437A (enExample) |
| IS (1) | IS8618A (enExample) |
| MX (1) | MX2007002390A (enExample) |
| NO (1) | NO344695B1 (enExample) |
| NZ (1) | NZ553241A (enExample) |
| WO (1) | WO2006029197A1 (enExample) |
Families Citing this family (89)
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| ES2383813T3 (es) * | 2004-09-08 | 2012-06-26 | Wisconsin Alumni Research Foundation | Método de cultivo y cultivo de células madre embrionarias |
| US7442548B2 (en) * | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| CA2613889A1 (en) | 2005-06-08 | 2006-12-14 | Centocor, Inc. | A cellular therapy for ocular degeneration |
| WO2007016245A2 (en) * | 2005-07-29 | 2007-02-08 | Vivicells International, Llc | Reprogramming of adult or neonic stem cells and methods of use |
| WO2007042225A2 (en) * | 2005-10-07 | 2007-04-19 | Cellartis Ab | A method for obtaining a xeno-free hbs cell line |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB0613756D0 (en) * | 2006-07-12 | 2006-08-23 | Univ Sheffield | Cell culture medium |
| JP5419279B2 (ja) * | 2007-01-17 | 2014-02-19 | ウィスコンシン アラムニ リサーチ ファンデーション | 改良された幹細胞の培養 |
| WO2008112323A1 (en) * | 2007-03-15 | 2008-09-18 | California Stem Cell, Inc. | Cardiomyocytes and methods of producing and purifying cardiomyocytes |
| FI20075417A0 (fi) * | 2007-06-05 | 2007-06-05 | Marjo-Riitta Suuronen | Koostumuksia ja menetelmiä alkion kantasolujen kasvatukseen |
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| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| KR101574989B1 (ko) * | 2007-12-28 | 2015-12-21 | 후지레비오 가부시키가이샤 | 포유 동물 체세포용 배지 및 이를 위한 첨가제 |
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| EP3260534A1 (en) | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| BRPI0921996A2 (pt) | 2008-11-20 | 2015-08-18 | Centocor Ortho Biotech Inc | Métodos e composições para cultura e ligação de células em substratos planos. |
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| CN102559587A (zh) * | 2010-12-16 | 2012-07-11 | 中国科学院上海药物研究所 | 诱导性多能干细胞的制备方法以及用于制备诱导性多能干细胞的培养基 |
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| JP5128946B2 (ja) * | 2004-05-21 | 2013-01-23 | ウィセル リサーチ インスティテュート インコーポレイテッド | 胚性幹細胞のフィーダー非依存性長期培養 |
| ES2383813T3 (es) * | 2004-09-08 | 2012-06-26 | Wisconsin Alumni Research Foundation | Método de cultivo y cultivo de células madre embrionarias |
| US7442548B2 (en) * | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
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