JP2018503357A5 - - Google Patents
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- JP2018503357A5 JP2018503357A5 JP2017526547A JP2017526547A JP2018503357A5 JP 2018503357 A5 JP2018503357 A5 JP 2018503357A5 JP 2017526547 A JP2017526547 A JP 2017526547A JP 2017526547 A JP2017526547 A JP 2017526547A JP 2018503357 A5 JP2018503357 A5 JP 2018503357A5
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- 150000001875 compounds Chemical class 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 230000004048 modification Effects 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 102000007238 Transferrin Receptors Human genes 0.000 claims 13
- 108010033576 Transferrin Receptors Proteins 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 239000012636 effector Substances 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 7
- 210000003169 central nervous system Anatomy 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 230000024203 complement activation Effects 0.000 claims 5
- 230000013595 glycosylation Effects 0.000 claims 5
- 238000006206 glycosylation reaction Methods 0.000 claims 5
- 201000001119 neuropathy Diseases 0.000 claims 5
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- 208000033808 peripheral neuropathy Diseases 0.000 claims 5
- 210000001995 reticulocyte Anatomy 0.000 claims 5
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- 102100021257 Beta-secretase 1 Human genes 0.000 claims 3
- 101710150192 Beta-secretase 1 Proteins 0.000 claims 3
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- 208000015439 Lysosomal storage disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 206010002022 amyloidosis Diseases 0.000 claims 3
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- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 2
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
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- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102000004018 Caspase 6 Human genes 0.000 claims 1
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
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- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
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- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 108010036933 Presenilin-1 Proteins 0.000 claims 1
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- 229930003779 Vitamin B12 Natural products 0.000 claims 1
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- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
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- 239000012581 transferrin Substances 0.000 claims 1
- 235000019163 vitamin B12 Nutrition 0.000 claims 1
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- 235000019154 vitamin C Nutrition 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081827P | 2014-11-19 | 2014-11-19 | |
| US62/081,827 | 2014-11-19 | ||
| PCT/US2015/061405 WO2016081643A1 (en) | 2014-11-19 | 2015-11-18 | Anti-transferrin receptor antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173079A Division JP2021035365A (ja) | 2014-11-19 | 2020-10-14 | 抗トランスフェリン受容体抗体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503357A JP2018503357A (ja) | 2018-02-08 |
| JP2018503357A5 true JP2018503357A5 (https=) | 2018-12-27 |
| JP6779876B2 JP6779876B2 (ja) | 2020-11-04 |
Family
ID=54780465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526547A Active JP6779876B2 (ja) | 2014-11-19 | 2015-11-18 | 抗トランスフェリン受容体抗体及びその使用方法 |
| JP2020173079A Withdrawn JP2021035365A (ja) | 2014-11-19 | 2020-10-14 | 抗トランスフェリン受容体抗体及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173079A Withdrawn JP2021035365A (ja) | 2014-11-19 | 2020-10-14 | 抗トランスフェリン受容体抗体及びその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10508151B2 (https=) |
| EP (1) | EP3221362B1 (https=) |
| JP (2) | JP6779876B2 (https=) |
| CN (1) | CN107001473B (https=) |
| WO (1) | WO2016081643A1 (https=) |
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- 2015-11-18 CN CN201580062928.5A patent/CN107001473B/zh active Active
- 2015-11-18 US US15/525,832 patent/US10508151B2/en active Active
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2019
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