CN107001473B - 抗-运铁蛋白受体抗体及使用方法 - Google Patents
抗-运铁蛋白受体抗体及使用方法 Download PDFInfo
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- CN107001473B CN107001473B CN201580062928.5A CN201580062928A CN107001473B CN 107001473 B CN107001473 B CN 107001473B CN 201580062928 A CN201580062928 A CN 201580062928A CN 107001473 B CN107001473 B CN 107001473B
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/00—Immunoglobulins specific features
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Ophthalmology & Optometry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081827P | 2014-11-19 | 2014-11-19 | |
| US62/081,827 | 2014-11-19 | ||
| PCT/US2015/061405 WO2016081643A1 (en) | 2014-11-19 | 2015-11-18 | Anti-transferrin receptor antibodies and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107001473A CN107001473A (zh) | 2017-08-01 |
| CN107001473B true CN107001473B (zh) | 2021-07-09 |
Family
ID=54780465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580062928.5A Active CN107001473B (zh) | 2014-11-19 | 2015-11-18 | 抗-运铁蛋白受体抗体及使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10508151B2 (https=) |
| EP (1) | EP3221362B1 (https=) |
| JP (2) | JP6779876B2 (https=) |
| CN (1) | CN107001473B (https=) |
| WO (1) | WO2016081643A1 (https=) |
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| EP3325006A4 (en) | 2015-07-17 | 2019-03-06 | The Trustees of Columbia University in the City of New York | METHOD FOR TREATING CD166-EXPRESSIVE CANCER |
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| WO2012075037A1 (en) * | 2010-11-30 | 2012-06-07 | Genentech, Inc. | Low affinity blood brain barrier receptor antibodies and uses therefor |
| WO2013177062A2 (en) * | 2012-05-21 | 2013-11-28 | Genentech, Inc. | Methods for improving safety of blood-brain barrier transport |
Non-Patent Citations (5)
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| A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo;ATWAL JASVINDER K等;《SCIENCE TRANSLATIONAL MEDICINE》;20110525;第3卷(第84期);第1-12页 * |
| Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier;COUCH JESSICA A等;《SCIENCE TRANSLATIONAL MEDICINE》;20130501;第5卷(第183期);第1-12页 * |
| Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target;YU Y JOY等;《SCIENCE TRANSLATIONAL MEDICINE》;20110525;第3卷(第84期);第1-8页 * |
| Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys;S.SOPPER等;《CYTOMETRY》;19971201;第29卷(第4期);第351-362页 * |
| Therapeutic antibodies for brain disorders;PAUL STEVEN M等;《SCIENCE TRANSLATIONAL MEDICINE》;20110525;第3卷(第84期);第1-5页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107001473A (zh) | 2017-08-01 |
| JP2018503357A (ja) | 2018-02-08 |
| US20180134797A1 (en) | 2018-05-17 |
| US20200123267A1 (en) | 2020-04-23 |
| US11098129B2 (en) | 2021-08-24 |
| JP6779876B2 (ja) | 2020-11-04 |
| US10508151B2 (en) | 2019-12-17 |
| EP3221362B1 (en) | 2019-07-24 |
| JP2021035365A (ja) | 2021-03-04 |
| WO2016081643A1 (en) | 2016-05-26 |
| EP3221362A1 (en) | 2017-09-27 |
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