|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4703004A
(en)
|
1984-01-24 |
1987-10-27 |
Immunex Corporation |
Synthesis of protein with an identification peptide
|
|
GB2183662B
(en)
|
1985-04-01 |
1989-01-25 |
Celltech Ltd |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
|
EP0739904A1
(en)
|
1989-06-29 |
1996-10-30 |
Medarex, Inc. |
Bispecific reagents for aids therapy
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
ES2139598T3
(es)
|
1990-07-10 |
2000-02-16 |
Medical Res Council |
Procedimientos para la produccion de miembros de parejas de union especifica.
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
ES2246502T3
(es)
|
1990-08-29 |
2006-02-16 |
Genpharm International, Inc. |
Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
ATE145428T1
(de)
|
1990-12-14 |
1996-12-15 |
Cell Genesys Inc |
Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
|
|
DE69233697T2
(de)
|
1991-03-01 |
2008-01-24 |
Dyax Corp., Cambridge |
Verfahren zur Entwicklung von bindenden Mikroproteinen
|
|
PT100379B
(pt)
|
1991-04-10 |
1999-01-29 |
Scripps Research Inst |
Bibliotecas de receptores heterodimericos usando fagomideos
|
|
WO1992020373A1
(en)
|
1991-05-14 |
1992-11-26 |
Repligen Corporation |
Heteroconjugate antibodies for treatment of hiv infection
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
FR2686901A1
(fr)
|
1992-01-31 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
DE69308573T2
(de)
|
1992-08-17 |
1997-08-07 |
Genentech Inc |
Bispezifische immunoadhesine
|
|
CA2141602A1
(en)
|
1992-08-26 |
1994-03-03 |
Philip Leder |
Use of the cytokine ip-10 as an anti-tumor agent
|
|
ATE139900T1
(de)
|
1992-11-13 |
1996-07-15 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
|
|
US7744877B2
(en)
|
1992-11-13 |
2010-06-29 |
Biogen Idec Inc. |
Expression and use of anti-CD20 Antibodies
|
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
|
CZ25697A3
(en)
|
1994-07-29 |
1997-09-17 |
Smithkline Beecham Plc |
Novel compounds
|
|
US5919905A
(en)
*
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
EP0859841B1
(en)
|
1995-08-18 |
2002-06-19 |
MorphoSys AG |
Protein/(poly)peptide libraries
|
|
WO1997033899A1
(en)
|
1996-03-14 |
1997-09-18 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
|
CA2249195A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
|
EP0904278A4
(en)
|
1996-03-22 |
1999-09-15 |
Human Genome Sciences Inc |
MOLECULE II INDUCER OF APOPTOSIS
|
|
CA2259157A1
(en)
|
1996-07-05 |
1998-01-15 |
Mount Sinai Hospital Corporation |
Oligomerized receptors which affect pathways regulated by transmembrane ligands for elk-related receptor tyrosine kinases
|
|
EP0983303B1
(en)
|
1997-05-21 |
2006-03-08 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
US5994076A
(en)
|
1997-05-21 |
1999-11-30 |
Clontech Laboratories, Inc. |
Methods of assaying differential expression
|
|
EP1992633A1
(en)
|
1997-11-03 |
2008-11-19 |
Human Genome Sciences, Inc. |
VEGI, an inhibitor of angiogenesis and tumor growth
|
|
WO1999029888A1
(en)
|
1997-12-05 |
1999-06-17 |
The Scripps Research Institute |
Humanization of murine antibody
|
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
JP4334141B2
(ja)
|
1998-04-20 |
2009-09-30 |
グリカート バイオテクノロジー アクチェンゲゼルシャフト |
抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
|
|
AUPP674898A0
(en)
|
1998-10-27 |
1998-11-19 |
Walter And Eliza Hall Institute Of Medical Research, The |
A method of treatment
|
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
|
HUP0104865A3
(en)
|
1999-01-15 |
2004-07-28 |
Genentech Inc |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
EP2275540B1
(en)
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
JP2003517816A
(ja)
|
1999-08-11 |
2003-06-03 |
イオス バイオテクノロジー, インコーポレイテッド |
新脈管形成の診断の新規方法、新脈管形成調節因子についてのスクリーニングの組成物および方法
|
|
US6927203B1
(en)
|
1999-08-17 |
2005-08-09 |
Purdue Research Foundation |
Treatment of metastatic disease
|
|
US20050100542A1
(en)
*
|
1999-10-08 |
2005-05-12 |
Young David S. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US6992170B2
(en)
*
|
1999-10-15 |
2006-01-31 |
Curagen Corporation |
Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin
|
|
CA2388245C
(en)
|
1999-10-19 |
2012-01-10 |
Kyowa Kirin Co., Ltd. |
The use of serum-free adapted rat cells for producing heterologous polypeptides
|
|
AU1574401A
(en)
|
1999-10-20 |
2001-04-30 |
Zymogenetics Inc. |
Granulocyte peptide homolog zgpa1
|
|
US6926898B2
(en)
|
2000-04-12 |
2005-08-09 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
JPWO2002030954A1
(ja)
|
2000-10-06 |
2004-02-19 |
協和醗酵工業株式会社 |
抗体を精製する方法
|
|
CN103333860B
(zh)
|
2000-10-06 |
2015-07-08 |
协和发酵麒麟株式会社 |
产生抗体组合物的细胞
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US7138496B2
(en)
|
2002-02-08 |
2006-11-21 |
Genetastix Corporation |
Human monoclonal antibodies against human CXCR4
|
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
|
WO2003064589A2
(en)
|
2001-01-23 |
2003-08-07 |
Curagen Corporation |
Therapeutic polypeptides, nucleic acids encoding same, and methods of use
|
|
US20040043928A1
(en)
|
2001-08-02 |
2004-03-04 |
Ramesh Kekuda |
Therapeutic polypeptides, nucleic acids encoding same, and methods of use
|
|
US20040247592A1
(en)
|
2001-07-03 |
2004-12-09 |
Roifman Chaim M. |
Ephrin and eph receptor mediated immune modulation
|
|
PL213948B1
(pl)
|
2001-10-25 |
2013-05-31 |
Genentech Inc |
Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje
|
|
WO2003040304A2
(en)
|
2001-11-09 |
2003-05-15 |
Neuronova Ab |
Method of proliferation in neurogenic regions
|
|
US7771951B2
(en)
|
2001-12-03 |
2010-08-10 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
|
JP2005533001A
(ja)
|
2002-03-04 |
2005-11-04 |
メディミューン,インコーポレーテッド |
インテグリンαvβ3アンタゴニストを他の物質と併用投与する癌の予防または治療方法
|
|
EP1575509B1
(en)
|
2002-05-10 |
2011-10-26 |
Purdue Research Foundation |
Epha2 agonistic monoclonal antibodies and methods of use thereof
|
|
JP2006507256A
(ja)
*
|
2002-09-24 |
2006-03-02 |
ザ バーナム インスティチュート |
Eph受容体活性を調節する新規薬剤
|
|
EP1852441B1
(en)
|
2002-09-24 |
2012-03-28 |
The Burnham Institute |
Agents that modulate EPH receptor activity
|
|
CA2832136C
(en)
|
2002-09-27 |
2015-11-17 |
Xencor |
Optimized fc variants and methods for their generation
|
|
AU2003272799A1
(en)
|
2002-09-27 |
2004-04-19 |
Incyte Corporation |
Receptors and membrane-associated proteins
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
AU2003298786A1
(en)
|
2002-11-26 |
2004-06-18 |
Protein Design Labs, Inc. |
Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
|
|
WO2004072266A2
(en)
|
2003-02-13 |
2004-08-26 |
Kalobios Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
|
US7619068B2
(en)
|
2003-05-09 |
2009-11-17 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
|
WO2005048917A2
(en)
|
2003-06-06 |
2005-06-02 |
Medimmune, Inc. |
Use of epha4 and modulator or epha4 for diagnosis, treatment and prevention of cancer
|
|
US20050153923A1
(en)
|
2003-12-04 |
2005-07-14 |
Kinch Michael S. |
Targeted drug delivery using EphA2 or EphA4 binding moieties
|
|
ES2414460T3
(es)
|
2004-08-04 |
2013-07-19 |
Amgen Inc. |
Anticuerpos para Dkk-1
|
|
AU2005277641A1
(en)
|
2004-08-16 |
2006-03-02 |
Medimmune, Llc |
Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity
|
|
CA2584804A1
(en)
|
2004-10-21 |
2006-05-04 |
The Penn State Research Foundation |
Eph receptor tumor biomarkers
|
|
US8222253B2
(en)
|
2004-10-23 |
2012-07-17 |
Case Western Reserve University |
Peptide and small molecule agonists of EphA and their uses
|
|
WO2006047639A2
(en)
|
2004-10-27 |
2006-05-04 |
Medimmune, Inc. |
Modulation of antibody specificity by tailoring the affinity to cognate antigens
|
|
KR20080080482A
(ko)
|
2005-09-07 |
2008-09-04 |
메디뮨 엘엘씨 |
독소가 컨쥬게이트된 eph 수용체 항체
|
|
US7807459B2
(en)
|
2005-09-27 |
2010-10-05 |
Reneuron, Inc. |
EphA4-positive human adult pancreatic endocrine progenitor cells
|
|
US20070123448A1
(en)
|
2005-11-23 |
2007-05-31 |
The Hospital For Sick Children |
Novel chemical entities affecting neuroblastoma tumor-initiating cells
|
|
CN101432022A
(zh)
|
2006-02-28 |
2009-05-13 |
肿瘤疗法科学股份有限公司 |
利用抗-EphA4抗体效应物作用损伤细胞的方法
|
|
JP5167155B2
(ja)
|
2006-03-09 |
2013-03-21 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ペプチド結合に基づく多数の細胞株のプロファイリングに関連した組成物および方法
|
|
US20080003210A1
(en)
|
2006-03-13 |
2008-01-03 |
Medimmune, Inc. |
Non-human primate receptor tyrosine kinases
|
|
EA015992B1
(ru)
|
2006-03-17 |
2012-01-30 |
Байоджен Айдек Эмэй Инк. |
Стабилизированное антитело и многовалентная антигенсвязывающая молекула на его основе, способы получения и использования вышеназванного стабилизированного антитела
|
|
WO2007145901A1
(en)
|
2006-06-06 |
2007-12-21 |
University Of Tennessee Research Foundation |
Compositions enriched in neoplastic stem cells and methods comprising same
|
|
CN105837690A
(zh)
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
ZA200900545B
(en)
*
|
2006-07-18 |
2010-03-31 |
Sanofi Aventis |
Antagonist antibody against EPHA2 for the treatment of cancer
|
|
JP2010501596A
(ja)
*
|
2006-08-31 |
2010-01-21 |
エー・シー・エヌ・135 493 391・プロプライエタリー・リミテッド・アズ・トラスティー・フォー・コンカ・ユニット・トラスト |
抗体含有組成物を用いた非感染性の病状の処置および/または予防
|
|
EP3207941B3
(en)
|
2006-09-07 |
2020-08-19 |
Scott & White Memorial Hospital |
Methods and compositions based on diphtheria toxin-interleukin-3 conjugates
|
|
US8907065B2
(en)
|
2006-12-15 |
2014-12-09 |
Ablynx N.V. |
Polypeptides that modulate the interaction between cells of the immune system
|
|
WO2008091908A2
(en)
|
2007-01-22 |
2008-07-31 |
Raven Biotechnologies |
Human cancer stem cells
|
|
EP3199180B1
(en)
*
|
2007-03-08 |
2022-01-05 |
Humanigen, Inc. |
Epha3 antibodies for the treatment of solid tumors
|
|
CA2693144A1
(en)
|
2007-07-17 |
2009-01-22 |
The General Hospital Corporation |
Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
|
|
EP2022848A1
(en)
|
2007-08-10 |
2009-02-11 |
Hubrecht Institut |
A method for identifying, expanding, and removing adult stem cells and cancer stem cells
|
|
CA2697922A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
CA2699394C
(en)
*
|
2007-09-17 |
2020-03-24 |
The Regents Of The University Of California |
Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
|
|
WO2009043051A2
(en)
|
2007-09-27 |
2009-04-02 |
Biogen Idec Ma Inc. |
Cd23 binding molecules and methods of use thereof
|
|
WO2009052830A1
(en)
|
2007-10-22 |
2009-04-30 |
Genmab A/S |
Novel antibody therapies
|
|
US20100113415A1
(en)
*
|
2008-05-29 |
2010-05-06 |
Rajapakse Hemaka A |
Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
|
|
US20100162416A1
(en)
|
2008-09-29 |
2010-06-24 |
Stemlifeline, Inc. |
Multi-stage stem cell carcinogenesis
|
|
WO2010066835A2
(en)
|
2008-12-10 |
2010-06-17 |
Ablynx Nv |
Eph receptor and ephrin ligand interaction
|
|
JP2012514981A
(ja)
|
2009-01-12 |
2012-07-05 |
イントレクソン コーポレイション |
細胞コロニーのレーザーを介在したセクション化及び移行
|
|
US20110020221A1
(en)
|
2009-04-09 |
2011-01-27 |
The Johns Hopkins University |
Cancer stem cell expression patterns and compounds to target cancer stem cells
|
|
WO2010141974A1
(en)
|
2009-06-10 |
2010-12-16 |
The University Of Melbourne |
Therapeutic applications
|
|
WO2013119964A2
(en)
|
2012-02-08 |
2013-08-15 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
US9778264B2
(en)
|
2010-09-03 |
2017-10-03 |
Abbvie Stemcentrx Llc |
Identification and enrichment of cell subpopulations
|
|
US20130061340A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
CA2809864A1
(en)
|
2010-09-03 |
2012-03-08 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
US20130061342A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
EP2446895A1
(en)
|
2010-10-01 |
2012-05-02 |
Stemgen S.P.A. |
EPH receptor expression in tumor stem cells
|
|
PH12013501137A1
(en)
|
2010-12-08 |
2021-06-02 |
Abbvie Stemcentrx Llc |
Novel modulators and methods of use
|
|
JP2016531915A
(ja)
|
2013-08-28 |
2016-10-13 |
ステムセントリックス, インコーポレイテッド |
部位特異的抗体コンジュゲーション方法および組成物
|
|
US20190209704A1
(en)
|
2014-10-20 |
2019-07-11 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions and methods of use
|
|
US11392902B2
(en)
|
2017-06-06 |
2022-07-19 |
United Parcel Service Of America, Inc. |
Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery
|