|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4703004A
(en)
|
1984-01-24 |
1987-10-27 |
Immunex Corporation |
Synthesis of protein with an identification peptide
|
|
EP0216846B2
(en)
|
1985-04-01 |
1995-04-26 |
Celltech Limited |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
WO1992010591A1
(en)
|
1990-12-14 |
1992-06-25 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
EP1820858B1
(en)
|
1991-03-01 |
2009-08-12 |
Dyax Corporation |
Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
WO1992020373A1
(en)
|
1991-05-14 |
1992-11-26 |
Repligen Corporation |
Heteroconjugate antibodies for treatment of hiv infection
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
FR2686901A1
(fr)
|
1992-01-31 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
CA2140280A1
(en)
|
1992-08-17 |
1994-03-03 |
Avi J. Ashkenazi |
Bispecific immunoadhesins
|
|
CA2141602A1
(en)
|
1992-08-26 |
1994-03-03 |
Philip Leder |
Use of the cytokine ip-10 as an anti-tumor agent
|
|
DK0752248T3
(da)
|
1992-11-13 |
2000-11-13 |
Idec Pharma Corp |
Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
|
|
US7744877B2
(en)
|
1992-11-13 |
2010-06-29 |
Biogen Idec Inc. |
Expression and use of anti-CD20 Antibodies
|
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
|
HUT76369A
(en)
|
1994-07-29 |
1997-08-28 |
Smithkline Beecham Corp |
Novel soluble protein compounds
|
|
US5919905A
(en)
*
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
ES2176484T3
(es)
|
1995-08-18 |
2002-12-01 |
Morphosys Ag |
Bancos de proteinas/(poli)peptidos.
|
|
AU5711196A
(en)
|
1996-03-14 |
1997-10-01 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
CA2248868A1
(en)
|
1996-03-22 |
1997-09-25 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule ii
|
|
CA2259157A1
(en)
|
1996-07-05 |
1998-01-15 |
Mount Sinai Hospital Corporation |
Oligomerized receptors which affect pathways regulated by transmembrane ligands for elk-related receptor tyrosine kinases
|
|
US5994076A
(en)
|
1997-05-21 |
1999-11-30 |
Clontech Laboratories, Inc. |
Methods of assaying differential expression
|
|
EP0983303B1
(en)
|
1997-05-21 |
2006-03-08 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
CA2309541C
(en)
|
1997-11-03 |
2011-01-11 |
Human Genome Sciences, Inc. |
Vegi, an inhibitor of angiogenesis and tumor growth
|
|
DK1034298T3
(da)
|
1997-12-05 |
2012-01-30 |
Scripps Research Inst |
Humanisering af murint antistof
|
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
AUPP674898A0
(en)
|
1998-10-27 |
1998-11-19 |
Walter And Eliza Hall Institute Of Medical Research, The |
A method of treatment
|
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
JP2003517816A
(ja)
|
1999-08-11 |
2003-06-03 |
イオス バイオテクノロジー, インコーポレイテッド |
新脈管形成の診断の新規方法、新脈管形成調節因子についてのスクリーニングの組成物および方法
|
|
US6927203B1
(en)
|
1999-08-17 |
2005-08-09 |
Purdue Research Foundation |
Treatment of metastatic disease
|
|
US20050100542A1
(en)
*
|
1999-10-08 |
2005-05-12 |
Young David S. |
Cytotoxicity mediation of cells evidencing surface expression of CD44
|
|
US6992170B2
(en)
*
|
1999-10-15 |
2006-01-31 |
Curagen Corporation |
Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin
|
|
EP1229125A4
(en)
|
1999-10-19 |
2005-06-01 |
Kyowa Hakko Kogyo Kk |
PROCESS FOR PREPARING A POLYPEPTIDE
|
|
AU1574401A
(en)
|
1999-10-20 |
2001-04-30 |
Zymogenetics Inc. |
Granulocyte peptide homolog zgpa1
|
|
EP2213743A1
(en)
|
2000-04-12 |
2010-08-04 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CA2953239A1
(en)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kirin Co., Ltd. |
Antibody composition-producing cell
|
|
CA2424977C
(en)
|
2000-10-06 |
2008-03-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US7138496B2
(en)
|
2002-02-08 |
2006-11-21 |
Genetastix Corporation |
Human monoclonal antibodies against human CXCR4
|
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
WO2003064589A2
(en)
|
2001-01-23 |
2003-08-07 |
Curagen Corporation |
Therapeutic polypeptides, nucleic acids encoding same, and methods of use
|
|
US20040043928A1
(en)
|
2001-08-02 |
2004-03-04 |
Ramesh Kekuda |
Therapeutic polypeptides, nucleic acids encoding same, and methods of use
|
|
WO2003004057A1
(en)
|
2001-07-03 |
2003-01-16 |
The Hospital For Sick Children |
Ephrin and eph receptor mediated immune modulation
|
|
CA2463879C
(en)
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
AU2002348854A1
(en)
|
2001-11-09 |
2003-05-19 |
Neuronova Ab |
Method of proliferation in neurogenic regions
|
|
US7771951B2
(en)
|
2001-12-03 |
2010-08-10 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
|
WO2003075957A1
(en)
|
2002-03-04 |
2003-09-18 |
Medimmune, Inc. |
The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
|
|
JP4585968B2
(ja)
|
2002-05-10 |
2010-11-24 |
パーデュー・リサーチ・ファウンデーション |
EphA2アゴニストモノクローナル抗体およびその使用法
|
|
AU2003268345A1
(en)
|
2002-09-24 |
2004-04-19 |
The Burnham Institute |
Novel agents that modulate eph receptor activity
|
|
EP1852441B1
(en)
|
2002-09-24 |
2012-03-28 |
The Burnham Institute |
Agents that modulate EPH receptor activity
|
|
AU2003272799A1
(en)
|
2002-09-27 |
2004-04-19 |
Incyte Corporation |
Receptors and membrane-associated proteins
|
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US20040253606A1
(en)
|
2002-11-26 |
2004-12-16 |
Protein Design Labs, Inc. |
Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
|
|
WO2004072266A2
(en)
|
2003-02-13 |
2004-08-26 |
Kalobios Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
|
WO2004101756A2
(en)
|
2003-05-09 |
2004-11-25 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
|
KR20060034231A
(ko)
|
2003-06-06 |
2006-04-21 |
메디뮨 인코포레이티드 |
암의 진단, 치료 및 예방에 있어서의 epha4 및epha4 조정제의 용도
|
|
US20050153923A1
(en)
|
2003-12-04 |
2005-07-14 |
Kinch Michael S. |
Targeted drug delivery using EphA2 or EphA4 binding moieties
|
|
WO2006015373A2
(en)
|
2004-08-04 |
2006-02-09 |
Amgen Inc |
Antibodies to dkk-1
|
|
EP1778726A4
(en)
|
2004-08-16 |
2009-03-18 |
Medimmune Inc |
INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY
|
|
AU2005299767A1
(en)
|
2004-10-21 |
2006-05-04 |
The Penn State Research Foundation |
Eph receptor tumor biomarkers
|
|
WO2006052409A2
(en)
|
2004-10-23 |
2006-05-18 |
Case Western Reserve University |
Peptide and small molecule agonists of epha and their uses
|
|
CA2585717A1
(en)
|
2004-10-27 |
2006-05-04 |
Medimmune Inc. |
Modulation of antibody specificity by tailoring the affinity to cognate antigens
|
|
EP1928912A4
(en)
|
2005-09-07 |
2010-02-24 |
Medimmune Inc |
EPH ANTI-RECEPTOR ANTIBODIES CONJUGATED TO TOXINS
|
|
US7807459B2
(en)
|
2005-09-27 |
2010-10-05 |
Reneuron, Inc. |
EphA4-positive human adult pancreatic endocrine progenitor cells
|
|
US20070123448A1
(en)
|
2005-11-23 |
2007-05-31 |
The Hospital For Sick Children |
Novel chemical entities affecting neuroblastoma tumor-initiating cells
|
|
US8003098B2
(en)
|
2006-02-28 |
2011-08-23 |
Oncotherapy Science, Inc. |
Methods for damaging cells using effector functions of anti-EphA4 antibodies
|
|
JP5167155B2
(ja)
|
2006-03-09 |
2013-03-21 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ペプチド結合に基づく多数の細胞株のプロファイリングに関連した組成物および方法
|
|
US20080003210A1
(en)
|
2006-03-13 |
2008-01-03 |
Medimmune, Inc. |
Non-human primate receptor tyrosine kinases
|
|
CA2646508A1
(en)
|
2006-03-17 |
2007-09-27 |
Biogen Idec Ma Inc. |
Stabilized polypeptide compositions
|
|
WO2007145901A1
(en)
|
2006-06-06 |
2007-12-21 |
University Of Tennessee Research Foundation |
Compositions enriched in neoplastic stem cells and methods comprising same
|
|
NZ573646A
(en)
*
|
2006-06-12 |
2012-04-27 |
Wyeth Llc |
Single-chain multivalent binding proteins with effector function
|
|
MX2009000709A
(es)
*
|
2006-07-18 |
2009-02-04 |
Sanofi Aventis |
Anticuerpo antagonista contra epha2 para el tratamiento de cancer.
|
|
DK2061510T3
(en)
*
|
2006-08-31 |
2016-09-05 |
A C N 135 493 391 Pty Ltd As Trustee For Conca Unit Trust |
Treatment and / or prevention of Barrett's esophagus using anti-EphB4 antibody-containing compositions
|
|
ES2987072T3
(es)
|
2006-09-07 |
2024-11-13 |
Scott & White Memorial Hospital |
Métodos y composiciones basados en conjugados de toxina diftérica-interleucina-3
|
|
AU2007331672A1
(en)
|
2006-12-15 |
2008-06-19 |
Ablynx N.V. |
Amino acid sequences that modulate the interaction between cells of the immune system
|
|
CA2675521C
(en)
|
2007-01-22 |
2016-04-26 |
Raven Biotechnologies |
Human cancer stem cells
|
|
PL3199180T3
(pl)
*
|
2007-03-08 |
2022-08-08 |
Humanigen, Inc. |
Przeciwciała przeciwko epha3 do leczenia guzów litych
|
|
US9289492B2
(en)
|
2007-07-17 |
2016-03-22 |
The General Hospital Corporation |
Collecting ovarian cancer stem cells from ovarian cancer cells
|
|
EP2022848A1
(en)
|
2007-08-10 |
2009-02-11 |
Hubrecht Institut |
A method for identifying, expanding, and removing adult stem cells and cancer stem cells
|
|
KR20100052545A
(ko)
|
2007-08-28 |
2010-05-19 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Igf―1r의 다중 에피토프에 결합하는 조성물
|
|
CA2699394C
(en)
*
|
2007-09-17 |
2020-03-24 |
The Regents Of The University Of California |
Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
|
|
WO2009043051A2
(en)
|
2007-09-27 |
2009-04-02 |
Biogen Idec Ma Inc. |
Cd23 binding molecules and methods of use thereof
|
|
EP2205277B1
(en)
*
|
2007-10-22 |
2017-07-26 |
Genmab A/S |
Novel antibody therapies
|
|
US20100113415A1
(en)
*
|
2008-05-29 |
2010-05-06 |
Rajapakse Hemaka A |
Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
|
|
WO2010037134A2
(en)
|
2008-09-29 |
2010-04-01 |
Stemlifeline, Inc. |
Multi-stage stem cell carcinogenesis
|
|
WO2010066835A2
(en)
|
2008-12-10 |
2010-06-17 |
Ablynx Nv |
Eph receptor and ephrin ligand interaction
|
|
KR20110108390A
(ko)
|
2009-01-12 |
2011-10-05 |
신텔렉트 인코포레이티드 |
레이저로 매개된 박막 절개 및 세포 군체의 이동
|
|
US20110020221A1
(en)
|
2009-04-09 |
2011-01-27 |
The Johns Hopkins University |
Cancer stem cell expression patterns and compounds to target cancer stem cells
|
|
WO2010141974A1
(en)
|
2009-06-10 |
2010-12-16 |
The University Of Melbourne |
Therapeutic applications
|
|
EP2689787A1
(en)
|
2010-09-03 |
2014-01-29 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
US20130061340A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
WO2013119964A2
(en)
|
2012-02-08 |
2013-08-15 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
US9778264B2
(en)
|
2010-09-03 |
2017-10-03 |
Abbvie Stemcentrx Llc |
Identification and enrichment of cell subpopulations
|
|
US20130061342A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
EP2446895A1
(en)
|
2010-10-01 |
2012-05-02 |
Stemgen S.P.A. |
EPH receptor expression in tumor stem cells
|
|
NZ611428A
(en)
|
2010-12-08 |
2015-07-31 |
Stemcentrx Inc |
Novel modulators and methods of use
|
|
SG11201601424PA
(en)
|
2013-08-28 |
2016-03-30 |
Stemcentrx Inc |
Site-specific antibody conjugation methods and compositions
|
|
EP3209334A2
(en)
|
2014-10-20 |
2017-08-30 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
US11392902B2
(en)
|
2017-06-06 |
2022-07-19 |
United Parcel Service Of America, Inc. |
Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery
|