JP2011505146A5 - - Google Patents
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- Publication number
- JP2011505146A5 JP2011505146A5 JP2010536185A JP2010536185A JP2011505146A5 JP 2011505146 A5 JP2011505146 A5 JP 2011505146A5 JP 2010536185 A JP2010536185 A JP 2010536185A JP 2010536185 A JP2010536185 A JP 2010536185A JP 2011505146 A5 JP2011505146 A5 JP 2011505146A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- VRGNUJQMOMSONU-WGYIJZORSA-N CC(C)=C(C(N[C@@H](CCCNC(N)=O)C(Nc(cc1)ccc1C(Nc(cc1)cc2c1[nH]c(C(N1c3cc(OC(N4CCN(C)CC4)=O)c(cccc4)c4c3[C@H](CCl)C1)=O)c2)=O)=O)=O)NCCNC(CCCN(C(C=C1)=O)C1=O)=O Chemical compound CC(C)=C(C(N[C@@H](CCCNC(N)=O)C(Nc(cc1)ccc1C(Nc(cc1)cc2c1[nH]c(C(N1c3cc(OC(N4CCN(C)CC4)=O)c(cccc4)c4c3[C@H](CCl)C1)=O)c2)=O)=O)=O)NCCNC(CCCN(C(C=C1)=O)C1=O)=O VRGNUJQMOMSONU-WGYIJZORSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US503407P | 2007-11-30 | 2007-11-30 | |
| PCT/US2008/084949 WO2009073546A2 (en) | 2007-11-30 | 2008-11-26 | Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505146A JP2011505146A (ja) | 2011-02-24 |
| JP2011505146A5 true JP2011505146A5 (enExample) | 2012-02-02 |
Family
ID=40718460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536185A Withdrawn JP2011505146A (ja) | 2007-11-30 | 2008-11-26 | タンパク質チロシンキナーゼ７（ｐｔｋ７）を対象とするモノクローナル抗体−パートナー分子複合体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120027782A1 (enExample) |
| EP (1) | EP2229187A2 (enExample) |
| JP (1) | JP2011505146A (enExample) |
| KR (1) | KR20100101124A (enExample) |
| CN (1) | CN101939028A (enExample) |
| AR (1) | AR069903A1 (enExample) |
| AU (1) | AU2008334076A1 (enExample) |
| CL (1) | CL2008003527A1 (enExample) |
| MX (1) | MX2010005966A (enExample) |
| TW (1) | TW200938223A (enExample) |
| WO (1) | WO2009073546A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1957539T3 (da) | 2005-12-08 | 2013-05-06 | Medarex Inc | Humane monoklonale antistoffer til proteintyrosinkinase 7 (ptk7) og deres anvendelse |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| CA2742568C (en) | 2008-11-03 | 2017-09-26 | Syntarga B.V. | Novel cc-1065 analogs and their conjugates |
| EP3108886B1 (en) | 2010-04-21 | 2020-06-17 | Syntarga B.V. | Conjugates of cc-1065 analogs and bifunctional linkers |
| EP2380909A1 (en) * | 2010-04-26 | 2011-10-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | PTK-7 protein involved in breast cancer |
| SA112330278B1 (ar) * | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| US20140323402A1 (en) * | 2011-08-12 | 2014-10-30 | Ascendis Phama A/S | Protein Carrier-Linked Prodrugs |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| TWI727919B (zh) * | 2013-12-19 | 2021-05-21 | 美商西雅圖遺傳學公司 | 與標的-藥物結合物併用之亞甲基胺基甲酸酯連接物 |
| TR201810856T4 (tr) | 2014-01-10 | 2018-08-27 | Synthon Biopharmaceuticals Bv | CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul. |
| HRP20210292T1 (hr) | 2014-04-30 | 2021-04-16 | Pfizer Inc. | Anti-ptk7 protutijelo-lijek konjugati |
| JP6449338B2 (ja) | 2014-06-06 | 2019-01-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| HUE050596T2 (hu) | 2014-11-21 | 2020-12-28 | Bristol Myers Squibb Co | Antitestek CD73 ellen és azok felhasználásai |
| LT3221346T (lt) | 2014-11-21 | 2020-11-10 | Bristol-Myers Squibb Company | Antikūnai, apimantys modifikuotas sunkiosios grandinės pastoviąsias sritis |
| AR103268A1 (es) | 2014-12-23 | 2017-04-26 | Bristol Myers Squibb Co | Anticuerpos contra tigit |
| CN108738324B (zh) | 2015-11-19 | 2022-06-21 | 百时美施贵宝公司 | 抗糖皮质激素诱导的肿瘤坏死因子受体(gitr)抗体及其用途 |
| IL295230A (en) | 2016-03-04 | 2022-10-01 | Bristol Myers Squibb Co | Combination therapy with anti-cd73 antibodies |
| BR112019016374A2 (pt) | 2017-02-17 | 2020-04-07 | Bristol-Myers Squibb Company | anticorpos para alfa-sinucleína e usos dos mesmos |
| KR20200006115A (ko) | 2017-05-16 | 2020-01-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-gitr 효능제 항체에 의한 암의 치료 |
| MX2019013132A (es) | 2017-05-25 | 2020-01-27 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas. |
| WO2020094670A1 (en) | 2018-11-05 | 2020-05-14 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
| CN110845480B (zh) * | 2019-11-22 | 2022-03-15 | 荣昌生物制药(烟台)股份有限公司 | 一种双功能细胞毒素及其用途 |
| WO2022015113A1 (ko) * | 2020-07-16 | 2022-01-20 | 연세대학교 산학협력단 | Ptk7에 특이적으로 결합하는 항체 및 이의 용도 |
| CN115894696A (zh) * | 2021-08-18 | 2023-04-04 | 和迈生物科技有限公司 | 抗ptk7单域抗体及其应用 |
| AU2023237619A1 (en) * | 2022-03-23 | 2024-08-29 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing ptk7 |
| GB202212077D0 (en) | 2022-08-18 | 2022-10-05 | Tribune Therapeutics Ab | Agents that inhibit ccn ligand-induced signalling for treating disease |
| US20260078201A1 (en) * | 2022-09-06 | 2026-03-19 | Uif (University Industry Foundation), Yonsei University | Anti-ptk7 antibody, and use thereof |
| CN118852442A (zh) | 2023-04-26 | 2024-10-29 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
| WO2025040588A1 (en) * | 2023-08-18 | 2025-02-27 | Oncoinvent As | Monoclonal anti-ptk7 antibodies and derivatives |
| AR133955A1 (es) * | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502703A (ja) * | 2001-09-07 | 2005-01-27 | ザ スクリプス リサーチ インスティテュート | Ｃｃ−１０６５およびデュオカルマイシンのｃｂｉ類似体 |
| GB0219776D0 (en) * | 2002-08-24 | 2002-10-02 | Oxford Glycosciences Uk Ltd | A protein involved in carcinoma |
| RU2402548C2 (ru) * | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| WO2005112919A2 (en) * | 2004-05-19 | 2005-12-01 | Medarex, Inc. | Self-immolative linkers and drug conjugates |
| EP1940470B1 (en) * | 2005-09-26 | 2013-04-17 | Medarex, Inc. | Antibody-drug conjugates and their use |
| DK1957539T3 (da) * | 2005-12-08 | 2013-05-06 | Medarex Inc | Humane monoklonale antistoffer til proteintyrosinkinase 7 (ptk7) og deres anvendelse |
-
2008
- 2008-11-26 TW TW097145713A patent/TW200938223A/zh unknown
- 2008-11-26 AR ARP080105143A patent/AR069903A1/es not_active Application Discontinuation
- 2008-11-26 WO PCT/US2008/084949 patent/WO2009073546A2/en not_active Ceased
- 2008-11-26 US US12/745,503 patent/US20120027782A1/en not_active Abandoned
- 2008-11-26 KR KR1020107014503A patent/KR20100101124A/ko not_active Withdrawn
- 2008-11-26 AU AU2008334076A patent/AU2008334076A1/en not_active Abandoned
- 2008-11-26 CL CL2008003527A patent/CL2008003527A1/es unknown
- 2008-11-26 EP EP08857264A patent/EP2229187A2/en not_active Withdrawn
- 2008-11-26 MX MX2010005966A patent/MX2010005966A/es not_active Application Discontinuation
- 2008-11-26 CN CN200880118641XA patent/CN101939028A/zh active Pending
- 2008-11-26 JP JP2010536185A patent/JP2011505146A/ja not_active Withdrawn
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