JP2011505146A5 - - Google Patents
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- Publication number
- JP2011505146A5 JP2011505146A5 JP2010536185A JP2010536185A JP2011505146A5 JP 2011505146 A5 JP2011505146 A5 JP 2011505146A5 JP 2010536185 A JP2010536185 A JP 2010536185A JP 2010536185 A JP2010536185 A JP 2010536185A JP 2011505146 A5 JP2011505146 A5 JP 2011505146A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101000606465 Homo sapiens Inactive tyrosine-protein kinase 7 Proteins 0.000 claims 1
- 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- VRGNUJQMOMSONU-WGYIJZORSA-N CC(C)=C(C(N[C@@H](CCCNC(N)=O)C(Nc(cc1)ccc1C(Nc(cc1)cc2c1[nH]c(C(N1c3cc(OC(N4CCN(C)CC4)=O)c(cccc4)c4c3[C@H](CCl)C1)=O)c2)=O)=O)=O)NCCNC(CCCN(C(C=C1)=O)C1=O)=O Chemical compound CC(C)=C(C(N[C@@H](CCCNC(N)=O)C(Nc(cc1)ccc1C(Nc(cc1)cc2c1[nH]c(C(N1c3cc(OC(N4CCN(C)CC4)=O)c(cccc4)c4c3[C@H](CCl)C1)=O)c2)=O)=O)=O)NCCNC(CCCN(C(C=C1)=O)C1=O)=O VRGNUJQMOMSONU-WGYIJZORSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US503407P | 2007-11-30 | 2007-11-30 | |
| PCT/US2008/084949 WO2009073546A2 (en) | 2007-11-30 | 2008-11-26 | Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505146A JP2011505146A (ja) | 2011-02-24 |
| JP2011505146A5 true JP2011505146A5 (enExample) | 2012-02-02 |
Family
ID=40718460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536185A Withdrawn JP2011505146A (ja) | 2007-11-30 | 2008-11-26 | タンパク質チロシンキナーゼ７（ｐｔｋ７）を対象とするモノクローナル抗体−パートナー分子複合体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120027782A1 (enExample) |
| EP (1) | EP2229187A2 (enExample) |
| JP (1) | JP2011505146A (enExample) |
| KR (1) | KR20100101124A (enExample) |
| CN (1) | CN101939028A (enExample) |
| AR (1) | AR069903A1 (enExample) |
| AU (1) | AU2008334076A1 (enExample) |
| CL (1) | CL2008003527A1 (enExample) |
| MX (1) | MX2010005966A (enExample) |
| TW (1) | TW200938223A (enExample) |
| WO (1) | WO2009073546A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1957539B1 (en) | 2005-12-08 | 2013-04-17 | Medarex, Inc. | Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| CN106967062A (zh) | 2008-11-03 | 2017-07-21 | 辛塔佳股份有限公司 | 新型cc‑1065类似物及其缀合物 |
| PT3056203T (pt) | 2010-04-21 | 2018-02-15 | Syntarga Bv | Conjugados de análogos de cc-1065 e ligantes bifuncionais |
| EP2380909A1 (en) * | 2010-04-26 | 2011-10-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | PTK-7 protein involved in breast cancer |
| SA112330278B1 (ar) * | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| AU2012296951B2 (en) * | 2011-08-12 | 2016-09-15 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| IL290330B2 (en) * | 2013-12-19 | 2023-09-01 | Seagen Inc | Methylene carbamate binders for use with drug-targeting conjugates |
| CN105899235B (zh) | 2014-01-10 | 2019-08-30 | 斯索恩生物制药有限公司 | 用于纯化cys连接的抗体-药物缀合物的方法 |
| SG11201608953WA (en) | 2014-04-30 | 2016-11-29 | Pfizer | Anti-ptk7 antibody-drug conjugates |
| ES2901705T3 (es) | 2014-06-06 | 2022-03-23 | Bristol Myers Squibb Co | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (GITR) y usos de los mismos |
| RS60998B1 (sr) | 2014-11-21 | 2020-11-30 | Bristol Myers Squibb Co | Antitela koja sadrže modifikovane regione teškog lanca |
| SI3221363T1 (sl) | 2014-11-21 | 2020-09-30 | Bristol-Myers Squibb Company | Protitelesa proti CD73 in njihova uporaba |
| CA2971732A1 (en) | 2014-12-23 | 2016-06-30 | Bristol-Myers Squibb Company | Antibodies to tigit |
| BR112018010172A2 (pt) | 2015-11-19 | 2018-11-21 | Bristol Myers Squibb Co | anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos |
| KR20230038311A (ko) | 2016-03-04 | 2023-03-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cd73 항체와의 조합 요법 |
| EP3583124A1 (en) | 2017-02-17 | 2019-12-25 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| US11685787B2 (en) | 2017-05-16 | 2023-06-27 | Bristol-Myers Squibb Company | Treatment of cancer with anti-GITR agonist antibodies |
| IL270596B1 (en) | 2017-05-25 | 2025-09-01 | Bristol Myers Squibb Co | Antibodies comprising modified heavy constant region for use in treating cancer |
| CN113260384A (zh) | 2018-11-05 | 2021-08-13 | 西纳福克斯股份有限公司 | 用于靶向表达trop-2的肿瘤的抗体缀合物 |
| CN110845480B (zh) * | 2019-11-22 | 2022-03-15 | 荣昌生物制药(烟台)股份有限公司 | 一种双功能细胞毒素及其用途 |
| US20250340670A1 (en) * | 2020-07-16 | 2025-11-06 | UIF, (University Industry Foundation), Yonsei University | Antibody specifically binding to ptk7 and use thereof |
| CN115894696A (zh) * | 2021-08-18 | 2023-04-04 | 和迈生物科技有限公司 | 抗ptk7单域抗体及其应用 |
| JP2025510623A (ja) * | 2022-03-23 | 2025-04-15 | シンアフィックス ビー．ブイ． | Ｐｔｋ７を発現する腫瘍を標的化するための抗体コンジュゲート |
| GB202212077D0 (en) | 2022-08-18 | 2022-10-05 | Tribune Therapeutics Ab | Agents that inhibit ccn ligand-induced signalling for treating disease |
| WO2024054030A1 (ko) * | 2022-09-06 | 2024-03-14 | 연세대학교 산학협력단 | 항-ptk7 항체 및 이의 용도 |
| CN118852442A (zh) * | 2023-04-26 | 2024-10-29 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
| WO2025040588A1 (en) * | 2023-08-18 | 2025-02-27 | Oncoinvent As | Monoclonal anti-ptk7 antibodies and derivatives |
| WO2025072406A1 (en) * | 2023-09-26 | 2025-04-03 | Profoundbio Us Co. | Ptk7 binding agents, conjugates thereof and methods of using the same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1423110A4 (en) * | 2001-09-07 | 2005-04-27 | Scripps Research Inst | CBI ANALOGUE OF CC-1065 AND DUOCARMYCINES |
| GB0219776D0 (en) * | 2002-08-24 | 2002-10-02 | Oxford Glycosciences Uk Ltd | A protein involved in carcinoma |
| US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| EP1747021B1 (en) * | 2004-05-19 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Self-immolative linkers and drug conjugates |
| EP2354163A3 (en) * | 2005-09-26 | 2013-04-24 | Medarex, Inc. | Conjugates of duocarmycin and anti-CD70 or anti-PSMA antibodies |
| EP1957539B1 (en) * | 2005-12-08 | 2013-04-17 | Medarex, Inc. | Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use |
-
2008
- 2008-11-26 TW TW097145713A patent/TW200938223A/zh unknown
- 2008-11-26 EP EP08857264A patent/EP2229187A2/en not_active Withdrawn
- 2008-11-26 MX MX2010005966A patent/MX2010005966A/es not_active Application Discontinuation
- 2008-11-26 KR KR1020107014503A patent/KR20100101124A/ko not_active Withdrawn
- 2008-11-26 US US12/745,503 patent/US20120027782A1/en not_active Abandoned
- 2008-11-26 WO PCT/US2008/084949 patent/WO2009073546A2/en not_active Ceased
- 2008-11-26 AR ARP080105143A patent/AR069903A1/es not_active Application Discontinuation
- 2008-11-26 JP JP2010536185A patent/JP2011505146A/ja not_active Withdrawn
- 2008-11-26 CL CL2008003527A patent/CL2008003527A1/es unknown
- 2008-11-26 CN CN200880118641XA patent/CN101939028A/zh active Pending
- 2008-11-26 AU AU2008334076A patent/AU2008334076A1/en not_active Abandoned