JP2017534282A5 - - Google Patents
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- JP2017534282A5 JP2017534282A5 JP2017523394A JP2017523394A JP2017534282A5 JP 2017534282 A5 JP2017534282 A5 JP 2017534282A5 JP 2017523394 A JP2017523394 A JP 2017523394A JP 2017523394 A JP2017523394 A JP 2017523394A JP 2017534282 A5 JP2017534282 A5 JP 2017534282A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion polypeptide
- ifnα2b
- seq
- amino acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001184 polypeptide Polymers 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 230000004927 fusion Effects 0.000 claims 25
- 102220473689 Ras-related protein Rab-5A_Y89A_mutation Human genes 0.000 claims 12
- 102220535515 tRNA wybutosine-synthesizing protein 5_Y85A_mutation Human genes 0.000 claims 12
- 102220548502 Macrophage-capping protein_Q61S_mutation Human genes 0.000 claims 10
- 102220522737 Mitogen-activated protein kinase kinase kinase 6_H57Y_mutation Human genes 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 102220496408 Bone marrow stromal antigen 2_N65A_mutation Human genes 0.000 claims 8
- 102220496875 DNA dC->dU-editing enzyme APOBEC-3C_L80A_mutation Human genes 0.000 claims 8
- 102220509128 Sphingosine 1-phosphate receptor 1_R120A_mutation Human genes 0.000 claims 8
- -1 HLA-SR Proteins 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 5
- 102220554170 APC membrane recruitment protein 1_L30A_mutation Human genes 0.000 claims 4
- 102220498199 Negative regulator of P-body association_R33A_mutation Human genes 0.000 claims 4
- 102220552408 Platelet-activating factor acetylhydrolase_L116A_mutation Human genes 0.000 claims 4
- 230000002238 attenuated effect Effects 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 102220482092 Nuclear cap-binding protein subunit 2_D114A_mutation Human genes 0.000 claims 3
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 3
- 102220497198 WD repeat domain phosphoinositide-interacting protein 4_D113A_mutation Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 2
- 102220554192 APC membrane recruitment protein 1_H34A_mutation Human genes 0.000 claims 2
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 2
- 108010045374 CD36 Antigens Proteins 0.000 claims 2
- 108010065524 CD52 Antigen Proteins 0.000 claims 2
- 102220516986 Double homeobox protein 4_R23A_mutation Human genes 0.000 claims 2
- 102100021056 Ferroptosis suppressor protein 1 Human genes 0.000 claims 2
- 101710204931 Ferroptosis suppressor protein 1 Proteins 0.000 claims 2
- 102220474004 Gamma-secretase subunit PEN-2_L26A_mutation Human genes 0.000 claims 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 2
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 2
- 102220608646 Methyl-CpG-binding domain protein 1_R22K_mutation Human genes 0.000 claims 2
- 102220564303 Natural killer cells antigen CD94_Q40A_mutation Human genes 0.000 claims 2
- 102220564245 Natural killer cells antigen CD94_S25A_mutation Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102220552456 Platelet-activating factor acetylhydrolase_K31A_mutation Human genes 0.000 claims 2
- 102220599460 Protein NPAT_F27A_mutation Human genes 0.000 claims 2
- 102220599466 Protein NPAT_L15A_mutation Human genes 0.000 claims 2
- 102200002501 c.98G>A Human genes 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102200044937 rs121913396 Human genes 0.000 claims 2
- 102220316641 rs146101365 Human genes 0.000 claims 2
- 102220157938 rs886063483 Human genes 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 claims 1
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 claims 1
- 102100026292 Asialoglycoprotein receptor 1 Human genes 0.000 claims 1
- 102100026293 Asialoglycoprotein receptor 2 Human genes 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 102000049320 CD36 Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 102100028801 Calsyntenin-1 Human genes 0.000 claims 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 101710088083 Glomulin Proteins 0.000 claims 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000785944 Homo sapiens Asialoglycoprotein receptor 1 Proteins 0.000 claims 1
- 101000785948 Homo sapiens Asialoglycoprotein receptor 2 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000740785 Homo sapiens Bone marrow stromal antigen 2 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 108010041012 Integrin alpha4 Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 1
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 102000002698 KIR Receptors Human genes 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 claims 1
- 102000010631 Kininogens Human genes 0.000 claims 1
- 108010077861 Kininogens Proteins 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 108010091175 Matriptase Proteins 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 102100031574 Platelet glycoprotein 4 Human genes 0.000 claims 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 1
- 102000018967 Platelet-Derived Growth Factor beta Receptor Human genes 0.000 claims 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 101000600776 Rattus norvegicus Podoplanin Proteins 0.000 claims 1
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 1
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 claims 1
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 claims 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims 1
- 102100035721 Syndecan-1 Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 108010033576 Transferrin Receptors Proteins 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000004248 saffron Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020046259A JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014904326A AU2014904326A0 (en) | 2014-10-29 | Interferon alpha 2b variants | |
| AU2014904326 | 2014-10-29 | ||
| PCT/AU2015/050654 WO2016065409A1 (en) | 2014-10-29 | 2015-10-23 | INTERFERON α2B VARIANTS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020046259A Division JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534282A JP2017534282A (ja) | 2017-11-24 |
| JP2017534282A5 true JP2017534282A5 (enExample) | 2018-11-15 |
| JP6730271B2 JP6730271B2 (ja) | 2020-07-29 |
Family
ID=55851917
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523394A Active JP6730271B2 (ja) | 2014-10-29 | 2015-10-23 | インターフェロンα２Ｂバリアント |
| JP2020046259A Active JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020046259A Active JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10544199B2 (enExample) |
| EP (1) | EP3212216A4 (enExample) |
| JP (2) | JP6730271B2 (enExample) |
| KR (1) | KR102639037B1 (enExample) |
| CN (1) | CN107106656B (enExample) |
| AU (1) | AU2015337858B2 (enExample) |
| CA (1) | CA2965414C (enExample) |
| CL (1) | CL2017001070A1 (enExample) |
| CO (1) | CO2017004318A2 (enExample) |
| EA (1) | EA037749B1 (enExample) |
| IL (1) | IL251822B2 (enExample) |
| MX (1) | MX393988B (enExample) |
| PE (1) | PE20170908A1 (enExample) |
| PH (1) | PH12017500785A1 (enExample) |
| SG (1) | SG11201703251TA (enExample) |
| UA (1) | UA125637C2 (enExample) |
| WO (1) | WO2016065409A1 (enExample) |
| ZA (1) | ZA201702891B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA034989B1 (ru) | 2011-10-28 | 2020-04-15 | Тева Фармасьютикал Австралия Пти Лтд | Полипептидная конструкция для применения при лечении рака, включающая аттенуированный альфа-интерферон |
| DK3677591T5 (da) | 2013-04-29 | 2024-08-26 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antistoffer og fusioner til svækket interferon alpha-2b |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| ES2657060T3 (es) * | 2013-07-18 | 2018-03-01 | Vib Vzw | Fusoquinas que implican citoquinas con afinidades de unión por el receptor fuertemente reducidas |
| UA119352C2 (uk) * | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| EA037749B1 (ru) * | 2014-10-29 | 2021-05-18 | Тева Фармасьютикалз Острэйлиа Пти Лтд | ВАРИАНТЫ ИНТЕРФЕРОНА 2b |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| WO2017123548A1 (en) * | 2016-01-14 | 2017-07-20 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Tumor-specific ifna secretion by car t-cells to reprogram the solid tumor microenvironment |
| EP3411407B1 (en) * | 2016-02-05 | 2024-04-03 | Orionis Biosciences BV | Bispecific signaling agents and uses thereof |
| WO2018014068A1 (en) * | 2016-07-19 | 2018-01-25 | Teva Pharmaceuticals Australia Pty Ltd | Attenuated type i ifn cd47 combination therapy |
| EP3487522A4 (en) * | 2016-07-19 | 2020-04-01 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd47 combination therapy |
| EP3576765B1 (en) | 2017-02-06 | 2025-07-16 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| US20200354424A1 (en) * | 2018-01-26 | 2020-11-12 | Orionis Biosciences, Inc. | Xcr1 binding agents and uses thereof |
| US20210024631A1 (en) * | 2018-03-28 | 2021-01-28 | Orionis Biosciences, Inc. | Bi-functional proteins and construction thereof |
| US12162947B2 (en) | 2018-09-04 | 2024-12-10 | Nanjing Umab-Biopharma Co., Ltd. | Fusion protein and its applicaton in preparing medicine for treating tumor and/or viral infection |
| WO2020048454A1 (zh) * | 2018-09-04 | 2020-03-12 | 南京优迈生物科技有限公司 | 融合蛋白及其在制备用于治疗肿瘤和/或病毒感染的药物中的应用 |
| IL293450A (en) | 2019-12-03 | 2022-07-01 | Evotec Int Gmbh | Interferon-associated antigen binding proteins and uses thereof |
| AR117715A1 (es) | 2019-12-17 | 2021-08-25 | Univ Nacional Del Litoral Unl | Interferón hiperglicosilado con inmunogenicidad reducida |
| US11767353B2 (en) * | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
| WO2023016568A1 (zh) * | 2021-08-12 | 2023-02-16 | 上海才致药成生物科技有限公司 | 一种双特异性重组蛋白及其用途 |
| CN119584982A (zh) * | 2022-05-18 | 2025-03-07 | 武田药品工业株式会社 | 抗cd38融合蛋白制剂 |
| CA3257502A1 (en) | 2022-05-27 | 2023-11-30 | Takeda Pharmaceutical Company Limited | CD38 BINDING FUSION PROTEIN ASSAY |
| WO2024069240A2 (en) | 2022-09-29 | 2024-04-04 | Takeda Pharmaceutical Company Limited | Cd38-binding fusion protein combination therapy |
| CN121127493A (zh) | 2023-05-08 | 2025-12-12 | 豪夫迈·罗氏有限公司 | 靶向干扰素 α 融合蛋白及使用方法 |
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