JP2017529379A5 - - Google Patents
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- Publication number
- JP2017529379A5 JP2017529379A5 JP2017516693A JP2017516693A JP2017529379A5 JP 2017529379 A5 JP2017529379 A5 JP 2017529379A5 JP 2017516693 A JP2017516693 A JP 2017516693A JP 2017516693 A JP2017516693 A JP 2017516693A JP 2017529379 A5 JP2017529379 A5 JP 2017529379A5
- Authority
- JP
- Japan
- Prior art keywords
- degrees
- methyl
- disease
- powder
- ray diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 1-methyl-1H-pyrazol-4-yl Chemical group 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 229940113081 5 Hydroxytryptamine 3 receptor antagonist Drugs 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010036631 Presenile dementia Diseases 0.000 claims 1
- 208000023835 Tendon disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 231100000736 substance abuse Toxicity 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021188428A JP2022036978A (ja) | 2014-09-29 | 2021-11-19 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462056982P | 2014-09-29 | 2014-09-29 | |
| US62/056,982 | 2014-09-29 | ||
| PCT/US2015/052806 WO2016053947A1 (en) | 2014-09-29 | 2015-09-29 | Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021188428A Division JP2022036978A (ja) | 2014-09-29 | 2021-11-19 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529379A JP2017529379A (ja) | 2017-10-05 |
| JP2017529379A5 true JP2017529379A5 (enExample) | 2018-11-08 |
| JP7055017B2 JP7055017B2 (ja) | 2022-04-15 |
Family
ID=54289137
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516693A Active JP7055017B2 (ja) | 2014-09-29 | 2015-09-29 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
| JP2021188428A Withdrawn JP2022036978A (ja) | 2014-09-29 | 2021-11-19 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021188428A Withdrawn JP2022036978A (ja) | 2014-09-29 | 2021-11-19 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10329306B2 (enExample) |
| EP (1) | EP3201203B1 (enExample) |
| JP (2) | JP7055017B2 (enExample) |
| CN (1) | CN106795172B (enExample) |
| CA (1) | CA2962429C (enExample) |
| DK (1) | DK3201203T3 (enExample) |
| ES (1) | ES2883295T3 (enExample) |
| HU (1) | HUE055175T2 (enExample) |
| MA (1) | MA40771B1 (enExample) |
| PL (1) | PL3201203T3 (enExample) |
| PT (1) | PT3201203T (enExample) |
| WO (1) | WO2016053947A1 (enExample) |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| FI74707C (fi) | 1982-06-29 | 1988-03-10 | Sandoz Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror. |
| JPS5936675A (ja) | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
| GB8510752D0 (en) | 1985-04-27 | 1985-06-05 | Beecham Group Plc | Compounds |
| DE3650772T2 (de) | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| US4910193A (en) | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
| DE3722069A1 (de) | 1986-08-21 | 1988-02-25 | Toyoda Gosei Kk | Signalhornschaltvorrichtung fuer ein steuerrad |
| DE3777805D1 (de) | 1986-11-21 | 1992-04-30 | Glaxo Group Ltd | Arzneimittel zur behandlung oder vorbeugung des entzugssyndromes. |
| IT1226389B (it) | 1988-07-12 | 1991-01-15 | Angeli Inst Spa | Nuovi derivati ammidinici e guanidinici |
| GB8829079D0 (en) | 1988-12-13 | 1989-01-25 | Beecham Group Plc | Novel compounds |
| JPH0421681A (ja) | 1990-05-14 | 1992-01-24 | Fujisawa Pharmaceut Co Ltd | ピロロピリジン誘導体 |
| JP3251954B2 (ja) | 1990-07-31 | 2002-01-28 | 日清ファルマ株式会社 | アザビシクロ誘導体 |
| US5187166A (en) | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
| HU211081B (en) | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5149962A (en) | 1991-06-03 | 1992-09-22 | Simmonds Precision Products, Inc. | Proximity detector using faraday effect and bidirectional transmission |
| US5344831A (en) | 1992-01-31 | 1994-09-06 | Nisshin Flour Milling Co., Ltd. | Diazabicyclo derivatives |
| GB9216154D0 (en) | 1992-07-30 | 1992-09-09 | Glaxo Group Ltd | Chemical compounds |
| GB9406857D0 (en) | 1994-04-07 | 1994-06-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| JP3904254B2 (ja) | 1994-10-20 | 2007-04-11 | 株式会社日清製粉グループ本社 | 5−ht4受容体作動薬 |
| CA2160420A1 (en) | 1994-10-20 | 1996-04-21 | Haruhiko Kikuchi | 5-ht4 receptor agonists |
| WO1996012722A1 (en) | 1994-10-20 | 1996-05-02 | Nisshin Flour Milling Co., Ltd. | 5-ht4 receptor agonist |
| WO2000044743A1 (en) | 1999-01-28 | 2000-08-03 | Nippon Shinyaku Co., Ltd. | Amide derivatives and drug compositions |
| AU1887401A (en) | 1999-12-14 | 2001-06-25 | Nippon Shinyaku Co. Ltd. | Medicinal composition |
| EP1427707A1 (en) | 2001-09-19 | 2004-06-16 | Pharmacia Corporation | Substituted indazole compounds for the treatment of inflammation |
| US20040038958A1 (en) | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| ES2405594T3 (es) | 2002-09-25 | 2013-05-31 | Memory Pharmaceuticals Corporation | Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos |
| NZ541008A (en) | 2003-01-13 | 2007-09-28 | Dynogen Pharmaceuticals Inc | Method of treating functional bowel disorders |
| DE602004027171D1 (de) | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
| BRPI0508771A (pt) | 2004-03-25 | 2007-08-14 | Memory Pharm Corp | indazóis, benzotiazóis, benzoisotiazóis, benzisoxazóis, e a preparação e usos dos mesmos |
| UA93348C2 (ru) | 2004-03-25 | 2011-02-10 | Меморі Фармас'Ютікалз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, их получение и применение |
| JP2008527028A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
| KR20080048550A (ko) | 2005-09-23 | 2008-06-02 | 메모리 파마슈티칼스 코포레이션 | 인다졸, 벤조티아졸, 벤조이소티아졸, 벤즈이속사졸,피라졸로피리딘, 이소티아졸로피리딘, 및 이들의 제법 및용도 |
| EP1984334B1 (en) | 2006-02-15 | 2014-04-09 | Allergan, Inc. | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
| CN101460458A (zh) | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1-磷酸-鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚-3-羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| KR101288781B1 (ko) | 2006-06-28 | 2013-07-22 | 암젠 인크 | 글리신 수송자-1 억제제 |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| WO2008097930A1 (en) | 2007-02-05 | 2008-08-14 | Amira Pharmaceuticals, Inc. | Reverse indoles as 5-lipoxygenase-activating protein (flap) inhibitors |
| MX2009008439A (es) | 2007-02-12 | 2009-08-13 | Intermune Inc | Nuevos inhibidores de la replicacion del virus de hepatitis c. |
| BRPI0812594A2 (pt) | 2007-08-10 | 2015-06-23 | Lundbeck & Co As H | Composto ou sal ou hidrato do mesmo, composição farmacêutica, métodos para modulação da atividade de um receptor p2x7, para tratamento de uma condição responsiva á modulação do receptor p2x7 em um paciente, para inibição de morte de células gangliônicas retinais em um paciente, para determinação da presença ou ausência de receptor p2x7 em uma amostra, preparação farmacêutica acondicionada, e, uso de um composto ou sal ou hidrato do mesmo. |
| WO2009108551A2 (en) | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| EP2310019A4 (en) | 2008-05-29 | 2011-06-01 | Albany Molecular Res Inc | 5-HT3 RECEPTOR MODULATORS, MANUFACTURING METHOD AND ITS USE |
| TWI429628B (zh) | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| JOP20130213B1 (ar) | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
-
2015
- 2015-09-29 CN CN201580052611.3A patent/CN106795172B/zh active Active
- 2015-09-29 JP JP2017516693A patent/JP7055017B2/ja active Active
- 2015-09-29 MA MA40771A patent/MA40771B1/fr unknown
- 2015-09-29 US US15/515,263 patent/US10329306B2/en active Active
- 2015-09-29 CA CA2962429A patent/CA2962429C/en active Active
- 2015-09-29 WO PCT/US2015/052806 patent/WO2016053947A1/en not_active Ceased
- 2015-09-29 PL PL15778162T patent/PL3201203T3/pl unknown
- 2015-09-29 HU HUE15778162A patent/HUE055175T2/hu unknown
- 2015-09-29 PT PT157781626T patent/PT3201203T/pt unknown
- 2015-09-29 EP EP15778162.6A patent/EP3201203B1/en active Active
- 2015-09-29 ES ES15778162T patent/ES2883295T3/es active Active
- 2015-09-29 DK DK15778162.6T patent/DK3201203T3/da active
-
2021
- 2021-11-19 JP JP2021188428A patent/JP2022036978A/ja not_active Withdrawn
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