JP2012532191A5 - - Google Patents
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- Publication number
- JP2012532191A5 JP2012532191A5 JP2012519596A JP2012519596A JP2012532191A5 JP 2012532191 A5 JP2012532191 A5 JP 2012532191A5 JP 2012519596 A JP2012519596 A JP 2012519596A JP 2012519596 A JP2012519596 A JP 2012519596A JP 2012532191 A5 JP2012532191 A5 JP 2012532191A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- polymorph
- chronic
- mixture
- ethylenediamine salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical class NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 206010006451 bronchitis Diseases 0.000 claims 4
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 206010001076 Acute sinusitis Diseases 0.000 claims 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010009137 Chronic sinusitis Diseases 0.000 claims 2
- 208000000592 Nasal Polyps Diseases 0.000 claims 2
- 102000009389 Prostaglandin D receptors Human genes 0.000 claims 2
- 108050000258 Prostaglandin D receptors Proteins 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 208000024716 acute asthma Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims 2
- 208000007451 chronic bronchitis Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002798 polar solvent Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- YKYONYBAUNKHLG-UHFFFAOYSA-N n-Propyl acetate Natural products CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 claims 1
- MPVNLHUOKQVEEG-UHFFFAOYSA-N n-[4-[[4,6-bis(dimethylamino)pyrimidin-2-yl]methyl]phenyl]-4-(trifluoromethyl)benzamide Chemical compound CN(C)C1=CC(N(C)C)=NC(CC=2C=CC(NC(=O)C=3C=CC(=CC=3)C(F)(F)F)=CC=2)=N1 MPVNLHUOKQVEEG-UHFFFAOYSA-N 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000003880 polar aprotic solvent Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 229940090181 propyl acetate Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22316509P | 2009-07-06 | 2009-07-06 | |
| US61/223,165 | 2009-07-06 | ||
| PCT/US2010/040733 WO2011005645A1 (en) | 2009-07-06 | 2010-07-01 | Polymorph of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl] |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532191A JP2012532191A (ja) | 2012-12-13 |
| JP2012532191A5 true JP2012532191A5 (enExample) | 2013-08-15 |
Family
ID=42352224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519596A Pending JP2012532191A (ja) | 2009-07-06 | 2010-07-01 | ［４，６−ビス（ジメチルアミノ）−２−（４−｛［４−（トリフルオロメチル）ベンゾイル］アミノ｝ベンジル）ピリミジン−５−イル］の多形体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20120142715A1 (enExample) |
| EP (1) | EP2451787B1 (enExample) |
| JP (1) | JP2012532191A (enExample) |
| WO (1) | WO2011005645A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010521496A (ja) | 2007-03-14 | 2010-06-24 | ノップ ニューロサイエンシーズ、インク． | キラル精製置換ベンゾチアゾールジアミンの合成 |
| CA2734491A1 (en) | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| CN105764507B (zh) | 2013-07-12 | 2019-07-19 | 诺普生物科学有限责任公司 | 治疗升高的嗜酸性粒细胞和/或嗜碱性粒细胞的水平 |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| EP3033081B1 (en) | 2013-08-13 | 2021-05-12 | Knopp Biosciences LLC | Compositions and methods for treating chronic urticaria |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| DK163640C (da) | 1985-07-30 | 1992-08-17 | Glaxo Group Ltd | Apparat til administrering af medikamenter |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| DE4318455A1 (de) | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| CN101558011B (zh) | 2006-08-03 | 2013-03-27 | 溴化物有限公司 | 用于水处理的方法、装置和系统 |
| CN101772489B (zh) * | 2007-06-21 | 2013-02-20 | 艾克提麦斯医药品有限公司 | 一种crth2拮抗剂的胺盐 |
| NZ581811A (en) | 2007-06-21 | 2012-11-30 | Actimis Pharmaceuticals Inc | Particulates of the CRTH2 antagonist { 4,6-bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)-benzyl)pyrimidin-5-yl} acetic acid |
-
2010
- 2010-07-01 EP EP10729777.2A patent/EP2451787B1/en not_active Not-in-force
- 2010-07-01 JP JP2012519596A patent/JP2012532191A/ja active Pending
- 2010-07-01 US US13/382,366 patent/US20120142715A1/en not_active Abandoned
- 2010-07-01 WO PCT/US2010/040733 patent/WO2011005645A1/en not_active Ceased
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