JP2013538206A5 - - Google Patents
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- Publication number
- JP2013538206A5 JP2013538206A5 JP2013525400A JP2013525400A JP2013538206A5 JP 2013538206 A5 JP2013538206 A5 JP 2013538206A5 JP 2013525400 A JP2013525400 A JP 2013525400A JP 2013525400 A JP2013525400 A JP 2013525400A JP 2013538206 A5 JP2013538206 A5 JP 2013538206A5
- Authority
- JP
- Japan
- Prior art keywords
- disorders
- benzenesulfonyl
- pyrrolidine
- methoxy
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NHPQGZOBHSVTAQ-IBGZPJMESA-N (2s)-n-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1[C@H](C(=O)NC=2C=C(C)C=C(C)C=2)CCC1 NHPQGZOBHSVTAQ-IBGZPJMESA-N 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000027559 Appetite disease Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 229940123730 Orexin receptor antagonist Drugs 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- LWZATQDWEXAGQR-NSHDSACASA-N (2s)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxylic acid Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1[C@H](C(O)=O)CCC1 LWZATQDWEXAGQR-NSHDSACASA-N 0.000 claims 1
- -1 3,5-dimethyl - phenyl Chemical group 0.000 claims 1
- MKARNSWMMBGSHX-UHFFFAOYSA-N 3,5-dimethylaniline Chemical compound CC1=CC(C)=CC(N)=C1 MKARNSWMMBGSHX-UHFFFAOYSA-N 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2010053799 | 2010-08-24 | ||
| IBPCT/IB2010/053799 | 2010-08-24 | ||
| PCT/IB2011/053693 WO2012025877A1 (en) | 2010-08-24 | 2011-08-23 | Proline sulfonamide derivatives as orexin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013538206A JP2013538206A (ja) | 2013-10-10 |
| JP2013538206A5 true JP2013538206A5 (enExample) | 2014-10-09 |
| JP5744203B2 JP5744203B2 (ja) | 2015-07-08 |
Family
ID=44658790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013525400A Expired - Fee Related JP5744203B2 (ja) | 2010-08-24 | 2011-08-23 | オレキシン受容体拮抗薬としてのプロリンスルフォンアミド誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8895606B2 (enExample) |
| EP (1) | EP2608787B1 (enExample) |
| JP (1) | JP5744203B2 (enExample) |
| KR (1) | KR101802726B1 (enExample) |
| CN (1) | CN103079563B (enExample) |
| CA (1) | CA2807000C (enExample) |
| ES (1) | ES2769607T3 (enExample) |
| TW (1) | TW201209037A (enExample) |
| WO (1) | WO2012025877A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2608787B1 (en) | 2010-08-24 | 2019-11-20 | Idorsia Pharmaceuticals Ltd | Proline sulfonamide derivatives as orexin receptor antagonists |
| DK2855453T3 (en) | 2012-06-04 | 2017-02-06 | Actelion Pharmaceuticals Ltd | Benzimidazol-proline derivatives |
| CN105793257B (zh) | 2013-12-03 | 2018-11-13 | 爱杜西亚药品有限公司 | 苯并咪唑环化合物的晶形及其用途 |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| SI3077391T1 (sl) | 2013-12-04 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Uporaba benzimidazol-prolinskih derivatov |
| WO2021207678A1 (en) * | 2020-04-09 | 2021-10-14 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Kappa opioid receptor antagonists for treating pain-related sleep disorders |
| EP4356909A1 (en) * | 2022-10-17 | 2024-04-24 | Selabtec Sciences, SLU | 1-(sulfonyl)-n-phenylpyrrolidine-2-carboxamides derivatives and use thereof |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5822111B2 (ja) | 1977-10-29 | 1983-05-06 | 協和醗酵工業株式会社 | 柑橘類果実の改質剤 |
| JPS5581857A (en) | 1978-12-15 | 1980-06-20 | Kyowa Hakko Kogyo Co Ltd | Modifier of citrus fruit |
| US6291453B1 (en) | 1997-07-31 | 2001-09-18 | Athena Neurosciences, Inc. | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| NZ507760A (en) | 1998-03-26 | 2002-10-25 | Japan Tobacco Inc | Amide derivatives and nociceptin antagonists |
| DE10035144A1 (de) | 2000-07-19 | 2002-01-31 | Merck Patent Gmbh | Cyclische Aminosäurederivate |
| GB0225938D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| WO2004073634A2 (en) | 2003-02-20 | 2004-09-02 | Encysive Pharmaceuticals Inc. | Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists |
| US7288538B2 (en) | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| EP1697337A2 (en) | 2003-12-22 | 2006-09-06 | Astellas Pharma Inc. | Ornithine derivatives as prostaglandin-e2-agonists or antagonists |
| RU2378257C2 (ru) | 2004-03-01 | 2010-01-10 | Актелион Фармасьютиклз Лтд | Замещенные производные 1,2,3,4-тетрагидроизохинолина |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| US8143288B2 (en) * | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| EA015256B1 (ru) | 2006-03-15 | 2011-06-30 | Актелион Фармасьютикалз Лтд. | Производные тетрагидроизохинолина для повышения функции памяти |
| EP2049526A2 (en) | 2006-07-14 | 2009-04-22 | Merck & Co., Inc. | 2-substituted proline bis-amide orexin receptor antagonists |
| PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| KR101343399B1 (ko) * | 2008-01-08 | 2013-12-19 | 퍼듀 퍼머 엘피 | 통증 치료를 위한 카나비노이드 수용체에 대한 리간드로서의 프롤린 유사체 |
| CN101918361B (zh) * | 2008-02-12 | 2014-05-28 | 弗·哈夫曼-拉罗切有限公司 | 哌啶磺酰胺衍生物 |
| US8629157B2 (en) | 2009-01-05 | 2014-01-14 | Boehringer Ingelheim International Gmbh | Pyrrolidine compounds which modulate the CB2 receptor |
| ES2350548B1 (es) | 2009-06-25 | 2011-09-29 | Institut Univ. De Ciència I Tecnologia, S.A. | N-fenil-1-sulfonil-2-pirrolidinacarboxamidas para la identificacion de actividad biologica y farmacologica. |
| ES2351323B1 (es) | 2009-06-26 | 2011-10-05 | Institut Univ. De Ciència I Tecnologia, S.A. | Bibliotecas de n-fenil-1-sulfonil-2-pirrolidinacarboxamidas para el descubrimiento de farmacos. |
| ES2351452B1 (es) | 2009-07-01 | 2011-10-05 | Institut Univ. De Ciència I Tecnologia, S.A. | Bibliotecas de n-fenil-1-sulfonil-2-pirrolidinacarboxamidas para la identificacion de actividad biologica y farmacologica. |
| EP2608787B1 (en) | 2010-08-24 | 2019-11-20 | Idorsia Pharmaceuticals Ltd | Proline sulfonamide derivatives as orexin receptor antagonists |
| DK2855453T3 (en) | 2012-06-04 | 2017-02-06 | Actelion Pharmaceuticals Ltd | Benzimidazol-proline derivatives |
-
2011
- 2011-08-23 EP EP11758563.8A patent/EP2608787B1/en active Active
- 2011-08-23 CN CN201180040497.4A patent/CN103079563B/zh not_active Expired - Fee Related
- 2011-08-23 ES ES11758563T patent/ES2769607T3/es active Active
- 2011-08-23 WO PCT/IB2011/053693 patent/WO2012025877A1/en not_active Ceased
- 2011-08-23 TW TW100130171A patent/TW201209037A/zh unknown
- 2011-08-23 KR KR1020137007125A patent/KR101802726B1/ko not_active Expired - Fee Related
- 2011-08-23 CA CA2807000A patent/CA2807000C/en active Active
- 2011-08-23 US US13/818,647 patent/US8895606B2/en active Active
- 2011-08-23 JP JP2013525400A patent/JP5744203B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-31 US US14/530,532 patent/US9000029B2/en active Active
-
2015
- 2015-03-05 US US14/639,934 patent/US9211279B2/en active Active
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