JP2015524816A5 - - Google Patents
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- Publication number
- JP2015524816A5 JP2015524816A5 JP2015524798A JP2015524798A JP2015524816A5 JP 2015524816 A5 JP2015524816 A5 JP 2015524816A5 JP 2015524798 A JP2015524798 A JP 2015524798A JP 2015524798 A JP2015524798 A JP 2015524798A JP 2015524816 A5 JP2015524816 A5 JP 2015524816A5
- Authority
- JP
- Japan
- Prior art keywords
- tfr1
- antibody
- antagonist
- isolated
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000007238 Transferrin Receptors Human genes 0.000 claims 11
- 108010033576 Transferrin Receptors Proteins 0.000 claims 11
- 239000005557 antagonist Substances 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 208000002903 Thalassemia Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305955.2 | 2012-08-02 | ||
| EP12305955 | 2012-08-02 | ||
| PCT/EP2013/066253 WO2014020140A1 (en) | 2012-08-02 | 2013-08-02 | Use of transferrin receptor antagonist for the treatment of thalassemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015524816A JP2015524816A (ja) | 2015-08-27 |
| JP2015524816A5 true JP2015524816A5 (enExample) | 2016-09-23 |
Family
ID=48979730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524798A Withdrawn JP2015524816A (ja) | 2012-08-02 | 2013-08-02 | サラセミアを処置するためのトランスフェリンレセプターアンタゴニストの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20150197574A1 (enExample) |
| EP (1) | EP2880059A1 (enExample) |
| JP (1) | JP2015524816A (enExample) |
| WO (1) | WO2014020140A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3247409B1 (en) * | 2015-01-21 | 2020-11-04 | Cornell University | Viral vectors for prophylaxis and therapy of hemoglobinopathies |
| TWI787796B (zh) | 2015-05-04 | 2022-12-21 | 美商Ｃｙｔｏｍｘ生物製藥公司 | 抗ｃｄ７１抗體類、可活化之抗ｃｄ７１抗體類及使用彼等之方法 |
| RU2737637C2 (ru) * | 2015-07-22 | 2020-12-01 | Инатерис | Антитела против tfr и их применение при лечении пролиферативных и воспалительных расстройств |
| AU2018231127A1 (en) | 2017-03-09 | 2019-09-19 | Cytomx Therapeutics, Inc. | CD147 antibodies, activatable CD147 antibodies, and methods of making and use thereof |
| WO2018185341A1 (en) | 2017-04-07 | 2018-10-11 | Ospedale San Raffaele S.R.L. | Regulator of bmp-smad signaling and uses thereof |
| WO2019173771A1 (en) | 2018-03-09 | 2019-09-12 | Cytomx Therapeutics, Inc. | Activatable cd147 antibodies and methods of making and use thereof |
| KR20210093974A (ko) * | 2018-11-20 | 2021-07-28 | 가부시키가이샤 페르세우스 프로테오믹스 | 세포내 철 흡수 억제제 |
| WO2021061867A1 (en) | 2019-09-23 | 2021-04-01 | Cytomx Therapeutics, Inc. | Anti-cd47 antibodies, activatable anti-cd47 antibodies, and methods of use thereof |
| WO2021195116A1 (en) * | 2020-03-23 | 2021-09-30 | The Regents Of The University Of California | Transferrin receptor 1 targeting for carcinogenesis prevention |
| US20240100049A1 (en) * | 2021-01-28 | 2024-03-28 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Reactivation of embryonic and fetal hemoglobin |
| US11939391B2 (en) * | 2021-12-06 | 2024-03-26 | MedAbome, Inc. | Anti-TfR1 antibody MAb11-22.1 conjugates for cancer treatment |
| WO2025024334A1 (en) * | 2023-07-21 | 2025-01-30 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| EP1244701A1 (en) * | 1999-12-23 | 2002-10-02 | Human Genome Sciences, Inc. | Transferrin polynucleotides, polypeptides, and antibodies |
| US8129504B2 (en) * | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| EP1740616B1 (en) | 2004-04-30 | 2011-12-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-tfr antibody. |
-
2013
- 2013-08-02 EP EP13748004.2A patent/EP2880059A1/en not_active Withdrawn
- 2013-08-02 US US14/418,457 patent/US20150197574A1/en not_active Abandoned
- 2013-08-02 WO PCT/EP2013/066253 patent/WO2014020140A1/en not_active Ceased
- 2013-08-02 JP JP2015524798A patent/JP2015524816A/ja not_active Withdrawn
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