JP2012518624A5 - - Google Patents
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- Publication number
- JP2012518624A5 JP2012518624A5 JP2011550652A JP2011550652A JP2012518624A5 JP 2012518624 A5 JP2012518624 A5 JP 2012518624A5 JP 2011550652 A JP2011550652 A JP 2011550652A JP 2011550652 A JP2011550652 A JP 2011550652A JP 2012518624 A5 JP2012518624 A5 JP 2012518624A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- toxin
- difficile
- composition according
- sheep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003053 toxin Substances 0.000 claims 15
- 231100000765 toxin Toxicity 0.000 claims 15
- 108700012359 toxins Proteins 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 241001494479 Pecora Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 5
- 101000963974 Hydrophis stokesii Alpha-elapitoxin-Ast2b Proteins 0.000 claims 4
- 101000964025 Naja naja Long neurotoxin 3 Proteins 0.000 claims 4
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims 4
- 101710182223 Toxin B Proteins 0.000 claims 4
- 101710182532 Toxin a Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000193163 Clostridioides difficile Species 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0902851.5 | 2009-02-20 | ||
| GB0902851A GB0902851D0 (en) | 2009-02-20 | 2009-02-20 | Antibodies to clostridium difficile toxins |
| GB0916153A GB0916153D0 (en) | 2009-09-15 | 2009-09-15 | Antibodies to clostridium difficile toxins |
| GB0916153.0 | 2009-09-15 | ||
| PCT/GB2010/050288 WO2010094970A1 (en) | 2009-02-20 | 2010-02-19 | Antibodies to clostridium difficile toxins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518624A JP2012518624A (ja) | 2012-08-16 |
| JP2012518624A5 true JP2012518624A5 (enExample) | 2013-03-07 |
| JP5740714B2 JP5740714B2 (ja) | 2015-06-24 |
Family
ID=42109880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550652A Active JP5740714B2 (ja) | 2009-02-20 | 2010-02-19 | クロストリジウム・ディフィシル（Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ）毒素に対する抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8709428B2 (enExample) |
| EP (1) | EP2405940B1 (enExample) |
| JP (1) | JP5740714B2 (enExample) |
| CN (1) | CN102365097A (enExample) |
| AU (1) | AU2010215275B2 (enExample) |
| CA (1) | CA2752815A1 (enExample) |
| WO (1) | WO2010094970A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| US8431361B2 (en) * | 2010-09-17 | 2013-04-30 | Board Of Regents Of The University Of Oklahoma | Bacterial cells, optimized nucleotide sequences and methods for improved expression of recombinant Clostridium difficile toxin B |
| MX391236B (es) * | 2011-04-22 | 2025-03-21 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos. |
| GB201110712D0 (en) | 2011-06-23 | 2011-08-10 | Univ Ulster | Diagnostic methods |
| WO2013038156A1 (en) * | 2011-09-16 | 2013-03-21 | Ucb Pharma S.A. | Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile |
| CA2856085C (en) | 2011-11-18 | 2020-06-30 | National Research Council Of Canada | Clostridium difficile lipoteichoic acid and uses thereof |
| SG11201402375VA (en) | 2011-12-08 | 2014-10-30 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| DE102011121237A1 (de) * | 2011-12-14 | 2013-06-20 | Universitätsklinikum Hamburg-Eppendorf | Einzeldomänen-Antikörper gegen Clostridium difficile Toxin CDTa |
| AR089797A1 (es) * | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| RU2628305C2 (ru) | 2012-03-02 | 2017-08-15 | Регенерон Фармасьютиказ, Инк. | Человеческие антитела к токсинам clostridium difficile |
| EP2921502A4 (en) | 2012-10-19 | 2016-09-28 | Evec Inc | AGAINST TOXIN FROM CLOSTRIDIUM DIFFICILE OR ANTIGENBINDING FRAGMENT SPECIFIC HUMAN ANTIBODY |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| JP2016501877A (ja) * | 2012-11-28 | 2016-01-21 | シーエヌジェー ホールディングス，インコーポレイテッド | クロストリジウム・ディフィシルに対する抗体 |
| US9493518B2 (en) * | 2013-03-14 | 2016-11-15 | National Health Research Institutes | Compositions and methods for treating clostridium difficile-associated diseases |
| CN105555309A (zh) * | 2013-04-19 | 2016-05-04 | 英穆伦有限公司 | 治疗和/或预防艰难梭菌相关疾病的方法和组合物 |
| CA2910200A1 (en) | 2013-04-22 | 2014-10-30 | Board Of Regents Of The University Of Oklahoma | Clostridium difficile vaccine and methods of use |
| CN103665141B (zh) * | 2013-12-31 | 2015-09-16 | 北京大学 | 与艰难梭菌细胞毒素b相互作用的蛋白 |
| WO2015150493A1 (en) * | 2014-04-01 | 2015-10-08 | Institut Pasteur | Predictive value of clostridium difficile-specific immune response for recurrence and disease outcome |
| EP3344276B1 (en) | 2015-09-03 | 2020-04-22 | The Board of Regents of the University of Oklahoma | Peptide inhibitors of clostridium difficile tcdb toxin |
| USD952157S1 (en) | 2020-06-19 | 2022-05-17 | Qualigen Inc. | Whole blood treatment cartridge |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS608225A (ja) | 1983-06-29 | 1985-01-17 | Kowa Co | 腸管吸収医薬組成物 |
| US5601823A (en) | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| AU702405B2 (en) | 1994-09-06 | 1999-02-18 | Immucell Corporation | Therapeutic treatment of clostridium difficile associated diseases |
| US6096310A (en) | 1997-04-15 | 2000-08-01 | Bier; Milan | Oral immunotherapy of bacterial overgrowth |
| AU746859B2 (en) | 1997-06-20 | 2002-05-02 | Imperial College Of Science, Technology And Medicine | Immonogenic fragments of toxin a of clostridium difficile |
| DE69829400T2 (de) * | 1997-10-20 | 2006-04-13 | Acambis, Inc., Cambridge | Passive immunisierung gegen durch clostridium difficile verursachte krankheit |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6074689A (en) | 1998-03-10 | 2000-06-13 | Immucell Corporation | Colonic delivery of protein or peptide compositions |
| US20020009429A1 (en) * | 1999-01-29 | 2002-01-24 | Galagen, Inc. | Pharmaceutical composition comprising a selected antigen and candida species antigen and methods |
| US6673574B2 (en) | 2000-11-30 | 2004-01-06 | Unigene Laboratories Inc. | Oral delivery of peptides using enzyme-cleavable membrane translocators |
| GB0205206D0 (en) | 2002-03-06 | 2002-04-17 | Oxoid Ltd | Synthetic peptides |
| AU2003299527A1 (en) | 2002-06-17 | 2004-06-07 | Jimmy D. Ballard | Mutant of clostridium difficile toxin b and methods of use |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| DK1766093T3 (da) * | 2004-02-06 | 2011-10-03 | Univ Massachusetts | Antistoffer mod clostridium difficile-toksiner og anvendelse deraf |
| EP1833510A4 (en) | 2004-12-27 | 2010-02-10 | Progenics Pharmaceuticals Neva | ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME |
| US7794721B2 (en) | 2006-12-13 | 2010-09-14 | Simon Michael R | Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith |
| CN101363867B (zh) * | 2008-05-26 | 2012-12-19 | 北京庄笛浩禾生物医学科技有限公司 | 一种艰难梭菌a、b毒素胶体金检测试纸条及其制备方法 |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
-
2010
- 2010-02-19 WO PCT/GB2010/050288 patent/WO2010094970A1/en not_active Ceased
- 2010-02-19 CA CA2752815A patent/CA2752815A1/en not_active Abandoned
- 2010-02-19 CN CN2010800086731A patent/CN102365097A/zh active Pending
- 2010-02-19 EP EP10706731.6A patent/EP2405940B1/en active Active
- 2010-02-19 US US13/202,557 patent/US8709428B2/en active Active
- 2010-02-19 AU AU2010215275A patent/AU2010215275B2/en active Active
- 2010-02-19 JP JP2011550652A patent/JP5740714B2/ja active Active
-
2014
- 2014-03-18 US US14/218,854 patent/US20150010580A1/en not_active Abandoned