JP2017519762A5 - - Google Patents
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- Publication number
- JP2017519762A5 JP2017519762A5 JP2016573549A JP2016573549A JP2017519762A5 JP 2017519762 A5 JP2017519762 A5 JP 2017519762A5 JP 2016573549 A JP2016573549 A JP 2016573549A JP 2016573549 A JP2016573549 A JP 2016573549A JP 2017519762 A5 JP2017519762 A5 JP 2017519762A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- polypeptide
- human
- composition according
- vwf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 108010047303 von Willebrand Factor Proteins 0.000 claims 13
- 102100036537 von Willebrand factor Human genes 0.000 claims 13
- 229960001134 von willebrand factor Drugs 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 10
- 102000043853 ADAMTS13 Human genes 0.000 claims 9
- 108091005670 ADAMTS13 Proteins 0.000 claims 9
- 230000008816 organ damage Effects 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 230000006378 damage Effects 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000000302 ischemic effect Effects 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 101000798281 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 13 Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 102000057210 human ADAMTS13 Human genes 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2013007A NL2013007B1 (en) | 2014-06-16 | 2014-06-16 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| NL2013007 | 2014-06-16 | ||
| US201462030817P | 2014-07-30 | 2014-07-30 | |
| US62/030,817 | 2014-07-30 | ||
| PCT/EP2015/063493 WO2015193326A1 (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020014229A Division JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519762A JP2017519762A (ja) | 2017-07-20 |
| JP2017519762A5 true JP2017519762A5 (enExample) | 2019-01-17 |
| JP6688746B2 JP6688746B2 (ja) | 2020-04-28 |
Family
ID=51541255
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016573549A Active JP6688746B2 (ja) | 2014-06-16 | 2015-06-16 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| JP2020014229A Active JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| JP2022110921A Pending JP2022160431A (ja) | 2014-06-16 | 2022-07-11 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020014229A Active JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| JP2022110921A Pending JP2022160431A (ja) | 2014-06-16 | 2022-07-11 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US10858445B2 (enExample) |
| EP (6) | EP3366305B1 (enExample) |
| JP (3) | JP6688746B2 (enExample) |
| KR (2) | KR102403388B1 (enExample) |
| CN (1) | CN106559985A (enExample) |
| AU (2) | AU2015276237B2 (enExample) |
| CA (1) | CA2952103A1 (enExample) |
| ES (5) | ES2831865T3 (enExample) |
| IL (1) | IL249540B (enExample) |
| NL (1) | NL2013007B1 (enExample) |
| PL (5) | PL3366305T3 (enExample) |
| PT (5) | PT3154569T (enExample) |
| RU (1) | RU2704444C2 (enExample) |
| SG (2) | SG11201610488QA (enExample) |
| WO (1) | WO2015193326A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CN107340225B (zh) * | 2017-07-13 | 2019-07-05 | 徐州医科大学 | 一种基于流式细胞术检测血小板受体GPIba胞外段酶切的方法 |
| CN111670202A (zh) * | 2018-02-06 | 2020-09-15 | 埃博灵克斯股份有限公司 | 以免疫球蛋白单可变结构域治疗ttp初次发作的方法 |
| US20230405096A1 (en) * | 2020-11-18 | 2023-12-21 | Green Cross Corporation | Adamts13 variant having increased escaping rate or activity against autoantibody |
| JP2024535249A (ja) | 2021-09-17 | 2024-09-30 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 合成ヒト化ラマナノボディライブラリーおよびｓａｒｓ－ｃｏｖ－２中和抗体を同定するためのその使用 |
| CN118715246A (zh) * | 2021-12-10 | 2024-09-27 | 李人浩 | 结合血管性血友病因子(vwf)a1结构域或自动抑制模块的多肽、变体及其用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB335768A (en) | 1929-10-24 | 1930-10-02 | Jacoviac Maurice | Improvements in protecting devices for gramophone disc records |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5043429B1 (en) | 1987-05-01 | 1997-10-14 | Scripps Research Inst | Protein fragments containing factor VIII binding domain of von willebrand factor |
| ES2052027T5 (es) | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| NZ513356A (en) | 1999-02-05 | 2004-01-30 | Univ Leiden | Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate |
| EP1198572A2 (en) | 1999-08-02 | 2002-04-24 | Keygene N.V. | Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| AU2003251238A1 (en) | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| BRPI0315666B8 (pt) | 2002-10-23 | 2021-05-25 | Ludwig Inst For Cancer Res Ltd | dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| NZ576284A (en) | 2003-01-10 | 2010-07-30 | Ablynx Nv | Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| EP1656128A4 (en) | 2003-08-12 | 2007-02-28 | William M Yarbrough | SINGLE ACNE TREATMENT AND METHOD OF USE |
| US7270976B2 (en) * | 2004-07-19 | 2007-09-18 | American Diagnostica, Inc. | Methods for measuring ADAMTS13 activity and protein on platelets and in plasma |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| CA2593328C (en) | 2005-01-14 | 2018-02-06 | Ablynx N.V. | Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between von willebrand factor (vwf) and platelets |
| MX2007014564A (es) | 2005-05-20 | 2008-02-07 | Ablynx Nv | Anticuerpos de vhh de dominio unico contra el factor de von willebrand. |
| CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| CN101663319A (zh) | 2007-02-21 | 2010-03-03 | 埃博灵克斯股份有限公司 | 针对血管内皮生长因子的氨基酸序列和包括其的多肽用于治疗特征在于过量和/或病理性血管发生或新血管形成的病症和疾病 |
| KR101264473B1 (ko) | 2007-05-24 | 2013-05-29 | 아블린쓰 엔.브이. | Ｒａｎｋ-ｌ에 대한 아미노산 서열, 및 이를 포함하는 골 질환 및 장애 치료용 폴리펩티드 |
| CA2718081A1 (en) | 2008-03-21 | 2009-09-24 | Ablynx Nv | Von willebrand factor specific binders and methods of use therefor |
| KR101593285B1 (ko) | 2008-10-29 | 2016-02-11 | 아블린쓰 엔.브이. | 단일 도메인 항원 결합 분자의 제형 |
| CA2739352C (en) | 2008-10-29 | 2021-07-13 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
| US20120321640A1 (en) | 2009-12-01 | 2012-12-20 | Ablynx N.V. | Von willebrand factor specific binding agents and uses thereof |
| TWI616204B (zh) * | 2010-11-05 | 2018-03-01 | 諾華公司 | Ｉｌ-１７抗體用於製備治療牛皮癬性關節炎之藥物之用途 |
| KR101969515B1 (ko) | 2011-06-10 | 2019-04-16 | 박스알타 인코퍼레이티드 | 재조합 vwf의 투여에 의한 응고 질환의 치료 |
| PE20141522A1 (es) | 2011-08-17 | 2014-11-17 | Glaxo Group Ltd | Proteinas y peptidos modificados |
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CN111670202A (zh) | 2018-02-06 | 2020-09-15 | 埃博灵克斯股份有限公司 | 以免疫球蛋白单可变结构域治疗ttp初次发作的方法 |
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2014
- 2014-06-16 NL NL2013007A patent/NL2013007B1/en active
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2015
- 2015-06-16 CN CN201580040020.4A patent/CN106559985A/zh active Pending
- 2015-06-16 ES ES18153676T patent/ES2831865T3/es active Active
- 2015-06-16 EP EP18153671.5A patent/EP3366305B1/en active Active
- 2015-06-16 PT PT157298290T patent/PT3154569T/pt unknown
- 2015-06-16 PL PL18153671T patent/PL3366305T3/pl unknown
- 2015-06-16 RU RU2017100077A patent/RU2704444C2/ru active
- 2015-06-16 PL PL18153673.1T patent/PL3335723T3/pl unknown
- 2015-06-16 CA CA2952103A patent/CA2952103A1/en not_active Abandoned
- 2015-06-16 KR KR1020177001152A patent/KR102403388B1/ko active Active
- 2015-06-16 PT PT181536715T patent/PT3366305T/pt unknown
- 2015-06-16 PL PL18153674.9T patent/PL3335724T3/pl unknown
- 2015-06-16 ES ES18153674T patent/ES2924199T3/es active Active
- 2015-06-16 EP EP18153676.4A patent/EP3332800B1/en active Active
- 2015-06-16 SG SG11201610488QA patent/SG11201610488QA/en unknown
- 2015-06-16 KR KR1020227012546A patent/KR102568585B1/ko active Active
- 2015-06-16 ES ES15729829T patent/ES2881331T3/es active Active
- 2015-06-16 ES ES18153673T patent/ES2915473T3/es active Active
- 2015-06-16 EP EP18153674.9A patent/EP3335724B1/en active Active
- 2015-06-16 AU AU2015276237A patent/AU2015276237B2/en active Active
- 2015-06-16 ES ES18153671T patent/ES2843642T3/es active Active
- 2015-06-16 JP JP2016573549A patent/JP6688746B2/ja active Active
- 2015-06-16 PL PL18153676T patent/PL3332800T3/pl unknown
- 2015-06-16 WO PCT/EP2015/063493 patent/WO2015193326A1/en not_active Ceased
- 2015-06-16 PL PL15729829T patent/PL3154569T3/pl unknown
- 2015-06-16 PT PT181536731T patent/PT3335723T/pt unknown
- 2015-06-16 PT PT181536749T patent/PT3335724T/pt unknown
- 2015-06-16 US US15/319,467 patent/US10858445B2/en active Active
- 2015-06-16 PT PT181536764T patent/PT3332800T/pt unknown
- 2015-06-16 EP EP18153673.1A patent/EP3335723B1/en active Active
- 2015-06-16 EP EP22172948.6A patent/EP4059513A1/en not_active Withdrawn
- 2015-06-16 SG SG10201811109PA patent/SG10201811109PA/en unknown
- 2015-06-16 EP EP15729829.0A patent/EP3154569B1/en active Active
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2016
- 2016-12-13 IL IL249540A patent/IL249540B/en unknown
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2018
- 2018-01-26 US US15/881,055 patent/US20180155443A1/en not_active Abandoned
- 2018-01-26 US US15/880,870 patent/US20180155440A1/en not_active Abandoned
- 2018-01-26 US US15/881,003 patent/US10919980B2/en active Active
- 2018-01-26 US US15/880,978 patent/US12269893B2/en active Active
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2020
- 2020-01-30 JP JP2020014229A patent/JP7105260B2/ja active Active
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2021
- 2021-05-03 AU AU2021202747A patent/AU2021202747B2/en active Active
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2022
- 2022-07-11 JP JP2022110921A patent/JP2022160431A/ja active Pending