JP2019522037A5 - - Google Patents
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- JP2019522037A5 JP2019522037A5 JP2019504916A JP2019504916A JP2019522037A5 JP 2019522037 A5 JP2019522037 A5 JP 2019522037A5 JP 2019504916 A JP2019504916 A JP 2019504916A JP 2019504916 A JP2019504916 A JP 2019504916A JP 2019522037 A5 JP2019522037 A5 JP 2019522037A5
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- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021078313A JP7208659B2 (ja) | 2016-07-29 | 2021-05-06 | インドリノン化合物の使用 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662368707P | 2016-07-29 | 2016-07-29 | |
| US62/368,707 | 2016-07-29 | ||
| US201662417572P | 2016-11-04 | 2016-11-04 | |
| US62/417,572 | 2016-11-04 | ||
| US201662422504P | 2016-11-15 | 2016-11-15 | |
| US62/422,504 | 2016-11-15 | ||
| US201662426107P | 2016-11-23 | 2016-11-23 | |
| US62/426,107 | 2016-11-23 | ||
| US201762503238P | 2017-05-08 | 2017-05-08 | |
| US62/503,238 | 2017-05-08 | ||
| US201762534067P | 2017-07-18 | 2017-07-18 | |
| US62/534,067 | 2017-07-18 | ||
| PCT/US2017/043979 WO2018022771A1 (en) | 2016-07-29 | 2017-07-26 | Uses of indolinone compounds |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020204766A Division JP7182304B2 (ja) | 2016-07-29 | 2020-12-10 | インドリノン化合物の使用 |
| JP2021078313A Division JP7208659B2 (ja) | 2016-07-29 | 2021-05-06 | インドリノン化合物の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522037A JP2019522037A (ja) | 2019-08-08 |
| JP2019522037A5 true JP2019522037A5 (enExample) | 2019-10-17 |
| JP6885629B2 JP6885629B2 (ja) | 2021-06-16 |
Family
ID=61011754
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504916A Active JP6885629B2 (ja) | 2016-07-29 | 2017-07-26 | インドリノン化合物の使用 |
| JP2020204766A Active JP7182304B2 (ja) | 2016-07-29 | 2020-12-10 | インドリノン化合物の使用 |
| JP2021078313A Active JP7208659B2 (ja) | 2016-07-29 | 2021-05-06 | インドリノン化合物の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020204766A Active JP7182304B2 (ja) | 2016-07-29 | 2020-12-10 | インドリノン化合物の使用 |
| JP2021078313A Active JP7208659B2 (ja) | 2016-07-29 | 2021-05-06 | インドリノン化合物の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10159660B2 (enExample) |
| EP (1) | EP3490553B1 (enExample) |
| JP (3) | JP6885629B2 (enExample) |
| KR (2) | KR102282794B1 (enExample) |
| CN (2) | CN109789127B (enExample) |
| CA (1) | CA3029851A1 (enExample) |
| MX (1) | MX395539B (enExample) |
| PH (1) | PH12019500070A1 (enExample) |
| SG (1) | SG11201811661TA (enExample) |
| TW (2) | TWI780061B (enExample) |
| WO (1) | WO2018022771A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX388564B (es) * | 2014-10-09 | 2025-03-20 | Oncternal Therapeutics Inc | Compuestos de indolinona y usos de los mismos. |
| JP6864379B2 (ja) | 2016-03-31 | 2021-04-28 | オンターナル セラピューティック インコーポレイテッドＯｎｃｔｅｒｎａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | インドール類似体及びその使用 |
| KR102282794B1 (ko) * | 2016-07-29 | 2021-07-27 | 온크터널 테라퓨틱스, 인코포레이티드. | 인돌리논 화합물의 용도 |
| CN110818611B (zh) * | 2018-08-13 | 2023-01-24 | 中国科学院上海药物研究所 | 一类吲哚酮类化合物、其制备方法、药物组合物和用途 |
| EP3886840A4 (en) * | 2018-11-30 | 2022-08-24 | Aptose Biosciences Inc. | Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations |
| WO2022266491A1 (en) * | 2021-06-18 | 2022-12-22 | University Of Maryland, Baltimore | Proteolysis targeting chimeras and polypharmacological agents targeting bcl-2, and methods of use thereof |
| JP2024526791A (ja) | 2021-07-16 | 2024-07-19 | セレーター ファーマシューティカルズ インコーポレイテッド | リポソーム製剤の調製方法 |
| WO2025235561A1 (en) * | 2024-05-08 | 2025-11-13 | Enspire Group LLC | Venetoclax oral drugs and uses thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU583793B2 (en) | 1983-07-22 | 1989-05-11 | Du Pont Pharmaceuticals Company | Phenylquinolinecarboxylic acids and derivatives as antitumor agents |
| WO2000033834A1 (en) | 1998-12-04 | 2000-06-15 | Neurosearch A/S | Use of isatin derivatives as ion channel activating agents |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| AU2001241798A1 (en) | 2000-02-28 | 2001-09-12 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
| CN1155572C (zh) | 2001-01-19 | 2004-06-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 吲哚类衍生物及其抗肿瘤用途 |
| US20030157486A1 (en) | 2001-06-21 | 2003-08-21 | Graff Jonathan M. | Methods to identify signal sequences |
| JP4584987B2 (ja) | 2004-04-30 | 2010-11-24 | アルニラム ファーマスーティカルズ インコーポレイテッド | Ｃ５修飾ピリミジンを含むオリゴヌクレオチド |
| AR056317A1 (es) | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| US20090217390A1 (en) | 2005-04-29 | 2009-08-27 | Fernando Lecanda Cordero | Non-human animal sarcoma model |
| WO2008046083A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of oxindole compounds as therapeutic agents |
| CA2711003C (en) | 2006-12-29 | 2017-02-21 | Georgetown University | Targeting of ews-fli1 as anti-tumor therapy |
| US8232310B2 (en) | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| JP5400032B2 (ja) | 2007-04-20 | 2014-01-29 | ザ リサーチ ファウンデーション オブ ザ ステイト ユニヴァーシティ オブ ニューヨーク | ベンズイミダゾール及びその医薬組成物 |
| US8377992B2 (en) | 2007-10-22 | 2013-02-19 | The Wistar Institute | TRBD-binding effectors and methods for using the same to modulate telomerase activity |
| EP2338056B1 (en) | 2008-10-10 | 2018-01-03 | Dana Farber Cancer Institute | Chemical modulators of pro-apoptotic bax and bcl-2 polypeptides |
| PE20120059A1 (es) | 2008-10-21 | 2012-02-27 | Onyx Therapeutics Inc | Combinaciones farmaceuticas con epoxicetonas peptidicas |
| WO2010083505A1 (en) | 2009-01-19 | 2010-07-22 | The Trustees Of The University Of Pennsylvania | Method of treating cancer using a survivin inhibitor |
| AR078161A1 (es) * | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| WO2012078519A2 (en) | 2010-12-06 | 2012-06-14 | Numerate, Inc. | 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2 |
| CN102516152B (zh) | 2011-12-12 | 2014-12-10 | 华东师范大学 | 一种α-二氟羰基取代的手性叔醇类化合物及其合成方法和应用 |
| WO2013151981A1 (en) | 2012-04-02 | 2013-10-10 | Gradalis, Inc. | Ewing's sarcoma bifunctional shrna design |
| WO2013155341A1 (en) | 2012-04-12 | 2013-10-17 | Georgetown University | Methods and compositions for treating ewings sarcoma family of tumors |
| WO2014015153A2 (en) * | 2012-07-20 | 2014-01-23 | Star Biotechnology, Llc | Compositions and methods for treating ewing's sarcoma and other disorders related to ews-fli1 |
| EP2968536B1 (en) | 2013-03-13 | 2023-06-28 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for modulating chemotherapeutic cytotoxicity |
| AU2014251028A1 (en) * | 2013-04-08 | 2015-11-05 | Janssen Pharmaceutica Nv | Ibrutinib combination therapy |
| WO2014173241A1 (en) * | 2013-04-26 | 2014-10-30 | Beigene, Ltd. | Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones |
| KR101500363B1 (ko) * | 2013-07-01 | 2015-03-16 | 현대자동차 주식회사 | 하이브리드 자동차의 동력전달장치 |
| KR20160037201A (ko) * | 2013-08-06 | 2016-04-05 | 온코에틱스 게엠베하 | Bet-브로모도메인 억제제를 사용한 미만성 거대 b-세포 림프종 (dlbcl)의 치료 방법 |
| CN103435606A (zh) | 2013-08-22 | 2013-12-11 | 中国药科大学 | CDK2与GSK3β双重抑制剂及用途 |
| CA2927148A1 (en) | 2013-10-24 | 2015-04-30 | Georgetown University | Methods and compositions for treating cancer |
| JP6508785B2 (ja) * | 2013-10-25 | 2019-05-08 | ファーマサイクリックス エルエルシー | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
| US9757385B2 (en) * | 2013-11-27 | 2017-09-12 | Merck Sharp & Dohme Corp. | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
| KR101813830B1 (ko) * | 2013-12-05 | 2017-12-29 | 에프. 호프만-라 로슈 아게 | 친전자성 작용기를 갖는 헤테로아릴 피리돈 및 아자-피리돈 화합물 |
| US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
| WO2015187848A1 (en) * | 2014-06-04 | 2015-12-10 | Sampath Deepa | Hdac inhibitor and btk inhibitor combinations |
| US20160022684A1 (en) * | 2014-07-25 | 2016-01-28 | Pharmacyclics Llc | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations |
| CN107427524A (zh) * | 2014-08-28 | 2017-12-01 | 翁科埃斯克斯有限公司 | 利用包含噻吩并三唑并二氮杂*化合物的药物组合物治疗急性髓细胞白血病或急性淋巴性白血病的方法 |
| MX388564B (es) * | 2014-10-09 | 2025-03-20 | Oncternal Therapeutics Inc | Compuestos de indolinona y usos de los mismos. |
| JP6864379B2 (ja) | 2016-03-31 | 2021-04-28 | オンターナル セラピューティック インコーポレイテッドＯｎｃｔｅｒｎａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | インドール類似体及びその使用 |
| KR102282794B1 (ko) * | 2016-07-29 | 2021-07-27 | 온크터널 테라퓨틱스, 인코포레이티드. | 인돌리논 화합물의 용도 |
| US20190255127A1 (en) | 2018-02-21 | 2019-08-22 | Batu Biologics, Inc. | Augmentation of Oncolytic Viral Efficacy through Immunological Targeting Tumor Endothelial Cells |
-
2017
- 2017-07-26 KR KR1020197005697A patent/KR102282794B1/ko active Active
- 2017-07-26 CN CN201780059006.8A patent/CN109789127B/zh active Active
- 2017-07-26 JP JP2019504916A patent/JP6885629B2/ja active Active
- 2017-07-26 CA CA3029851A patent/CA3029851A1/en active Pending
- 2017-07-26 US US15/660,566 patent/US10159660B2/en active Active
- 2017-07-26 KR KR1020217023307A patent/KR20210095721A/ko not_active Ceased
- 2017-07-26 WO PCT/US2017/043979 patent/WO2018022771A1/en not_active Ceased
- 2017-07-26 EP EP17835216.7A patent/EP3490553B1/en active Active
- 2017-07-26 SG SG11201811661TA patent/SG11201811661TA/en unknown
- 2017-07-26 MX MX2019000867A patent/MX395539B/es unknown
- 2017-07-26 CN CN202210216619.0A patent/CN114569606B/zh active Active
- 2017-07-28 TW TW106125399A patent/TWI780061B/zh active
- 2017-07-28 TW TW111135922A patent/TWI857351B/zh active
-
2018
- 2018-08-27 US US16/114,076 patent/US10646470B2/en active Active
-
2019
- 2019-01-10 PH PH12019500070A patent/PH12019500070A1/en unknown
-
2020
- 2020-04-13 US US16/847,516 patent/US11285132B2/en active Active
- 2020-12-10 JP JP2020204766A patent/JP7182304B2/ja active Active
-
2021
- 2021-05-06 JP JP2021078313A patent/JP7208659B2/ja active Active
-
2022
- 2022-03-28 US US17/705,746 patent/US12161626B2/en active Active
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