NL2013007B1 - Methods of treating TTP with immunoglobulin single variable domains and uses thereof. - Google Patents
Methods of treating TTP with immunoglobulin single variable domains and uses thereof. Download PDFInfo
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- NL2013007B1 NL2013007B1 NL2013007A NL2013007A NL2013007B1 NL 2013007 B1 NL2013007 B1 NL 2013007B1 NL 2013007 A NL2013007 A NL 2013007A NL 2013007 A NL2013007 A NL 2013007A NL 2013007 B1 NL2013007 B1 NL 2013007B1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Priority Applications (45)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2013007A NL2013007B1 (en) | 2014-06-16 | 2014-06-16 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| PL15729829T PL3154569T3 (pl) | 2014-06-16 | 2015-06-16 | Pojedyncze domeny zmienne immunoglobuliny do zastosowania w leczeniu TTP |
| PT157298290T PT3154569T (pt) | 2014-06-16 | 2015-06-16 | Domínios variáveis únicos de imunoglobulina para utilização no tratamento da ptt |
| PL18153674.9T PL3335724T3 (pl) | 2014-06-16 | 2015-06-16 | Pojedyncze domeny zmienne immunoglobuliny do zastosowania w sposobach leczenia TTP |
| RU2019131713A RU2807602C2 (ru) | 2014-06-16 | 2015-06-16 | Способы лечения ттп иммуноглобулиновыми одиночными вариабельными доменами и их применение |
| EP18153671.5A EP3366305B1 (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| CA2952103A CA2952103A1 (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| SG11201610488QA SG11201610488QA (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| PL18153676T PL3332800T3 (pl) | 2014-06-16 | 2015-06-16 | Pojedyncze domeny zmienne immunoglobuliny do stosowania w sposobach leczenia TTP |
| AU2015276237A AU2015276237B2 (en) | 2014-06-16 | 2015-06-16 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof |
| ES18153676T ES2831865T3 (es) | 2014-06-16 | 2015-06-16 | Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP |
| PT181536731T PT3335723T (pt) | 2014-06-16 | 2015-06-16 | Domínios variáveis únicos de imunoglobulina para utilização em métodos de tratamento da ptt |
| JP2016573549A JP6688746B2 (ja) | 2014-06-16 | 2015-06-16 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| EP18153673.1A EP3335723B1 (en) | 2014-06-16 | 2015-06-16 | Immunoglobulin single variable domains for use in methods of treating ttp |
| ES18153671T ES2843642T3 (es) | 2014-06-16 | 2015-06-16 | Métodos de tratamiento de TTP con dominios variables únicos de inmunoglobulina y usos de los mismos |
| CN201580040020.4A CN106559985A (zh) | 2014-06-16 | 2015-06-16 | 用免疫球蛋白单可变结构域治疗ttp的方法及其用途 |
| US15/319,467 US10858445B2 (en) | 2014-06-16 | 2015-06-16 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof |
| KR1020227012546A KR102568585B1 (ko) | 2014-06-16 | 2015-06-16 | 면역글로불린 단일 가변 도메인을 이용한 ttp의 치료 방법 및 그의 용도 |
| EP22172948.6A EP4059513A1 (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| PT181536715T PT3366305T (pt) | 2014-06-16 | 2015-06-16 | Métodos de tratamento de ttp com domínios variáveis únicos de imunoglobulina e seus usos |
| SG10201811109PA SG10201811109PA (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| RU2017100077A RU2704444C2 (ru) | 2014-06-16 | 2015-06-16 | Способы лечения ттп иммуноглобулиновыми одиночными вариабельными доменами и их применение |
| ES15729829T ES2881331T3 (es) | 2014-06-16 | 2015-06-16 | Dominios variables únicos de inmunoglobulina para su uso en el tratamiento de TTP |
| PT181536764T PT3332800T (pt) | 2014-06-16 | 2015-06-16 | Domínios variáveis únicos de imunoglobulina para utilização em métodos de tratamento da ptt |
| PCT/EP2015/063493 WO2015193326A1 (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| EP18153676.4A EP3332800B1 (en) | 2014-06-16 | 2015-06-16 | Immunoglobulin single variable domains for use in methods of treating ttp |
| EP18153674.9A EP3335724B1 (en) | 2014-06-16 | 2015-06-16 | Immunoglobulin single variable domains for use in methods of treating ttp |
| PT181536749T PT3335724T (pt) | 2014-06-16 | 2015-06-16 | Domínios variáveis únicos de imunoglobulina para utilização no tratamento da ptt |
| PL18153671T PL3366305T3 (pl) | 2014-06-16 | 2015-06-16 | Sposoby leczenia ttp za pomocą pojedyńczych immunoglobulinowych domen zmiennych i ich zastosowania |
| EP15729829.0A EP3154569B1 (en) | 2014-06-16 | 2015-06-16 | Immunoglobulin single variable domains for use in treating ttp |
| ES18153673T ES2915473T3 (es) | 2014-06-16 | 2015-06-16 | Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP |
| KR1020177001152A KR102403388B1 (ko) | 2014-06-16 | 2015-06-16 | 면역글로불린 단일 가변 도메인을 이용한 ttp의 치료 방법 및 그의 용도 |
| ES18153674T ES2924199T3 (es) | 2014-06-16 | 2015-06-16 | Dominios variables individuales de inmunoglobulina para el uso en métodos para tratar TTP |
| PL18153673.1T PL3335723T3 (pl) | 2014-06-16 | 2015-06-16 | Pojedyncze domeny zmienne immunoglobuliny do zastosowania w sposobach leczenia TTP |
| IL249540A IL249540B (en) | 2014-06-16 | 2016-12-13 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| US15/881,055 US20180155443A1 (en) | 2014-06-16 | 2018-01-26 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| US15/881,003 US10919980B2 (en) | 2014-06-16 | 2018-01-26 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof |
| US15/880,978 US12269893B2 (en) | 2014-06-16 | 2018-01-26 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof |
| US15/880,870 US20180155440A1 (en) | 2014-06-16 | 2018-01-26 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| HK18115787.5A HK1256730B (en) | 2014-06-16 | 2018-12-10 | Immunoglobulin single variable domains for use in methods of treating ttp |
| HK18115789.3A HK1256731B (en) | 2014-06-16 | 2018-12-10 | Immunoglobulin single variable domains for use in methods of treating ttp |
| HK19100857.1A HK1258508B (en) | 2014-06-16 | 2019-01-17 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
| JP2020014229A JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| AU2021202747A AU2021202747B2 (en) | 2014-06-16 | 2021-05-03 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof |
| JP2022110921A JP2022160431A (ja) | 2014-06-16 | 2022-07-11 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Applications Claiming Priority (1)
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|---|---|---|---|
| NL2013007A NL2013007B1 (en) | 2014-06-16 | 2014-06-16 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
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| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CN107340225B (zh) * | 2017-07-13 | 2019-07-05 | 徐州医科大学 | 一种基于流式细胞术检测血小板受体GPIba胞外段酶切的方法 |
| CN111670202A (zh) | 2018-02-06 | 2020-09-15 | 埃博灵克斯股份有限公司 | 以免疫球蛋白单可变结构域治疗ttp初次发作的方法 |
| CA3201986A1 (en) * | 2020-11-18 | 2022-05-27 | Green Cross Corporation | Adamts13 variant having increased escaping rate or activity against autoantibody |
| US20240401239A1 (en) | 2021-09-17 | 2024-12-05 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies |
| WO2023108095A1 (en) * | 2021-12-10 | 2023-06-15 | Emory University | Polypeptides that bind to von willebrand factor (vwf) al domain or an autoinhibitory module, variants, and uses thereof |
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| WO2006122825A2 (en) * | 2005-05-20 | 2006-11-23 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
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| GB335768A (en) | 1929-10-24 | 1930-10-02 | Jacoviac Maurice | Improvements in protecting devices for gramophone disc records |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5043429B1 (en) | 1987-05-01 | 1997-10-14 | Scripps Research Inst | Protein fragments containing factor VIII binding domain of von willebrand factor |
| DE68913658T3 (de) | 1988-11-11 | 2005-07-21 | Stratagene, La Jolla | Klonierung von Immunglobulin Sequenzen aus den variablen Domänen |
| DE69330523T4 (de) | 1992-08-21 | 2012-08-23 | Vrije Universiteit Brussel | Immunoglobuline ohne leichte ketten |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| JP2002535993A (ja) | 1999-02-05 | 2002-10-29 | リイクスニフェルシタイト ライデン | 組換え体細胞における代謝物の生合成を変調する方法 |
| IL147920A0 (en) | 1999-08-02 | 2002-08-14 | Keygene Nv | Method for generating cgmmv resistant plants, genetic constructs, and the obtained cgmmv-resistant plants |
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| WO2004037999A2 (en) | 2002-10-23 | 2004-05-06 | Ludwig Institute For Cancer Research | A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same |
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| ATE473446T1 (de) | 2005-01-14 | 2010-07-15 | Ablynx Nv | Verfahren und testvorrichtungen zur unterscheidung verschiedener formen von krankheiten und leiden, die durch thrombocytopenia und/oder durch spontane interaktionen zwischen dem von-willebrand-faktor und plättchen gekennzeichnet sind |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
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| CN101977654A (zh) | 2008-03-21 | 2011-02-16 | 埃博灵克斯股份有限公司 | 冯威勒布兰特因子特异性结合物及其应用方法 |
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| KR20110079693A (ko) | 2008-10-29 | 2011-07-07 | 와이어쓰 엘엘씨 | 단일 도메인 항원 결합 분자의 정제 방법 |
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| SI3757126T1 (sl) * | 2010-11-05 | 2025-12-31 | Novartis Ag | Postopki za zdravljenje psoriatičnega artritisa z antagonisti il-17 |
| DK3412305T3 (da) | 2011-06-10 | 2021-03-01 | Baxalta GmbH | Behandling af koagulationssygdom ved administration af rekombinant vwf |
| EA027160B1 (ru) | 2011-08-17 | 2017-06-30 | Глаксо Груп Лимитед | Модифицированные белки и пептиды |
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CN111670202A (zh) | 2018-02-06 | 2020-09-15 | 埃博灵克斯股份有限公司 | 以免疫球蛋白单可变结构域治疗ttp初次发作的方法 |
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2014
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2015
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| WO2006122825A2 (en) * | 2005-05-20 | 2006-11-23 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
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