JP2015524816A - サラセミアを処置するためのトランスフェリンレセプターアンタゴニストの使用 - Google Patents

サラセミアを処置するためのトランスフェリンレセプターアンタゴニストの使用 Download PDF

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Publication number
JP2015524816A
JP2015524816A JP2015524798A JP2015524798A JP2015524816A JP 2015524816 A JP2015524816 A JP 2015524816A JP 2015524798 A JP2015524798 A JP 2015524798A JP 2015524798 A JP2015524798 A JP 2015524798A JP 2015524816 A JP2015524816 A JP 2015524816A
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JP
Japan
Prior art keywords
tfr1
antibody
thalassemia
antagonist
transferrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2015524798A
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English (en)
Japanese (ja)
Other versions
JP2015524816A5 (enExample
Inventor
クルス−モウラ，イヴァン
エルミーヌ，オリヴィエ
デュシオ，ミッシェル
プベル，エティエンヌ
トロヴァティ，マシェル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Assistance Publique - Hôpitaux de Paris
Université Paris Descartes
Université Paris Diderot - Paris 7
Université Paris-Sud
Fondation Imagine
Original Assignee
Centre National de la Recherche Scientifique
Assistance Publique - Hôpitaux de Paris
Université Paris Descartes
Université Paris Diderot - Paris 7
Université Paris-Sud
Fondation Imagine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique, Assistance Publique - Hôpitaux de Paris, Université Paris Descartes, Université Paris Diderot - Paris 7, Université Paris-Sud, Fondation Imagine filed Critical Centre National de la Recherche Scientifique
Publication of JP2015524816A publication Critical patent/JP2015524816A/ja
Publication of JP2015524816A5 publication Critical patent/JP2015524816A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015524798A 2012-08-02 2013-08-02 サラセミアを処置するためのトランスフェリンレセプターアンタゴニストの使用 Withdrawn JP2015524816A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305955 2012-08-02
EP12305955.2 2012-08-02
PCT/EP2013/066253 WO2014020140A1 (en) 2012-08-02 2013-08-02 Use of transferrin receptor antagonist for the treatment of thalassemia

Publications (2)

Publication Number Publication Date
JP2015524816A true JP2015524816A (ja) 2015-08-27
JP2015524816A5 JP2015524816A5 (enExample) 2016-09-23

Family

ID=48979730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015524798A Withdrawn JP2015524816A (ja) 2012-08-02 2013-08-02 サラセミアを処置するためのトランスフェリンレセプターアンタゴニストの使用

Country Status (4)

Country Link
US (1) US20150197574A1 (enExample)
EP (1) EP2880059A1 (enExample)
JP (1) JP2015524816A (enExample)
WO (1) WO2014020140A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020105621A1 (ja) * 2018-11-20 2020-05-28 株式会社ペルセウスプロテオミクス 細胞内への鉄の取り込み阻害剤

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6760964B2 (ja) * 2015-01-21 2020-09-23 コーネル ユニバーシティ 異常ヘモグロビン症の予防及び治療のためのウイルスベクター
TWI787796B (zh) 2015-05-04 2022-12-21 美商Ｃｙｔｏｍｘ生物製藥公司 抗ｃｄ７１抗體類、可活化之抗ｃｄ７１抗體類及使用彼等之方法
IL257065B (en) * 2015-07-22 2022-07-01 Inatherys Antibodies to tfr for use in the treatment of proliferative and inflammatory diseases
JP2020511130A (ja) 2017-03-09 2020-04-16 サイトメックス セラピューティクス インコーポレイテッド Ｃｄ１４７抗体、活性化可能ｃｄ１４７抗体、ならびにその作製および使用の方法
WO2018185341A1 (en) 2017-04-07 2018-10-11 Ospedale San Raffaele S.R.L. Regulator of bmp-smad signaling and uses thereof
WO2019173771A1 (en) 2018-03-09 2019-09-12 Cytomx Therapeutics, Inc. Activatable cd147 antibodies and methods of making and use thereof
EP4034171A1 (en) 2019-09-23 2022-08-03 Cytomx Therapeutics Inc. Anti-cd47 antibodies, activatable anti-cd47 antibodies, and methods of use thereof
US20230159652A1 (en) * 2020-03-23 2023-05-25 The Regents Of The University Of California Transferrin receptor 1 targeting for carcinogenesis prevention
WO2022165045A1 (en) * 2021-01-28 2022-08-04 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Reactivation of embryonic and fetal hemoglobin
US11939391B2 (en) * 2021-12-06 2024-03-26 MedAbome, Inc. Anti-TfR1 antibody MAb11-22.1 conjugates for cancer treatment
KR20260044219A (ko) * 2023-07-21 2026-04-01 매로우 테라퓨틱스, 인크. 조혈 세포 표적화 접합체 및 관련 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JP2003517847A (ja) * 1999-12-23 2003-06-03 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド トランスフェリンポリヌクレオチド、ポリペプチド、および抗体
US8129504B2 (en) * 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
EP1740616B1 (en) 2004-04-30 2011-12-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-tfr antibody.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020105621A1 (ja) * 2018-11-20 2020-05-28 株式会社ペルセウスプロテオミクス 細胞内への鉄の取り込み阻害剤
JPWO2020105621A1 (ja) * 2018-11-20 2021-10-07 株式会社ペルセウスプロテオミクス 細胞内への鉄の取り込み阻害剤
JP7410051B2 (ja) 2018-11-20 2024-01-09 株式会社ペルセウスプロテオミクス 細胞内への鉄の取り込み阻害剤

Also Published As

Publication number Publication date
US20150197574A1 (en) 2015-07-16
EP2880059A1 (en) 2015-06-10
WO2014020140A1 (en) 2014-02-06

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