JP2017527559A5 - - Google Patents
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- Publication number
- JP2017527559A5 JP2017527559A5 JP2017511927A JP2017511927A JP2017527559A5 JP 2017527559 A5 JP2017527559 A5 JP 2017527559A5 JP 2017511927 A JP2017511927 A JP 2017511927A JP 2017511927 A JP2017511927 A JP 2017511927A JP 2017527559 A5 JP2017527559 A5 JP 2017527559A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- isoindol
- pyridin
- imaging agent
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043644P | 2014-08-29 | 2014-08-29 | |
| US62/043,644 | 2014-08-29 | ||
| PCT/US2015/047396 WO2016033436A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016705A Division JP6843282B2 (ja) | 2014-08-29 | 2020-02-04 | ハンチントンタンパク質のイメージング用プローブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527559A JP2017527559A (ja) | 2017-09-21 |
| JP2017527559A5 true JP2017527559A5 (enExample) | 2018-10-04 |
Family
ID=55400644
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511927A Ceased JP2017527559A (ja) | 2014-08-29 | 2015-08-28 | ハンチントンタンパク質のイメージング用プローブ |
| JP2020016705A Active JP6843282B2 (ja) | 2014-08-29 | 2020-02-04 | ハンチントンタンパク質のイメージング用プローブ |
| JP2021026146A Active JP7042940B2 (ja) | 2014-08-29 | 2021-02-22 | ハンチントンタンパク質のイメージング用プローブ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016705A Active JP6843282B2 (ja) | 2014-08-29 | 2020-02-04 | ハンチントンタンパク質のイメージング用プローブ |
| JP2021026146A Active JP7042940B2 (ja) | 2014-08-29 | 2021-02-22 | ハンチントンタンパク質のイメージング用プローブ |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11071793B2 (enExample) |
| EP (1) | EP3186241B1 (enExample) |
| JP (3) | JP2017527559A (enExample) |
| KR (1) | KR102410760B1 (enExample) |
| CN (2) | CN118005611A (enExample) |
| AU (1) | AU2015308765B2 (enExample) |
| BR (1) | BR112017004136B1 (enExample) |
| CA (1) | CA2959531C (enExample) |
| DK (1) | DK3186241T3 (enExample) |
| EA (1) | EA037275B1 (enExample) |
| ES (1) | ES2841746T3 (enExample) |
| HR (1) | HRP20202032T1 (enExample) |
| HU (1) | HUE052892T2 (enExample) |
| IL (1) | IL250805B (enExample) |
| MX (2) | MX383202B (enExample) |
| PL (1) | PL3186241T3 (enExample) |
| PT (1) | PT3186241T (enExample) |
| SG (1) | SG11201701578YA (enExample) |
| SI (1) | SI3186241T1 (enExample) |
| WO (1) | WO2016033436A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| KR102586736B1 (ko) | 2014-08-29 | 2023-10-11 | 씨에이치디아이 파운데이션, 인코포레이티드 | 헌팅틴을 단백질 영상화하기 위한 프로브 |
| CA2959505A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| US11071793B2 (en) | 2014-08-29 | 2021-07-27 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| EP3340796B1 (en) | 2015-08-28 | 2021-04-21 | CHDI Foundation, Inc. | Probes for imaging huntingtin protein |
| EP3509588B1 (en) | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclic compounds useful as gpr120 modulators |
| KR102537985B1 (ko) | 2016-09-12 | 2023-05-30 | 인테그랄 헬스 인코퍼레이티드 | Gpr120 조정제로서 유용한 단환형 화합물 |
| WO2020176424A1 (en) | 2019-02-25 | 2020-09-03 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| US11992535B2 (en) | 2019-12-18 | 2024-05-28 | Chdi Foundation, Inc. | Compounds and probes for imaging huntingtin protein |
| CN116075512A (zh) * | 2020-06-11 | 2023-05-05 | Chdi基金会股份有限公司 | 用于对亨廷顿蛋白成像的杂环化合物和显像剂 |
| WO2022216947A1 (en) * | 2021-04-08 | 2022-10-13 | Chdi Foundation, Inc. | Isoindolinone compounds and imaging agents for imaging huntingtin protein |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726197A (en) * | 1992-11-02 | 1998-03-10 | Syntex (U.S.A.) Inc. | Isoindolinyl derivatives |
| YU86801A (sh) | 1999-06-10 | 2004-07-15 | Warner-Lambert Company | Izoindol derivati korisni u inhibiciji agregacije amiloidnih proteina i snimanju amiloidnih naslaga |
| PL371366A1 (en) * | 2002-03-01 | 2005-06-13 | Takeda Pharmaceutical Company Limited | Antidepressant |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
| EP2573080A1 (en) * | 2007-09-27 | 2013-03-27 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| WO2009072581A1 (ja) * | 2007-12-05 | 2009-06-11 | Aska Pharmaceutical Co., Ltd. | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| WO2010104324A2 (ko) * | 2009-03-10 | 2010-09-16 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도 |
| MX360323B (es) | 2012-04-25 | 2018-10-29 | Raqualia Pharma Inc | Derivados de pirrolopiridinona como bloqueadores de ttx-s. |
| CN104903312B (zh) * | 2013-10-07 | 2019-01-29 | 卡德门企业有限公司 | Rho激酶抑制剂 |
| US11071793B2 (en) | 2014-08-29 | 2021-07-27 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CA2959505A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| KR102586736B1 (ko) | 2014-08-29 | 2023-10-11 | 씨에이치디아이 파운데이션, 인코포레이티드 | 헌팅틴을 단백질 영상화하기 위한 프로브 |
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| EP3340796B1 (en) | 2015-08-28 | 2021-04-21 | CHDI Foundation, Inc. | Probes for imaging huntingtin protein |
-
2015
- 2015-08-28 US US15/507,214 patent/US11071793B2/en active Active
- 2015-08-28 CN CN202311625463.2A patent/CN118005611A/zh active Pending
- 2015-08-28 EA EA201790432A patent/EA037275B1/ru unknown
- 2015-08-28 WO PCT/US2015/047396 patent/WO2016033436A1/en not_active Ceased
- 2015-08-28 MX MX2017002704A patent/MX383202B/es unknown
- 2015-08-28 JP JP2017511927A patent/JP2017527559A/ja not_active Ceased
- 2015-08-28 DK DK15836970.2T patent/DK3186241T3/da active
- 2015-08-28 ES ES15836970T patent/ES2841746T3/es active Active
- 2015-08-28 CA CA2959531A patent/CA2959531C/en active Active
- 2015-08-28 HU HUE15836970A patent/HUE052892T2/hu unknown
- 2015-08-28 BR BR112017004136-7A patent/BR112017004136B1/pt active IP Right Grant
- 2015-08-28 EP EP15836970.2A patent/EP3186241B1/en active Active
- 2015-08-28 KR KR1020177008418A patent/KR102410760B1/ko active Active
- 2015-08-28 PT PT158369702T patent/PT3186241T/pt unknown
- 2015-08-28 HR HRP20202032TT patent/HRP20202032T1/hr unknown
- 2015-08-28 SG SG11201701578YA patent/SG11201701578YA/en unknown
- 2015-08-28 SI SI201531461T patent/SI3186241T1/sl unknown
- 2015-08-28 PL PL15836970T patent/PL3186241T3/pl unknown
- 2015-08-28 AU AU2015308765A patent/AU2015308765B2/en active Active
- 2015-08-28 CN CN201580058254.1A patent/CN107074817B/zh active Active
-
2017
- 2017-02-27 IL IL250805A patent/IL250805B/en active IP Right Grant
- 2017-02-28 MX MX2021005891A patent/MX2021005891A/es unknown
-
2020
- 2020-02-04 JP JP2020016705A patent/JP6843282B2/ja active Active
-
2021
- 2021-02-22 JP JP2021026146A patent/JP7042940B2/ja active Active
- 2021-06-21 US US17/353,611 patent/US12036291B2/en active Active
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