SG11201701580XA - Probes for imaging huntingtin protein - Google Patents

Probes for imaging huntingtin protein

Info

Publication number
SG11201701580XA
SG11201701580XA SG11201701580XA SG11201701580XA SG11201701580XA SG 11201701580X A SG11201701580X A SG 11201701580XA SG 11201701580X A SG11201701580X A SG 11201701580XA SG 11201701580X A SG11201701580X A SG 11201701580XA SG 11201701580X A SG11201701580X A SG 11201701580XA
Authority
SG
Singapore
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Application number
SG11201701580XA
Inventor
Celia Dominguez
John Wityak
Jonathan Bard
Christopher John Brown
Michael Edward Prime
Derek Alexander Weddell
Daryl Simon Walter
Paul Richard Giles
Ian James Wigginton
Malcolm George Taylor
Sébastien René Gabriel Galan
Peter David Johnson
Thomas Martin Krülle
Inaki Morao
Daniel Clark-Frew
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of SG11201701580XA publication Critical patent/SG11201701580XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/0412Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
SG11201701580XA 2014-08-29 2015-08-28 Probes for imaging huntingtin protein SG11201701580XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043617P 2014-08-29 2014-08-29
PCT/US2015/047427 WO2016033460A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (1)

Publication Number Publication Date
SG11201701580XA true SG11201701580XA (en) 2017-03-30

Family

ID=55400659

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201701580XA SG11201701580XA (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Country Status (14)

Country Link
US (1) US10907197B2 (en)
EP (1) EP3190888B1 (en)
JP (1) JP2017528520A (en)
KR (1) KR20170047341A (en)
CN (1) CN107105655A (en)
AU (2) AU2015308709B2 (en)
BR (1) BR112017004134A2 (en)
CA (1) CA2959505A1 (en)
EA (1) EA201790408A1 (en)
ES (1) ES2818107T3 (en)
IL (1) IL250804A0 (en)
MX (1) MX2017002705A (en)
SG (1) SG11201701580XA (en)
WO (1) WO2016033460A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2959531C (en) 2014-08-29 2023-01-10 Chdi Foundation, Inc. Probes for imaging huntingtin protein
PL3186233T3 (en) 2014-08-29 2022-02-28 Chdi Foundation, Inc. Probes for imaging huntingtin protein
PL3197277T3 (en) 2014-08-29 2022-04-04 Chdi Foundation, Inc. Probes for imaging huntingtin protein
MX2018002338A (en) 2015-08-28 2018-07-06 Chdi Foundation Inc Probes for imaging huntingtin protein.
CN106632002A (en) * 2016-09-28 2017-05-10 贵州大学 Preparation technology of etoricoxib and reference substance 5-chloro-3-(4-(methyl sulphonyl)phenyl)-2,3-bipyridine of etoricoxib
GB201617339D0 (en) 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
CN108178764A (en) * 2018-01-09 2018-06-19 天津科技大学 Furans simultaneously [2,3-b] pyridine compounds and their and the synthetic method without metal catalytic
WO2020176424A1 (en) 2019-02-25 2020-09-03 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof

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FR2524468B1 (en) * 1982-04-06 1985-10-18 Sandoz Sa NOVEL CONDENSED THIOPHENE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS OPTICAL BRIGHTENERS
JPS60146877A (en) * 1984-01-11 1985-08-02 Chisso Corp 2-substituted-6-(5-substituted-2-pyrimidinyl)naphthalene
JPH11171886A (en) * 1997-12-08 1999-06-29 Mitsui Chem Inc Pyprolylbenzimidazole derivative having amidine or guanidine in side chain
CN1309385C (en) * 2001-12-20 2007-04-11 惠氏公司 Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
CA2438032C (en) 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
PL1611115T3 (en) * 2003-03-14 2013-01-31 Univ Pittsburgh Commonwealth Sys Higher Education Benzothiazole derivative compounds, compositions and uses
WO2005040337A2 (en) 2003-05-20 2005-05-06 The Regents Of The University Of California METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES
AU2003304416A1 (en) * 2003-08-13 2005-03-07 Bf Research Institute, Inc. Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change
AU2007288124B2 (en) 2006-08-24 2013-04-04 Australian Nuclear Science & Technology Organisation Fluorinated ligands for targeting peripheral benzodiazepine receptors
WO2008134618A2 (en) 2007-04-27 2008-11-06 The General Hospital Corporation Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders
KR101469275B1 (en) 2007-06-01 2014-12-08 재단법인서울대학교산학협력재단 Heterocyclic indene derivatives and their radioisotope labeled compounds for imaging β-amyloid deposition
US20090123373A1 (en) 2007-11-05 2009-05-14 Yanming Wang Amyloid-imaging agents
US8153813B2 (en) 2007-12-20 2012-04-10 Abbott Laboratories Benzothiazole and benzooxazole derivatives and methods of use
WO2009146388A1 (en) * 2008-05-28 2009-12-03 The Trustees Of Columbia University In The City Of New York Voxel-based methods for assessing subjects using positron emission tomography
WO2009155017A2 (en) * 2008-05-30 2009-12-23 Merck & Co., Inc. Novel substituted azabenzoxazoles
AU2009309027A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
ES2548571T3 (en) * 2009-04-02 2015-10-19 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Imidazo derivatives [2,1-b] [1,3,4] thiadiazole
GB0905664D0 (en) 2009-04-02 2009-05-13 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
ES2620177T3 (en) * 2009-10-15 2017-06-27 Guerbet Imaging agents and their use for in vivo diagnosis of neurodegenerative diseases, particularly Alzheimer's disease and derived diseases
JP2011168515A (en) 2010-02-17 2011-09-01 Kowa Co 2-arylbenzoxazole compound having erythropoietin production-promoting action
PL3197277T3 (en) 2014-08-29 2022-04-04 Chdi Foundation, Inc. Probes for imaging huntingtin protein
PL3186233T3 (en) 2014-08-29 2022-02-28 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CA2959531C (en) 2014-08-29 2023-01-10 Chdi Foundation, Inc. Probes for imaging huntingtin protein
MX2018002338A (en) 2015-08-28 2018-07-06 Chdi Foundation Inc Probes for imaging huntingtin protein.

Also Published As

Publication number Publication date
EP3190888A1 (en) 2017-07-19
AU2020202226A1 (en) 2020-04-16
CA2959505A1 (en) 2016-03-03
KR20170047341A (en) 2017-05-04
US10907197B2 (en) 2021-02-02
AU2015308709A1 (en) 2017-03-23
IL250804A0 (en) 2017-04-30
MX2017002705A (en) 2017-12-20
CN107105655A (en) 2017-08-29
BR112017004134A2 (en) 2017-12-12
JP2017528520A (en) 2017-09-28
EP3190888A4 (en) 2018-05-09
EP3190888B1 (en) 2020-06-10
ES2818107T3 (en) 2021-04-09
US20170292150A1 (en) 2017-10-12
AU2015308709B2 (en) 2020-01-02
WO2016033460A1 (en) 2016-03-03
EA201790408A1 (en) 2017-09-29

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