MX383202B - Sondas para la proyección de imagen de la proteína huntingtina. - Google Patents
Sondas para la proyección de imagen de la proteína huntingtina.Info
- Publication number
- MX383202B MX383202B MX2017002704A MX2017002704A MX383202B MX 383202 B MX383202 B MX 383202B MX 2017002704 A MX2017002704 A MX 2017002704A MX 2017002704 A MX2017002704 A MX 2017002704A MX 383202 B MX383202 B MX 383202B
- Authority
- MX
- Mexico
- Prior art keywords
- imaging
- probes
- huntingtin protein
- huntingtin
- protein
- Prior art date
Links
- 102000016252 Huntingtin Human genes 0.000 title 1
- 108050004784 Huntingtin Proteins 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 239000000523 sample Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043644P | 2014-08-29 | 2014-08-29 | |
| PCT/US2015/047396 WO2016033436A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017002704A MX2017002704A (es) | 2017-10-23 |
| MX383202B true MX383202B (es) | 2025-03-13 |
Family
ID=55400644
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017002704A MX383202B (es) | 2014-08-29 | 2015-08-28 | Sondas para la proyección de imagen de la proteína huntingtina. |
| MX2021005891A MX2021005891A (es) | 2014-08-29 | 2017-02-28 | Sondas para la proyeccion de imagen de la proteina huntingtina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021005891A MX2021005891A (es) | 2014-08-29 | 2017-02-28 | Sondas para la proyeccion de imagen de la proteina huntingtina. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11071793B2 (enExample) |
| EP (1) | EP3186241B1 (enExample) |
| JP (3) | JP2017527559A (enExample) |
| KR (1) | KR102410760B1 (enExample) |
| CN (2) | CN107074817B (enExample) |
| AU (1) | AU2015308765B2 (enExample) |
| BR (1) | BR112017004136B1 (enExample) |
| CA (1) | CA2959531C (enExample) |
| DK (1) | DK3186241T3 (enExample) |
| EA (1) | EA037275B1 (enExample) |
| ES (1) | ES2841746T3 (enExample) |
| HR (1) | HRP20202032T1 (enExample) |
| HU (1) | HUE052892T2 (enExample) |
| IL (1) | IL250805B (enExample) |
| MX (2) | MX383202B (enExample) |
| PL (1) | PL3186241T3 (enExample) |
| PT (1) | PT3186241T (enExample) |
| SG (1) | SG11201701578YA (enExample) |
| SI (1) | SI3186241T1 (enExample) |
| WO (1) | WO2016033436A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3197277T3 (da) | 2014-08-29 | 2022-01-31 | Chdi Foundation Inc | Prober til billeddannelse af huntingtin-protein |
| KR102456946B1 (ko) | 2014-08-29 | 2022-10-21 | 씨에이치디아이 파운데이션, 인코포레이티드 | 헌팅틴을 단백질 영상화하기 위한 프로브 |
| CN107074817B (zh) | 2014-08-29 | 2023-12-15 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| SG11201701580XA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
| CN110225752B (zh) | 2016-09-12 | 2023-05-05 | 整体健康 | 用作gpr120调节器的单环化合物 |
| CA3041038A1 (en) | 2016-09-12 | 2018-03-15 | Numerate, Inc. | Bicyclic compounds useful as gpr120 modulators |
| US11389438B2 (en) | 2019-02-25 | 2022-07-19 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| ES3029867T3 (en) * | 2019-12-18 | 2025-06-25 | Chdi Foundation Inc | Compounds and probes for imaging huntingtin protein |
| CN116075512A (zh) * | 2020-06-11 | 2023-05-05 | Chdi基金会股份有限公司 | 用于对亨廷顿蛋白成像的杂环化合物和显像剂 |
| CA3214756A1 (en) * | 2021-04-08 | 2022-10-13 | Longbin Liu | Isoindolinone compounds and imaging agents for imaging huntingtin protein |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726197A (en) * | 1992-11-02 | 1998-03-10 | Syntex (U.S.A.) Inc. | Isoindolinyl derivatives |
| CN1156445C (zh) * | 1999-06-10 | 2004-07-07 | 沃尼尔·朗伯公司 | 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法 |
| WO2003074046A1 (en) * | 2002-03-01 | 2003-09-12 | Takeda Chemical Industries, Ltd. | Antidepressant |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
| CA2700841A1 (en) * | 2007-09-27 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| JP5632612B2 (ja) * | 2007-12-05 | 2014-11-26 | あすか製薬株式会社 | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| WO2010104324A2 (ko) * | 2009-03-10 | 2010-09-16 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도 |
| KR102090944B1 (ko) * | 2012-04-25 | 2020-03-19 | 라퀄리아 파마 인코포레이티드 | Ttx-s 차단제로서의 피롤로피리디논 유도체 |
| EP3055301B1 (en) * | 2013-10-07 | 2019-11-20 | Kadmon Corporation, LLC | (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases |
| CN107074817B (zh) | 2014-08-29 | 2023-12-15 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| SG11201701580XA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| KR102456946B1 (ko) | 2014-08-29 | 2022-10-21 | 씨에이치디아이 파운데이션, 인코포레이티드 | 헌팅틴을 단백질 영상화하기 위한 프로브 |
| DK3197277T3 (da) | 2014-08-29 | 2022-01-31 | Chdi Foundation Inc | Prober til billeddannelse af huntingtin-protein |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
-
2015
- 2015-08-28 CN CN201580058254.1A patent/CN107074817B/zh active Active
- 2015-08-28 EA EA201790432A patent/EA037275B1/ru unknown
- 2015-08-28 CA CA2959531A patent/CA2959531C/en active Active
- 2015-08-28 JP JP2017511927A patent/JP2017527559A/ja not_active Ceased
- 2015-08-28 CN CN202311625463.2A patent/CN118005611A/zh active Pending
- 2015-08-28 HU HUE15836970A patent/HUE052892T2/hu unknown
- 2015-08-28 EP EP15836970.2A patent/EP3186241B1/en active Active
- 2015-08-28 BR BR112017004136-7A patent/BR112017004136B1/pt active IP Right Grant
- 2015-08-28 ES ES15836970T patent/ES2841746T3/es active Active
- 2015-08-28 US US15/507,214 patent/US11071793B2/en active Active
- 2015-08-28 AU AU2015308765A patent/AU2015308765B2/en active Active
- 2015-08-28 DK DK15836970.2T patent/DK3186241T3/da active
- 2015-08-28 WO PCT/US2015/047396 patent/WO2016033436A1/en not_active Ceased
- 2015-08-28 PL PL15836970T patent/PL3186241T3/pl unknown
- 2015-08-28 KR KR1020177008418A patent/KR102410760B1/ko active Active
- 2015-08-28 SG SG11201701578YA patent/SG11201701578YA/en unknown
- 2015-08-28 HR HRP20202032TT patent/HRP20202032T1/hr unknown
- 2015-08-28 MX MX2017002704A patent/MX383202B/es unknown
- 2015-08-28 SI SI201531461T patent/SI3186241T1/sl unknown
- 2015-08-28 PT PT158369702T patent/PT3186241T/pt unknown
-
2017
- 2017-02-27 IL IL250805A patent/IL250805B/en active IP Right Grant
- 2017-02-28 MX MX2021005891A patent/MX2021005891A/es unknown
-
2020
- 2020-02-04 JP JP2020016705A patent/JP6843282B2/ja active Active
-
2021
- 2021-02-22 JP JP2021026146A patent/JP7042940B2/ja active Active
- 2021-06-21 US US17/353,611 patent/US12036291B2/en active Active
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