JP2009541311A5 - - Google Patents
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- JP2009541311A5 JP2009541311A5 JP2009516446A JP2009516446A JP2009541311A5 JP 2009541311 A5 JP2009541311 A5 JP 2009541311A5 JP 2009516446 A JP2009516446 A JP 2009516446A JP 2009516446 A JP2009516446 A JP 2009516446A JP 2009541311 A5 JP2009541311 A5 JP 2009541311A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- isoindol
- phenyl
- amine
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 111
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 30
- 125000002877 alkyl aryl group Chemical group 0.000 claims 29
- 125000003118 aryl group Chemical group 0.000 claims 23
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 12
- -1 alkenyl R 6 Chemical compound 0.000 claims 11
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 7
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 6
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 6
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 230000003902 lesion Effects 0.000 claims 4
- LAQKOENYJDDTDY-UHFFFAOYSA-N 4-[3-amino-1-(4-hydroxyphenyl)isoindol-1-yl]phenol Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 LAQKOENYJDDTDY-UHFFFAOYSA-N 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- RXPHIWHATFBINA-UHFFFAOYSA-N 2-[3-amino-1-(4-hydroxyphenyl)isoindol-1-yl]phenol Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C(=CC=CC=1)O)C1=CC=C(O)C=C1 RXPHIWHATFBINA-UHFFFAOYSA-N 0.000 claims 2
- GTKIGDZXPDCIKR-UHFFFAOYSA-N 2-phenylbenzamide Chemical compound NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GTKIGDZXPDCIKR-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- KTVJPEWAPJPEOK-UHFFFAOYSA-N [3-[3-amino-1-(4-fluoro-3-pyrimidin-5-ylphenyl)isoindol-1-yl]phenyl] trifluoromethanesulfonate Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C(F)=CC=1)C=1C=NC=NC=1)C1=CC=CC(OS(=O)(=O)C(F)(F)F)=C1 KTVJPEWAPJPEOK-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 1
- RSWYTHKZAKEODI-UHFFFAOYSA-N 3,3-dimethylisoindol-1-amine Chemical compound C1=CC=C2C(C)(C)N=C(N)C2=C1 RSWYTHKZAKEODI-UHFFFAOYSA-N 0.000 claims 1
- FYQHSDGQCJETLW-UHFFFAOYSA-N 3,3-diphenylisoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=CC=CC=1)C1=CC=CC=C1 FYQHSDGQCJETLW-UHFFFAOYSA-N 0.000 claims 1
- YFRVXHOJYFHAOP-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C2OCOC2=CC=1)C1=CC=CC(Br)=C1 YFRVXHOJYFHAOP-UHFFFAOYSA-N 0.000 claims 1
- YSHQEJDYWRDFNV-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C12=CC=CC=C2C(N)=NC1(C=1C=C2OCOC2=CC=1)C(C=1)=CC=CC=1C1=CN=CN=C1 YSHQEJDYWRDFNV-UHFFFAOYSA-N 0.000 claims 1
- PQRUSXIAEQXMOU-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C12=CC=CC=C2C(N)=NC1(C=1C=C2OCOC2=CC=1)C(C=1)=CC=CC=1C1=CC=CN=C1F PQRUSXIAEQXMOU-UHFFFAOYSA-N 0.000 claims 1
- HRNPAIOJTACERQ-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-3-[3-(3-methoxyphenyl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CC=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=C3OCOC3=CC=2)=C1 HRNPAIOJTACERQ-UHFFFAOYSA-N 0.000 claims 1
- VZDJIRZZYSFVRR-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-3-[3-(5-methoxypyridin-3-yl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CN=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=C3OCOC3=CC=2)=C1 VZDJIRZZYSFVRR-UHFFFAOYSA-N 0.000 claims 1
- KROAJEYJMROWNY-UHFFFAOYSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3-pyridin-3-ylphenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C2OCCOC2=CC=1)C(C=1)=CC=CC=1C1=CC=CN=C1 KROAJEYJMROWNY-UHFFFAOYSA-N 0.000 claims 1
- KEKAVQSDOJVSNU-UHFFFAOYSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C2OCCOC2=CC=1)C(C=1)=CC=CC=1C1=CN=CN=C1 KEKAVQSDOJVSNU-UHFFFAOYSA-N 0.000 claims 1
- XLVJMWWGXURWKV-UHFFFAOYSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C12=CC=CC=C2C(N)=NC1(C=1C=C2OCCOC2=CC=1)C(C=1)=CC=CC=1C1=CC=CN=C1F XLVJMWWGXURWKV-UHFFFAOYSA-N 0.000 claims 1
- HGLAOFZAFIFUKA-UHFFFAOYSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(3-methoxyphenyl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CC=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=C3OCCOC3=CC=2)=C1 HGLAOFZAFIFUKA-UHFFFAOYSA-N 0.000 claims 1
- MXVJZGAFZLJLQZ-UHFFFAOYSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[3-(5-methoxypyridin-3-yl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CN=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=C3OCCOC3=CC=2)=C1 MXVJZGAFZLJLQZ-UHFFFAOYSA-N 0.000 claims 1
- USZVXCYBGOQIKE-UHFFFAOYSA-N 3-(2-chloropyridin-4-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(Cl)N=CC=1)C(C=1)=CC=CC=1C1=CN=CN=C1 USZVXCYBGOQIKE-UHFFFAOYSA-N 0.000 claims 1
- VOFJGSZKPNRYLS-UHFFFAOYSA-N 3-(2-chloropyridin-4-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C=CC=1)C=1C(=NC=CC=1)F)C1=CC=NC(Cl)=C1 VOFJGSZKPNRYLS-UHFFFAOYSA-N 0.000 claims 1
- SRJWFQRFHSLIHN-UHFFFAOYSA-N 3-(2-ethylpyridin-4-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C1=NC(CC)=CC(C2(C3=CC=CC=C3C(N)=N2)C=2C=C(C=CC=2)C=2C=NC=NC=2)=C1 SRJWFQRFHSLIHN-UHFFFAOYSA-N 0.000 claims 1
- QXZLSUXNFCVKSB-UHFFFAOYSA-N 3-(2-ethylpyridin-4-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine Chemical compound C1=NC(CC)=CC(C2(C3=CC=CC=C3C(N)=N2)C=2C=C(C=CC=2)C=2C(=NC=CC=2)F)=C1 QXZLSUXNFCVKSB-UHFFFAOYSA-N 0.000 claims 1
- FJKNWPNCHKXVKK-UHFFFAOYSA-N 3-(2-fluoropyridin-4-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C=CC=1)C=1C(=NC=CC=1)F)C1=CC=NC(F)=C1 FJKNWPNCHKXVKK-UHFFFAOYSA-N 0.000 claims 1
- AQWJKONBZLFXLD-UHFFFAOYSA-N 3-(2-methoxypyrimidin-5-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C1=NC(OC)=NC=C1C1(C=2C=C(C=CC=2)C=2C=NC=NC=2)C2=CC=CC=C2C(N)=N1 AQWJKONBZLFXLD-UHFFFAOYSA-N 0.000 claims 1
- BSJUWHOXOHIPGJ-UHFFFAOYSA-N 3-(2-propan-2-ylpyridin-4-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C1=NC(C(C)C)=CC(C2(C3=CC=CC=C3C(N)=N2)C=2C=C(C=CC=2)C=2C=NC=NC=2)=C1 BSJUWHOXOHIPGJ-UHFFFAOYSA-N 0.000 claims 1
- LJUZMVAHVKHGST-UHFFFAOYSA-N 3-(3-bromophenyl)-3-(4-methoxyphenyl)isoindol-1-amine Chemical compound C1=CC(OC)=CC=C1C1(C=2C=C(Br)C=CC=2)C2=CC=CC=C2C(N)=N1 LJUZMVAHVKHGST-UHFFFAOYSA-N 0.000 claims 1
- JSLVKTXNNUWZNM-UHFFFAOYSA-N 3-(3-fluoropyridin-4-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C(=CN=CC=1)F)C(C=1)=CC=CC=1C1=CN=CN=C1 JSLVKTXNNUWZNM-UHFFFAOYSA-N 0.000 claims 1
- PZYOMIWKDHGKSK-UHFFFAOYSA-N 3-(3-fluoropyridin-4-yl)-3-(4-fluoro-3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C(=CN=CC=1)F)C(C=1)=CC=C(F)C=1C1=CN=CN=C1 PZYOMIWKDHGKSK-UHFFFAOYSA-N 0.000 claims 1
- HOUJQAJPWSQDKH-UHFFFAOYSA-N 3-(3-fluoropyridin-4-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C(=CN=CC=1)F)C(C=1)=CC=CC=1C1=CC=CN=C1F HOUJQAJPWSQDKH-UHFFFAOYSA-N 0.000 claims 1
- SJYZHZUENNZOKO-UHFFFAOYSA-N 3-(3-fluoropyridin-4-yl)-3-[3-(5-fluoropyridin-3-yl)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C(=CN=CC=1)F)C(C=1)=CC=CC=1C1=CN=CC(F)=C1 SJYZHZUENNZOKO-UHFFFAOYSA-N 0.000 claims 1
- LJHBNAAXZYVNAM-UHFFFAOYSA-N 3-(3-pyrimidin-5-ylphenyl)-3-[4-(trifluoromethoxy)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C=CC=1)C=1C=NC=NC=1)C1=CC=C(OC(F)(F)F)C=C1 LJHBNAAXZYVNAM-UHFFFAOYSA-N 0.000 claims 1
- RRIIPJUEPHJBNE-UHFFFAOYSA-N 3-(3-pyrimidin-5-ylphenyl)-3-[4-(trifluoromethyl)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C=CC=1)C=1C=NC=NC=1)C1=CC=C(C(F)(F)F)C=C1 RRIIPJUEPHJBNE-UHFFFAOYSA-N 0.000 claims 1
- ZYLDGJNRPVVNPD-UHFFFAOYSA-N 3-(3-pyrimidin-5-ylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C=CC=1)C=1C=NC=NC=1)C1=CC=C(C(F)(F)F)N=C1 ZYLDGJNRPVVNPD-UHFFFAOYSA-N 0.000 claims 1
- MSERYTUPLPTPDE-UHFFFAOYSA-N 3-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-(4-methoxy-3-methylphenyl)isoindol-1-amine Chemical compound C1=C(C)C(OC)=CC=C1C1(C=2C=C(C(F)=CC=2)C=2C=NC=NC=2)C2=CC=CC=C2C(N)=N1 MSERYTUPLPTPDE-UHFFFAOYSA-N 0.000 claims 1
- GGFAIDPBYPUUNF-UHFFFAOYSA-N 3-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-pyridin-4-ylisoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(C(F)=CC=1)C=1C=NC=NC=1)C1=CC=NC=C1 GGFAIDPBYPUUNF-UHFFFAOYSA-N 0.000 claims 1
- TXRDWFIBWSXSBA-UHFFFAOYSA-N 3-(4-methoxy-3-methylphenyl)-3-(3-pyridin-3-ylphenyl)isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C(C)C(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2C=NC=CC=2)C2=CC=CC=C2C(N)=N1 TXRDWFIBWSXSBA-UHFFFAOYSA-N 0.000 claims 1
- SNPJMUOGKNZXET-UHFFFAOYSA-N 3-(4-methoxy-3-methylphenyl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C(C)C(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2C=NC=NC=2)C2=CC=CC=C2C(N)=N1 SNPJMUOGKNZXET-UHFFFAOYSA-N 0.000 claims 1
- MBCXQRNZTXKTKR-UHFFFAOYSA-N 3-(4-methoxy-3-methylphenyl)-3-[3-(3-methoxyphenyl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CC=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=C(C)C(OC)=CC=2)=C1 MBCXQRNZTXKTKR-UHFFFAOYSA-N 0.000 claims 1
- LROAOFBLCCRMGM-UHFFFAOYSA-N 3-(4-methoxy-3-methylphenyl)-3-[3-(5-methoxypyridin-3-yl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CN=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=C(C)C(OC)=CC=2)=C1 LROAOFBLCCRMGM-UHFFFAOYSA-N 0.000 claims 1
- MKYWJTMYZCYVJX-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-(3-pyridin-3-ylphenyl)isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2C=NC=CC=2)C2=CC=CC=C2C(N)=N1 MKYWJTMYZCYVJX-UHFFFAOYSA-N 0.000 claims 1
- IOHWCZWSDVRWJX-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2C=NC=NC=2)C2=CC=CC=C2C(N)=N1 IOHWCZWSDVRWJX-UHFFFAOYSA-N 0.000 claims 1
- GDOBIUCVRRCMFC-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-[3-(3-methoxyphenyl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2C=C(OC)C=CC=2)C2=CC=CC=C2C(N)=N1 GDOBIUCVRRCMFC-UHFFFAOYSA-N 0.000 claims 1
- QLEQZKQBZIKYEV-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-[3-(5-methoxypyridin-3-yl)phenyl]isoindol-1-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2C=C(OC)C=NC=2)C2=CC=CC=C2C(N)=N1 QLEQZKQBZIKYEV-UHFFFAOYSA-N 0.000 claims 1
- RMAISUWIHRUGBW-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-[3-(5-methylfuran-2-yl)phenyl]isoindol-1-amine Chemical compound C1=CC(OC)=CC=C1C1(C=2C=C(C=CC=2)C=2OC(C)=CC=2)C2=CC=CC=C2C(N)=N1 RMAISUWIHRUGBW-UHFFFAOYSA-N 0.000 claims 1
- FFJATXOBCVGDHP-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-[3-[1-(2-methylpropyl)pyrazol-4-yl]phenyl]isoindol-1-amine Chemical compound C1=CC(OC)=CC=C1C1(C=2C=C(C=CC=2)C2=CN(CC(C)C)N=C2)C2=CC=CC=C2C(N)=N1 FFJATXOBCVGDHP-UHFFFAOYSA-N 0.000 claims 1
- NBDIOATZZYXJOM-UHFFFAOYSA-N 3-(5-fluoropyridin-3-yl)-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(F)C=NC=1)C(C=1)=CC=CC=1C1=CN=CN=C1 NBDIOATZZYXJOM-UHFFFAOYSA-N 0.000 claims 1
- HYXOWQSRITZXBL-UHFFFAOYSA-N 3-(5-fluoropyridin-3-yl)-3-[3-(2-fluoropyridin-3-yl)phenyl]isoindol-1-amine Chemical compound C12=CC=CC=C2C(N)=NC1(C=1C=C(F)C=NC=1)C(C=1)=CC=CC=1C1=CC=CN=C1F HYXOWQSRITZXBL-UHFFFAOYSA-N 0.000 claims 1
- JEJCXMJBQASTNC-UHFFFAOYSA-N 3-[3-(2-fluoro-3-methoxyphenyl)phenyl]-3-(2-methoxypyrimidin-5-yl)isoindol-1-amine Chemical compound C1=NC(OC)=NC=C1C1(C=2C=C(C=CC=2)C=2C(=C(OC)C=CC=2)F)C2=CC=CC=C2C(N)=N1 JEJCXMJBQASTNC-UHFFFAOYSA-N 0.000 claims 1
- NHHIRTVYIYKDOS-UHFFFAOYSA-N 3-[3-(2-fluoro-3-methoxyphenyl)phenyl]-3-(3-fluoropyridin-4-yl)isoindol-1-amine Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C(=CN=CC=2)F)=C1F NHHIRTVYIYKDOS-UHFFFAOYSA-N 0.000 claims 1
- VKJAINYSPZGFJO-UHFFFAOYSA-N 3-[3-(2-fluoro-3-methoxyphenyl)phenyl]-3-pyridin-4-ylisoindol-1-amine Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)C2(C3=CC=CC=C3C(N)=N2)C=2C=CN=CC=2)=C1F VKJAINYSPZGFJO-UHFFFAOYSA-N 0.000 claims 1
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| EP1896448A1 (en) | 2005-06-30 | 2008-03-12 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
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| US7601751B2 (en) | 2005-09-01 | 2009-10-13 | Bristol-Myers Squibb Company | Indole acetic acid acyl guanidines as β-secretase inhibitors |
| EP2612854B1 (en) | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
| ATE478070T1 (de) | 2005-10-27 | 2010-09-15 | Schering Corp | Heterozyklische aspartyl-proteasehemmer |
| EP1943246A1 (en) | 2005-10-31 | 2008-07-16 | Schering Corporation | Aspartyl protease inhibitors |
| CN101360722A (zh) | 2005-11-15 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | 新颖的2-氨基嘧啶衍生物及其用途 |
| TW200804290A (en) | 2005-11-15 | 2008-01-16 | Astrazeneca Ab | Compounds and uses thereof |
| JP2009515949A (ja) | 2005-11-15 | 2009-04-16 | アストラゼネカ・アクチエボラーグ | 新規な２−アミノピリミジノン誘導体およびそれらの使用 |
| US20080318985A1 (en) | 2005-11-15 | 2008-12-25 | Astrazeneca Ab | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use |
| TW200734311A (en) | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
| WO2007058601A1 (en) | 2005-11-21 | 2007-05-24 | Astrazeneca Ab | Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer’s disease, neurodegeneration and dementia |
| AR058381A1 (es) | 2005-12-19 | 2008-01-30 | Astrazeneca Ab | Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica |
| JP2009532464A (ja) | 2006-04-05 | 2009-09-10 | アストラゼネカ・アクチエボラーグ | ２−アミノピリミジン−４−オン及びＡβ−関連の病理を治療又は予防するためのその使用 |
| TW200808751A (en) | 2006-04-13 | 2008-02-16 | Astrazeneca Ab | New compounds |
| EP2032542A2 (en) | 2006-06-12 | 2009-03-11 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TW200808796A (en) | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
| TW200815447A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
| TW200815449A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
| TW200815443A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| WO2008063114A1 (en) | 2006-11-20 | 2008-05-29 | Astrazeneca Ab | Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia |
| WO2008076043A1 (en) | 2006-12-20 | 2008-06-26 | Astrazeneca Ab | Novel 2-amino-5,5-diaryl-imidazol-4-ones |
| TW200831091A (en) | 2006-12-20 | 2008-08-01 | Astrazeneca Ab | New compounds |
| TW200831484A (en) | 2006-12-20 | 2008-08-01 | Astrazeneca Ab | New compounds |
| TW200902503A (en) | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
| TW200902499A (en) | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
| WO2009005471A1 (en) | 2007-07-05 | 2009-01-08 | Astrazeneca Ab | Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors |
| WO2009005470A1 (en) | 2007-07-05 | 2009-01-08 | Astrazeneca Ab | Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors |
| US20100125081A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 574 |
| TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
| US20100125087A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 575 |
-
2007
- 2007-06-11 TW TW096121008A patent/TW200815349A/zh unknown
- 2007-06-13 US US11/762,487 patent/US7855213B2/en not_active Expired - Fee Related
- 2007-06-20 AU AU2007261749A patent/AU2007261749B2/en not_active Ceased
- 2007-06-20 WO PCT/SE2007/000601 patent/WO2007149033A1/en not_active Ceased
- 2007-06-20 NZ NZ574262A patent/NZ574262A/en not_active IP Right Cessation
- 2007-06-20 JP JP2009516446A patent/JP2009541311A/ja active Pending
- 2007-06-20 EP EP07748264A patent/EP2035378A4/en not_active Withdrawn
- 2007-06-20 MX MX2008015719A patent/MX2008015719A/es active IP Right Grant
- 2007-06-20 KR KR1020097001336A patent/KR20090031585A/ko not_active Ceased
- 2007-06-20 MY MYPI20085213A patent/MY147390A/en unknown
- 2007-06-20 CA CA002656625A patent/CA2656625A1/en not_active Abandoned
- 2007-06-21 AR ARP070102733A patent/AR061564A1/es not_active Application Discontinuation
- 2007-06-21 UY UY30426A patent/UY30426A1/es not_active Application Discontinuation
- 2007-06-21 CL CL200701830A patent/CL2007001830A1/es unknown
-
2008
- 2008-12-02 IL IL195670A patent/IL195670A0/en unknown
- 2008-12-12 EC EC2008008972A patent/ECSP088972A/es unknown
-
2009
- 2009-01-15 NO NO20090246A patent/NO20090246L/no not_active Application Discontinuation
-
2010
- 2010-11-11 US US12/944,145 patent/US20110059992A1/en not_active Abandoned
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