JP2017520242A5 - - Google Patents

Download PDF

Info

Publication number
JP2017520242A5
JP2017520242A5 JP2016571259A JP2016571259A JP2017520242A5 JP 2017520242 A5 JP2017520242 A5 JP 2017520242A5 JP 2016571259 A JP2016571259 A JP 2016571259A JP 2016571259 A JP2016571259 A JP 2016571259A JP 2017520242 A5 JP2017520242 A5 JP 2017520242A5
Authority
JP
Japan
Prior art keywords
culture medium
liquid culture
volume
period
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016571259A
Other languages
English (en)
Japanese (ja)
Other versions
JP6915992B2 (ja
JP2017520242A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/034494 external-priority patent/WO2015188106A2/en
Publication of JP2017520242A publication Critical patent/JP2017520242A/ja
Publication of JP2017520242A5 publication Critical patent/JP2017520242A5/ja
Priority to JP2021116795A priority Critical patent/JP7350810B2/ja
Application granted granted Critical
Publication of JP6915992B2 publication Critical patent/JP6915992B2/ja
Priority to JP2023102970A priority patent/JP7769663B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016571259A 2014-06-06 2015-06-05 灌流培養方法およびその使用 Active JP6915992B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021116795A JP7350810B2 (ja) 2014-06-06 2021-07-15 灌流培養方法およびその使用
JP2023102970A JP7769663B2 (ja) 2014-06-06 2023-06-23 灌流培養方法およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462009058P 2014-06-06 2014-06-06
US62/009,058 2014-06-06
PCT/US2015/034494 WO2015188106A2 (en) 2014-06-06 2015-06-05 Perfusion culturing methods and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021116795A Division JP7350810B2 (ja) 2014-06-06 2021-07-15 灌流培養方法およびその使用

Publications (3)

Publication Number Publication Date
JP2017520242A JP2017520242A (ja) 2017-07-27
JP2017520242A5 true JP2017520242A5 (OSRAM) 2018-07-12
JP6915992B2 JP6915992B2 (ja) 2021-08-11

Family

ID=53484156

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016571259A Active JP6915992B2 (ja) 2014-06-06 2015-06-05 灌流培養方法およびその使用
JP2021116795A Active JP7350810B2 (ja) 2014-06-06 2021-07-15 灌流培養方法およびその使用
JP2023102970A Active JP7769663B2 (ja) 2014-06-06 2023-06-23 灌流培養方法およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021116795A Active JP7350810B2 (ja) 2014-06-06 2021-07-15 灌流培養方法およびその使用
JP2023102970A Active JP7769663B2 (ja) 2014-06-06 2023-06-23 灌流培養方法およびその使用

Country Status (15)

Country Link
US (3) US11060058B2 (OSRAM)
EP (1) EP3152293B1 (OSRAM)
JP (3) JP6915992B2 (OSRAM)
KR (2) KR102611855B1 (OSRAM)
CN (1) CN106795495A (OSRAM)
AU (2) AU2015269184B2 (OSRAM)
BR (1) BR112016028512A8 (OSRAM)
CA (1) CA2951255A1 (OSRAM)
ES (1) ES3040723T3 (OSRAM)
IL (1) IL249384A0 (OSRAM)
MX (2) MX2016016142A (OSRAM)
RU (3) RU2733539C2 (OSRAM)
SG (2) SG10202008131WA (OSRAM)
TW (2) TWI743024B (OSRAM)
WO (1) WO2015188106A2 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014218723B2 (en) 2013-02-22 2019-12-05 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
EP3460049A1 (en) 2013-02-22 2019-03-27 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
US11306341B2 (en) 2014-12-22 2022-04-19 Genzyme Corporation Methods of culturing a mammalian cell
US11292999B2 (en) 2016-08-30 2022-04-05 Finesse Solutions, Inc. Bioreactor with multiple coupled vessels
JP7453151B2 (ja) * 2018-11-02 2024-03-19 協和キリン株式会社 液体培地の調製方法
US20220250063A1 (en) * 2021-02-10 2022-08-11 Koniku Inc. Assay system, methods, and multi-well plate for gas stimulation of biological cells, proteins or materials
KR20230170728A (ko) * 2021-04-14 2023-12-19 젠자임 코포레이션 포유류 세포의 관류 배양 방법
JP7732842B2 (ja) * 2021-10-14 2025-09-02 株式会社三共 遊技機
JP7732839B2 (ja) * 2021-10-14 2025-09-02 株式会社三共 遊技機
JP7732843B2 (ja) * 2021-10-14 2025-09-02 株式会社三共 遊技機
JP7732840B2 (ja) * 2021-10-14 2025-09-02 株式会社三共 遊技機
JP7732841B2 (ja) * 2021-10-14 2025-09-02 株式会社三共 遊技機
WO2024112917A1 (en) * 2022-11-22 2024-05-30 The University Of North Carolina At Chapel Hill Laminar flow incorporated scaffold-based 3d cell cultures
DE102022214275A1 (de) * 2022-12-22 2024-06-27 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zur Kultivierung von Zellen
US20240263122A1 (en) * 2023-02-08 2024-08-08 National Central University Bioreactor apparatus, ion-exchange substrate and method for regulation of ion concentration and cell culture thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
RU2058992C1 (ru) 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
RU2215748C2 (ru) 1999-04-09 2003-11-10 Сентро Де Инмунология Молекулар Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция
WO2000063403A2 (en) 1999-04-15 2000-10-26 Crucell Holland B.V. Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
UA74557C2 (en) 1999-09-03 2006-01-16 Applied Research Systems A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
AU2002232726A1 (en) 2000-12-20 2002-07-01 Bayer Pharmaceuticals Corporation A device and method for seed-train expansion of mammalian cells
US6544788B2 (en) 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
JP2005509406A (ja) 2001-05-09 2005-04-14 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞株のための低温保存袋アセンブリー
KR100909316B1 (ko) 2001-08-31 2009-07-24 바이엘 헬스케어 아게 고세포밀도 발효를 수행하기 위한 유닛 및 방법
PL368119A1 (en) 2001-10-02 2005-03-21 Novo Nordisk Health Care Ag Method for production of recombinant proteins in eukaryote cells
WO2003033935A1 (de) 2001-10-11 2003-04-24 Siemens Aktiengesellschaft Dämpfungsvorrichtung sowie verfahren zum bedämpfen von bewegungen in einer dämpfungsvorrichtung
AU2002348151A1 (en) 2001-11-05 2003-05-19 Genvec, Inc. Viral vector production methods and compositions
US20030091976A1 (en) 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
US6953692B2 (en) 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
AR046510A1 (es) 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
EP1508576A1 (en) 2003-08-20 2005-02-23 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
DE102005007512A1 (de) 2004-02-20 2005-09-08 CESCO Bioengineering Co., Ltd., Chutung Vorrichtung und Verfahren zum Präparieren und Kultivieren von Zellen
ES2459367T3 (es) 2004-05-19 2014-05-09 Massachusetts Institute Of Technology Modelos tridimensionales de enfermedades de células/tejidos perfundidos
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
AU2005287162B2 (en) 2004-09-16 2010-12-23 Becton, Dickinson And Company Perfusion bioreactor for culturing cells
US7767446B2 (en) * 2004-09-16 2010-08-03 Becton, Dickinson And Company Perfusion bioreactors for culturing cells
EP1807101B1 (en) 2004-09-30 2016-04-13 Bayer Healthcare LLC Devices and methods for integrated continuous manufacturing of biological molecules
ES2662589T3 (es) 2005-06-15 2018-04-09 Zhejiang Jinyishengshi Bioengineering Co., Ltd. Recipientes para cultivo en suspensión
WO2006138143A1 (en) 2005-06-15 2006-12-28 Amprotein Corporation Suspension culture vessels
JP2009529888A (ja) 2006-03-14 2009-08-27 ユニバーシティ オブ ロチェスター 超薄多孔質メンブレンを有する細胞培養装置およびその使用
WO2008024769A2 (en) 2006-08-21 2008-02-28 Raven Biotechnologies, Inc. Intensified perfusion production method
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
JP2010525789A (ja) 2007-01-08 2010-07-29 ミリポア・コーポレイション １つ又はそれ以上のきょう雑物の低下したレベルの存在下で組換えタンパク質を生産するための細胞培養法
WO2008106515A1 (en) * 2007-02-27 2008-09-04 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
JP5467415B2 (ja) 2007-03-02 2014-04-09 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト タンパク質製造の改良
EP2155347B1 (en) 2007-04-17 2013-07-17 Xendo Holding B.V. Method and device for continuous membrane adsorption
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
WO2009023562A2 (en) 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2009034186A2 (en) 2007-09-13 2009-03-19 Helmholtz-Zentrum für Infektionsforschung GmbH Process for cell cultivation
US20090233334A1 (en) 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
DE102008019691A1 (de) * 2008-04-15 2009-10-29 Technische Universität Ilmenau Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion
WO2009137712A1 (en) 2008-05-07 2009-11-12 Guided Delivery Systems Inc. Deflectable guide
US20100076380A1 (en) 2008-06-16 2010-03-25 Amprotein Corporation Bioreactors
AU2009308354A1 (en) * 2008-10-22 2010-04-29 Biovest International, Inc. Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products
WO2010110754A1 (en) * 2009-03-26 2010-09-30 Agency For Science, Technology And Research Apparatus for cell or tissue culture
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
CN101875917B (zh) 2009-04-28 2012-07-04 北京清大天一科技有限公司 生物反应器微载体培养动物细胞生产猪瘟疫苗的方法
US20120329151A1 (en) 2009-07-06 2012-12-27 F. Hoffmann-La Roche Ag Method of culturing eukaryotic cells
CA2791565C (fr) 2010-03-02 2018-08-28 Universite Technologie De Compiegne - Utc Boite multi-reacteurs pour culture cellulaire dynamique
CN201933090U (zh) 2010-11-22 2011-08-17 朱学仁 细胞微载体灌注培养截留装置
CN105107228B (zh) 2010-12-06 2017-03-29 颇尔公司 生物制品的连续加工方法
HRP20211494T1 (hr) 2011-01-17 2021-12-24 F. Hoffmann - La Roche Ag Uređaj za odvajanje
CA2804568A1 (en) * 2011-03-22 2012-09-27 Tokai Hit Co., Ltd. Culture apparatus for microscopic viewing and method of use therefor
EP2707488B1 (en) 2011-05-12 2017-11-15 ProBioGen AG Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase
KR20230114317A (ko) 2011-07-01 2023-08-01 암젠 인크 포유동물 세포 배양
WO2013011616A1 (ja) * 2011-07-15 2013-01-24 パナソニック株式会社 携帯端末
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
DK2620561T3 (en) 2012-01-30 2015-02-16 Dannrup Neils Device and method for filtering surface
US20150004686A1 (en) 2012-02-02 2015-01-01 Corning Incorporated Automatic continuous perfusion cell culture microplate consumables
SG10201803961VA (en) * 2012-04-01 2018-07-30 Emd Millipore Corp Cell culture and gradient migration assay methods and devices
US9946845B2 (en) 2012-10-02 2018-04-17 Rxsafe Llc System and method for filling and dispensing orders
CN104903436B (zh) 2012-10-23 2018-03-30 建新公司 灌注培养方法及其用途
EP3460049A1 (en) 2013-02-22 2019-03-27 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
AU2014218723B2 (en) 2013-02-22 2019-12-05 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
IL274646B (en) 2013-03-08 2022-09-01 Genzyme Corp Integrated continuous production of medicinal substances from medical protein
RU2668796C2 (ru) 2013-03-15 2018-10-02 Джензим Корпорейшн Способы формирования банка клеток высокой плотности (варианты)
US9481901B2 (en) * 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
CA2924332C (en) 2013-09-16 2023-03-14 Genzyme Corporation Method of culturing cells using an open circuit filtration system with tangential flow filtration
EP2881622A1 (de) 2013-12-05 2015-06-10 Continental Automotive GmbH Aktuator
WO2015095809A1 (en) 2013-12-20 2015-06-25 Biogen Idec Ma Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
HUE042277T2 (hu) 2014-06-04 2019-06-28 Amgen Inc Eljárások fehérjék begyûjtésére emlõssejttenyészetekbõl
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
CN104480897B (zh) 2014-11-28 2017-01-04 上海市政工程设计研究总院（集团）有限公司 陆域占地少应用范围广的防汛墙
CN104450597B (zh) 2014-12-10 2020-07-28 青岛农业大学 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法
US11306341B2 (en) 2014-12-22 2022-04-19 Genzyme Corporation Methods of culturing a mammalian cell

Similar Documents

Publication Publication Date Title
JP2017520242A5 (OSRAM)
RU2020131199A (ru) Способ тестирования производственного процесса получения рекомбинантного белка
Heathman et al. Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum‐free microcarrier process
Yuan et al. Improved expansion of human bone marrow‐derived mesenchymal stem cells in microcarrier‐based suspension culture
TWI659965B (zh) 治療性蛋白質藥物物質之整合連續製造
JP2019201661A5 (OSRAM)
CN104903436B (zh) 灌注培养方法及其用途
ATE414144T1 (de) Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon
JP2013524825A5 (OSRAM)
DK1576182T3 (da) Produktkvalitetsforbedring ved fremgangsmåde med dyrkning af pattedyreceller til proteinfremstilling
TW200512297A (en) Mammalian cell culture processes for protein production
JP2013500724A5 (OSRAM)
JP2017538435A5 (OSRAM)
MX2012003654A (es) Metodos de produccion de glucoproteinas en cultivos de celulas de mamiferos usando glucocorticoides.
RU2014128987A (ru) Быстрый способ клонирования и экспрессии сегментов гена родственной вариабельной области антитела
RU2009143635A (ru) Улучшение титра полипептида фактора viii в клеточных культурах
US20200172606A1 (en) Methods of replicating a large scale eculizumab production cell culture
JP2016513478A5 (OSRAM)
MX2012007117A (es) Metodo para cultivar celulas adherentes.
Ritter et al. Deletion of a telomeric region on chromosome 8 correlates with higher productivity and stability of CHO cell lines
RU2017126045A (ru) Способы культивирования клетки млекопитающего
JP2013531967A5 (OSRAM)
JPWO2020032153A5 (OSRAM)
EP1739167A4 (en) PROCESS FOR VIRUS PRODUCTION
JP2005511087A5 (OSRAM)