JP2017509342A5 - - Google Patents
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- JP2017509342A5 JP2017509342A5 JP2016558087A JP2016558087A JP2017509342A5 JP 2017509342 A5 JP2017509342 A5 JP 2017509342A5 JP 2016558087 A JP2016558087 A JP 2016558087A JP 2016558087 A JP2016558087 A JP 2016558087A JP 2017509342 A5 JP2017509342 A5 JP 2017509342A5
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- Prior art keywords
- car
- antigen receptor
- chimeric antigen
- domain
- engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 35
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 25
- 210000002865 immune cell Anatomy 0.000 claims description 24
- 108020001756 ligand binding domains Proteins 0.000 claims description 13
- 230000003211 malignant effect Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 102000040430 polynucleotide Human genes 0.000 claims description 7
- 108091033319 polynucleotide Proteins 0.000 claims description 7
- 239000002157 polynucleotide Substances 0.000 claims description 7
- 210000004896 polypeptide structure Anatomy 0.000 claims description 7
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims description 5
- 230000000139 costimulatory effect Effects 0.000 claims description 5
- 230000001086 cytosolic effect Effects 0.000 claims description 5
- 230000011664 signaling Effects 0.000 claims description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 4
- 229940041181 antineoplastic drug Drugs 0.000 claims description 4
- 201000001268 lymphoproliferative syndrome Diseases 0.000 claims description 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 229940044683 chemotherapy drug Drugs 0.000 claims description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 201000003444 follicular lymphoma Diseases 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 229940124589 immunosuppressive drug Drugs 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 description 3
- 201000005787 hematologic cancer Diseases 0.000 description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 2
- 208000004736 B-Cell Leukemia Diseases 0.000 description 1
- 208000003950 B-cell lymphoma Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020068935A JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470137 | 2014-03-19 | ||
| DKPA201470137 | 2014-03-19 | ||
| PCT/EP2015/055848 WO2015140268A1 (en) | 2014-03-19 | 2015-03-19 | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020068935A Division JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509342A JP2017509342A (ja) | 2017-04-06 |
| JP2017509342A5 true JP2017509342A5 (Direct) | 2018-04-19 |
| JP6689202B2 JP6689202B2 (ja) | 2020-04-28 |
Family
ID=58702463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558087A Active JP6689202B2 (ja) | 2014-03-19 | 2015-03-19 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
| JP2020068935A Active JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020068935A Active JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9944709B2 (Direct) |
| EP (2) | EP3569619B1 (Direct) |
| JP (2) | JP6689202B2 (Direct) |
| KR (1) | KR102157411B1 (Direct) |
| CN (1) | CN106103490B (Direct) |
| AU (1) | AU2015233461B2 (Direct) |
| CA (1) | CA2943008C (Direct) |
| DK (2) | DK3569619T3 (Direct) |
| ES (2) | ES2877606T3 (Direct) |
| HU (1) | HUE045480T2 (Direct) |
| IL (1) | IL247172B (Direct) |
| MX (2) | MX370272B (Direct) |
| PL (1) | PL3119807T3 (Direct) |
| PT (1) | PT3119807T (Direct) |
| RU (1) | RU2727290C2 (Direct) |
| TR (1) | TR201910814T4 (Direct) |
| WO (1) | WO2015140268A1 (Direct) |
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