JP2017537622A5 - - Google Patents
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- JP2017537622A5 JP2017537622A5 JP2017529284A JP2017529284A JP2017537622A5 JP 2017537622 A5 JP2017537622 A5 JP 2017537622A5 JP 2017529284 A JP2017529284 A JP 2017529284A JP 2017529284 A JP2017529284 A JP 2017529284A JP 2017537622 A5 JP2017537622 A5 JP 2017537622A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- acid sequence
- domain
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 51
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 239000013598 vector Substances 0.000 claims 10
- 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims 9
- 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims 9
- 230000011664 signaling Effects 0.000 claims 9
- 102000003816 Interleukin-13 Human genes 0.000 claims 8
- 108090000176 Interleukin-13 Proteins 0.000 claims 8
- 210000004962 mammalian cell Anatomy 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 230000001086 cytosolic effect Effects 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 208000029824 high grade glioma Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 201000011614 malignant glioma Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 102200146131 rs1131692037 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086346P | 2014-12-02 | 2014-12-02 | |
| US62/086,346 | 2014-12-02 | ||
| PCT/US2015/063267 WO2016089916A1 (en) | 2014-12-02 | 2015-12-01 | Methods and compositons for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537622A JP2017537622A (ja) | 2017-12-21 |
| JP2017537622A5 true JP2017537622A5 (Direct) | 2019-01-10 |
Family
ID=56078487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529284A Pending JP2017537622A (ja) | 2014-12-02 | 2015-12-01 | がんを治療するための方法及び組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9650428B2 (Direct) |
| EP (1) | EP3227317A4 (Direct) |
| JP (1) | JP2017537622A (Direct) |
| KR (1) | KR20180041087A (Direct) |
| CN (1) | CN107709353A (Direct) |
| AR (1) | AR102879A1 (Direct) |
| AU (1) | AU2015355084A1 (Direct) |
| BR (1) | BR112017011771A2 (Direct) |
| CA (1) | CA2969714A1 (Direct) |
| EA (1) | EA201791210A1 (Direct) |
| HK (1) | HK1251862A1 (Direct) |
| IL (1) | IL252610A0 (Direct) |
| MX (1) | MX2017007272A (Direct) |
| PH (1) | PH12017501031A1 (Direct) |
| SG (2) | SG11201704519YA (Direct) |
| TW (1) | TW201636425A (Direct) |
| UY (1) | UY36418A (Direct) |
| WO (1) | WO2016089916A1 (Direct) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9512194B2 (en) | 2012-01-27 | 2016-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Modified IL-13 polypeptides |
| CN104619334A (zh) | 2012-08-09 | 2015-05-13 | 利兰斯坦福初级大学董事会 | 超级因子和合成因子:具有新的和增强的信号传导活性的经改造细胞因子 |
| ES2776698T3 (es) | 2012-12-20 | 2020-07-31 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| EP3049525B1 (en) | 2013-09-24 | 2025-07-23 | Medicenna Therapeutics, Inc. | Interleukin-4 receptor-binding fusion proteins and uses thereof |
| CA2969714A1 (en) | 2014-12-02 | 2016-06-09 | Sadhak SENGUPTA | Methods and compositions for treating cancer |
| ES2870174T3 (es) * | 2015-06-19 | 2021-10-26 | Sebastian Kobold | Proteínas de fusión PD-1-CD28 y su uso en medicina |
| RU2724738C2 (ru) * | 2015-08-05 | 2020-06-25 | СеллабМЕД ИНК. | Химерный антигенный рецептор и т-клетки, в которых экспрессируется химерный антигенный рецептор |
| US12144850B2 (en) | 2016-04-08 | 2024-11-19 | Purdue Research Foundation | Methods and compositions for car T cell therapy |
| WO2018112266A1 (en) * | 2016-12-14 | 2018-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13 superkine: immune cell targeting constructs and methods of use thereof |
| CA3051481A1 (en) | 2017-02-07 | 2018-08-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (ple) car t cell tumor targeting (ctct) agents |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| KR20190142775A (ko) | 2017-04-19 | 2019-12-27 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 조작된 항원 수용체를 발현하는 면역 세포 |
| US12274735B2 (en) | 2017-10-10 | 2025-04-15 | Medicenna Therapeutics Inc. | IL-4-fusion formulations for treatment of central nervous system (CNS) tumors |
| MX2020005251A (es) * | 2017-11-20 | 2021-01-29 | Prospect Chartercare Rwmc Llc D/B/A Roger Williams Medical Center | Composiciones para mejorar la funcionalidad de células car-t y uso de las mismas. |
| WO2019126574A1 (en) * | 2017-12-20 | 2019-06-27 | Poseida Therapeutics, Inc. | Vcar compositions and methods for use |
| CA3089051A1 (en) | 2018-01-22 | 2019-07-25 | Endocyte, Inc. | Methods of use for car t cells |
| WO2019148006A1 (en) * | 2018-01-26 | 2019-08-01 | City Of Hope | Chimeric antigen receptors and methods for reducing off target toxicity |
| AU2019218729B2 (en) | 2018-02-06 | 2025-12-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors |
| CN110144326A (zh) * | 2018-02-12 | 2019-08-20 | 深圳宾德生物技术有限公司 | 一种靶向性抗肿瘤t细胞及其制备方法和应用 |
| CN110157674A (zh) * | 2018-02-12 | 2019-08-23 | 深圳宾德生物技术有限公司 | 一种靶向性t淋巴细胞及其制备方法和应用 |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| CN108440674A (zh) * | 2018-04-28 | 2018-08-24 | 杭州荣泽生物科技有限公司 | 一种Trop-2特异性嵌合抗原受体细胞制备及其用途 |
| US12404497B2 (en) | 2018-06-01 | 2025-09-02 | Medicenna Therapeutics Inc. | Uses and methods for oncolytic virus targeting of IL-4/IL-13 and fusions thereof |
| US12419954B2 (en) * | 2020-01-31 | 2025-09-23 | City Of Hope | Targeted chimeric antigen receptor modified T cells for treatment of IL13Rα2 positive malignancies |
| JPWO2021241719A1 (Direct) * | 2020-05-28 | 2021-12-02 | ||
| EP4203990A4 (en) * | 2020-08-26 | 2025-10-01 | Univ California | METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLIOBLASTOMA |
| WO2022056398A1 (en) * | 2020-09-11 | 2022-03-17 | University Of Georgia Research Foundation, Inc. | Compositions and methods of use thereof for prevention and treatment of influenza infections |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN118146395A (zh) * | 2021-02-08 | 2024-06-07 | 浙江大学 | 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体 |
| CN113304267B (zh) * | 2021-06-11 | 2022-03-15 | 河南大学 | 肺癌的治疗靶点及其应用 |
| CN114014941B (zh) * | 2022-01-10 | 2022-04-12 | 卡瑞济(北京)生命科技有限公司 | 靶向IL13Rα2的嵌合抗原受体及其用途 |
| CN116549667B (zh) * | 2023-05-29 | 2024-02-09 | 四川普锐特药业有限公司 | 一种pas修饰的脂质纳米粒、包含其的药物制剂，及其制备方法和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965126A (en) * | 1996-03-25 | 1999-10-12 | The Penn State Research Foundation | use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents |
| JP2004500047A (ja) * | 1999-10-20 | 2004-01-08 | ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン | キメラ免疫原性組成物およびこれらをコードする核酸 |
| IL163515A0 (en) * | 2002-03-01 | 2005-12-18 | Bristol Myers Squibb Co | Transgenic non-human mammals |
| AU2003223497A1 (en) * | 2002-04-05 | 2003-10-27 | Centocor, Inc. | Asthma-related anti-il-13 immunoglobulin derived proteins, compositions, methods and uses |
| US7709625B2 (en) * | 2004-06-10 | 2010-05-04 | The Board Of Regents Of The University Of Texas | Methods and compositions for bone marrow stem cell-derived macrophage delivery of genes for gene therapy |
| CA2630334C (en) * | 2005-11-16 | 2013-07-23 | Universidad Nacional Autonoma De Mexico | Use of transcriptome-modifying agents and chemotherapy or radiotherapy against cancer |
| CN101616685B (zh) * | 2006-03-06 | 2013-07-24 | 阿穆尼克斯运营公司 | 非结构化重组聚合物和其应用 |
| US20080206139A1 (en) * | 2006-11-03 | 2008-08-28 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| EP4032552B1 (en) * | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| US9273283B2 (en) * | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| AU2011230590C1 (en) * | 2010-03-26 | 2016-09-15 | Memorial Sloan-Kettering Cancer Center | Antibodies to MUC16 and methods of use thereof |
| WO2014090985A1 (en) * | 2012-12-13 | 2014-06-19 | Universität Leipzig | T-cell modulation by exon skipping |
| ES2653487T3 (es) * | 2013-02-15 | 2018-02-07 | The Regents Of The University Of California | Receptor de antígeno quimérico y métodos de uso del mismo |
| US20160024175A1 (en) * | 2013-03-10 | 2016-01-28 | Baylor College Of Medicine | Chemotherapy-resistant immune cells |
| WO2015120363A1 (en) | 2014-02-10 | 2015-08-13 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
| CA2969714A1 (en) | 2014-12-02 | 2016-06-09 | Sadhak SENGUPTA | Methods and compositions for treating cancer |
-
2015
- 2015-12-01 CA CA2969714A patent/CA2969714A1/en not_active Abandoned
- 2015-12-01 AU AU2015355084A patent/AU2015355084A1/en not_active Abandoned
- 2015-12-01 MX MX2017007272A patent/MX2017007272A/es unknown
- 2015-12-01 EP EP15865800.5A patent/EP3227317A4/en not_active Withdrawn
- 2015-12-01 US US14/956,299 patent/US9650428B2/en not_active Expired - Fee Related
- 2015-12-01 SG SG11201704519YA patent/SG11201704519YA/en unknown
- 2015-12-01 KR KR1020177018139A patent/KR20180041087A/ko not_active Withdrawn
- 2015-12-01 BR BR112017011771A patent/BR112017011771A2/pt not_active Application Discontinuation
- 2015-12-01 EA EA201791210A patent/EA201791210A1/ru unknown
- 2015-12-01 SG SG10202103475XA patent/SG10202103475XA/en unknown
- 2015-12-01 WO PCT/US2015/063267 patent/WO2016089916A1/en not_active Ceased
- 2015-12-01 JP JP2017529284A patent/JP2017537622A/ja active Pending
- 2015-12-01 HK HK18110565.4A patent/HK1251862A1/zh unknown
- 2015-12-01 CN CN201580074883.3A patent/CN107709353A/zh active Pending
- 2015-12-02 TW TW104140317A patent/TW201636425A/zh unknown
- 2015-12-02 UY UY0001036418A patent/UY36418A/es not_active Application Discontinuation
- 2015-12-02 AR ARP150103939A patent/AR102879A1/es unknown
-
2017
- 2017-05-09 US US15/590,961 patent/US20180072789A1/en not_active Abandoned
- 2017-06-01 IL IL252610A patent/IL252610A0/en unknown
- 2017-06-02 PH PH12017501031A patent/PH12017501031A1/en unknown
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