JP2017537627A5 - - Google Patents
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- Publication number
- JP2017537627A5 JP2017537627A5 JP2017529682A JP2017529682A JP2017537627A5 JP 2017537627 A5 JP2017537627 A5 JP 2017537627A5 JP 2017529682 A JP2017529682 A JP 2017529682A JP 2017529682 A JP2017529682 A JP 2017529682A JP 2017537627 A5 JP2017537627 A5 JP 2017537627A5
- Authority
- JP
- Japan
- Prior art keywords
- signaling domain
- antigen receptor
- chimeric antigen
- domain
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000011664 signaling Effects 0.000 claims 50
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 32
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 125000006850 spacer group Chemical group 0.000 claims 22
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 20
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 20
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 13
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 3
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022001433A JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Ｃｓ１標的化キメラ抗原受容体修飾ｔ細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088423P | 2014-12-05 | 2014-12-05 | |
| US62/088,423 | 2014-12-05 | ||
| PCT/US2015/064303 WO2016090369A1 (en) | 2014-12-05 | 2015-12-07 | Cs1 targeted chimeric antigen receptor-modified t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001433A Division JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Ｃｓ１標的化キメラ抗原受容体修飾ｔ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537627A JP2017537627A (ja) | 2017-12-21 |
| JP2017537627A5 true JP2017537627A5 (Direct) | 2019-01-17 |
| JP7098325B2 JP7098325B2 (ja) | 2022-07-11 |
Family
ID=55069093
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529682A Active JP7098325B2 (ja) | 2014-12-05 | 2015-12-07 | Ｃｓ１標的化キメラ抗原レセプター改変ｔ細胞 |
| JP2022001433A Active JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Ｃｓ１標的化キメラ抗原受容体修飾ｔ細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001433A Active JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Ｃｓ１標的化キメラ抗原受容体修飾ｔ細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10821161B2 (Direct) |
| EP (2) | EP3227315B1 (Direct) |
| JP (2) | JP7098325B2 (Direct) |
| KR (1) | KR102558502B1 (Direct) |
| CN (2) | CN114085856A (Direct) |
| AU (2) | AU2015357485B2 (Direct) |
| BR (1) | BR112017011893A2 (Direct) |
| CA (1) | CA2969704C (Direct) |
| IL (3) | IL290459B2 (Direct) |
| MX (2) | MX384964B (Direct) |
| RU (1) | RU2727451C2 (Direct) |
| WO (1) | WO2016090369A1 (Direct) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2776698T3 (es) | 2012-12-20 | 2020-07-31 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| BR112016024579A2 (pt) | 2014-04-23 | 2017-10-10 | Juno Therapeutics Inc | métodos para isolamento, cultura e engenharia genética de populações de célula imune para terapia adotiva |
| BR112017011893A2 (pt) | 2014-12-05 | 2018-07-24 | City Of Hope | células t modificadas no receptor de antígeno quimérico direcionado para cs1 |
| AU2016212158B2 (en) | 2015-01-26 | 2021-06-03 | Allogene Therapeutics, Inc. | mAb-driven chimeric antigen receptor systems for sorting/depleting engineered immune cells |
| ES2848478T3 (es) | 2015-09-11 | 2021-08-09 | Biosceptre Uk Ltd | Receptores quiméricos para antígenos y usos de estos |
| WO2017130223A2 (en) | 2016-01-29 | 2017-08-03 | Virocan Therapeutics Pvt. Ltd. | A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| KR102120815B1 (ko) | 2016-04-01 | 2020-06-12 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| PE20190120A1 (es) | 2016-04-01 | 2019-01-17 | Kite Pharma Inc | Moleculas de union a bcma y metodos de uso de las mismas |
| WO2017173256A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
| US12144850B2 (en) | 2016-04-08 | 2024-11-19 | Purdue Research Foundation | Methods and compositions for car T cell therapy |
| JP7175769B2 (ja) * | 2016-06-30 | 2022-11-21 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 改善された養子ｔ細胞療法 |
| CN105949324B (zh) * | 2016-06-30 | 2019-08-27 | 上海恒润达生生物科技有限公司 | 靶向gpc3的嵌合抗原受体及其用途 |
| EP3518944A4 (en) * | 2016-09-30 | 2020-06-17 | Baylor College of Medicine | ADAPTIVE CHIMERIC ANTIGENT RECEPTOR T-CELL DESIGN |
| WO2018156711A1 (en) * | 2017-02-22 | 2018-08-30 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Il13ra2-binding chimeric antigen receptors |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| WO2018169922A2 (en) | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| CN110636849A (zh) * | 2017-03-20 | 2019-12-31 | 希望之城公司 | 用于治疗al淀粉样变的经cs1靶向性嵌合抗原受体修饰的t细胞 |
| BR112019020168A2 (pt) | 2017-03-27 | 2020-06-02 | F. Hoffmann-La Roche Ag | Receptores de ligação ao antígeno, células t transduzidas, polinucleotídeo isolado, vetor, kits, métodos para tratar uma doença e para induzir a lise de uma célula alvo e uso do receptor de ligação ao antígeno |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| WO2018197675A1 (en) * | 2017-04-28 | 2018-11-01 | Julius-Maximilians-Universität Würzburg | Ror1-specific chimeric antigen receptors (car) with humanized targeting domains |
| CA3071303A1 (en) * | 2017-08-01 | 2019-02-07 | Julius-Maximilians-Universitat Wurzburg | Use of flt3 car-t cells and flt3 inhibitors to treat acute myeloid leukemia |
| EP3666032B1 (en) | 2017-08-11 | 2026-02-11 | InterDigital Patent Holdings, Inc. | Traffic steering and switching between multiple access networks |
| US12258580B2 (en) * | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| WO2019099433A2 (en) * | 2017-11-14 | 2019-05-23 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| EP3710471A1 (en) | 2017-11-16 | 2020-09-23 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
| CA3089051A1 (en) | 2018-01-22 | 2019-07-25 | Endocyte, Inc. | Methods of use for car t cells |
| SG11202007513PA (en) | 2018-02-16 | 2020-09-29 | Kite Pharma Inc | Modified pluripotent stem cells and methods of making and use |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| CN112166193A (zh) * | 2018-05-21 | 2021-01-01 | 生物权威（英国）有限公司 | 具有经修饰的接头结构域的嵌合抗原受体及其用途 |
| WO2020009868A1 (en) * | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| US12281152B2 (en) | 2018-08-01 | 2025-04-22 | City Of Hope | TAG72 targeted chimeric antigen receptor modified T cells for treatment of TAG72-positive tumors |
| CN112469734A (zh) * | 2018-08-03 | 2021-03-09 | 南京驯鹿医疗技术有限公司 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
| IL280659B2 (en) | 2018-08-09 | 2024-11-01 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| IL316392A (en) | 2018-12-12 | 2024-12-01 | Kite Pharma Inc | Chimeric antigen receptors and CAR-T cells and methods of use |
| WO2020206248A1 (en) | 2019-04-03 | 2020-10-08 | Precision Biosciences, Inc. | Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir) |
| WO2020243007A1 (en) * | 2019-05-24 | 2020-12-03 | City Of Hope | Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies |
| CA3143108A1 (en) * | 2019-06-19 | 2020-12-24 | Julius-Maximilians-Universitat Wurzburg | Ultramodular igg3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design |
| CN112442126B (zh) * | 2019-09-04 | 2022-07-29 | 杭州济元基因科技有限公司 | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 |
| JP2023525049A (ja) * | 2020-05-08 | 2023-06-14 | シアトル・チルドレンズ・ホスピタル・ドゥーイング／ビジネス／アズ・シアトル・チルドレンズ・リサーチ・インスティテュート | ナチュラルキラー細胞を標的とするキメラ抗原受容体（ｃａｒ） |
| WO2021242719A1 (en) * | 2020-05-27 | 2021-12-02 | The Medical College Of Wisconsin, Inc. | Improved lentiviral vector transfer plasmid and methods of use |
| WO2022031602A1 (en) * | 2020-08-06 | 2022-02-10 | Promab Biotechnologies, Inc. | Cs1- antibody and anti-cs1-car-t cells |
| EP4192873A1 (en) * | 2020-08-10 | 2023-06-14 | Julius-Maximilians-Universität Würzburg | Siglec-6-binding polypeptides |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN117083292A (zh) * | 2021-04-02 | 2023-11-17 | 科济生物医药（上海）有限公司 | Cs1工程化细胞及其组合物 |
| WO2023107898A1 (en) * | 2021-12-06 | 2023-06-15 | The Children's Hospital Of Philadelphia | Dual targeting of pediatric malignancies through car t-cells secreting bispecific innate immune cell engagers (bices) |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
| EP4499230A1 (en) * | 2022-03-25 | 2025-02-05 | F. Hoffmann-La Roche AG | Improved chimeric receptors |
| WO2024114691A1 (en) * | 2022-12-02 | 2024-06-06 | Guangzhou Litai Biotechnology Co., Ltd. | Human cs1 car-t cells |
| CN119019554B (zh) * | 2023-05-25 | 2025-08-12 | 东莞市朋志生物科技有限公司 | 抗白介素6抗体、检测白介素6的试剂和试剂盒 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991002063A1 (en) | 1989-08-11 | 1991-02-21 | Amrad Corporation Limited | Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof |
| WO2006074399A2 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| NZ612578A (en) | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
| WO2007047829A2 (en) | 2005-10-19 | 2007-04-26 | Laboratoires Serono S.A. | Novel heterodimeric proteins and uses thereof |
| GB0523954D0 (en) * | 2005-11-24 | 2006-01-04 | Ucb Celltech | Bioassays |
| MX363905B (es) * | 2006-06-12 | 2019-04-08 | Aptevo Res & Development Llc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
| WO2011100566A2 (en) | 2010-02-12 | 2011-08-18 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| CA3116051C (en) | 2012-03-23 | 2023-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| AU2013243861A1 (en) | 2012-04-05 | 2014-10-23 | Ac Immune S.A. | Humanized Tau antibody |
| US10358494B2 (en) | 2013-05-03 | 2019-07-23 | Ohio State Innovation Foundation | CS1-specific chimeric antigen receptor engineered immune effector cells |
| US20160333108A1 (en) * | 2014-01-13 | 2016-11-17 | Stephen J. Forman | CHIMERIC ANTIGEN RECEPTORS (CARs) HAVING MUTATIONS IN THE FC SPACER REGION AND METHODS FOR THEIR USE |
| PL3105317T3 (pl) | 2014-02-14 | 2019-02-28 | Cellectis | Komórki do immunoterapii zaprojektowane do celowania antygenu obecnego zarówno na komórkach odpornościowych, jak i komórkach patologicznych |
| EP3137498A1 (en) * | 2014-05-02 | 2017-03-08 | Cellectis | Cs1 specific multi-chain chimeric antigen receptor |
| BR112017011893A2 (pt) * | 2014-12-05 | 2018-07-24 | City Of Hope | células t modificadas no receptor de antígeno quimérico direcionado para cs1 |
| CN110636849A (zh) * | 2017-03-20 | 2019-12-31 | 希望之城公司 | 用于治疗al淀粉样变的经cs1靶向性嵌合抗原受体修饰的t细胞 |
-
2015
- 2015-12-07 BR BR112017011893-9A patent/BR112017011893A2/pt not_active Application Discontinuation
- 2015-12-07 US US15/533,153 patent/US10821161B2/en active Active
- 2015-12-07 AU AU2015357485A patent/AU2015357485B2/en not_active Ceased
- 2015-12-07 EP EP15819937.2A patent/EP3227315B1/en not_active Not-in-force
- 2015-12-07 IL IL290459A patent/IL290459B2/en unknown
- 2015-12-07 KR KR1020177018597A patent/KR102558502B1/ko active Active
- 2015-12-07 WO PCT/US2015/064303 patent/WO2016090369A1/en not_active Ceased
- 2015-12-07 MX MX2017007250A patent/MX384964B/es unknown
- 2015-12-07 CN CN202111214014.XA patent/CN114085856A/zh active Pending
- 2015-12-07 JP JP2017529682A patent/JP7098325B2/ja active Active
- 2015-12-07 RU RU2017121826A patent/RU2727451C2/ru active
- 2015-12-07 CA CA2969704A patent/CA2969704C/en active Active
- 2015-12-07 EP EP22208847.8A patent/EP4219530A1/en not_active Withdrawn
- 2015-12-07 CN CN201580075401.6A patent/CN107429253B/zh not_active Expired - Fee Related
-
2017
- 2017-06-04 IL IL252645A patent/IL252645B/en active IP Right Grant
- 2017-06-05 MX MX2021008498A patent/MX2021008498A/es unknown
-
2020
- 2020-08-13 US US16/992,361 patent/US11730797B2/en active Active
-
2021
- 2021-01-11 AU AU2021200122A patent/AU2021200122B2/en not_active Ceased
- 2021-02-16 IL IL280917A patent/IL280917B/en unknown
-
2022
- 2022-01-07 JP JP2022001433A patent/JP7252379B2/ja active Active
-
2023
- 2023-07-10 US US18/349,678 patent/US12497440B2/en active Active
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