DK3569619T3 - Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi - Google Patents

Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi Download PDF

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DK3569619T3
DK3569619T3 DK19169002.3T DK19169002T DK3569619T3 DK 3569619 T3 DK3569619 T3 DK 3569619T3 DK 19169002 T DK19169002 T DK 19169002T DK 3569619 T3 DK3569619 T3 DK 3569619T3
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cells
producing
cancer immunotherapy
specific car
car
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DK19169002.3T
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Roman Galetto
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Cellectis
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK19169002.3T 2014-03-19 2015-03-19 Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi DK3569619T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201470137 2014-03-19
EP15712105.4A EP3119807B1 (en) 2014-03-19 2015-03-19 Cd123 specific chimeric antigen receptors for cancer immunotherapy

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DK3569619T3 true DK3569619T3 (da) 2021-06-14

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DK19169002.3T DK3569619T3 (da) 2014-03-19 2015-03-19 Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi
DK15712105.4T DK3119807T3 (da) 2014-03-19 2015-03-19 Cd123-specifikke kimære antigenreceptorer til cancerimmunterapi

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US (3) US9944709B2 (Direct)
EP (2) EP3569619B1 (Direct)
JP (2) JP6689202B2 (Direct)
KR (1) KR102157411B1 (Direct)
CN (1) CN106103490B (Direct)
AU (1) AU2015233461B2 (Direct)
CA (1) CA2943008C (Direct)
DK (2) DK3569619T3 (Direct)
ES (2) ES2877606T3 (Direct)
HU (1) HUE045480T2 (Direct)
IL (1) IL247172B (Direct)
MX (2) MX370272B (Direct)
PL (1) PL3119807T3 (Direct)
PT (1) PT3119807T (Direct)
RU (1) RU2727290C2 (Direct)
TR (1) TR201910814T4 (Direct)
WO (1) WO2015140268A1 (Direct)

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