MX2021004868A - Diacuerpos cd123 x cd3 biespecificos para el tratamiento de neoplasias hematologicas. - Google Patents
Diacuerpos cd123 x cd3 biespecificos para el tratamiento de neoplasias hematologicas.Info
- Publication number
- MX2021004868A MX2021004868A MX2021004868A MX2021004868A MX2021004868A MX 2021004868 A MX2021004868 A MX 2021004868A MX 2021004868 A MX2021004868 A MX 2021004868A MX 2021004868 A MX2021004868 A MX 2021004868A MX 2021004868 A MX2021004868 A MX 2021004868A
- Authority
- MX
- Mexico
- Prior art keywords
- expression
- patient
- genes
- hematologic malignancy
- bispecific
- Prior art date
Links
- 208000002250 Hematologic Neoplasms Diseases 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 201000005787 hematologic cancer Diseases 0.000 abstract 3
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 abstract 3
- 201000003793 Myelodysplastic syndrome Diseases 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 229940075628 hypomethylating agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención está dirigida a un método para tratar una neoplasia maligna hematológica como la leucemia mieloide aguda (AML) o el síndrome mielodisplásico (MDS), que incluye neoplasias hematológicas que son refractivas a agentes quimioterapéuticos y/o hipometilantes. El método se refiere a la administración de una molécula de unión biespecífica CD123 x CD3 a un paciente en una cantidad eficaz para estimular la destrucción de células de dicha neoplasia maligna hematológica en dicho paciente. La presente invención se dirige además a la modalidad de dicho método en donde una muestra celular del paciente evidencia una expresión de uno o más genes objetivo que se incrementa en relación con un nivel de línea de base de expresión de dichos genes, por ejemplo, un nivel de línea de base de expresión de dichos genes en una población de referencia de individuos que padecen neoplasia maligna hematológica, o con respecto al nivel de expresión de un gen de referencia.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862752659P | 2018-10-30 | 2018-10-30 | |
US201862769078P | 2018-11-19 | 2018-11-19 | |
US201962878368P | 2019-07-25 | 2019-07-25 | |
PCT/US2019/058616 WO2020092404A1 (en) | 2018-10-30 | 2019-10-29 | Bispecific cd123 x cd3 diabodies for the treatment of hematologic malignancies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021004868A true MX2021004868A (es) | 2021-09-08 |
Family
ID=70464448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021004868A MX2021004868A (es) | 2018-10-30 | 2019-10-29 | Diacuerpos cd123 x cd3 biespecificos para el tratamiento de neoplasias hematologicas. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210395374A1 (es) |
EP (1) | EP3873606A4 (es) |
JP (1) | JP2022513402A (es) |
KR (1) | KR20210110567A (es) |
CN (1) | CN113286633A (es) |
AU (1) | AU2019371243A1 (es) |
BR (1) | BR112021008283A2 (es) |
CA (1) | CA3118081A1 (es) |
IL (1) | IL282827A (es) |
MX (1) | MX2021004868A (es) |
SG (1) | SG11202104367RA (es) |
WO (1) | WO2020092404A1 (es) |
ZA (1) | ZA202102775B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021257334A1 (en) * | 2020-06-18 | 2021-12-23 | Macrogenics, Inc. | Use of bispecific cd123 x cd3 diabodies for the treatment of hematologic malignancies |
KR20230157315A (ko) | 2021-01-28 | 2023-11-16 | 리제너론 파마슈티칼스 인코포레이티드 | 사이토카인 방출 증후군을 치료하기 위한 조성물 및 방법 |
CA3211006A1 (en) * | 2021-02-20 | 2022-08-25 | Kite Pharma, Inc. | Gene markers for sellecting immunotherapies |
WO2023092119A2 (en) * | 2021-11-22 | 2023-05-25 | Ludwig Institute For Cancer Research Ltd | Methods for predicting responsiveness to a cancer therapy |
TW202346337A (zh) * | 2022-03-29 | 2023-12-01 | 美商恩格姆生物製藥公司 | Ilt3及cd3結合劑以及其使用方法 |
WO2023201226A1 (en) | 2022-04-11 | 2023-10-19 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR048945A1 (es) * | 2004-05-06 | 2006-06-14 | Veridex Llc | Pronostico para leucemia mieloide cronica |
US8518405B2 (en) * | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
EP2839842A1 (en) * | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
US20160272720A1 (en) * | 2013-11-06 | 2016-09-22 | Memorial Sloan-Kettering Cancer Center | Compositions and Methods for the Treatment of Acute Myeloid Leukemias and Myelodysplastic Syndromes |
MX370272B (es) * | 2014-03-19 | 2019-12-09 | Cellectis | Receptores de antigeno quimerico especifico de cd123 para inmunoterapia de cancer. |
EP3364966A1 (en) * | 2015-10-23 | 2018-08-29 | Daiichi Sankyo Company, Limited | Pharmaceutical composition for use in treating aml and method of treating aml in a subject in need thereof |
JP2019517539A (ja) * | 2016-06-07 | 2019-06-24 | マクロジェニクス,インコーポレーテッド | 併用療法 |
TWI790206B (zh) * | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至cd3和cd123的雙特異性抗體樣結合蛋白 |
US20210061911A1 (en) * | 2017-09-07 | 2021-03-04 | Macrogenics, Inc. | Dosing Regiments of Bi-Specific CD123 x CD3 Diabodies in the Treatment of Hematologic Malignancies |
-
2019
- 2019-10-29 SG SG11202104367RA patent/SG11202104367RA/en unknown
- 2019-10-29 JP JP2021548536A patent/JP2022513402A/ja active Pending
- 2019-10-29 MX MX2021004868A patent/MX2021004868A/es unknown
- 2019-10-29 AU AU2019371243A patent/AU2019371243A1/en active Pending
- 2019-10-29 EP EP19878838.2A patent/EP3873606A4/en active Pending
- 2019-10-29 KR KR1020217014961A patent/KR20210110567A/ko unknown
- 2019-10-29 BR BR112021008283-2A patent/BR112021008283A2/pt unknown
- 2019-10-29 WO PCT/US2019/058616 patent/WO2020092404A1/en unknown
- 2019-10-29 US US17/290,061 patent/US20210395374A1/en active Pending
- 2019-10-29 CN CN201980087139.5A patent/CN113286633A/zh active Pending
- 2019-10-29 CA CA3118081A patent/CA3118081A1/en active Pending
-
2021
- 2021-04-26 ZA ZA2021/02775A patent/ZA202102775B/en unknown
- 2021-04-29 IL IL282827A patent/IL282827A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3873606A4 (en) | 2022-10-26 |
ZA202102775B (en) | 2022-03-30 |
AU2019371243A1 (en) | 2021-05-27 |
US20210395374A1 (en) | 2021-12-23 |
IL282827A (en) | 2021-06-30 |
SG11202104367RA (en) | 2021-05-28 |
WO2020092404A8 (en) | 2021-05-20 |
BR112021008283A2 (pt) | 2021-09-14 |
CA3118081A1 (en) | 2020-05-07 |
KR20210110567A (ko) | 2021-09-08 |
JP2022513402A (ja) | 2022-02-07 |
WO2020092404A1 (en) | 2020-05-07 |
EP3873606A1 (en) | 2021-09-08 |
CN113286633A (zh) | 2021-08-20 |
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