JP2017506666A - 高インスリン血症に関連した症状の処置 - Google Patents
高インスリン血症に関連した症状の処置 Download PDFInfo
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- JP2017506666A JP2017506666A JP2016554661A JP2016554661A JP2017506666A JP 2017506666 A JP2017506666 A JP 2017506666A JP 2016554661 A JP2016554661 A JP 2016554661A JP 2016554661 A JP2016554661 A JP 2016554661A JP 2017506666 A JP2017506666 A JP 2017506666A
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- Prior art keywords
- alkyl
- alkylene
- aryl
- heteroaryl
- heterocycloalkyl
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- MQIXMONQZBAABB-HNNXBMFYSA-N CC(C)(C)OC(C[C@@H](c1nnc(C(F)(F)F)[n]1-c1c2c(C)c(C)[s]1)N=C2c(cc1)ccc1Cl)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(C(F)(F)F)[n]1-c1c2c(C)c(C)[s]1)N=C2c(cc1)ccc1Cl)=O MQIXMONQZBAABB-HNNXBMFYSA-N 0.000 description 1
- NEOVTYQDNTUFDO-SFHVURJKSA-N CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O NEOVTYQDNTUFDO-SFHVURJKSA-N 0.000 description 1
- ACFYVOWECVLYMP-KRWDZBQOSA-N CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2cc[s]1)N=C2c1ccc(C)cc1)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(C)[n]1-c1c2cc[s]1)N=C2c1ccc(C)cc1)=O ACFYVOWECVLYMP-KRWDZBQOSA-N 0.000 description 1
- DNMKBLRJHYUGOG-SFHVURJKSA-N CC(C)(C)OC(C[C@@H](c1nnc(COC)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O Chemical compound CC(C)(C)OC(C[C@@H](c1nnc(COC)[n]1-c1c2c(C)c(C)[s]1)N=C2c1ccc(C)cc1)=O DNMKBLRJHYUGOG-SFHVURJKSA-N 0.000 description 1
- RKJJOHJEISURKY-ZENAZSQFSA-N CCC1N2c([s]c(C)c3C)c3C(c(cc3)ccc3Cl)=N[C@@H](CC(OC(C)(C)C)=O)C2=NN1 Chemical compound CCC1N2c([s]c(C)c3C)c3C(c(cc3)ccc3Cl)=N[C@@H](CC(OC(C)(C)C)=O)C2=NN1 RKJJOHJEISURKY-ZENAZSQFSA-N 0.000 description 1
- XOFSUERZLYLNTE-FQEVSTJZSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCCNCCNC)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCCNCCNC)=O)c1nnc(C)[n]-21 XOFSUERZLYLNTE-FQEVSTJZSA-N 0.000 description 1
- CVPIVJUAWTWRAZ-NRFANRHFSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCN(C)CC1)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCN(C)CC1)=O)c1nnc(C)[n]-21 CVPIVJUAWTWRAZ-NRFANRHFSA-N 0.000 description 1
- KULOTNHGHJGDQB-FQEVSTJZSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCOCC1)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(NCCN1CCOCC1)=O)c1nnc(C)[n]-21 KULOTNHGHJGDQB-FQEVSTJZSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461946682P | 2014-02-28 | 2014-02-28 | |
US61/946,682 | 2014-02-28 | ||
US201462019777P | 2014-07-01 | 2014-07-01 | |
US62/019,777 | 2014-07-01 | ||
US201462054620P | 2014-09-24 | 2014-09-24 | |
US62/054,620 | 2014-09-24 | ||
PCT/US2015/018118 WO2015131113A1 (en) | 2014-02-28 | 2015-02-27 | Treatment of conditions associated with hyperinsulinaemia |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018222642A Division JP6629947B2 (ja) | 2014-02-28 | 2018-11-28 | 高インスリン血症に関連した症状の処置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017506666A true JP2017506666A (ja) | 2017-03-09 |
JP2017506666A5 JP2017506666A5 (id) | 2018-02-22 |
Family
ID=52693055
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016554661A Withdrawn JP2017506666A (ja) | 2014-02-28 | 2015-02-27 | 高インスリン血症に関連した症状の処置 |
JP2018222642A Expired - Fee Related JP6629947B2 (ja) | 2014-02-28 | 2018-11-28 | 高インスリン血症に関連した症状の処置 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018222642A Expired - Fee Related JP6629947B2 (ja) | 2014-02-28 | 2018-11-28 | 高インスリン血症に関連した症状の処置 |
Country Status (12)
Country | Link |
---|---|
US (1) | US10925881B2 (id) |
EP (1) | EP3110424A1 (id) |
JP (2) | JP2017506666A (id) |
KR (1) | KR20160130778A (id) |
CN (1) | CN106456653A (id) |
AU (1) | AU2015222805B2 (id) |
CA (1) | CA2940472A1 (id) |
IL (1) | IL247354B (id) |
MX (1) | MX2016011160A (id) |
RU (1) | RU2722179C2 (id) |
SG (1) | SG11201607108XA (id) |
WO (1) | WO2015131113A1 (id) |
Families Citing this family (15)
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CN104311562B (zh) | 2010-05-14 | 2017-07-04 | 达那-法伯癌症研究所 | 用于治疗瘤形成、炎性疾病和其他失调的组合物和方法 |
BR112012029057A2 (pt) | 2010-05-14 | 2020-10-13 | Dana-Farber Cancer Institute, Inc. | composições e métodos de tratamento de leucemia |
JP6637884B2 (ja) | 2013-11-08 | 2020-01-29 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ブロモドメインおよびエクストラターミナル(bet)タンパク質インヒビターを使用するがんのための併用療法 |
EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
MX2016011160A (es) | 2014-02-28 | 2017-04-27 | Tensha Therapeutics Inc | Tratamiento de afecciones asociadas con la hiperinsulinemia. |
SG11201703414VA (en) | 2014-10-27 | 2017-05-30 | Tensha Therapeutics Inc | Bromodomain inhibitors |
CA2989313A1 (en) | 2015-06-26 | 2016-12-29 | Tensha Therapeutics, Inc. | Treatment of nut midline carcinoma |
JP2018526424A (ja) | 2015-09-11 | 2018-09-13 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | アセトアミドチエノトリアゾロジアゼピンおよびこれらの使用 |
MX2018003031A (es) | 2015-09-11 | 2018-08-01 | Dana Farber Cancer Inst Inc | Ciano tienotriazolpirazinas y usos de las mismas. |
RU2742035C2 (ru) | 2015-11-25 | 2021-02-01 | Дана-Фарбер Кэнсер Инститьют, Инк. | Бивалентные ингибиторы бромодоменов и пути их применения |
CA3041949A1 (en) * | 2016-12-16 | 2018-06-21 | F. Hoffmann-La Roche Ag | Process for the manufacture of diazepine derivatives |
CN111094263A (zh) * | 2017-09-14 | 2020-05-01 | 豪夫迈·罗氏有限公司 | 可用于制造药物的新化合物 |
KR20210020889A (ko) | 2018-06-13 | 2021-02-24 | 디블라이 아게 | 응축된 트리아제핀 유도체의 제조 및 이의 bet 억제제로서 용도 |
CN111253871A (zh) * | 2020-03-13 | 2020-06-09 | 东莞市永益诚电子有限公司 | 一种钢化膜及其制备方法 |
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AU2015222805A1 (en) | 2016-09-15 |
CA2940472A1 (en) | 2015-09-03 |
JP6629947B2 (ja) | 2020-01-15 |
RU2016138027A3 (id) | 2018-10-29 |
JP2019059751A (ja) | 2019-04-18 |
AU2015222805B2 (en) | 2020-05-21 |
RU2722179C2 (ru) | 2020-05-28 |
US20170209461A1 (en) | 2017-07-27 |
MX2016011160A (es) | 2017-04-27 |
KR20160130778A (ko) | 2016-11-14 |
WO2015131113A1 (en) | 2015-09-03 |
IL247354B (en) | 2020-06-30 |
EP3110424A1 (en) | 2017-01-04 |
CN106456653A (zh) | 2017-02-22 |
SG11201607108XA (en) | 2016-09-29 |
IL247354A0 (en) | 2016-11-30 |
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