JP2017504601A - 免疫療法のためにマルチインプットシグナル感受性ｔ細胞を操作する方法 - Google Patents

免疫療法のためにマルチインプットシグナル感受性ｔ細胞を操作する方法 Download PDF

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JP2017504601A
JP2017504601A JP2016541194A JP2016541194A JP2017504601A JP 2017504601 A JP2017504601 A JP 2017504601A JP 2016541194 A JP2016541194 A JP 2016541194A JP 2016541194 A JP2016541194 A JP 2016541194A JP 2017504601 A JP2017504601 A JP 2017504601A
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JP2017504601A5 (enExample
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アレキサンドル ジュイラ
アレキサンドル ジュイラ
クラウディア ベルトナティ
クラウディア ベルトナティ
ジュリアン ヴァルトン
ジュリアン ヴァルトン
フィリップ デュシャトー
フィリップ デュシャトー
ローラン ポワロ
ローラン ポワロ
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12N2510/00—Genetically modified cells
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JP2016541194A 2013-12-20 2014-12-19 免疫療法のためにマルチインプットシグナル感受性ｔ細胞を操作する方法 Pending JP2017504601A (ja)

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DKPA201370806 2013-12-20
DKPA201370806 2013-12-20
PCT/EP2014/078876 WO2015092024A2 (en) 2013-12-20 2014-12-19 Method of engineering multi-input signal sensitive t cell for immunotherapy

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EP (2) EP3808410A1 (enExample)
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Cited By (7)

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JP2020512019A (ja) * 2017-03-31 2020-04-23 セレクティス ソシエテ アノニム ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞
WO2020175366A1 (ja) * 2019-02-25 2020-09-03 国立大学法人東京医科歯科大学 キメラ抗原受容体
JPWO2021131944A1 (enExample) * 2019-12-27 2021-07-01
JP2022520285A (ja) * 2019-02-19 2022-03-29 キングス カレッジ ロンドン 低酸素応答性キメラ抗原受容体
JP2022533806A (ja) * 2018-11-06 2022-07-26 イミュニティーバイオ、インコーポレイテッド キメラ抗原受容体で修飾されたｎｋ－９２細胞
JP2024001096A (ja) * 2018-05-22 2024-01-09 イミュニティーバイオ、インコーポレイテッド ＦｃイプシロンＣＡＲ
US12109238B2 (en) 2018-11-06 2024-10-08 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells

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