JP2017500880A5 - - Google Patents
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- Publication number
- JP2017500880A5 JP2017500880A5 JP2016544159A JP2016544159A JP2017500880A5 JP 2017500880 A5 JP2017500880 A5 JP 2017500880A5 JP 2016544159 A JP2016544159 A JP 2016544159A JP 2016544159 A JP2016544159 A JP 2016544159A JP 2017500880 A5 JP2017500880 A5 JP 2017500880A5
- Authority
- JP
- Japan
- Prior art keywords
- gram
- modified
- positive bacterial
- mutation
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001580 bacterial effect Effects 0.000 claims 31
- 230000035772 mutation Effects 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 14
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 101150084945 pdhA gene Proteins 0.000 claims 9
- 101150028177 pdhB gene Proteins 0.000 claims 8
- 101150015354 pdhD gene Proteins 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 238000012239 gene modification Methods 0.000 claims 6
- 230000005017 genetic modification Effects 0.000 claims 6
- 235000013617 genetically modified food Nutrition 0.000 claims 6
- 241000192125 Firmicutes Species 0.000 claims 4
- 101150037483 bkdA gene Proteins 0.000 claims 4
- 101150103637 bkdB gene Proteins 0.000 claims 4
- 101150086832 pdhC gene Proteins 0.000 claims 4
- 230000037432 silent mutation Effects 0.000 claims 3
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922038P | 2013-12-30 | 2013-12-30 | |
| US61/922,038 | 2013-12-30 | ||
| PCT/US2014/068745 WO2015102809A1 (en) | 2013-12-30 | 2014-12-05 | Enhanced protein expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500880A JP2017500880A (ja) | 2017-01-12 |
| JP2017500880A5 true JP2017500880A5 (enExample) | 2017-12-28 |
| JP6573891B2 JP6573891B2 (ja) | 2019-09-11 |
Family
ID=52273522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544159A Active JP6573891B2 (ja) | 2013-12-30 | 2014-12-05 | タンパク質発現の増大 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190032065A1 (enExample) |
| EP (1) | EP3089990B1 (enExample) |
| JP (1) | JP6573891B2 (enExample) |
| CN (1) | CN106103470B (enExample) |
| CA (1) | CA2935063C (enExample) |
| DK (1) | DK3089990T3 (enExample) |
| MX (1) | MX2016008716A (enExample) |
| WO (1) | WO2015102809A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109355303B (zh) * | 2018-11-14 | 2022-05-06 | 天津大学 | 抑制和/或敲除基因在提高单克隆抗体的表达量中的应用 |
| CN113366108B (zh) * | 2018-11-28 | 2024-11-22 | 丹尼斯科美国公司 | 新颖启动子序列及其增强芽孢杆菌属细胞蛋白生产的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1926431A (zh) * | 2004-01-09 | 2007-03-07 | 诺维信股份有限公司 | 地衣芽孢杆菌染色体 |
| WO2005069762A2 (en) * | 2004-01-09 | 2005-08-04 | Novozymes Inc. | Bacillus licheniformis chromosome |
| JP2009538603A (ja) * | 2006-06-02 | 2009-11-12 | ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド | 微生物の検出および分析に使用するための微生物改変核酸 |
| US20100064393A1 (en) * | 2006-11-29 | 2010-03-11 | Novozymes, Inc. | Bacillus liceniformis chromosome |
-
2014
- 2014-12-05 DK DK14821373.9T patent/DK3089990T3/da active
- 2014-12-05 JP JP2016544159A patent/JP6573891B2/ja active Active
- 2014-12-05 EP EP14821373.9A patent/EP3089990B1/en active Active
- 2014-12-05 US US15/108,106 patent/US20190032065A1/en not_active Abandoned
- 2014-12-05 CN CN201480076466.8A patent/CN106103470B/zh active Active
- 2014-12-05 CA CA2935063A patent/CA2935063C/en active Active
- 2014-12-05 WO PCT/US2014/068745 patent/WO2015102809A1/en not_active Ceased
- 2014-12-05 MX MX2016008716A patent/MX2016008716A/es unknown
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