JP2017500880A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017500880A5 JP2017500880A5 JP2016544159A JP2016544159A JP2017500880A5 JP 2017500880 A5 JP2017500880 A5 JP 2017500880A5 JP 2016544159 A JP2016544159 A JP 2016544159A JP 2016544159 A JP2016544159 A JP 2016544159A JP 2017500880 A5 JP2017500880 A5 JP 2017500880A5
- Authority
- JP
- Japan
- Prior art keywords
- gram
- modified
- positive bacterial
- mutation
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001580 bacterial effect Effects 0.000 claims 31
- 230000035772 mutation Effects 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 14
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 101150084945 pdhA gene Proteins 0.000 claims 9
- 101150028177 pdhB gene Proteins 0.000 claims 8
- 101150015354 pdhD gene Proteins 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 238000012239 gene modification Methods 0.000 claims 6
- 230000005017 genetic modification Effects 0.000 claims 6
- 235000013617 genetically modified food Nutrition 0.000 claims 6
- 241000192125 Firmicutes Species 0.000 claims 4
- 101150037483 bkdA gene Proteins 0.000 claims 4
- 101150103637 bkdB gene Proteins 0.000 claims 4
- 101150086832 pdhC gene Proteins 0.000 claims 4
- 230000037432 silent mutation Effects 0.000 claims 3
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922038P | 2013-12-30 | 2013-12-30 | |
| US61/922,038 | 2013-12-30 | ||
| PCT/US2014/068745 WO2015102809A1 (en) | 2013-12-30 | 2014-12-05 | Enhanced protein expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500880A JP2017500880A (ja) | 2017-01-12 |
| JP2017500880A5 true JP2017500880A5 (enExample) | 2017-12-28 |
| JP6573891B2 JP6573891B2 (ja) | 2019-09-11 |
Family
ID=52273522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544159A Active JP6573891B2 (ja) | 2013-12-30 | 2014-12-05 | タンパク質発現の増大 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190032065A1 (enExample) |
| EP (1) | EP3089990B1 (enExample) |
| JP (1) | JP6573891B2 (enExample) |
| CN (1) | CN106103470B (enExample) |
| CA (1) | CA2935063C (enExample) |
| DK (1) | DK3089990T3 (enExample) |
| MX (1) | MX2016008716A (enExample) |
| WO (1) | WO2015102809A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109355303B (zh) * | 2018-11-14 | 2022-05-06 | 天津大学 | 抑制和/或敲除基因在提高单克隆抗体的表达量中的应用 |
| KR20210096629A (ko) * | 2018-11-28 | 2021-08-05 | 다니스코 유에스 인크. | 바실러스 세포에서의 향상된 단백질 생산을 위한 신규 프로모터 서열 및 이의 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2284185A3 (en) * | 2004-01-09 | 2011-05-18 | Novozymes A/S | Bacillus protein inactivation |
| CN1926431A (zh) * | 2004-01-09 | 2007-03-07 | 诺维信股份有限公司 | 地衣芽孢杆菌染色体 |
| CA2654010A1 (en) * | 2006-06-02 | 2007-12-13 | Human Genetic Signatures Pty Ltd | Modified microbial nucleic acid for use in detection and analysis of microorganisms |
| WO2008066931A2 (en) * | 2006-11-29 | 2008-06-05 | Novozymes, Inc. | Bacillus licheniformis chromosome |
-
2014
- 2014-12-05 MX MX2016008716A patent/MX2016008716A/es unknown
- 2014-12-05 CN CN201480076466.8A patent/CN106103470B/zh active Active
- 2014-12-05 DK DK14821373.9T patent/DK3089990T3/da active
- 2014-12-05 CA CA2935063A patent/CA2935063C/en active Active
- 2014-12-05 WO PCT/US2014/068745 patent/WO2015102809A1/en not_active Ceased
- 2014-12-05 EP EP14821373.9A patent/EP3089990B1/en active Active
- 2014-12-05 JP JP2016544159A patent/JP6573891B2/ja active Active
- 2014-12-05 US US15/108,106 patent/US20190032065A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Park et al. | Low‐pH production of d‐lactic acid using newly isolated acid tolerant yeast Pichia kudriavzevii NG7 | |
| RU2013134401A (ru) | Микроорганизм с повышенной продукцией l-аминокислот и способ получения l-аминокислот с его применением | |
| JP6660181B2 (ja) | トリコデルマリーセイＱＭ６ａおよびその誘導体中の交配障害と関連する遺伝子／遺伝要素ならびにその同定方法 | |
| CN103146772A (zh) | 用乌头酸酶表达弱化和/或酶活性降低的细菌发酵生产l-赖氨酸的方法 | |
| CN106995817A (zh) | 一种编码叶绿体碳酸酐酶基因在构建耐高浓度co2且快速生长的工业工程微藻中的应用 | |
| MY194223A (en) | Method and microorganism for methionine production by fermentation with improved methionine efflux | |
| Davolos et al. | A molecular and bioinformatic study on the ochratoxin A (OTA)-producing Aspergillus affinis (section Circumdati) | |
| JP2017500880A5 (enExample) | ||
| CN108603160A (zh) | 突变丝状菌的制造方法 | |
| CN112553090B (zh) | 一株高产sorbicillinoids的里氏木霉工程菌及其构建方法与应用 | |
| CN107058264B (zh) | 比活提高的α-淀粉酶JcAmy突变体及其编码基因和应用 | |
| KR20160111947A (ko) | 재조합 미생물의 생산 방법 | |
| CN105087632B (zh) | 一种酿酒酵母染色体及其构建方法与应用 | |
| CN105331601B (zh) | 一种基于自然转化的副猪嗜血杆菌高效遗传重组方法及应用 | |
| JP2017500879A5 (enExample) | ||
| CN103614408B (zh) | 一种敲除prcK基因的自杀质粒pYTKLKRT及其构建方法 | |
| CN103131738B (zh) | 用改变乌头酸酶调控元件的细菌发酵生产l-赖氨酸的方法 | |
| Sun et al. | Draft genome sequence of Bacillus amyloliquefaciens XK-4-1, a plant growth-promoting endophyte with antifungal activity | |
| CN103194439A (zh) | 一种工业黄酒酵母单倍体的分离方法 | |
| CN104046635A (zh) | 特异响应逆境信号的nfiS基因的用途及其使用方法 | |
| JP6465470B2 (ja) | 糖化酵素の生産方法、及び草木類バイオマスの糖化処理方法 | |
| Wang et al. | A simple and efficient method for successful gene silencing of HspA1 in Trametes hirsuta AH28-2 | |
| Kadam et al. | Connecting Biology With Biotechnology: Industrial Applications of Adaptive Laboratory Evolution | |
| CN103173505B (zh) | 用改变乌头酸酶调控元件的细菌发酵生产l-苏氨酸的方法 | |
| CN107267541A (zh) | 利用galT基因缺失菌株通过发酵生产L‑氨基酸的方法 |