DK3089990T3 - Forbedret proteinekspression - Google Patents
Forbedret proteinekspression Download PDFInfo
- Publication number
- DK3089990T3 DK3089990T3 DK14821373.9T DK14821373T DK3089990T3 DK 3089990 T3 DK3089990 T3 DK 3089990T3 DK 14821373 T DK14821373 T DK 14821373T DK 3089990 T3 DK3089990 T3 DK 3089990T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein expression
- improved protein
- improved
- expression
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2445—Beta-glucosidase (3.2.1.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922038P | 2013-12-30 | 2013-12-30 | |
| PCT/US2014/068745 WO2015102809A1 (en) | 2013-12-30 | 2014-12-05 | Enhanced protein expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3089990T3 true DK3089990T3 (da) | 2020-08-24 |
Family
ID=52273522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14821373.9T DK3089990T3 (da) | 2013-12-30 | 2014-12-05 | Forbedret proteinekspression |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190032065A1 (enExample) |
| EP (1) | EP3089990B1 (enExample) |
| JP (1) | JP6573891B2 (enExample) |
| CN (1) | CN106103470B (enExample) |
| CA (1) | CA2935063C (enExample) |
| DK (1) | DK3089990T3 (enExample) |
| MX (1) | MX2016008716A (enExample) |
| WO (1) | WO2015102809A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109355303B (zh) * | 2018-11-14 | 2022-05-06 | 天津大学 | 抑制和/或敲除基因在提高单克隆抗体的表达量中的应用 |
| KR20210096629A (ko) * | 2018-11-28 | 2021-08-05 | 다니스코 유에스 인크. | 바실러스 세포에서의 향상된 단백질 생산을 위한 신규 프로모터 서열 및 이의 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1926431A (zh) * | 2004-01-09 | 2007-03-07 | 诺维信股份有限公司 | 地衣芽孢杆菌染色体 |
| WO2005069762A2 (en) * | 2004-01-09 | 2005-08-04 | Novozymes Inc. | Bacillus licheniformis chromosome |
| JP2009538603A (ja) * | 2006-06-02 | 2009-11-12 | ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド | 微生物の検出および分析に使用するための微生物改変核酸 |
| EP2099818A2 (en) * | 2006-11-29 | 2009-09-16 | Novozymes Inc. | Bacillus licheniformis chromosome |
-
2014
- 2014-12-05 MX MX2016008716A patent/MX2016008716A/es unknown
- 2014-12-05 US US15/108,106 patent/US20190032065A1/en not_active Abandoned
- 2014-12-05 CA CA2935063A patent/CA2935063C/en active Active
- 2014-12-05 WO PCT/US2014/068745 patent/WO2015102809A1/en not_active Ceased
- 2014-12-05 JP JP2016544159A patent/JP6573891B2/ja active Active
- 2014-12-05 CN CN201480076466.8A patent/CN106103470B/zh active Active
- 2014-12-05 EP EP14821373.9A patent/EP3089990B1/en active Active
- 2014-12-05 DK DK14821373.9T patent/DK3089990T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3089990B1 (en) | 2020-05-20 |
| EP3089990A1 (en) | 2016-11-09 |
| JP2017500880A (ja) | 2017-01-12 |
| CN106103470B (zh) | 2020-10-27 |
| CA2935063A1 (en) | 2015-07-09 |
| CN106103470A (zh) | 2016-11-09 |
| CA2935063C (en) | 2022-06-21 |
| JP6573891B2 (ja) | 2019-09-11 |
| MX2016008716A (es) | 2016-10-13 |
| WO2015102809A1 (en) | 2015-07-09 |
| US20190032065A1 (en) | 2019-01-31 |
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