JP2017522898A5 - - Google Patents
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- Publication number
- JP2017522898A5 JP2017522898A5 JP2017507820A JP2017507820A JP2017522898A5 JP 2017522898 A5 JP2017522898 A5 JP 2017522898A5 JP 2017507820 A JP2017507820 A JP 2017507820A JP 2017507820 A JP2017507820 A JP 2017507820A JP 2017522898 A5 JP2017522898 A5 JP 2017522898A5
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- JP
- Japan
- Prior art keywords
- bacterium
- gene
- parent
- compared
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000894006 Bacteria Species 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 230000035772 mutation Effects 0.000 claims description 17
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 15
- 108010031234 carbon monoxide dehydrogenase Proteins 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 8
- 230000014509 gene expression Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- 241000193403 Clostridium Species 0.000 claims description 4
- 101150047711 acs gene Proteins 0.000 claims description 4
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 230000006698 induction Effects 0.000 claims description 4
- 241001656809 Clostridium autoethanogenum Species 0.000 claims description 3
- 241001611023 Clostridium ragsdalei Species 0.000 claims description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 11
- 244000005700 microbiome Species 0.000 description 9
- 239000000047 product Substances 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000000446 fuel Substances 0.000 description 2
- 238000012239 gene modification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000002708 random mutagenesis Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462036101P | 2014-08-11 | 2014-08-11 | |
| US201462036107P | 2014-08-11 | 2014-08-11 | |
| US201462036104P | 2014-08-11 | 2014-08-11 | |
| US62/036,107 | 2014-08-11 | ||
| US62/036,104 | 2014-08-11 | ||
| US62/036,101 | 2014-08-11 | ||
| PCT/US2015/038395 WO2016025096A1 (en) | 2014-08-11 | 2015-06-29 | Genetically engineered bacterium with altered carbon monoxide dehydrogenase (codh) activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522898A JP2017522898A (ja) | 2017-08-17 |
| JP2017522898A5 true JP2017522898A5 (enExample) | 2018-11-22 |
| JP6454000B2 JP6454000B2 (ja) | 2019-01-16 |
Family
ID=55266958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017507820A Active JP6454000B2 (ja) | 2014-08-11 | 2015-06-29 | 一酸化炭素デヒドロゲナーゼ（ｃｏｄｈ）活性が改変された遺伝子組換え微生物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9365873B2 (enExample) |
| EP (1) | EP3180421B1 (enExample) |
| JP (1) | JP6454000B2 (enExample) |
| KR (1) | KR102308556B1 (enExample) |
| CN (1) | CN107223152B (enExample) |
| CA (1) | CA2956204C (enExample) |
| ES (1) | ES2728726T3 (enExample) |
| MY (1) | MY178182A (enExample) |
| PL (1) | PL3180421T3 (enExample) |
| PT (1) | PT3180421T (enExample) |
| WO (1) | WO2016025096A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2018070141A1 (ja) * | 2016-10-13 | 2019-08-08 | 積水化学工業株式会社 | 偏性嫌気性酢酸生成微生物、並びに、組換え微生物 |
| KR102397454B1 (ko) * | 2020-07-24 | 2022-05-12 | 울산과학기술원 | 전자전달체에 대한 친화도 및 반응 속도가 우수한 일산화탄소 탈수소효소 및 그의 용도 |
| KR102393114B1 (ko) * | 2020-07-24 | 2022-05-02 | 울산과학기술원 | 산소 내성 및 효소 활성이 우수한 일산화탄소 탈수소효소 및 그의 용도 |
| KR20250103852A (ko) * | 2023-12-28 | 2025-07-08 | 울산과학기술원 | 대기 조건하에서 산소 내성 및 효소 활성이 우수한 일산화탄소 탈수소효소 및 그의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
| US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
| CN102876609A (zh) | 2007-11-13 | 2013-01-16 | 兰扎泰克新西兰有限公司 | 新型菌及其使用方法 |
| AU2009327490A1 (en) * | 2008-12-16 | 2011-07-28 | Genomatica, Inc. | Microorganisms and methods for conversion of syngas and other carbon sources to useful products |
| US8039239B2 (en) * | 2008-12-16 | 2011-10-18 | Coskata, Inc. | Recombinant microorganisms having modified production of alcohols and acids |
| CA2802015C (en) * | 2010-06-09 | 2018-01-16 | Coskata, Inc. | Cloning and expression of the genes encoding key clostridial catalyzing mechanisms for syngas to ethanol production and functional characterization thereof |
| KR101865779B1 (ko) * | 2011-11-16 | 2018-06-12 | 한국과학기술원 | 이산화탄소 고정능을 가지는 재조합 미생물 및 이를 이용한 유용물질의 제조 방법 |
| KR101511639B1 (ko) | 2012-01-31 | 2015-04-16 | 란자테크 뉴질랜드 리미티드 | 재조합 미생물 및 이의 사용 방법 |
-
2015
- 2015-06-29 MY MYPI2017700269A patent/MY178182A/en unknown
- 2015-06-29 PT PT15831619T patent/PT3180421T/pt unknown
- 2015-06-29 WO PCT/US2015/038395 patent/WO2016025096A1/en not_active Ceased
- 2015-06-29 CN CN201580046080.7A patent/CN107223152B/zh active Active
- 2015-06-29 EP EP15831619.0A patent/EP3180421B1/en active Active
- 2015-06-29 CA CA2956204A patent/CA2956204C/en active Active
- 2015-06-29 ES ES15831619T patent/ES2728726T3/es active Active
- 2015-06-29 PL PL15831619T patent/PL3180421T3/pl unknown
- 2015-06-29 US US14/753,191 patent/US9365873B2/en active Active
- 2015-06-29 KR KR1020177005901A patent/KR102308556B1/ko active Active
- 2015-06-29 JP JP2017507820A patent/JP6454000B2/ja active Active
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