JP2017500879A5 - - Google Patents
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- Publication number
- JP2017500879A5 JP2017500879A5 JP2016544103A JP2016544103A JP2017500879A5 JP 2017500879 A5 JP2017500879 A5 JP 2017500879A5 JP 2016544103 A JP2016544103 A JP 2016544103A JP 2016544103 A JP2016544103 A JP 2016544103A JP 2017500879 A5 JP2017500879 A5 JP 2017500879A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- gram
- modified
- modification
- positive bacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 32
- 230000001580 bacterial effect Effects 0.000 claims 24
- 238000012239 gene modification Methods 0.000 claims 21
- 230000005017 genetic modification Effects 0.000 claims 21
- 235000013617 genetically modified food Nutrition 0.000 claims 21
- 230000004048 modification Effects 0.000 claims 19
- 238000012986 modification Methods 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 101150071070 ykfA gene Proteins 0.000 claims 5
- 230000008859 change Effects 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922613P | 2013-12-31 | 2013-12-31 | |
| US61/922,613 | 2013-12-31 | ||
| PCT/US2014/069019 WO2015102814A1 (en) | 2013-12-31 | 2014-12-08 | Enhanced protein expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500879A JP2017500879A (ja) | 2017-01-12 |
| JP2017500879A5 true JP2017500879A5 (enExample) | 2017-12-28 |
| JP6585602B2 JP6585602B2 (ja) | 2019-10-02 |
Family
ID=52273531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544103A Active JP6585602B2 (ja) | 2013-12-31 | 2014-12-08 | タンパク質発現の増大 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10287591B2 (enExample) |
| EP (1) | EP3089991B1 (enExample) |
| JP (1) | JP6585602B2 (enExample) |
| CN (1) | CN106068273B (enExample) |
| CA (1) | CA2935066C (enExample) |
| DK (1) | DK3089991T3 (enExample) |
| MX (1) | MX2016008595A (enExample) |
| WO (1) | WO2015102814A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106599611B (zh) * | 2016-12-09 | 2019-04-30 | 中南大学 | 蛋白质功能标注方法及系统 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302544A (en) | 1979-10-15 | 1981-11-24 | University Of Rochester | Asporogenous mutant of B. subtilis for use as host component of HV1 system |
| US4450235A (en) | 1982-04-21 | 1984-05-22 | Cpc International Inc. | Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system |
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5310675A (en) | 1983-06-24 | 1994-05-10 | Genencor, Inc. | Procaryotic carbonyl hydrolases |
| NZ208806A (en) | 1983-07-06 | 1988-07-28 | Gist Brocades Nv | Genetic engineering of industrial microorganism species: readily-transformable host used as intermediate in transfer of dna to the industrial species; plasmids |
| US5264366A (en) | 1984-05-29 | 1993-11-23 | Genencor, Inc. | Protease deficient bacillus |
| US5801038A (en) | 1984-05-29 | 1998-09-01 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| EP0254735B2 (en) | 1986-01-15 | 1998-06-17 | Amgen Inc. | METHOD FOR PRODUCTION OF THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS |
| US4980288A (en) | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
| GB8608194D0 (en) | 1986-04-03 | 1986-05-08 | Massey Ferguson Services Nv | Valve control system |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| JP3026567B2 (ja) | 1987-02-27 | 2000-03-27 | ジェネンコー インターナショナル インコーポレイテッド | 分子のクローニング及びタンパク分解酵素をコードする遺伝子の発現 |
| US4914031A (en) | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| PT89702B (pt) | 1988-02-11 | 1994-04-29 | Gist Brocades Nv | Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem |
| US5665587A (en) | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
| US5482849A (en) | 1990-12-21 | 1996-01-09 | Novo Nordisk A/S | Subtilisin mutants |
| EP0583339B1 (en) | 1991-05-01 | 1998-07-08 | Novo Nordisk A/S | Stabilized enzymes and detergent compositions |
| DE4411223A1 (de) | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren |
| AR015977A1 (es) | 1997-10-23 | 2001-05-30 | Genencor Int | Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes |
| US6835550B1 (en) | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US6617148B2 (en) * | 2000-06-29 | 2003-09-09 | E. I. Du Pont De Nemours And Company | Natural promoters for gene expression and metabolic monitoring in bacillus species |
| WO2003070963A2 (en) | 2002-02-15 | 2003-08-28 | Genencor International, Inc. | Improved protein expression in bacillus subtilis |
| WO2006057341A1 (ja) * | 2004-11-26 | 2006-06-01 | Kyowa Hakko Kogyo Co., Ltd. | 工業的に有用な微生物 |
| WO2008066931A2 (en) * | 2006-11-29 | 2008-06-05 | Novozymes, Inc. | Bacillus licheniformis chromosome |
| US20100022861A1 (en) | 2008-07-28 | 2010-01-28 | Medtronic, Inc. | Implantable optical hemodynamic sensor including an extension member |
| AR076941A1 (es) | 2009-06-11 | 2011-07-20 | Danisco Us Inc | Cepa de bacillus para una mayor produccion de proteina |
-
2014
- 2014-12-08 WO PCT/US2014/069019 patent/WO2015102814A1/en not_active Ceased
- 2014-12-08 MX MX2016008595A patent/MX2016008595A/es unknown
- 2014-12-08 CA CA2935066A patent/CA2935066C/en active Active
- 2014-12-08 DK DK14821382T patent/DK3089991T3/da active
- 2014-12-08 CN CN201480076332.6A patent/CN106068273B/zh active Active
- 2014-12-08 JP JP2016544103A patent/JP6585602B2/ja active Active
- 2014-12-08 EP EP14821382.0A patent/EP3089991B1/en active Active
- 2014-12-08 US US15/108,074 patent/US10287591B2/en active Active
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