JP6585602B2 - タンパク質発現の増大 - Google Patents

タンパク質発現の増大 Download PDF

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Publication number
JP6585602B2
JP6585602B2 JP2016544103A JP2016544103A JP6585602B2 JP 6585602 B2 JP6585602 B2 JP 6585602B2 JP 2016544103 A JP2016544103 A JP 2016544103A JP 2016544103 A JP2016544103 A JP 2016544103A JP 6585602 B2 JP6585602 B2 JP 6585602B2
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protein
gram
positive bacterial
amino acid
modified
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Japanese (ja)
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JP2017500879A (ja
JP2017500879A5 (enExample
Inventor
ボンジョルニ、クリスティーナ
シュミット、ブライアン・エフ
オオツカ、レイ
ヴァン・キンメネード、アニータ
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ダニスコ・ユーエス・インク
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2016544103A 2013-12-31 2014-12-08 タンパク質発現の増大 Active JP6585602B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361922613P 2013-12-31 2013-12-31
US61/922,613 2013-12-31
PCT/US2014/069019 WO2015102814A1 (en) 2013-12-31 2014-12-08 Enhanced protein expression

Publications (3)

Publication Number Publication Date
JP2017500879A JP2017500879A (ja) 2017-01-12
JP2017500879A5 JP2017500879A5 (enExample) 2017-12-28
JP6585602B2 true JP6585602B2 (ja) 2019-10-02

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Family Applications (1)

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JP2016544103A Active JP6585602B2 (ja) 2013-12-31 2014-12-08 タンパク質発現の増大

Country Status (8)

Country Link
US (1) US10287591B2 (enExample)
EP (1) EP3089991B1 (enExample)
JP (1) JP6585602B2 (enExample)
CN (1) CN106068273B (enExample)
CA (1) CA2935066C (enExample)
DK (1) DK3089991T3 (enExample)
MX (1) MX2016008595A (enExample)
WO (1) WO2015102814A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106599611B (zh) * 2016-12-09 2019-04-30 中南大学 蛋白质功能标注方法及系统

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302544A (en) 1979-10-15 1981-11-24 University Of Rochester Asporogenous mutant of B. subtilis for use as host component of HV1 system
US4450235A (en) 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5310675A (en) 1983-06-24 1994-05-10 Genencor, Inc. Procaryotic carbonyl hydrolases
NZ208806A (en) 1983-07-06 1988-07-28 Gist Brocades Nv Genetic engineering of industrial microorganism species: readily-transformable host used as intermediate in transfer of dna to the industrial species; plasmids
US5264366A (en) 1984-05-29 1993-11-23 Genencor, Inc. Protease deficient bacillus
US5801038A (en) 1984-05-29 1998-09-01 Genencor International Inc. Modified subtilisins having amino acid alterations
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
EP0254735B2 (en) 1986-01-15 1998-06-17 Amgen Inc. METHOD FOR PRODUCTION OF THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS
US4980288A (en) 1986-02-12 1990-12-25 Genex Corporation Subtilisin with increased thermal stability
GB8608194D0 (en) 1986-04-03 1986-05-08 Massey Ferguson Services Nv Valve control system
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
JP3026567B2 (ja) 1987-02-27 2000-03-27 ジェネンコー インターナショナル インコーポレイテッド 分子のクローニング及びタンパク分解酵素をコードする遺伝子の発現
US4914031A (en) 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
PT89702B (pt) 1988-02-11 1994-04-29 Gist Brocades Nv Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem
US5665587A (en) 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
DK97190D0 (da) 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
US5482849A (en) 1990-12-21 1996-01-09 Novo Nordisk A/S Subtilisin mutants
EP0583339B1 (en) 1991-05-01 1998-07-08 Novo Nordisk A/S Stabilized enzymes and detergent compositions
DE4411223A1 (de) 1994-03-31 1995-10-05 Solvay Enzymes Gmbh & Co Kg Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren
AR015977A1 (es) 1997-10-23 2001-05-30 Genencor Int Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6617148B2 (en) * 2000-06-29 2003-09-09 E. I. Du Pont De Nemours And Company Natural promoters for gene expression and metabolic monitoring in bacillus species
WO2003070963A2 (en) 2002-02-15 2003-08-28 Genencor International, Inc. Improved protein expression in bacillus subtilis
WO2006057341A1 (ja) * 2004-11-26 2006-06-01 Kyowa Hakko Kogyo Co., Ltd. 工業的に有用な微生物
WO2008066931A2 (en) * 2006-11-29 2008-06-05 Novozymes, Inc. Bacillus licheniformis chromosome
US20100022861A1 (en) 2008-07-28 2010-01-28 Medtronic, Inc. Implantable optical hemodynamic sensor including an extension member
AR076941A1 (es) 2009-06-11 2011-07-20 Danisco Us Inc Cepa de bacillus para una mayor produccion de proteina

Also Published As

Publication number Publication date
DK3089991T3 (da) 2019-12-02
JP2017500879A (ja) 2017-01-12
CA2935066A1 (en) 2015-07-09
MX2016008595A (es) 2016-10-28
CN106068273A (zh) 2016-11-02
CA2935066C (en) 2022-06-21
US20160319288A1 (en) 2016-11-03
US10287591B2 (en) 2019-05-14
WO2015102814A1 (en) 2015-07-09
CN106068273B (zh) 2021-01-08
EP3089991B1 (en) 2019-08-28
EP3089991A1 (en) 2016-11-09

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