JP2017114876A5 - - Google Patents

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Publication number
JP2017114876A5
JP2017114876A5 JP2017018192A JP2017018192A JP2017114876A5 JP 2017114876 A5 JP2017114876 A5 JP 2017114876A5 JP 2017018192 A JP2017018192 A JP 2017018192A JP 2017018192 A JP2017018192 A JP 2017018192A JP 2017114876 A5 JP2017114876 A5 JP 2017114876A5
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JP
Japan
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group
nitrogen
oxygen
sulfur
membered
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JP2017018192A
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English (en)
Japanese (ja)
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JP6786410B2 (ja
JP2017114876A (ja
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JP2017018192A 2008-04-08 2017-02-03 トリテルペンであるサポニン、その合成法および使用 Active JP6786410B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4319708P 2008-04-08 2008-04-08
US61/043,197 2008-04-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2015038239A Division JP2015134793A (ja) 2008-04-08 2015-02-27 トリテルペンであるサポニン、その合成法および使用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019000534A Division JP6770596B2 (ja) 2008-04-08 2019-01-07 トリテルペンであるサポニン、その合成法および使用

Publications (3)

Publication Number Publication Date
JP2017114876A JP2017114876A (ja) 2017-06-29
JP2017114876A5 true JP2017114876A5 (enExample) 2017-10-12
JP6786410B2 JP6786410B2 (ja) 2020-11-18

Family

ID=40875147

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2011504157A Expired - Fee Related JP5706815B2 (ja) 2008-04-08 2009-04-08 トリテルペンであるサポニン、その合成法および使用
JP2015038239A Withdrawn JP2015134793A (ja) 2008-04-08 2015-02-27 トリテルペンであるサポニン、その合成法および使用
JP2017018192A Active JP6786410B2 (ja) 2008-04-08 2017-02-03 トリテルペンであるサポニン、その合成法および使用
JP2019000534A Active JP6770596B2 (ja) 2008-04-08 2019-01-07 トリテルペンであるサポニン、その合成法および使用
JP2020117691A Pending JP2020169206A (ja) 2008-04-08 2020-07-08 トリテルペンであるサポニン、その合成法および使用

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2011504157A Expired - Fee Related JP5706815B2 (ja) 2008-04-08 2009-04-08 トリテルペンであるサポニン、その合成法および使用
JP2015038239A Withdrawn JP2015134793A (ja) 2008-04-08 2015-02-27 トリテルペンであるサポニン、その合成法および使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019000534A Active JP6770596B2 (ja) 2008-04-08 2019-01-07 トリテルペンであるサポニン、その合成法および使用
JP2020117691A Pending JP2020169206A (ja) 2008-04-08 2020-07-08 トリテルペンであるサポニン、その合成法および使用

Country Status (11)

Country Link
US (6) US8283456B2 (enExample)
EP (3) EP2280987B1 (enExample)
JP (5) JP5706815B2 (enExample)
KR (6) KR102085687B1 (enExample)
CN (2) CN102112484B (enExample)
AU (1) AU2009233757B2 (enExample)
CA (3) CA2720771C (enExample)
ES (1) ES2827804T3 (enExample)
HK (1) HK1211591A1 (enExample)
IL (4) IL208535A (enExample)
WO (1) WO2009126737A2 (enExample)

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AU2013204005B2 (en) * 2012-05-23 2015-04-16 Oncology Research International Limited Improved synthesis
AU2014203977B2 (en) 2013-01-04 2016-11-17 Obi Pharma, Inc. Vaccines with higher carbohydrate antigen density and novel saponin adjuvant
US10806119B2 (en) 2013-06-05 2020-10-20 Yeda Research And Development Co. Ltd. Plant with altered content of steroidal alkaloids
BR112015032713B1 (pt) 2013-09-17 2023-03-21 Obi Pharma, Inc Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto
CN106573951B (zh) * 2014-05-30 2020-09-11 索隆-基特林癌症研究协会 微小皂苷类似物、合成及其用途
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
JP2018532990A (ja) 2015-09-04 2018-11-08 オービーアイ ファーマ，インコーポレイテッド グリカンアレイおよび使用の方法
KR20180077180A (ko) 2015-11-06 2018-07-06 아쥬반스 테크놀로지스 인코포레이티드 트리테르펜 사포닌 유사체
KR20180121786A (ko) 2016-03-29 2018-11-08 오비아이 파머 인코퍼레이티드 항체, 제약 조성물 및 방법
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
KR20250048399A (ko) 2016-04-22 2025-04-08 오비아이 파머 인코퍼레이티드 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법
US11642400B2 (en) 2016-07-27 2023-05-09 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
JP7121724B2 (ja) 2016-07-29 2022-08-18 オービーアイ ファーマ，インコーポレイテッド ヒト抗体、医薬組成物及び方法
CA3044274A1 (en) 2016-11-21 2018-05-24 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR20190137808A (ko) * 2017-04-13 2019-12-11 아쥬반스 테크놀로지스 인코포레이티드 트리테르펜 사포닌, 중간체 및 보조제 배합물
WO2018200656A1 (en) * 2017-04-25 2018-11-01 Adjuvance Technologies, Inc. Triterpene saponin analogues
AU2018258070A1 (en) * 2017-04-25 2019-10-24 Adjuvance Technologies, Inc. Triterpene saponin analogues
JP2020536946A (ja) * 2017-10-16 2020-12-17 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
WO2019133878A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
WO2019183159A1 (en) * 2018-03-20 2019-09-26 The Uab Research Foundation Saponin-based vaccine adjuvants
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
JP2022500023A (ja) 2018-09-06 2022-01-04 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド セルロース合成酵素様酵素及びその使用
EP3849521A1 (en) 2018-09-14 2021-07-21 Massachusetts Institute Of Technology Nanoparticle vaccine adjuvant and methods of use thereof
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP3902797A1 (en) 2018-12-27 2021-11-03 GlycoMimetics, Inc. Galectin-3 inhibiting c-glycosides
IL292796A (en) * 2019-11-05 2022-07-01 Adjuvance Tech Inc Varicella zoster immunogenic compositions and uses thereof
US20230128815A1 (en) * 2020-03-23 2023-04-27 Adjuvance Technologies, Inc. Adjuvant compounds, salt forms, and formulations
US20250282811A1 (en) * 2021-10-02 2025-09-11 Desert King Chile S.A A 3-o-monodesmosidic saponins extract, stable at physiological ph, method for preparing it from a quillaja plant extract cultured with a microbial consortium, uses and such microbial consortium
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
US20230190920A1 (en) 2021-12-19 2023-06-22 Massachusetts Institute Of Technology Compositions and methods for long-lasting germinal center responses to a priming immunization
WO2023139145A1 (en) 2022-01-19 2023-07-27 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin-based adjuvants and vaccines
WO2024218268A1 (en) 2023-04-20 2024-10-24 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin derivatives as adjuvants and photoaffinity probes

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US5583112A (en) 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
US5057540A (en) * 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
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US6231859B1 (en) * 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
ATE385809T1 (de) * 1996-12-02 2008-03-15 Antigenics Inc Saponin-zusammensetzungen und deren verwendung
KR100578317B1 (ko) 1997-05-20 2006-05-11 갈레니카 파마슈티칼스 인크. 면역보강성 및 면역자극 활성을 갖는 트리테르펜 사포닌유사체
US6080725A (en) * 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
EP0988053A1 (en) * 1997-06-11 2000-03-29 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
AU5565599A (en) 1998-08-14 2000-03-06 Dante J. Marciani Chemically modified saponins and the use thereof as adjuvants
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US6716428B1 (en) 1999-10-06 2004-04-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
WO2004092329A2 (en) * 2003-04-08 2004-10-28 Galenica Pharmaceuticals, Inc. Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
US20090210959A1 (en) * 2005-05-04 2009-08-20 National Research Council Of Canada Method for production of saponaria from microspores
CN100335073C (zh) * 2005-08-19 2007-09-05 浙江大学 木鳖子含三萜皂甙成分提取物的制备方法
EP2280987B1 (en) * 2008-04-08 2018-05-23 Sloan-Kettering Institute for Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
CN101322734B (zh) 2008-07-22 2013-05-29 沈阳药科大学 具有抗炎免疫作用的轮叶党参总皂苷及其制备方法
CN106573951B (zh) * 2014-05-30 2020-09-11 索隆-基特林癌症研究协会 微小皂苷类似物、合成及其用途

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