JP2017114876A5 - - Google Patents

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Publication number
JP2017114876A5
JP2017114876A5 JP2017018192A JP2017018192A JP2017114876A5 JP 2017114876 A5 JP2017114876 A5 JP 2017114876A5 JP 2017018192 A JP2017018192 A JP 2017018192A JP 2017018192 A JP2017018192 A JP 2017018192A JP 2017114876 A5 JP2017114876 A5 JP 2017114876A5
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JP
Japan
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group
nitrogen
oxygen
sulfur
membered
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JP2017018192A
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English (en)
Japanese (ja)
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JP2017114876A (ja
JP6786410B2 (ja
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Publication of JP2017114876A5 publication Critical patent/JP2017114876A5/ja
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JP2017018192A 2008-04-08 2017-02-03 トリテルペンであるサポニン、その合成法および使用 Active JP6786410B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4319708P 2008-04-08 2008-04-08
US61/043,197 2008-04-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2015038239A Division JP2015134793A (ja) 2008-04-08 2015-02-27 トリテルペンであるサポニン、その合成法および使用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019000534A Division JP6770596B2 (ja) 2008-04-08 2019-01-07 トリテルペンであるサポニン、その合成法および使用

Publications (3)

Publication Number Publication Date
JP2017114876A JP2017114876A (ja) 2017-06-29
JP2017114876A5 true JP2017114876A5 (enExample) 2017-10-12
JP6786410B2 JP6786410B2 (ja) 2020-11-18

Family

ID=40875147

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2011504157A Expired - Fee Related JP5706815B2 (ja) 2008-04-08 2009-04-08 トリテルペンであるサポニン、その合成法および使用
JP2015038239A Withdrawn JP2015134793A (ja) 2008-04-08 2015-02-27 トリテルペンであるサポニン、その合成法および使用
JP2017018192A Active JP6786410B2 (ja) 2008-04-08 2017-02-03 トリテルペンであるサポニン、その合成法および使用
JP2019000534A Active JP6770596B2 (ja) 2008-04-08 2019-01-07 トリテルペンであるサポニン、その合成法および使用
JP2020117691A Pending JP2020169206A (ja) 2008-04-08 2020-07-08 トリテルペンであるサポニン、その合成法および使用

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2011504157A Expired - Fee Related JP5706815B2 (ja) 2008-04-08 2009-04-08 トリテルペンであるサポニン、その合成法および使用
JP2015038239A Withdrawn JP2015134793A (ja) 2008-04-08 2015-02-27 トリテルペンであるサポニン、その合成法および使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019000534A Active JP6770596B2 (ja) 2008-04-08 2019-01-07 トリテルペンであるサポニン、その合成法および使用
JP2020117691A Pending JP2020169206A (ja) 2008-04-08 2020-07-08 トリテルペンであるサポニン、その合成法および使用

Country Status (11)

Country Link
US (6) US8283456B2 (enExample)
EP (3) EP2280987B1 (enExample)
JP (5) JP5706815B2 (enExample)
KR (6) KR101651695B1 (enExample)
CN (2) CN102112484B (enExample)
AU (1) AU2009233757B2 (enExample)
CA (3) CA2993582C (enExample)
ES (1) ES2827804T3 (enExample)
HK (1) HK1211591A1 (enExample)
IL (4) IL208535A (enExample)
WO (1) WO2009126737A2 (enExample)

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AU2013204005B2 (en) * 2012-05-23 2015-04-16 Oncology Research International Limited Improved synthesis
ES2843509T3 (es) 2013-01-04 2021-07-19 Obi Pharma Inc Vacunas con mayor densidad de antígeno carbohidratado y nuevo adyuvante de saponina
US10806119B2 (en) 2013-06-05 2020-10-20 Yeda Research And Development Co. Ltd. Plant with altered content of steroidal alkaloids
RU2666141C2 (ru) 2013-09-17 2018-09-06 Оби Фарма, Инк. Композиции углеводной вакцины для индукции иммунного ответа и их применение при лечении рака
SG11201610004PA (en) * 2014-05-30 2016-12-29 Sloan Kettering Inst Cancer Minimal saponin analogues, synthesis and use thereof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
JP2018532990A (ja) 2015-09-04 2018-11-08 オービーアイ ファーマ，インコーポレイテッド グリカンアレイおよび使用の方法
IL286493B (en) * 2015-11-06 2022-07-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof
US11041017B2 (en) 2016-03-29 2021-06-22 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
KR20250048399A (ko) 2016-04-22 2025-04-08 오비아이 파머 인코퍼레이티드 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법
WO2018022933A1 (en) 2016-07-27 2018-02-01 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND PROCESSES
JP2019535731A (ja) 2016-11-21 2019-12-12 オービーアイ ファーマ，インコーポレイテッド コンジュゲートさせた生物学的分子、医薬組成物及び方法
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018191598A1 (en) * 2017-04-13 2018-10-18 Adjuvance Technologies, Inc. Triterpene saponin synthesis, intermediates and adjuvant combinations
AU2018258070A1 (en) 2017-04-25 2019-10-24 Adjuvance Technologies, Inc. Triterpene saponin analogues
WO2018200656A1 (en) * 2017-04-25 2018-11-01 Adjuvance Technologies, Inc. Triterpene saponin analogues
WO2019079160A1 (en) 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. TRITERPENIC SAPONIN ANALOGS
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
US12497429B2 (en) * 2018-03-20 2025-12-16 The Uab Research Foundation Saponin-based vaccine adjuvants
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
US12041907B2 (en) 2018-09-06 2024-07-23 Yeda Research And Development Co. Ltd. Cellulose-synthase-like enzymes and uses thereof
EP3849521A1 (en) 2018-09-14 2021-07-21 Massachusetts Institute Of Technology Nanoparticle vaccine adjuvant and methods of use thereof
CA3122321A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Galectin-3 inhibiting c-glycosides
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
KR20220097396A (ko) * 2019-11-05 2022-07-07 아쥬반스 테크놀로지스 인코포레이티드 바리셀라 조스터
US20230128815A1 (en) * 2020-03-23 2023-04-27 Adjuvance Technologies, Inc. Adjuvant compounds, salt forms, and formulations
CN116249553A (zh) * 2020-06-24 2023-06-09 萨普雷米科技有限公司 抗体-药物缀合物和抗体-皂苷缀合物的组合
US20250282811A1 (en) * 2021-10-02 2025-09-11 Desert King Chile S.A A 3-o-monodesmosidic saponins extract, stable at physiological ph, method for preparing it from a quillaja plant extract cultured with a microbial consortium, uses and such microbial consortium
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
US20230190920A1 (en) 2021-12-19 2023-06-22 Massachusetts Institute Of Technology Compositions and methods for long-lasting germinal center responses to a priming immunization
US20250114448A1 (en) 2022-01-19 2025-04-10 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin-based adjuvants and vaccines
WO2024218268A1 (en) 2023-04-20 2024-10-24 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin derivatives as adjuvants and photoaffinity probes
CN121852499A (zh) * 2026-03-17 2026-04-14 武汉糖智药业有限公司 Qs-7生物合成乙酰化的方法

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US5583112A (en) 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
US5057540A (en) * 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
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US6231859B1 (en) 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
US6080725A (en) 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
WO1998052573A1 (en) 1997-05-20 1998-11-26 Galenica Pharmaceuticals, Inc. Triterpene saponin analogs having adjuvant and immunostimulatory activity
WO1998056415A1 (en) * 1997-06-11 1998-12-17 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
WO2000009075A2 (en) 1998-08-14 2000-02-24 Galenica Pharmaceuticals, Inc. Chemically modified saponins and the use thereof as adjuvants
US7457415B2 (en) 1998-08-20 2008-11-25 Akikaze Technologies, Llc Secure information distribution system utilizing information segment scrambling
US6716428B1 (en) 1999-10-06 2004-04-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
WO2004092329A2 (en) * 2003-04-08 2004-10-28 Galenica Pharmaceuticals, Inc. Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
EP1876882A4 (en) * 2005-05-04 2009-01-14 Ca Nat Research Council Method for production of saponaria from microspores
CN100335073C (zh) * 2005-08-19 2007-09-05 浙江大学 木鳖子含三萜皂甙成分提取物的制备方法
EP2280987B1 (en) * 2008-04-08 2018-05-23 Sloan-Kettering Institute for Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
CN101322734B (zh) 2008-07-22 2013-05-29 沈阳药科大学 具有抗炎免疫作用的轮叶党参总皂苷及其制备方法
SG11201610004PA (en) * 2014-05-30 2016-12-29 Sloan Kettering Inst Cancer Minimal saponin analogues, synthesis and use thereof

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