ES2827804T3 - Métodos de síntesis de prosapogeninas triterpénicas y saponinas triterpénicas - Google Patents
Métodos de síntesis de prosapogeninas triterpénicas y saponinas triterpénicas Download PDFInfo
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- ES2827804T3 ES2827804T3 ES18161023T ES18161023T ES2827804T3 ES 2827804 T3 ES2827804 T3 ES 2827804T3 ES 18161023 T ES18161023 T ES 18161023T ES 18161023 T ES18161023 T ES 18161023T ES 2827804 T3 ES2827804 T3 ES 2827804T3
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- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
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| EP2280987B1 (en) | 2008-04-08 | 2018-05-23 | Sloan-Kettering Institute for Cancer Research | Triterpene saponins, methods of synthesis, and uses thereof |
| CN102068446B (zh) * | 2011-01-10 | 2013-08-21 | 武汉道一堂医药研究院 | 三萜皂苷化合物在制备抗病原微生物药物中的应用 |
| AU2013204005B2 (en) * | 2012-05-23 | 2015-04-16 | Oncology Research International Limited | Improved synthesis |
| ES2843509T3 (es) | 2013-01-04 | 2021-07-19 | Obi Pharma Inc | Vacunas con mayor densidad de antígeno carbohidratado y nuevo adyuvante de saponina |
| US10806119B2 (en) | 2013-06-05 | 2020-10-20 | Yeda Research And Development Co. Ltd. | Plant with altered content of steroidal alkaloids |
| RU2666141C2 (ru) | 2013-09-17 | 2018-09-06 | Оби Фарма, Инк. | Композиции углеводной вакцины для индукции иммунного ответа и их применение при лечении рака |
| SG11201610004PA (en) * | 2014-05-30 | 2016-12-29 | Sloan Kettering Inst Cancer | Minimal saponin analogues, synthesis and use thereof |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ，インコーポレイテッド | グリカンアレイおよび使用の方法 |
| IL286493B (en) * | 2015-11-06 | 2022-07-01 | Memorial Sloan Kettering Cancer Center | Triterpene saponin analogues, methods of producing same, compositions comprising same and uses thereof |
| US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20250048399A (ko) | 2016-04-22 | 2025-04-08 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법 |
| WO2018022933A1 (en) | 2016-07-27 | 2018-02-01 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| EP3491026A4 (en) | 2016-07-29 | 2020-07-29 | OBI Pharma, Inc. | HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND PROCESSES |
| JP2019535731A (ja) | 2016-11-21 | 2019-12-12 | オービーアイ ファーマ，インコーポレイテッド | コンジュゲートさせた生物学的分子、医薬組成物及び方法 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2018191598A1 (en) * | 2017-04-13 | 2018-10-18 | Adjuvance Technologies, Inc. | Triterpene saponin synthesis, intermediates and adjuvant combinations |
| AU2018258070A1 (en) | 2017-04-25 | 2019-10-24 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| WO2018200656A1 (en) * | 2017-04-25 | 2018-11-01 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| WO2019079160A1 (en) | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | TRITERPENIC SAPONIN ANALOGS |
| EP3732186A1 (en) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| US12497429B2 (en) * | 2018-03-20 | 2025-12-16 | The Uab Research Foundation | Saponin-based vaccine adjuvants |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| US12041907B2 (en) | 2018-09-06 | 2024-07-23 | Yeda Research And Development Co. Ltd. | Cellulose-synthase-like enzymes and uses thereof |
| EP3849521A1 (en) | 2018-09-14 | 2021-07-21 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
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| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
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