JP2017075173A5 - - Google Patents
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- Publication number
- JP2017075173A5 JP2017075173A5 JP2016249232A JP2016249232A JP2017075173A5 JP 2017075173 A5 JP2017075173 A5 JP 2017075173A5 JP 2016249232 A JP2016249232 A JP 2016249232A JP 2016249232 A JP2016249232 A JP 2016249232A JP 2017075173 A5 JP2017075173 A5 JP 2017075173A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- amyloidosis
- condition associated
- pathological condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010002022 amyloidosis Diseases 0.000 claims 5
- 230000001575 pathological effect Effects 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007505 plaque formation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 0 *C(C1*)[C@](*)C(*)C(*)[C@]1O Chemical compound *C(C1*)[C@](*)C(*)C(*)[C@]1O 0.000 description 14
- PXKXMLOHKWCCGD-XNIMQTFVSA-N O[C@@H](C(C(C(OCc1ccccc1)=C1OCc2ccccc2)OCc2ccccc2)OCc2ccccc2)C1O Chemical compound O[C@@H](C(C(C(OCc1ccccc1)=C1OCc2ccccc2)OCc2ccccc2)OCc2ccccc2)C1O PXKXMLOHKWCCGD-XNIMQTFVSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3857108P | 2008-03-21 | 2008-03-21 | |
| US61/038,571 | 2008-03-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046341A Division JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017075173A JP2017075173A (ja) | 2017-04-20 |
| JP2017075173A5 true JP2017075173A5 (enExample) | 2017-11-24 |
| JP6370361B2 JP6370361B2 (ja) | 2018-08-08 |
Family
ID=41091569
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501009A Expired - Fee Related JP5501339B2 (ja) | 2008-03-21 | 2009-03-23 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2014046341A Expired - Fee Related JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2016249232A Expired - Fee Related JP6370361B2 (ja) | 2008-03-21 | 2016-12-22 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501009A Expired - Fee Related JP5501339B2 (ja) | 2008-03-21 | 2009-03-23 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
| JP2014046341A Expired - Fee Related JP6140090B2 (ja) | 2008-03-21 | 2014-03-10 | アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US8450466B2 (enExample) |
| EP (2) | EP3231804B1 (enExample) |
| JP (3) | JP5501339B2 (enExample) |
| CN (2) | CN102046638B (enExample) |
| AU (1) | AU2009225407B2 (enExample) |
| CA (2) | CA2978149C (enExample) |
| MX (2) | MX375108B (enExample) |
| WO (1) | WO2009117728A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| EP3231804B1 (en) | 2008-03-21 | 2021-03-03 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| BR112013003754B1 (pt) | 2010-08-16 | 2021-11-09 | Cognoptix, Inc. | Dispositivo para detectar uma proteína amiloide em um olho de um mamífero |
| EP2665737A1 (en) * | 2011-01-18 | 2013-11-27 | General Atomics | Hydrolase enzyme substrates and uses thereof |
| EP2911664B1 (en) * | 2012-10-25 | 2019-05-08 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| AU2014340182B2 (en) | 2013-10-22 | 2019-05-23 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| AU2015231239B2 (en) * | 2014-03-19 | 2018-11-29 | Amydis, Inc. | Amyloid targeting agents and methods of using the same |
| CA3033079A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| US10675365B2 (en) | 2016-09-29 | 2020-06-09 | Korea Atomic Energy Research Institute | Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque |
| KR20210070232A (ko) | 2017-07-20 | 2021-06-14 | 아즈테라피즈 인코포레이티드 | 크로몰린 나트륨 및 이부프로펜의 분말화된 제형 |
| CN112424606B9 (zh) | 2018-05-31 | 2025-03-07 | 阿米达斯公司 | 用于检测创伤性脑损伤的组合物和方法 |
| CA3105392A1 (en) | 2018-07-02 | 2020-01-09 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and .alpha.-lactose |
| TW202023625A (zh) | 2018-08-23 | 2020-07-01 | 美商西雅圖遺傳學公司 | 抗tigit抗體 |
| EP3893945A4 (en) | 2018-12-10 | 2022-11-30 | The General Hospital Corporation | CROMOGLYC ESTERS AND THEIR USES |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| JPWO2022059776A1 (enExample) * | 2020-09-17 | 2022-03-24 | ||
| CA3251622A1 (en) | 2022-02-07 | 2023-08-10 | Martin J. MOSKOVITZ | Cryosurgical devices and materials and their method of use |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1009897A (en) | 1911-03-27 | 1911-11-28 | Us Electrographic Company | Projection apparatus. |
| CH375356A (de) | 1959-03-25 | 1964-02-29 | Sandoz Ag | Verfahren zur Herstellung von neuen substituierten Succinimiden |
| CH449628A (de) * | 1962-04-16 | 1968-01-15 | Sandoz Ag | Verfahren zur Herstellung substituierter Succinimide |
| US3207780A (en) * | 1962-11-15 | 1965-09-21 | Upjohn Co | 1-deoxy-1-guanidino-3-o-carbamoyl-scyllo-inositol and acylates thereof |
| US4069262A (en) | 1977-03-07 | 1978-01-17 | E. I. Du Pont De Nemours And Company | Preparation of 2-fluoronitrobenzene |
| FR2498594A1 (fr) | 1981-01-23 | 1982-07-30 | Rhone Poulenc Ind | Procede de preparation de monoesters d'acides carboxyliques b,g-insatures |
| US4446123A (en) | 1982-10-13 | 1984-05-01 | Hahnemann University | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
| NL8401907A (nl) * | 1983-06-27 | 1985-01-16 | Sandoz Ag | Spirosuccinimiden en werkwijzen voor het bereiden en toepassen van deze spirosuccinimiden. |
| BE900003A (fr) * | 1983-06-27 | 1984-12-27 | Sandoz Sa | Derives du spirosuccinimide utilisables comme medicaments. |
| US4606908A (en) | 1983-10-04 | 1986-08-19 | Washington Research Foundation | Methods and compositions for plasma and organ imaging |
| EP0273659A1 (en) * | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiro compounds, their production and use |
| US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| SE9002117L (sv) | 1990-06-14 | 1991-08-26 | Nils Elander | Mikrovaagsanordning foer behandling av precessvaetskor |
| US5139034A (en) * | 1990-11-15 | 1992-08-18 | Philip Morris Incorporated | Smoking compositions containing a menthol-release additive |
| IT1244546B (it) * | 1991-02-01 | 1994-07-15 | Mediolanum Farmaceutici Spa | Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica |
| US5315043A (en) | 1992-02-05 | 1994-05-24 | E. I. Du Pont De Nemours And Company | Aromatic nucleophilic fluorination |
| US5264570A (en) * | 1992-08-05 | 1993-11-23 | General Electric Company | Method for making 2-[18 F]fluoro-2-deoxy-D-glucose |
| US5493026A (en) | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
| US6168776B1 (en) | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| WO1997026919A2 (en) | 1996-01-24 | 1997-07-31 | Warner-Lambert Company | Method of imaging amyloid deposits |
| JP3816570B2 (ja) * | 1996-02-16 | 2006-08-30 | 塩水港精糖株式会社 | アシル化剤 |
| TW593290B (en) | 1996-05-10 | 2004-06-21 | Janssen Pharmaceutica Nv | Alkylaminobenzothiazole and -benzoxazole derivatives |
| DE19624705A1 (de) * | 1996-06-20 | 1998-01-08 | Deutsches Krebsforsch | Dendrimere auf Saccharid-Basis |
| US5817877A (en) | 1996-09-23 | 1998-10-06 | Yale University | Metal-catalyzed amination of organic sulfonates to organic amines |
| US6187286B1 (en) | 1996-12-27 | 2001-02-13 | The General Hospital Corporation | Tumor imaging agents, methods and kits |
| AU7723198A (en) | 1997-06-04 | 1998-12-21 | University Of Tennessee Research Corporation, The | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
| EP1011738A1 (en) | 1997-09-08 | 2000-06-28 | The General Hospital Corporation | Imaging agents for early detection of cardiovascular plaque |
| JP4177472B2 (ja) * | 1997-10-02 | 2008-11-05 | 株式会社横浜国際バイオ研究所 | 窒素官能基を含有するアシル化剤及びその製造法 |
| US6660832B1 (en) | 1999-08-20 | 2003-12-09 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds and preparation methods thereof |
| CA2384879C (en) | 1999-09-13 | 2010-11-30 | Pola Chemical Industries, Inc. | Nitroimidazole derivative and diagnostic imaging agent containing the same |
| EP1294663B1 (en) | 2000-06-12 | 2004-05-06 | University of Florida Research Foundation | Fluorinated benzene manufacturing process |
| UY27003A1 (es) | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
| KR20040058111A (ko) | 2001-04-23 | 2004-07-03 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 아밀로이드 플라크 응집 억제제 및 진단 영상화제 |
| WO2003065882A2 (en) | 2002-02-06 | 2003-08-14 | The Johns Hopkins University | Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts |
| DE10210195B4 (de) * | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| US20080063599A1 (en) | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| CN100536837C (zh) * | 2003-02-27 | 2009-09-09 | 乔安妮·麦克劳林 | 鲨肌醇在制备诊断试剂中的用途 |
| GB0304640D0 (en) | 2003-02-28 | 2003-04-02 | Novartis Ag | Organic compounds |
| US7295831B2 (en) | 2003-08-12 | 2007-11-13 | 3E Technologies International, Inc. | Method and system for wireless intrusion detection prevention and security management |
| WO2005016384A1 (ja) | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤 |
| EP2610234A1 (en) | 2004-02-24 | 2013-07-03 | The General Hospital Corporation | Catalytic radiofluorination |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| KR100578732B1 (ko) * | 2004-03-05 | 2006-05-12 | 학교법인 포항공과대학교 | 분자 수송체로서의 이노시톨 유도체 및 이의 제조방법 |
| AU2005304931A1 (en) * | 2004-11-05 | 2006-05-18 | Wyeth | Pet and magnetic resonance for screening Alzheimer's disease therapeutics |
| EP1824496A4 (en) | 2004-11-17 | 2008-07-16 | Joanne Mclaurin | COMPOSITIONS OF SCYLLO-INOSITOL DERIVATIVES AND METHOD FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS |
| US7138540B1 (en) | 2005-09-06 | 2006-11-21 | Institute Of Nuclear Energy Research | Convenient method for the preparation of new precursor of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine) |
| JP2009511568A (ja) | 2005-10-13 | 2009-03-19 | ワラタ ファーマシューティカルズ， インコーポレイテッド | イノシトール誘導体、ならびに異常なタンパク質の折りたたみまたは凝集、あるいはアミロイドの形成、沈着、蓄積または残存を特徴とする疾患の処置におけるその使用 |
| JP2007194369A (ja) * | 2006-01-18 | 2007-08-02 | Toei Kogyo Kk | 高出力Ｅｒ：ＹＡＧレーザ装置 |
| NO325976B1 (no) * | 2006-01-26 | 2008-08-25 | Gba Marine As | Anordning for absorpsjon av gass eller damp i vaeske og fremgangsmate ved reintrodusering av damp eller gass i vaeske som gassen eller dampen stammer fra |
| US20070197452A1 (en) * | 2006-02-17 | 2007-08-23 | Mclaurin Joanne | Treatment of amyloid-related diseases |
| BRPI0721424A2 (pt) | 2007-03-01 | 2014-03-25 | Bayer Schering Pharma Ag | Métodos de radiofluoração |
| WO2009014203A1 (ja) * | 2007-07-26 | 2009-01-29 | Hokko Chemical Industry Co., Ltd. | （１，３，５／２，４，６）－１－フルオロ－２，３，４，５，６－シクロヘキサンペントールの製造方法 |
| EP3231804B1 (en) | 2008-03-21 | 2021-03-03 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders |
| WO2010072342A2 (en) | 2008-12-22 | 2010-07-01 | Bayer Schering Pharma Aktiengesellschaft | A method for the synthesis of a radionuclide-labeled compound |
| GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
| US20150246142A1 (en) | 2012-09-25 | 2015-09-03 | The Regents Of The University Of Michigan | Imaging agents |
| US20170334804A1 (en) | 2014-10-31 | 2017-11-23 | The General Hospital Corporation | F-18 labeled tracer and methods of manufacture |
-
2009
- 2009-03-23 EP EP17152886.2A patent/EP3231804B1/en active Active
- 2009-03-23 CA CA2978149A patent/CA2978149C/en active Active
- 2009-03-23 MX MX2013012279A patent/MX375108B/es unknown
- 2009-03-23 EP EP09723502.2A patent/EP2268647B1/en active Active
- 2009-03-23 WO PCT/US2009/037928 patent/WO2009117728A2/en not_active Ceased
- 2009-03-23 JP JP2011501009A patent/JP5501339B2/ja not_active Expired - Fee Related
- 2009-03-23 MX MX2010010314A patent/MX2010010314A/es active IP Right Grant
- 2009-03-23 US US12/933,139 patent/US8450466B2/en not_active Expired - Fee Related
- 2009-03-23 AU AU2009225407A patent/AU2009225407B2/en not_active Ceased
- 2009-03-23 CA CA2718035A patent/CA2718035C/en active Active
- 2009-03-23 CN CN200980119032.0A patent/CN102046638B/zh not_active Expired - Fee Related
- 2009-03-23 CN CN201510221345.4A patent/CN104974024B/zh not_active Expired - Fee Related
-
2013
- 2013-05-28 US US13/903,362 patent/US9005578B2/en active Active
-
2014
- 2014-03-10 JP JP2014046341A patent/JP6140090B2/ja not_active Expired - Fee Related
- 2014-12-15 US US14/569,855 patent/US20150098903A1/en not_active Abandoned
-
2016
- 2016-12-22 JP JP2016249232A patent/JP6370361B2/ja not_active Expired - Fee Related
-
2019
- 2019-08-29 US US16/555,290 patent/US10857247B2/en not_active Expired - Fee Related
-
2020
- 2020-12-08 US US17/115,344 patent/US20210338849A1/en not_active Abandoned
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