AU2009225407B2 - Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders - Google Patents

Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders Download PDF

Info

Publication number
AU2009225407B2
AU2009225407B2 AU2009225407A AU2009225407A AU2009225407B2 AU 2009225407 B2 AU2009225407 B2 AU 2009225407B2 AU 2009225407 A AU2009225407 A AU 2009225407A AU 2009225407 A AU2009225407 A AU 2009225407A AU 2009225407 B2 AU2009225407 B2 AU 2009225407B2
Authority
AU
Australia
Prior art keywords
compound
hydrogen
certain embodiments
present
attendant definitions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009225407A
Other languages
English (en)
Other versions
AU2009225407A1 (en
Inventor
David R. Elmaleh
Hongning Fu
Timothy Shoup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of AU2009225407A1 publication Critical patent/AU2009225407A1/en
Application granted granted Critical
Publication of AU2009225407B2 publication Critical patent/AU2009225407B2/en
Priority to AU2013248197A priority Critical patent/AU2013248197B2/en
Assigned to THE GENERAL HOSPITAL CORPORATION reassignment THE GENERAL HOSPITAL CORPORATION Request for Assignment Assignors: FLUOROPHARMA, INC., THE GENERAL HOSPITAL CORPORATION
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/192—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/253—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/21—Acetic acid esters of hydroxy compounds with more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2009225407A 2008-03-21 2009-03-23 Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders Ceased AU2009225407B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013248197A AU2013248197B2 (en) 2008-03-21 2013-10-23 Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3857108P 2008-03-21 2008-03-21
US61/038,571 2008-03-21
PCT/US2009/037928 WO2009117728A2 (en) 2008-03-21 2009-03-23 Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013248197A Division AU2013248197B2 (en) 2008-03-21 2013-10-23 Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders

Publications (2)

Publication Number Publication Date
AU2009225407A1 AU2009225407A1 (en) 2009-09-24
AU2009225407B2 true AU2009225407B2 (en) 2013-09-05

Family

ID=41091569

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009225407A Ceased AU2009225407B2 (en) 2008-03-21 2009-03-23 Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders

Country Status (8)

Country Link
US (5) US8450466B2 (enExample)
EP (2) EP3231804B1 (enExample)
JP (3) JP5501339B2 (enExample)
CN (2) CN102046638B (enExample)
AU (1) AU2009225407B2 (enExample)
CA (2) CA2978149C (enExample)
MX (2) MX2010010314A (enExample)
WO (1) WO2009117728A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
WO2009117728A2 (en) 2008-03-21 2009-09-24 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
SG188227A1 (en) 2010-08-16 2013-04-30 Cognoptix Inc System and method for detecting amyloid proteins
WO2012099904A1 (en) * 2011-01-18 2012-07-26 General Atomics Hydrolase enzyme substrates and uses thereof
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
EP3563849A3 (en) 2012-10-25 2020-02-12 The General Hospital Corporation Combination therapies for the treatment of alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
CN110305095A (zh) 2013-10-22 2019-10-08 综合医院公司 色甘酸衍生物以及成像和治疗的相关方法
CN110483335B (zh) * 2014-03-19 2023-08-11 阿米达斯公司 淀粉样蛋白靶向剂及其使用方法
EP3506894B1 (en) 2016-08-31 2023-08-23 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
US10675365B2 (en) 2016-09-29 2020-06-09 Korea Atomic Energy Research Institute Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque
WO2019017995A1 (en) 2017-07-20 2019-01-24 Aztherapies, Inc. FORMULATIONS OF CROMOLYNE SODIUM POWDER AND IBUPROFEN
CN119985995A (zh) 2018-05-31 2025-05-13 阿米达斯公司 用于检测创伤性脑损伤的组合物和方法
JP2021529771A (ja) 2018-07-02 2021-11-04 ザ ジェネラル ホスピタル コーポレイション クロモリンナトリウムおよびα−ラクトースの粉末製剤
WO2020041541A2 (en) 2018-08-23 2020-02-27 Seattle Genetics, Inc. Anti-tigit antibodies
EP3893945A4 (en) 2018-12-10 2022-11-30 The General Hospital Corporation CROMOGLYC ESTERS AND THEIR USES
WO2021207060A1 (en) 2020-04-06 2021-10-14 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions
US20230364119A1 (en) * 2020-09-17 2023-11-16 Resonac Corporation Autophagy activator
EP4475888A2 (en) 2022-02-07 2024-12-18 Moskovitz, Martin J. Cryo-surgical device and materials and method of use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH375356A (de) * 1959-03-25 1964-02-29 Sandoz Ag Verfahren zur Herstellung von neuen substituierten Succinimiden
GB1041015A (en) * 1962-04-16 1966-09-01 Westminster Bank Ltd Improvements in or relating to spiropiperidyl-succinimide derivatives
WO1985000171A1 (fr) * 1983-06-27 1985-01-17 Sandoz Ag Spiroxuccinimides, leur fabrication et leur utilisation
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
WO2007041855A1 (en) * 2005-10-13 2007-04-19 Waratah Pharmaceuticals, Inc. Scyllo-inositol derivatives and their use in the treatment of diseases characterised by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1009897A (en) 1911-03-27 1911-11-28 Us Electrographic Company Projection apparatus.
US3207780A (en) * 1962-11-15 1965-09-21 Upjohn Co 1-deoxy-1-guanidino-3-o-carbamoyl-scyllo-inositol and acylates thereof
US4069262A (en) 1977-03-07 1978-01-17 E. I. Du Pont De Nemours And Company Preparation of 2-fluoronitrobenzene
FR2498594A1 (fr) 1981-01-23 1982-07-30 Rhone Poulenc Ind Procede de preparation de monoesters d'acides carboxyliques b,g-insatures
US4446123A (en) 1982-10-13 1984-05-01 Hahnemann University Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
BE900003A (fr) * 1983-06-27 1984-12-27 Sandoz Sa Derives du spirosuccinimide utilisables comme medicaments.
US4606908A (en) 1983-10-04 1986-08-19 Washington Research Foundation Methods and compositions for plasma and organ imaging
EP0273659A1 (en) * 1986-12-27 1988-07-06 Takeda Chemical Industries, Ltd. Azaspiro compounds, their production and use
US4847082A (en) * 1987-01-21 1989-07-11 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
SE465348B (sv) 1990-06-14 1991-08-26 Nils Elander Mikrovaagsanordning foer behandling av precessvaetskor
US5139034A (en) * 1990-11-15 1992-08-18 Philip Morris Incorporated Smoking compositions containing a menthol-release additive
IT1244546B (it) * 1991-02-01 1994-07-15 Mediolanum Farmaceutici Spa Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica
US5315043A (en) 1992-02-05 1994-05-24 E. I. Du Pont De Nemours And Company Aromatic nucleophilic fluorination
US5264570A (en) * 1992-08-05 1993-11-23 General Electric Company Method for making 2-[18 F]fluoro-2-deoxy-D-glucose
US5493026A (en) 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
WO1997026919A2 (en) 1996-01-24 1997-07-31 Warner-Lambert Company Method of imaging amyloid deposits
JP3816570B2 (ja) * 1996-02-16 2006-08-30 塩水港精糖株式会社 アシル化剤
TW593290B (en) 1996-05-10 2004-06-21 Janssen Pharmaceutica Nv Alkylaminobenzothiazole and -benzoxazole derivatives
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
US5817877A (en) 1996-09-23 1998-10-06 Yale University Metal-catalyzed amination of organic sulfonates to organic amines
US6187286B1 (en) 1996-12-27 2001-02-13 The General Hospital Corporation Tumor imaging agents, methods and kits
US6019957A (en) 1997-06-04 2000-02-01 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
CA2302837A1 (en) 1997-09-08 1999-03-18 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
JP4177472B2 (ja) * 1997-10-02 2008-11-05 株式会社横浜国際バイオ研究所 窒素官能基を含有するアシル化剤及びその製造法
US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
ES2237447T3 (es) 1999-09-13 2005-08-01 Pola Chemical Industries, Inc. Derivado de nitroimidazol y agente de diagnostico formador de imagenes que lo contiene.
JP2004516241A (ja) 2000-06-12 2004-06-03 ユニヴァーシティー オヴ フロリダ リサーチ ファウンデーション フッ化ベンゼンの製造方法
UY27003A1 (es) 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
AU2002258915B2 (en) 2001-04-23 2007-11-15 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
JP4530665B2 (ja) 2002-02-06 2010-08-25 ジョンズ ホプキンス ユニバーシティ 放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
US20080063599A1 (en) 2002-11-18 2008-03-13 Jorge Setoain Quinquer Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils
CN101385722A (zh) * 2003-02-27 2009-03-18 乔安妮·麦克劳林 预防、治疗和诊断蛋白聚集疾病的方法
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
GB0304640D0 (en) 2003-02-28 2003-04-02 Novartis Ag Organic compounds
US7295831B2 (en) 2003-08-12 2007-11-13 3E Technologies International, Inc. Method and system for wireless intrusion detection prevention and security management
AU2003304416A1 (en) 2003-08-13 2005-03-07 Bf Research Institute, Inc. Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US7632485B2 (en) 2004-02-24 2009-12-15 Massachusetts General Hospital Catalytic radiofluorination
KR100578732B1 (ko) * 2004-03-05 2006-05-12 학교법인 포항공과대학교 분자 수송체로서의 이노시톨 유도체 및 이의 제조방법
BRPI0517672A (pt) * 2004-11-05 2008-10-14 Wyeth Corp modalidades de formação de imagens para seleção terapêutica de doença de alzheimer
BRPI0517733A (pt) * 2004-11-17 2008-10-21 Joanne Mclaurin composições compreendendo derivados de scilo-inositol e métodos para tratar transtornos de agregação de proteìna
US7138540B1 (en) 2005-09-06 2006-11-21 Institute Of Nuclear Energy Research Convenient method for the preparation of new precursor of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine)
JP2007194369A (ja) * 2006-01-18 2007-08-02 Toei Kogyo Kk 高出力Ｅｒ：ＹＡＧレーザ装置
NO325976B1 (no) * 2006-01-26 2008-08-25 Gba Marine As Anordning for absorpsjon av gass eller damp i vaeske og fremgangsmate ved reintrodusering av damp eller gass i vaeske som gassen eller dampen stammer fra
MX2009009291A (es) 2007-03-01 2009-12-14 Bayer Schering Pharma Ag Compuestos activos biologicamente marcados con fluoro-benzoilo 18f como agentes de diagnostico por imagenes asi como precursores de benzotriazol-1-iloxi-benzoilo, 2,5-dioxo-pirrolidin-1-iloxi benzoilo y trimetilamonio benzoilo.
WO2009014203A1 (ja) * 2007-07-26 2009-01-29 Hokko Chemical Industry Co., Ltd. （１，３，５／２，４，６）－１－フルオロ－２，３，４，５，６－シクロヘキサンペントールの製造方法
WO2009117728A2 (en) 2008-03-21 2009-09-24 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
EP2379757A2 (en) 2008-12-22 2011-10-26 Bayer Pharma Aktiengesellschaft A method for the synthesis of a radionuclide-labeled compound
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
WO2014052454A1 (en) 2012-09-25 2014-04-03 The Regents Of The University Of Michigan Imaging agents
WO2016070074A1 (en) 2014-10-31 2016-05-06 The General Hospital Corporation F-18 labeled tracer and methods of manufacture

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH375356A (de) * 1959-03-25 1964-02-29 Sandoz Ag Verfahren zur Herstellung von neuen substituierten Succinimiden
GB1041015A (en) * 1962-04-16 1966-09-01 Westminster Bank Ltd Improvements in or relating to spiropiperidyl-succinimide derivatives
WO1985000171A1 (fr) * 1983-06-27 1985-01-17 Sandoz Ag Spiroxuccinimides, leur fabrication et leur utilisation
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
WO2007041855A1 (en) * 2005-10-13 2007-04-19 Waratah Pharmaceuticals, Inc. Scyllo-inositol derivatives and their use in the treatment of diseases characterised by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CIGNARELLA, G. et al, "Synthesis of a new series of 2,8-disubstituted-2,8-diazaspiro[4,5]decan-1-ones as potential muscarinic agonists." European Journal of Medicinal Chemistry, 1994, 29(12), 955-961. *
MAILEY, E. et al, "Synthesis of Derivatives of Alkylated and Arylated Piperidones and Piperidinols." Journal of Organic Chemistry, 1957, 22, 1061-1065. *
NAGAI, Y. et al, "Studies on Psychotropic Agents. I. Synthesis of 3,8-Disubstituted-1-oxa-3,8- diazaspiro[4,5]decan-2,4-dione derivatives." Chemical and Pharmaceutical Bulletin, 1976, 24(6), 1179-1188. *
SANDOZ AG, "Regiospezifische Reduktionen von 1,3,3-trisubstituierten Succinimiden mit Diboran." Helvetica Chimica Acta, 1977, 60(5), 1650-1656. *
TSUKAMOTO, S-I. et al, Journal of Medicinal Chemistry, 1993, 36(16), 2292-2299. *
VALENT, V. et al, "Potential Cholinergic and Anticholinergic Compounds: Synthesis of 2,8-substituted 2,8-diazaspiro[4,5]decane-1,3-diones." Collection of Czechoslovak Chemical Communications, 1990, 55(9), 2304-2316. *

Also Published As

Publication number Publication date
US10857247B2 (en) 2020-12-08
EP3231804B1 (en) 2021-03-03
CN102046638A (zh) 2011-05-04
JP2014177457A (ja) 2014-09-25
EP2268647A4 (en) 2011-05-18
CN104974024B (zh) 2017-11-14
HK1217100A1 (zh) 2016-12-23
US8450466B2 (en) 2013-05-28
AU2009225407A1 (en) 2009-09-24
WO2009117728A2 (en) 2009-09-24
WO2009117728A3 (en) 2010-02-18
US20190381199A1 (en) 2019-12-19
JP2017075173A (ja) 2017-04-20
CA2978149C (en) 2019-02-12
CA2978149A1 (en) 2009-09-24
CN102046638B (zh) 2015-06-03
JP6140090B2 (ja) 2017-05-31
EP2268647A2 (en) 2011-01-05
EP3231804A1 (en) 2017-10-18
JP5501339B2 (ja) 2014-05-21
US9005578B2 (en) 2015-04-14
CN104974024A (zh) 2015-10-14
CA2718035C (en) 2017-10-24
CA2718035A1 (en) 2009-09-24
US20130315827A1 (en) 2013-11-28
MX375108B (es) 2025-03-06
US20210338849A1 (en) 2021-11-04
JP2011515417A (ja) 2011-05-19
EP2268647B1 (en) 2017-01-25
US20150098903A1 (en) 2015-04-09
HK1157323A1 (en) 2012-06-29
MX2010010314A (es) 2011-04-12
US20110060138A1 (en) 2011-03-10
JP6370361B2 (ja) 2018-08-08

Similar Documents

Publication Publication Date Title
US10857247B2 (en) Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders
US8558003B2 (en) Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders
JP2011512354A (ja) 神経機能障害を検知するための新規の造影剤
KR20090007781A (ko) 방사성 표지된 디히드로테트라베나진 유도체 및 조영제로서의 이의 용도
KR101469275B1 (ko) 베타아밀로이드 침착의 영상화를 위한 헤테로사이클릭 인덴계열의 유도체 및 그의 방사성 동위원소 표지화합물
AU2013248197B2 (en) Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders
JP2010520275A (ja) 新規な２−ヘテロアリール置換インドール６９５
AU2016213801A1 (en) Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders
HK1217100B (en) Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
CN102223900A (zh) 用于多巴胺d2受体的成像配体
HK1157323B (en) Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
JP2021102593A (ja) タウを画像化する新規化合物
JP2009203166A (ja) ジフェニルオキサジアゾール誘導体含有診断用組成物

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: THE GENERAL HOSPITAL CORPORATION

Free format text: FORMER OWNER WAS: FLUOROPHARMA, INC.; THE GENERAL HOSPITAL CORPORATION

MK14 Patent ceased section 143(a) (annual fees not paid) or expired