CA2718035C - Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders - Google Patents

Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders Download PDF

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Publication number
CA2718035C
CA2718035C CA2718035A CA2718035A CA2718035C CA 2718035 C CA2718035 C CA 2718035C CA 2718035 A CA2718035 A CA 2718035A CA 2718035 A CA2718035 A CA 2718035A CA 2718035 C CA2718035 C CA 2718035C
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relates
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French (fr)
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CA2718035A1 (en
Inventor
David R. Elmaleh
Timothy Shoup
Hongning Fu
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General Hospital Corp
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General Hospital Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/192—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/253—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/21—Acetic acid esters of hydroxy compounds with more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA2718035A 2008-03-21 2009-03-23 Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders Active CA2718035C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2978149A CA2978149C (en) 2008-03-21 2009-03-23 Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3857108P 2008-03-21 2008-03-21
US61/038,571 2008-03-21
PCT/US2009/037928 WO2009117728A2 (en) 2008-03-21 2009-03-23 Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders

Related Child Applications (1)

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CA2978149A Division CA2978149C (en) 2008-03-21 2009-03-23 Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders

Publications (2)

Publication Number Publication Date
CA2718035A1 CA2718035A1 (en) 2009-09-24
CA2718035C true CA2718035C (en) 2017-10-24

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CA2718035A Active CA2718035C (en) 2008-03-21 2009-03-23 Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders
CA2978149A Active CA2978149C (en) 2008-03-21 2009-03-23 Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders

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US (5) US8450466B2 (enExample)
EP (2) EP3231804B1 (enExample)
JP (3) JP5501339B2 (enExample)
CN (2) CN102046638B (enExample)
AU (1) AU2009225407B2 (enExample)
CA (2) CA2718035C (enExample)
MX (2) MX375108B (enExample)
WO (1) WO2009117728A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
CN102046638B (zh) 2008-03-21 2015-06-03 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
SG188227A1 (en) 2010-08-16 2013-04-30 Cognoptix Inc System and method for detecting amyloid proteins
JP2014505059A (ja) * 2011-01-18 2014-02-27 ジェネラル アトミクス ヒドロラーゼ酵素基質およびその使用
US9855276B2 (en) 2012-10-25 2018-01-02 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
AU2014340182B2 (en) 2013-10-22 2019-05-23 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
ES2946754T3 (es) 2014-03-19 2023-07-25 Amydis Diagnostics Inc Agentes para detección de amiloides y métodos para utilizar los mismos
CA3033079A1 (en) 2016-08-31 2018-03-08 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
US10675365B2 (en) 2016-09-29 2020-06-09 Korea Atomic Energy Research Institute Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque
JP7202376B2 (ja) 2017-07-20 2023-01-11 エーゼットセラピーズ， インコーポレイテッド クロモリンナトリウムおよびイブプロフェンの粉末製剤
MA52796A (fr) 2018-05-31 2021-04-14 Amydis Inc Compositions et procédés de détection d'une lésion cérébrale traumatique
WO2020010049A1 (en) 2018-07-02 2020-01-09 The General Hospital Corporation POWDERED FORMULATIONS OF CROMOLYN SODIUM AND α-LACTOSE
TW202023625A (zh) 2018-08-23 2020-07-01 美商西雅圖遺傳學公司 抗tigit抗體
MX2021006869A (es) 2018-12-10 2021-07-02 Massachusetts Gen Hospital Esteres de cromolin y usos de los mismos.
JP2023520580A (ja) 2020-04-06 2023-05-17 ザ ジェネラル ホスピタル コーポレイション コロナウイルス誘発炎症状態の処置方法
CN116600815A (zh) * 2020-09-17 2023-08-15 株式会社力森诺科 自噬激活剂
KR20240148356A (ko) 2022-02-07 2024-10-11 마틴 제이. 모스코비츠 극저온 수술 장치와 재료 및 그 사용 방법

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1009897A (en) 1911-03-27 1911-11-28 Us Electrographic Company Projection apparatus.
CH375356A (de) 1959-03-25 1964-02-29 Sandoz Ag Verfahren zur Herstellung von neuen substituierten Succinimiden
CH449628A (de) 1962-04-16 1968-01-15 Sandoz Ag Verfahren zur Herstellung substituierter Succinimide
US3207780A (en) * 1962-11-15 1965-09-21 Upjohn Co 1-deoxy-1-guanidino-3-o-carbamoyl-scyllo-inositol and acylates thereof
US4069262A (en) 1977-03-07 1978-01-17 E. I. Du Pont De Nemours And Company Preparation of 2-fluoronitrobenzene
FR2498594A1 (fr) 1981-01-23 1982-07-30 Rhone Poulenc Ind Procede de preparation de monoesters d'acides carboxyliques b,g-insatures
US4446123A (en) 1982-10-13 1984-05-01 Hahnemann University Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
BE900003A (fr) * 1983-06-27 1984-12-27 Sandoz Sa Derives du spirosuccinimide utilisables comme medicaments.
NL8401907A (nl) 1983-06-27 1985-01-16 Sandoz Ag Spirosuccinimiden en werkwijzen voor het bereiden en toepassen van deze spirosuccinimiden.
US4606908A (en) 1983-10-04 1986-08-19 Washington Research Foundation Methods and compositions for plasma and organ imaging
EP0273659A1 (en) * 1986-12-27 1988-07-06 Takeda Chemical Industries, Ltd. Azaspiro compounds, their production and use
US4847082A (en) * 1987-01-21 1989-07-11 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
SE465348B (sv) 1990-06-14 1991-08-26 Nils Elander Mikrovaagsanordning foer behandling av precessvaetskor
US5139034A (en) * 1990-11-15 1992-08-18 Philip Morris Incorporated Smoking compositions containing a menthol-release additive
IT1244546B (it) * 1991-02-01 1994-07-15 Mediolanum Farmaceutici Spa Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica
US5315043A (en) 1992-02-05 1994-05-24 E. I. Du Pont De Nemours And Company Aromatic nucleophilic fluorination
US5264570A (en) * 1992-08-05 1993-11-23 General Electric Company Method for making 2-[18 F]fluoro-2-deoxy-D-glucose
US5493026A (en) 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6001331A (en) 1996-01-24 1999-12-14 Warner-Lambert Company Method of imaging amyloid deposits
JP3816570B2 (ja) * 1996-02-16 2006-08-30 塩水港精糖株式会社 アシル化剤
TW593290B (en) 1996-05-10 2004-06-21 Janssen Pharmaceutica Nv Alkylaminobenzothiazole and -benzoxazole derivatives
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
US5817877A (en) 1996-09-23 1998-10-06 Yale University Metal-catalyzed amination of organic sulfonates to organic amines
US6187286B1 (en) 1996-12-27 2001-02-13 The General Hospital Corporation Tumor imaging agents, methods and kits
AU7723198A (en) 1997-06-04 1998-12-21 University Of Tennessee Research Corporation, The Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
AU9307498A (en) 1997-09-08 1999-03-29 General Hospital Corporation, The Imaging agents for early detection and monitoring of cardiovascular plaque
JP4177472B2 (ja) * 1997-10-02 2008-11-05 株式会社横浜国際バイオ研究所 窒素官能基を含有するアシル化剤及びその製造法
US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6743925B1 (en) 1999-09-13 2004-06-01 Pola Chemical Industries, Inc. Nitroimidazole derivative and diagnostic imaging agent containing the same
EP1294663B1 (en) 2000-06-12 2004-05-06 University of Florida Research Foundation Fluorinated benzene manufacturing process
UY27003A1 (es) 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
WO2002085903A2 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
CN101838289A (zh) 2002-02-06 2010-09-22 约翰·霍普金斯大学 使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
US20080063599A1 (en) 2002-11-18 2008-03-13 Jorge Setoain Quinquer Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
CN100536837C (zh) * 2003-02-27 2009-09-09 乔安妮·麦克劳林 鲨肌醇在制备诊断试剂中的用途
GB0304640D0 (en) 2003-02-28 2003-04-02 Novartis Ag Organic compounds
US7295831B2 (en) 2003-08-12 2007-11-13 3E Technologies International, Inc. Method and system for wireless intrusion detection prevention and security management
WO2005016384A1 (ja) 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
CA2825161C (en) 2004-02-24 2016-10-04 The General Hospital Corporation Catalytic radiofluorination
KR100578732B1 (ko) * 2004-03-05 2006-05-12 학교법인 포항공과대학교 분자 수송체로서의 이노시톨 유도체 및 이의 제조방법
CA2586220A1 (en) 2004-11-05 2006-05-18 Wyeth Pet and magnetic resonance for screening alzheimer's disease therapeutics
WO2006053428A1 (en) 2004-11-17 2006-05-26 Joanne Mclaurin Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation
US7138540B1 (en) 2005-09-06 2006-11-21 Institute Of Nuclear Energy Research Convenient method for the preparation of new precursor of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine)
US20090170957A1 (en) * 2005-10-13 2009-07-02 Antonio Cruz Scyllo-inositol derivatives and their use in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
JP2007194369A (ja) * 2006-01-18 2007-08-02 Toei Kogyo Kk 高出力Ｅｒ：ＹＡＧレーザ装置
NO325976B1 (no) * 2006-01-26 2008-08-25 Gba Marine As Anordning for absorpsjon av gass eller damp i vaeske og fremgangsmate ved reintrodusering av damp eller gass i vaeske som gassen eller dampen stammer fra
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
CA2679514A1 (en) 2007-03-01 2008-09-04 Bayer Schering Pharma Aktiengesellschaft 18f fluoro-benzoyl labelled biologically active compounds as diagnostic imaging agents as well as benzotriazol-1-yloxy-benzoyl, 2,5-dioxo-pyrrolidin-1-yloxy-benzoyl and trimethylammonio-benzoyl precursers
JPWO2009014203A1 (ja) * 2007-07-26 2010-10-07 北興化学工業株式会社 （１，３，５／２，４，６）−１−フルオロ−２，３，４，５，６−シクロヘキサンペントールの製造方法
CN102046638B (zh) * 2008-03-21 2015-06-03 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
CN102292461A (zh) 2008-12-22 2011-12-21 拜耳先灵医药股份有限公司 使用交换树脂合成放射性核素标记的化合物的方法
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
WO2014052454A1 (en) 2012-09-25 2014-04-03 The Regents Of The University Of Michigan Imaging agents
WO2016070074A1 (en) 2014-10-31 2016-05-06 The General Hospital Corporation F-18 labeled tracer and methods of manufacture

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Publication number Publication date
CN104974024A (zh) 2015-10-14
US9005578B2 (en) 2015-04-14
JP2017075173A (ja) 2017-04-20
EP2268647A4 (en) 2011-05-18
JP6370361B2 (ja) 2018-08-08
EP2268647A2 (en) 2011-01-05
CN102046638A (zh) 2011-05-04
CA2718035A1 (en) 2009-09-24
CN104974024B (zh) 2017-11-14
US20110060138A1 (en) 2011-03-10
US10857247B2 (en) 2020-12-08
JP5501339B2 (ja) 2014-05-21
HK1157323A1 (en) 2012-06-29
JP2014177457A (ja) 2014-09-25
US8450466B2 (en) 2013-05-28
WO2009117728A2 (en) 2009-09-24
AU2009225407B2 (en) 2013-09-05
CN102046638B (zh) 2015-06-03
JP2011515417A (ja) 2011-05-19
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US20150098903A1 (en) 2015-04-09
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US20210338849A1 (en) 2021-11-04
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