CN104974024A - 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 - Google Patents
检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 Download PDFInfo
- Publication number
- CN104974024A CN104974024A CN201510221345.4A CN201510221345A CN104974024A CN 104974024 A CN104974024 A CN 104974024A CN 201510221345 A CN201510221345 A CN 201510221345A CN 104974024 A CN104974024 A CN 104974024A
- Authority
- CN
- China
- Prior art keywords
- compound
- present
- certain embodiments
- definition
- enclosing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*P(N(*)*)(OC)=O Chemical compound C*P(N(*)*)(OC)=O 0.000 description 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/192—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/253—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/21—Acetic acid esters of hydroxy compounds with more than three hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3857108P | 2008-03-21 | 2008-03-21 | |
US61/038571 | 2008-03-21 | ||
CN200980119032.0A CN102046638B (zh) | 2008-03-21 | 2009-03-23 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980119032.0A Division CN102046638B (zh) | 2008-03-21 | 2009-03-23 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104974024A true CN104974024A (zh) | 2015-10-14 |
CN104974024B CN104974024B (zh) | 2017-11-14 |
Family
ID=41091569
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510221345.4A Active CN104974024B (zh) | 2008-03-21 | 2009-03-23 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
CN200980119032.0A Active CN102046638B (zh) | 2008-03-21 | 2009-03-23 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980119032.0A Active CN102046638B (zh) | 2008-03-21 | 2009-03-23 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
Country Status (9)
Country | Link |
---|---|
US (5) | US8450466B2 (zh) |
EP (2) | EP3231804B1 (zh) |
JP (3) | JP5501339B2 (zh) |
CN (2) | CN104974024B (zh) |
AU (1) | AU2009225407B2 (zh) |
CA (2) | CA2718035C (zh) |
HK (2) | HK1157323A1 (zh) |
MX (1) | MX2010010314A (zh) |
WO (1) | WO2009117728A2 (zh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
CN104974024B (zh) * | 2008-03-21 | 2017-11-14 | 综合医院公司 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
NZ607257A (en) * | 2010-08-16 | 2015-02-27 | Cognoptix Inc | System and method for detecting amyloid proteins |
CA2824858A1 (en) | 2011-01-18 | 2012-07-26 | General Atomics | Hydrolase enzyme substrates and uses thereof |
EP3563849A3 (en) | 2012-10-25 | 2020-02-12 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
CA2928028A1 (en) | 2013-10-22 | 2015-04-30 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
CA2942975C (en) * | 2014-03-19 | 2023-08-29 | Amydis Diagnostics, Inc. | Substituted acrylamide and substituted ethenesulfonamide derivatives and pharmaceutical compositions thereof useful as amyloid targeting agents |
CN116889562A (zh) | 2016-08-31 | 2023-10-17 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
WO2018062588A1 (ko) | 2016-09-29 | 2018-04-05 | 한국원자력연구원 | 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제 |
AU2017423862A1 (en) | 2017-07-20 | 2020-02-06 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and ibuprofen |
AU2019299347A1 (en) | 2018-07-02 | 2021-01-21 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and alpha-lactose |
MX2021002002A (es) | 2018-08-23 | 2021-05-31 | Seagen Inc | Anticuerpos anti inmunorreceptor de celulas t con dominios ig y motivo inhibidor inmunorreceptor basado en tirosina (tigit). |
WO2023150739A2 (en) * | 2022-02-07 | 2023-08-10 | Moskovitz Martin J | Cryo-surgical device and materials and method of use thereof |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1009897A (en) | 1911-03-27 | 1911-11-28 | Us Electrographic Company | Projection apparatus. |
CH375356A (de) | 1959-03-25 | 1964-02-29 | Sandoz Ag | Verfahren zur Herstellung von neuen substituierten Succinimiden |
CH449628A (de) | 1962-04-16 | 1968-01-15 | Sandoz Ag | Verfahren zur Herstellung substituierter Succinimide |
US3207780A (en) * | 1962-11-15 | 1965-09-21 | Upjohn Co | 1-deoxy-1-guanidino-3-o-carbamoyl-scyllo-inositol and acylates thereof |
US4069262A (en) | 1977-03-07 | 1978-01-17 | E. I. Du Pont De Nemours And Company | Preparation of 2-fluoronitrobenzene |
FR2498594A1 (fr) | 1981-01-23 | 1982-07-30 | Rhone Poulenc Ind | Procede de preparation de monoesters d'acides carboxyliques b,g-insatures |
US4446123A (en) | 1982-10-13 | 1984-05-01 | Hahnemann University | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
NL8401907A (nl) | 1983-06-27 | 1985-01-16 | Sandoz Ag | Spirosuccinimiden en werkwijzen voor het bereiden en toepassen van deze spirosuccinimiden. |
BE900003A (fr) * | 1983-06-27 | 1984-12-27 | Sandoz Sa | Derives du spirosuccinimide utilisables comme medicaments. |
US4606908A (en) | 1983-10-04 | 1986-08-19 | Washington Research Foundation | Methods and compositions for plasma and organ imaging |
EP0273659A1 (en) * | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiro compounds, their production and use |
US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
SE465348B (sv) | 1990-06-14 | 1991-08-26 | Nils Elander | Mikrovaagsanordning foer behandling av precessvaetskor |
US5139034A (en) * | 1990-11-15 | 1992-08-18 | Philip Morris Incorporated | Smoking compositions containing a menthol-release additive |
IT1244546B (it) * | 1991-02-01 | 1994-07-15 | Mediolanum Farmaceutici Spa | Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica |
US5315043A (en) | 1992-02-05 | 1994-05-24 | E. I. Du Pont De Nemours And Company | Aromatic nucleophilic fluorination |
US5264570A (en) * | 1992-08-05 | 1993-11-23 | General Electric Company | Method for making 2-[18 F]fluoro-2-deoxy-D-glucose |
US5493026A (en) | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
US6168776B1 (en) | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
WO1997026919A2 (en) | 1996-01-24 | 1997-07-31 | Warner-Lambert Company | Method of imaging amyloid deposits |
JP3816570B2 (ja) * | 1996-02-16 | 2006-08-30 | 塩水港精糖株式会社 | アシル化剤 |
TW593290B (en) | 1996-05-10 | 2004-06-21 | Janssen Pharmaceutica Nv | Alkylaminobenzothiazole and -benzoxazole derivatives |
DE19624705A1 (de) * | 1996-06-20 | 1998-01-08 | Deutsches Krebsforsch | Dendrimere auf Saccharid-Basis |
US5817877A (en) | 1996-09-23 | 1998-10-06 | Yale University | Metal-catalyzed amination of organic sulfonates to organic amines |
US6187286B1 (en) | 1996-12-27 | 2001-02-13 | The General Hospital Corporation | Tumor imaging agents, methods and kits |
WO1998055153A1 (en) | 1997-06-04 | 1998-12-10 | The University Of Tennessee Research Corporation | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
EP1011738A1 (en) | 1997-09-08 | 2000-06-28 | The General Hospital Corporation | Imaging agents for early detection of cardiovascular plaque |
JP4177472B2 (ja) * | 1997-10-02 | 2008-11-05 | 株式会社横浜国際バイオ研究所 | 窒素官能基を含有するアシル化剤及びその製造法 |
US6660832B1 (en) | 1999-08-20 | 2003-12-09 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds and preparation methods thereof |
EP1218351B1 (en) | 1999-09-13 | 2005-04-20 | Pola Chemical Industries, Inc. | Nitroimidazole derivative and diagnostic imaging agent containing the same |
ATE265994T1 (de) | 2000-06-12 | 2004-05-15 | Univ Florida | Verfahren zur herstellung von fluorierten benzolen |
UY27003A1 (es) | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
CN100422180C (zh) | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
CA2474142C (en) | 2002-02-06 | 2013-02-05 | The Johns Hopkins University | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
DE10210195B4 (de) * | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
US20080063599A1 (en) | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
CN101385722A (zh) * | 2003-02-27 | 2009-03-18 | 乔安妮·麦克劳林 | 预防、治疗和诊断蛋白聚集疾病的方法 |
US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
GB0304640D0 (en) | 2003-02-28 | 2003-04-02 | Novartis Ag | Organic compounds |
US7295831B2 (en) | 2003-08-12 | 2007-11-13 | 3E Technologies International, Inc. | Method and system for wireless intrusion detection prevention and security management |
AU2003304416A1 (en) | 2003-08-13 | 2005-03-07 | Bf Research Institute, Inc. | Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change |
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
AU2005216949B2 (en) | 2004-02-24 | 2011-09-22 | The General Hospital Corporation | Catalytic radiofluorination |
KR100578732B1 (ko) * | 2004-03-05 | 2006-05-12 | 학교법인 포항공과대학교 | 분자 수송체로서의 이노시톨 유도체 및 이의 제조방법 |
AU2005304931A1 (en) * | 2004-11-05 | 2006-05-18 | Wyeth | Pet and magnetic resonance for screening Alzheimer's disease therapeutics |
JP2008520589A (ja) | 2004-11-17 | 2008-06-19 | ジョアン マクローリン, | シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 |
US7138540B1 (en) | 2005-09-06 | 2006-11-21 | Institute Of Nuclear Energy Research | Convenient method for the preparation of new precursor of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine) |
JP2009511568A (ja) | 2005-10-13 | 2009-03-19 | ワラタ ファーマシューティカルズ, インコーポレイテッド | イノシトール誘導体、ならびに異常なタンパク質の折りたたみまたは凝集、あるいはアミロイドの形成、沈着、蓄積または残存を特徴とする疾患の処置におけるその使用 |
JP2007194369A (ja) * | 2006-01-18 | 2007-08-02 | Toei Kogyo Kk | 高出力Er:YAGレーザ装置 |
NO325976B1 (no) * | 2006-01-26 | 2008-08-25 | Gba Marine As | Anordning for absorpsjon av gass eller damp i vaeske og fremgangsmate ved reintrodusering av damp eller gass i vaeske som gassen eller dampen stammer fra |
US20070197452A1 (en) * | 2006-02-17 | 2007-08-23 | Mclaurin Joanne | Treatment of amyloid-related diseases |
AU2007348145A1 (en) | 2007-03-01 | 2008-09-04 | Bayer Schering Pharma Aktiengesellschaft | 18F fluoro-benzoyl labelled biological active coumpounds as diagnositic imaging agents as well as benzotriazol-1-yloxy-benzoyl, 2,5-dioxo-pyrrolidin-1-yloxy) benzoyl and trimethylammonio-benzoyl precursers |
WO2009014203A1 (ja) * | 2007-07-26 | 2009-01-29 | Hokko Chemical Industry Co., Ltd. | (1,3,5/2,4,6)-1-フルオロ-2,3,4,5,6-シクロヘキサンペントールの製造方法 |
CN104974024B (zh) | 2008-03-21 | 2017-11-14 | 综合医院公司 | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 |
CN102292461A (zh) | 2008-12-22 | 2011-12-21 | 拜耳先灵医药股份有限公司 | 使用交换树脂合成放射性核素标记的化合物的方法 |
GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
WO2014052454A1 (en) | 2012-09-25 | 2014-04-03 | The Regents Of The University Of Michigan | Imaging agents |
WO2016070074A1 (en) | 2014-10-31 | 2016-05-06 | The General Hospital Corporation | F-18 labeled tracer and methods of manufacture |
-
2009
- 2009-03-23 CN CN201510221345.4A patent/CN104974024B/zh active Active
- 2009-03-23 US US12/933,139 patent/US8450466B2/en active Active
- 2009-03-23 AU AU2009225407A patent/AU2009225407B2/en active Active
- 2009-03-23 JP JP2011501009A patent/JP5501339B2/ja active Active
- 2009-03-23 EP EP17152886.2A patent/EP3231804B1/en active Active
- 2009-03-23 CN CN200980119032.0A patent/CN102046638B/zh active Active
- 2009-03-23 MX MX2010010314A patent/MX2010010314A/es active IP Right Grant
- 2009-03-23 EP EP09723502.2A patent/EP2268647B1/en active Active
- 2009-03-23 CA CA2718035A patent/CA2718035C/en active Active
- 2009-03-23 WO PCT/US2009/037928 patent/WO2009117728A2/en active Application Filing
- 2009-03-23 CA CA2978149A patent/CA2978149C/en active Active
-
2011
- 2011-10-24 HK HK11111431.1A patent/HK1157323A1/zh unknown
-
2013
- 2013-05-28 US US13/903,362 patent/US9005578B2/en active Active
-
2014
- 2014-03-10 JP JP2014046341A patent/JP6140090B2/ja active Active
- 2014-12-15 US US14/569,855 patent/US20150098903A1/en not_active Abandoned
-
2016
- 2016-04-11 HK HK16104068.1A patent/HK1217100A1/zh unknown
- 2016-12-22 JP JP2016249232A patent/JP6370361B2/ja active Active
-
2019
- 2019-08-29 US US16/555,290 patent/US10857247B2/en active Active
-
2020
- 2020-12-08 US US17/115,344 patent/US20210338849A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102046638B (zh) | 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物 | |
EP2852572B1 (en) | Carboline and carbazole based imaging agents for detecting neurological dysfunction | |
CA2715390A1 (en) | Imaging agents for detecting neurological dysfunction | |
EP2436666B1 (en) | Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of alzheimer 's disease | |
EP2501696A2 (en) | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases | |
CN105358558A (zh) | 作为tau-pet-配体的二氮杂咔唑衍生物 | |
WO2008134618A2 (en) | Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders | |
BRPI0808503B1 (pt) | Composto, uso de um composto, e, composição farmacêutica | |
WO2008065785A1 (fr) | Nouveau composé ayant une affinité pour l'amyloïde | |
CN104478862A (zh) | 适于作为用于对淀粉样沉积物成像的化合物的前体的新的苯并呋喃 | |
JP5954737B2 (ja) | 放射性フッ素標識キノキサリン化合物 | |
JP2016534145A (ja) | Pbrリガンドとしての四環式インドール誘導体のs−エナンチオマー | |
AU2013248197B2 (en) | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders | |
AU2016213801A1 (en) | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders | |
JP2021102593A (ja) | タウを画像化する新規化合物 | |
JPH02286662A (ja) | ドーパミン受容体リガンド及び結像剤 | |
EP3377058A1 (en) | Formulations for 2-heteroaryl substituted benzofurans |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1217100 Country of ref document: HK |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20161216 Address after: Massachusetts, USA Applicant after: The General Hospital Corporation Address before: Massachusetts, USA Applicant before: The General Hospital Corporation Applicant before: Fluoropharma Inc. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1217100 Country of ref document: HK |